Starting NMTRAN
  
 WARNINGS AND ERRORS (IF ANY) FOR PROBLEM    1
             
 (WARNING  2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
             
 (WARNING  23) $PK DOES NOT DEFINE A SCALE PARAMETER FOR THE CENTRAL
 COMPARTMENT.  WITH THIS TRANS, IT MAY NOT BE POSSIBLE TO SEPARATELY
 OBTAIN ESTIMATES OF PARAMETERS AFFECTING CLEARANCE AND VOLUME.
Recompiling certain components
Building NONMEM Executable
Starting nonmem execution ...
License Registered to: Uppsala University Dept of Pharmacy
Expiration Date:    14 MAR 2023
Current Date:        7 OCT 2022
Days until program expires : 162


 First Order
 MONITORING OF SEARCH:


0ITERATION NO.:    0    OBJECTIVE VALUE:  -1289.10024188735        NO. OF FUNC. EVALS.:   8
 CUMULATIVE NO. OF FUNC. EVALS.:        8
 NPARAMETR:  2.4533E+01  1.0423E+02  4.3368E-01  2.4533E+01  5.2115E+00  4.8186E-01  5.9365E-01  1.0000E-02  2.0997E-01
 PARAMETER:  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01
 GRADIENT:  -7.3245E+01  1.2346E+02  1.0013E+01  1.4826E+00  6.2055E+00  1.7603E-01 -2.6350E+01 -1.4048E+00 -1.5641E+01

0ITERATION NO.:   30    OBJECTIVE VALUE:  -1307.30123487968        NO. OF FUNC. EVALS.: 302
 CUMULATIVE NO. OF FUNC. EVALS.:      310
 NPARAMETR:  2.4006E+01  5.9115E+01  8.4250E-01  4.7804E+01  3.3852E+01  4.7053E-01  1.5153E+00  2.0537E-01  1.9344E-01
 PARAMETER:  7.8284E-02 -4.6712E-01  7.6407E-01  7.6713E-01  1.9711E+00  8.8106E-02  5.6852E-01  1.6111E+00  5.8994E-02
 GRADIENT:  -7.8157E-03  2.4847E-02  2.1899E-02  6.6946E-03  1.0197E-02  4.8441E-03 -9.7808E-03  7.0317E-04 -1.9044E-02
 Elapsed estimation  time in seconds:     0.33
 Elapsed postprocess time in seconds:     0.02
 Elapsed finaloutput time in seconds:     0.04
Done with nonmem execution
