@prefix Aeolus: <http://translator.ncats.nih.gov/Aeolus_> .
@prefix CHADO: <http://gmod.org/wiki/Chado/> .
@prefix CHEMBL.MECHANISM: <https://www.ebi.ac.uk/chembl/mechanism/inspect/> .
@prefix CPT: <https://www.ama-assn.org/practice-management/cpt/> .
@prefix CTD: <http://translator.ncats.nih.gov/CTD_> .
@prefix DGIdb: <https://www.dgidb.org/interaction_types> .
@prefix DrugCentral: <http://translator.ncats.nih.gov/DrugCentral_> .
@prefix ECTO: <http://purl.obolibrary.org/obo/ECTO_> .
@prefix EDAM-DATA: <http://edamontology.org/data_> .
@prefix EFO: <http://www.ebi.ac.uk/efo/EFO_> .
@prefix ExO: <http://purl.obolibrary.org/obo/ExO_> .
@prefix GAMMA: <http://translator.renci.org/GAMMA_> .
@prefix GOP: <http://purl.obolibrary.org/obo/go#> .
@prefix GOREL: <http://purl.obolibrary.org/obo/GOREL_> .
@prefix GTEx: <https://www.gtexportal.org/home/gene/> .
@prefix HANCESTRO: <http://www.ebi.ac.uk/ancestro/ancestro_> .
@prefix HCPCS: <http://purl.bioontology.org/ontology/HCPCS/> .
@prefix HsapDv: <http://purl.obolibrary.org/obo/HsapDv_> .
@prefix IAO: <http://purl.obolibrary.org/obo/IAO_> .
@prefix LOINC: <http://loinc.org/rdf/> .
@prefix MI: <http://purl.obolibrary.org/obo/MI_> .
@prefix NDDF: <http://purl.bioontology.org/ontology/NDDF/> .
@prefix OBAN: <http://purl.org/oban/> .
@prefix OIO: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix ORPHA: <http://www.orpha.net/ORDO/Orphanet_> .
@prefix PATO-PROPERTY: <http://purl.obolibrary.org/obo/pato#> .
@prefix PDQ: <https://www.cancer.gov/publications/pdq#> .
@prefix PHAROS: <http://pharos.nih.gov> .
@prefix PathWhiz: <http://smpdb.ca/pathways/#> .
@prefix REPODB: <http://apps.chiragjpgroup.org/repoDB/> .
@prefix RO: <http://purl.obolibrary.org/obo/RO_> .
@prefix RTXKG1: <http://kg1endpoint.rtx.ai/> .
@prefix RXNORM: <http://purl.bioontology.org/ontology/RXNORM/> .
@prefix SEMMEDDB: <https://skr3.nlm.nih.gov/SemMedDB> .
@prefix SIO: <http://semanticscience.org/resource/SIO_> .
@prefix SNPEFF: <http://translator.ncats.nih.gov/SNPEFF_> .
@prefix UBERGRAPH: <http://translator.renci.org/ubergraph-axioms.ofn#> .
@prefix UBERON_CORE: <http://purl.obolibrary.org/obo/uberon/core#> .
@prefix UMLSSC: <https://metamap.nlm.nih.gov/Docs/SemanticTypes_2018AB.txt/code#> .
@prefix UMLSSG: <https://metamap.nlm.nih.gov/Docs/SemGroups_2018.txt/group#> .
@prefix UMLSST: <https://metamap.nlm.nih.gov/Docs/SemanticTypes_2018AB.txt/type#> .
@prefix VANDF: <https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/VANDF/> .
@prefix VMC: <https://github.com/ga4gh/vr-spec/> .
@prefix WBVocab: <http://bio2rdf.org/wormbase_vocabulary> .
@prefix WIKIDATA: <https://www.wikidata.org/wiki/> .
@prefix WIKIDATA_PROPERTY: <https://www.wikidata.org/wiki/Property:> .
@prefix alliancegenome: <https://www.alliancegenome.org/> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix chembio: <http://translator.ncats.nih.gov/chembio_> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dcmitype: <http://purl.org/dc/dcmitype/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix gff3: <https://github.com/The-Sequence-Ontology/Specifications/blob/master/gff3.md#> .
@prefix gpi: <https://github.com/geneontology/go-annotation/blob/master/specs/gpad-gpi-2-0.md#> .
@prefix hetio: <http://translator.ncats.nih.gov/hetio_> .
@prefix linkml: <https://w3id.org/linkml/> .
@prefix oboformat: <http://www.geneontology.org/formats/oboInOWL#> .
@prefix os: <https://github.com/cmungall/owlstar/blob/master/owlstar.ttl> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix qud: <http://qudt.org/1.1/schema/qudt#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema1: <http://schema.org/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix wgs: <http://www.w3.org/2003/01/geo/wgs84_pos> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://w3id.org/biolink/biolink-model> a owl:Ontology ;
    rdfs:label "Biolink-Model" ;
    IAO:0000700 biolink:Annotation,
        biolink:CaseToEntityAssociationMixin,
        biolink:CellLineToEntityAssociationMixin,
        biolink:ChemicalOrDrugOrTreatment,
        biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin,
        biolink:DiseaseToEntityAssociationMixin,
        biolink:Entity,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin,
        biolink:EntityToExposureEventAssociationMixin,
        biolink:EntityToOutcomeAssociationMixin,
        biolink:ExposureEvent,
        biolink:ExposureEventToEntityAssociationMixin,
        biolink:FrequencyQualifierMixin,
        biolink:GeneExpressionMixin,
        biolink:GeneGroupingMixin,
        biolink:GeneToEntityAssociationMixin,
        biolink:GenotypeToEntityAssociationMixin,
        biolink:MacromolecularMachineMixin,
        biolink:MacromolecularMachineToEntityAssociationMixin,
        biolink:MaterialSampleToEntityAssociationMixin,
        biolink:Mixture,
        biolink:ModelToDiseaseAssociationMixin,
        biolink:MolecularEntityToEntityAssociationMixin,
        biolink:OntologyClass,
        biolink:OrganismTaxonToEntityAssociation,
        biolink:Outcome,
        biolink:PathologicalEntityMixin,
        biolink:PhysicalEssenceOrOccurrent,
        biolink:RelationshipQuantifier,
        biolink:SubjectOfInvestigation,
        biolink:ThingWithTaxon,
        biolink:VariantToEntityAssociationMixin ;
    dct:license "https://creativecommons.org/publicdomain/zero/1.0/" ;
    pav:version "1.8.2" ;
    skos:definition "Entity and association taxonomy and datamodel for life-sciences data" ;
    linkml:generation_date "2022-01-05T01:09:09" ;
    linkml:metamodel_version "1.7.0" ;
    linkml:source_file "biolink-model.yaml" ;
    linkml:source_file_date "2022-01-05T01:06:03" ;
    linkml:source_file_size 267853 .

biolink:Activity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "activity" ;
    rdfs:subClassOf biolink:ActivityAndBehavior,
        biolink:NamedThing ;
    skos:definition "An activity is something that occurs over a period of time and acts upon or with entities; it may include consuming, processing, transforming, modifying, relocating, using, or generating entities." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C43431>,
        prov:Activity,
        UMLSSC:T052,
        UMLSST:acty ;
    skos:narrowMatch UMLSSC:T056,
        UMLSSC:T057,
        UMLSSC:T058,
        UMLSSC:T062,
        UMLSSC:T064,
        UMLSSC:T065,
        UMLSSC:T066,
        UMLSST:dora,
        UMLSST:edac,
        UMLSST:gora,
        UMLSST:hlca,
        UMLSST:mcha,
        UMLSST:ocac,
        UMLSST:resa .

biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "anatomical entity to anatomical entity ontogenic association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    skos:definition "A relationship between two anatomical entities where the relationship is ontogenic, i.e. the two entities are related by development. A number of different relationship types can be used to specify the precise nature of the relationship." .

biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "anatomical entity to anatomical entity part of association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    skos:definition "A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood. This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms" .

biolink:Article a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "article" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:onClass linkml:Uriorcurie ;
            owl:onProperty biolink:published_in ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:issue ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:iso_abbreviation ],
        biolink:Publication .

biolink:BehaviorToBehavioralFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "behavior to behavioral feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:BehavioralFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:Behavior ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    skos:definition "An association between an aggregate behavior and a behavioral feature manifested by the individual exhibited or has exhibited the behavior." .

biolink:BehavioralExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "behavioral exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Behavior,
        biolink:ExposureEvent ;
    skos:definition "A behavioral exposure is a factor relating to behavior impacting an individual." .

biolink:BehavioralOutcome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "behavioral outcome" ;
    rdfs:subClassOf biolink:Behavior,
        biolink:Outcome ;
    skos:definition "An outcome resulting from an exposure event which is the manifestation of human behavior." .

biolink:BioticExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "biotic exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:ExposureEvent,
        biolink:OrganismTaxon ;
    skos:altLabel "bacterial exposure",
        "viral exposure" ;
    skos:definition "An external biotic exposure is an intake of (sometimes pathological) biological organisms (including viruses)." .

biolink:Book a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "book" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty rdf:type ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        biolink:Publication ;
    skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." .

biolink:Carbohydrate a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "carbohydrate" ;
    rdfs:subClassOf biolink:ChemicalSubstance ;
    skos:exactMatch UMLSSC:T088,
        UMLSST:crbs .

biolink:CaseToPhenotypicFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "case to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        biolink:Association,
        biolink:CaseToEntityAssociationMixin,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    skos:definition "An association between a case (e.g. individual patient) and a phenotypic feature in which the individual has or has had the phenotype." .

biolink:Cell a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "cell" ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CL_0000000>,
        <http://purl.obolibrary.org/obo/GO_0005623>,
        SIO:010001,
        UMLSSC:T025,
        UMLSST:cell,
        WIKIDATA:Q7868 .

biolink:CellLineAsAModelOfDiseaseAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "cell line as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:CellLine ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin .

biolink:ChemicalToChemicalDerivationAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "chemical to chemical derivation association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:MacromolecularMachineMixin ;
            owl:onProperty biolink:catalyst_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:ChemicalSubstance ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:ChemicalSubstance ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:ChemicalToChemicalAssociation ;
    skos:definition """A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction:
  IF
  R has-input C1 AND
  R has-output C2 AND
  R enabled-by P AND
  R type Reaction
  THEN
  C1 derives-into C2 <<catalyst qualifier P>>""" .

biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "chemical to disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:ChemicalToEntityAssociationMixin,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    skos:definition "An interaction between a chemical entity and a phenotype or disease, where the presence of the chemical gives rise to or exacerbates the phenotype." ;
    skos:narrowMatch SIO:000993 .

biolink:ChemicalToGeneAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "chemical to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:ChemicalToEntityAssociationMixin ;
    skos:definition "An interaction between a chemical entity and a gene or gene product." ;
    skos:exactMatch SIO:001257 .

biolink:ChemicalToPathwayAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "chemical to pathway association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Pathway ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:ChemicalToEntityAssociationMixin ;
    skos:definition "An interaction between a chemical entity and a biological process or pathway." ;
    skos:exactMatch SIO:001250 .

biolink:ClinicalFinding a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "clinical finding" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ClinicalAttribute ;
            owl:onProperty biolink:has_attribute ],
        biolink:PhenotypicFeature ;
    skos:definition "this category is currently considered broad enough to tag clinical lab measurements and other biological attributes taken as 'clinical traits' with some statistical score, for example, a p value in genetic associations." .

biolink:ClinicalMeasurement a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "clinical measurement" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:has_attribute_type ;
            owl:qualifiedCardinality 1 ],
        biolink:ClinicalAttribute ;
    skos:definition "A clinical measurement is a special kind of attribute which results from a laboratory observation from a subject individual or sample. Measurements can be connected to their subject by the 'has attribute' slot." ;
    skos:exactMatch EFO:0001444 .

biolink:ClinicalTrial a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "clinical trial" ;
    rdfs:subClassOf biolink:ClinicalEntity .

biolink:Cohort a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "cohort" ;
    rdfs:subClassOf biolink:StudyPopulation ;
    skos:definition "A group of people banded together or treated as a group who share common characteristics. A cohort 'study' is a particular form of longitudinal study that samples a cohort, performing a cross-section at intervals through time." ;
    skos:exactMatch WIKIDATA:Q1303415 ;
    skos:narrowMatch UMLSSC:T097,
        UMLSSC:T099,
        UMLSSC:T100,
        UMLSSC:T101,
        UMLSST:aggp,
        UMLSST:famg,
        UMLSST:podg,
        UMLSST:prog .

biolink:ComplexChemicalExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "complex chemical exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalSubstance ;
            owl:onProperty biolink:has_constituent ],
        biolink:ChemicalExposure,
        biolink:Mixture ;
    skos:definition "A complex chemical exposure is an intake of a chemical mixture (e.g. gasoline), other than a drug." .

biolink:ContributorAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "contributor association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Agent ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:InformationContentEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:qualifiers ],
        biolink:Association ;
    skos:definition "Any association between an entity (such as a publication) and various agents that contribute to its realisation" .

biolink:DiseaseOrPhenotypicFeatureAssociationToLocationAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease or phenotypic feature association to location association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin .

biolink:DiseaseOrPhenotypicFeatureExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease or phenotypic feature exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:DiseaseOrPhenotypicFeature,
        biolink:ExposureEvent,
        biolink:PathologicalEntityMixin ;
    skos:definition "A disease or phenotypic feature state, when viewed as an exposure, represents an precondition, leading to or influencing an outcome, e.g. HIV predisposing an individual to infections; a relative deficiency of skin pigmentation predisposing an individual to skin cancer." .

biolink:DiseaseOrPhenotypicFeatureOutcome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease or phenotypic feature outcome" ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeature,
        biolink:Outcome ;
    skos:definition "Physiological outcomes resulting from an exposure event which is the manifestation of a disease or other characteristic phenotype." .

biolink:DiseaseOrPhenotypicFeatureToLocationAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease or phenotypic feature to location association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    skos:definition "An association between either a disease or a phenotypic feature and an anatomical entity, where the disease/feature manifests in that site." .

biolink:DiseaseToExposureEventAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease to exposure event association" ;
    rdfs:subClassOf biolink:Association,
        biolink:DiseaseToEntityAssociationMixin,
        biolink:EntityToExposureEventAssociationMixin ;
    skos:definition "An association between an exposure event and a disease." .

biolink:DiseaseToPhenotypicFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        biolink:Association,
        biolink:DiseaseToEntityAssociationMixin,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    skos:definition "An association between a disease and a phenotypic feature in which the phenotypic feature is associated with the disease in some way." .

biolink:DrugToGeneAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "drug to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:DrugToEntityAssociationMixin ;
    skos:definition "An interaction between a drug and a gene or gene product." ;
    skos:relatedMatch SIO:001257 .

biolink:DrugToGeneInteractionExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "drug to gene interaction exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        biolink:DrugExposure,
        biolink:GeneGroupingMixin ;
    skos:definition "drug to gene interaction exposure is a drug exposure is where the interactions of the drug with specific genes are known to constitute an 'exposure' to the organism, leading to or influencing an outcome." .

biolink:EnvironmentalExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "environmental exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:EnvironmentalProcess,
        biolink:ExposureEvent ;
    skos:definition "A environmental exposure is a factor relating to abiotic processes in the environment including sunlight (UV-B), atmospheric (heat, cold, general pollution) and water-born contaminants." .

biolink:EnvironmentalFeature a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "environmental feature" ;
    rdfs:subClassOf biolink:PlanetaryEntity ;
    skos:exactMatch <http://purl.obolibrary.org/obo/ENVO_01000254> .

biolink:EnvironmentalFoodContaminant a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "environmental food contaminant" ;
    rdfs:subClassOf biolink:ChemicalSubstance ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_78299> .

biolink:EpidemiologicalOutcome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "epidemiological outcome" ;
    rdfs:subClassOf biolink:BiologicalEntity,
        biolink:Outcome ;
    skos:definition "An epidemiological outcome, such as societal disease burden, resulting from an exposure event." ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/NCIT_C19291> .

biolink:ExonToTranscriptRelationship a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "exon to transcript relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Transcript ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Exon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:SequenceFeatureRelationship ;
    skos:definition "A transcript is formed from multiple exons" .

biolink:ExposureEventToOutcomeAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "exposure event to outcome association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty biolink:has_population_context ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:has_temporal_context ],
        biolink:Association,
        biolink:EntityToOutcomeAssociationMixin,
        biolink:ExposureEventToEntityAssociationMixin ;
    skos:definition "An association between an exposure event and an outcome." .

biolink:ExposureEventToPhenotypicFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "exposure event to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:ExposureEvent ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    skos:definition "Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype." .

biolink:Food a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "food" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalSubstance ;
            owl:onProperty biolink:has_constituent ],
        biolink:Mixture,
        biolink:MolecularEntity ;
    skos:definition "A substance consumed by a living organism as a source of nutrition" ;
    skos:exactMatch UMLSSC:T168,
        UMLSST:food .

biolink:FoodAdditive a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "food additive" ;
    rdfs:subClassOf biolink:ChemicalSubstance ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_64047> .

biolink:FoodComponent a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "food component" ;
    rdfs:subClassOf biolink:ChemicalSubstance ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_78295> .

biolink:GeneAsAModelOfDiseaseAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToDiseaseAssociationMixin,
        biolink:GeneToDiseaseAssociation,
        biolink:ModelToDiseaseAssociationMixin .

biolink:GeneFamily a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene family" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        biolink:GeneGroupingMixin,
        biolink:MolecularEntity ;
    skos:altLabel "orthogroup",
        "protein family" ;
    skos:definition "any grouping of multiple genes or gene products related by common descent" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C26004>,
        WIKIDATA:Q2278983 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C20130>,
        SIO:001380,
        WIKIDATA:Q417841 .

biolink:GeneHasVariantThatContributesToDiseaseAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene has variant that contributes to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty biolink:sequence_variant_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:GeneToDiseaseAssociation .

biolink:GeneRegulatoryRelationship a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene regulatory relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "A regulatory relationship between two genes" .

biolink:GeneToExpressionSiteAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene to expression site association" ;
    rdfs:seeAlso "https://github.com/monarch-initiative/ingest-artifacts/tree/master/sources/BGee" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "An association between a gene and an expression site, possibly qualified by stage/timing info." ;
    skos:editorialNote "TBD: introduce subclasses for distinction between wild-type and experimental conditions?" .

biolink:GeneToGeneCoexpressionAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene to gene coexpression association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:expression_site ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:phenotypic_state ],
        biolink:GeneExpressionMixin,
        biolink:GeneToGeneAssociation ;
    skos:definition "Indicates that two genes are co-expressed, generally under the same conditions." .

biolink:GeneToGeneHomologyAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene to gene homology association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:GeneToGeneAssociation ;
    skos:definition "A homology association between two genes. May be orthology (in which case the species of subject and object should differ) or paralogy (in which case the species may be the same)" .

biolink:GeneToGeneProductRelationship a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene to gene product relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneProductMixin ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:SequenceFeatureRelationship ;
    skos:definition "A gene is transcribed and potentially translated to a gene product" .

biolink:GeneToGoTermAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene to go term association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOntologyClass ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:MolecularEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:FunctionalAssociation ;
    skos:altLabel "functional association" ;
    skos:exactMatch WBVocab:Gene-GO-Association .

biolink:GeneToPhenotypicFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:GeneToEntityAssociationMixin ;
    skos:exactMatch WBVocab:Gene-Phenotype-Association .

biolink:Genome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genome" ;
    rdfs:subClassOf biolink:GenomicEntity ;
    skos:definition "A genome is the sum of genetic material within a cell or virion." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001026>,
        SIO:000984,
        WIKIDATA:Q7020 .

biolink:GenomicBackgroundExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genomic background exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:ExposureEvent,
        biolink:GeneGroupingMixin,
        biolink:GenomicEntity ;
    skos:definition "A genomic background exposure is where an individual's specific genomic background of genes, sequence variants or other pre-existing genomic conditions constitute a kind of 'exposure' to the organism, leading to or influencing an outcome." .

biolink:GenotypeAsAModelOfDiseaseAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genotype as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToDiseaseAssociationMixin,
        biolink:GenotypeToDiseaseAssociation,
        biolink:ModelToDiseaseAssociationMixin .

biolink:GenotypeToGeneAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genotype to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Any association between a genotype and a gene. The genotype have have multiple variants in that gene or a single one. There is no assumption of cardinality" .

biolink:GenotypeToGenotypePartAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genotype to genotype part association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Any association between one genotype and a genotypic entity that is a sub-component of it" .

biolink:GenotypeToPhenotypicFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genotype to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:GenotypeToEntityAssociationMixin ;
    skos:definition "Any association between one genotype and a phenotypic feature, where having the genotype confers the phenotype, either in isolation or through environment" .

biolink:GenotypeToVariantAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genotype to variant association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Any association between a genotype and a sequence variant." .

biolink:GenotypicSex a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genotypic sex" ;
    rdfs:subClassOf biolink:BiologicalSex ;
    skos:definition "An attribute corresponding to the genotypic sex of the individual, based upon genotypic composition of sex chromosomes." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0020000> .

biolink:GeographicExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "geographic exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:ExposureEvent,
        biolink:GeographicLocation ;
    skos:definition "A geographic exposure is a factor relating to geographic proximity to some impactful entity." .

biolink:GeographicLocationAtTime a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "geographic location at time" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:GeographicLocation ;
    skos:definition "a location that can be described in lat/long coordinates, for a particular time" .

biolink:GrossAnatomicalStructure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gross anatomical structure" ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    skos:altLabel "organ",
        "tissue" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/UBERON_0010000>,
        UMLSSC:T017,
        UMLSSC:T021,
        UMLSST:anst,
        UMLSST:ffas,
        WIKIDATA:Q4936952 ;
    skos:narrowMatch UMLSSC:T018,
        UMLSSC:T023,
        UMLSSC:T024,
        UMLSST:bpoc,
        UMLSST:emst,
        UMLSST:tisu .

biolink:Haplotype a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "haplotype" ;
    rdfs:subClassOf biolink:GenomicEntity ;
    skos:definition "A set of zero or more Alleles on a single instance of a Sequence[VMC]" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000871>,
        <http://purl.obolibrary.org/obo/SO_0001024>,
        VMC:Haplotype .

biolink:HospitalizationOutcome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "hospitalization outcome" ;
    rdfs:subClassOf biolink:Hospitalization,
        biolink:Outcome ;
    skos:definition "An outcome resulting from an exposure event which is the increased manifestation of acute (e.g. emergency room visit) or chronic (inpatient) hospitalization." .

biolink:Inheritance a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "inheritance" ;
    rdfs:subClassOf biolink:OrganismAttribute ;
    skos:definition "The pattern or 'mode' in which a particular genetic trait or disorder is passed from one generation to the next, e.g. autosomal dominant, autosomal recessive, etc." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000141>,
        <http://purl.obolibrary.org/obo/HP_0000005>,
        <http://purl.obolibrary.org/obo/NCIT_C45827> .

biolink:MacromolecularComplexMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "macromolecular complex mixin" ;
    rdfs:subClassOf biolink:MacromolecularMachineMixin,
        linkml:mixin ;
    skos:definition "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0032991>,
        WIKIDATA:Q22325163 .

biolink:MacromolecularMachineToBiologicalProcessAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "macromolecular machine to biological process association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:BiologicalProcess ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:FunctionalAssociation,
        biolink:MacromolecularMachineToEntityAssociationMixin ;
    skos:definition "A functional association between a macromolecular machine (gene, gene product or complex) and a biological process or pathway (as represented in the GO biological process branch), where the entity carries out some part of the process, regulates it, or acts upstream of it." .

biolink:MacromolecularMachineToCellularComponentAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "macromolecular machine to cellular component association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:CellularComponent ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:FunctionalAssociation,
        biolink:MacromolecularMachineToEntityAssociationMixin ;
    skos:definition "A functional association between a macromolecular machine (gene, gene product or complex) and a cellular component (as represented in the GO cellular component branch), where the entity carries out its function in the cellular component." .

biolink:MacromolecularMachineToMolecularActivityAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "macromolecular machine to molecular activity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MolecularActivity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:FunctionalAssociation,
        biolink:MacromolecularMachineToEntityAssociationMixin ;
    skos:definition "A functional association between a macromolecular machine (gene, gene product or complex) and a molecular activity (as represented in the GO molecular function branch), where the entity carries out the activity, or contributes to its execution." .

biolink:Macronutrient a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "macronutrient" ;
    rdfs:subClassOf biolink:Nutrient ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_33937> .

biolink:MaterialSampleDerivationAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "material sample derivation association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MaterialSample ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "An association between a material sample and the material entity from which it is derived." .

biolink:MaterialSampleToDiseaseOrPhenotypicFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "material sample to disease or phenotypic feature association" ;
    rdfs:subClassOf biolink:Association,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin,
        biolink:MaterialSampleToEntityAssociationMixin ;
    skos:definition "An association between a material sample and a disease or phenotype." .

biolink:Metabolite a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "metabolite" ;
    rdfs:subClassOf biolink:ChemicalSubstance ;
    skos:definition "Any intermediate or product resulting from metabolism. Includes primary and secondary metabolites." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> ;
    skos:note "The CHEBI ID represents a role rather than a substance" .

biolink:MicroRNA a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "microRNA" ;
    rdfs:subClassOf biolink:NoncodingRNAProduct ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000276>,
        SIO:001397,
        WIKIDATA:Q310899 .

biolink:MortalityOutcome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "mortality outcome" ;
    rdfs:subClassOf biolink:Death,
        biolink:Outcome ;
    skos:definition "An outcome of death from resulting from an exposure event." .

biolink:OrganismTaxonToEnvironmentAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "organism taxon to environment association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:OrganismTaxonToEntityAssociation .

biolink:OrganismTaxonToOrganismTaxonInteraction a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "organism taxon to organism taxon interaction" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:associated_environmental_context ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:OrganismTaxonToOrganismTaxonAssociation ;
    skos:definition "An interaction relationship between two taxa. This may be a symbiotic relationship (encompassing mutualism and parasitism), or it may be non-symbiotic. Example: plague transmitted_by flea; cattle domesticated_by Homo sapiens; plague infects Homo sapiens" .

biolink:OrganismTaxonToOrganismTaxonSpecialization a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "organism taxon to organism taxon specialization" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:OrganismTaxonToOrganismTaxonAssociation ;
    skos:definition "A child-parent relationship between two taxa. For example: Homo sapiens subclass_of Homo" .

biolink:OrganismalEntityAsAModelOfDiseaseAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "organismal entity as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        biolink:Association,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin .

biolink:PairwiseMolecularInteraction a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pairwise molecular interaction" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MolecularEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:MolecularEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:interacting_molecules_category ],
        [ a owl:Restriction ;
            owl:onClass linkml:Uriorcurie ;
            owl:onProperty biolink:relation ;
            owl:qualifiedCardinality 1 ],
        biolink:PairwiseGeneToGeneInteraction ;
    skos:definition "An interaction at the molecular level between two physical entities" .

biolink:PathognomonicityQuantifier a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pathognomonicity quantifier" ;
    rdfs:subClassOf biolink:SpecificityQuantifier,
        linkml:mixin ;
    skos:definition "A relationship quantifier between a variant or symptom and a disease, which is high when the presence of the feature implies the existence of the disease" .

biolink:PathologicalAnatomicalExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pathological anatomical exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:ExposureEvent,
        biolink:PathologicalAnatomicalStructure ;
    skos:definition "An abnormal anatomical structure, when viewed as an exposure, representing an precondition, leading to or influencing an outcome, e.g. thrombosis leading to an ischemic disease outcome." .

biolink:PathologicalAnatomicalOutcome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pathological anatomical outcome" ;
    rdfs:subClassOf biolink:Outcome,
        biolink:PathologicalAnatomicalStructure ;
    skos:definition "An outcome resulting from an exposure event which is the manifestation of an abnormal anatomical structure." .

biolink:PathologicalProcessExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pathological process exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:ExposureEvent,
        biolink:PathologicalProcess ;
    skos:definition "A pathological process, when viewed as an exposure, representing an precondition, leading to or influencing an outcome, e.g. autoimmunity leading to disease." .

biolink:PathologicalProcessOutcome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pathological process outcome" ;
    rdfs:subClassOf biolink:Outcome,
        biolink:PathologicalProcess ;
    skos:definition "An outcome resulting from an exposure event which is the manifestation of a pathological process." .

biolink:PercentageFrequencyValue a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "percentage frequency value" ;
    rdfs:subClassOf linkml:Double .

biolink:Phenomenon a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "phenomenon" ;
    rdfs:subClassOf biolink:NamedThing,
        biolink:Occurrent ;
    skos:broadMatch UMLSSC:T067,
        UMLSSC:T068,
        UMLSSC:T070,
        UMLSST:hcpp,
        UMLSST:npop,
        UMLSST:phpr ;
    skos:definition "a fact or situation that is observed to exist or happen, especially one whose cause or explanation is in question" ;
    skos:exactMatch UMLSSG:PHEN ;
    skos:narrowMatch UMLSSC:T034,
        UMLSSC:T038,
        UMLSSC:T069,
        UMLSST:biof,
        UMLSST:eehu,
        UMLSST:lbtr .

biolink:PhenotypicQuality a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "phenotypic quality" ;
    rdfs:subClassOf biolink:OrganismAttribute ;
    skos:altLabel "phenotypic properties" ;
    skos:definition "A property of a phenotype" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0000001> .

biolink:PhenotypicSex a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "phenotypic sex" ;
    rdfs:subClassOf biolink:BiologicalSex ;
    skos:definition "An attribute corresponding to the phenotypic sex of the individual, based upon the reproductive organs present." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0001894> .

biolink:PhysiologicalProcess a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "physiological process" ;
    rdfs:subClassOf biolink:BiologicalProcess,
        biolink:OntologyClass ;
    skos:altLabel "physiology" ;
    skos:closeMatch UMLSSG:PHYS ;
    skos:exactMatch UMLSSC:T039,
        UMLSST:phsf,
        WIKIDATA:Q30892994 ;
    skos:narrowMatch UMLSSC:T040,
        UMLSSC:T042,
        UMLSSC:T043,
        UMLSSC:T045,
        UMLSST:celf,
        UMLSST:genf,
        UMLSST:orgf,
        UMLSST:ortf .

biolink:PopulationToPopulationAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "population to population association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "An association between a two populations" .

biolink:ProcessedMaterial a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "processed material" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalSubstance ;
            owl:onProperty biolink:has_constituent ],
        biolink:ChemicalSubstance,
        biolink:Mixture,
        biolink:OntologyClass ;
    skos:definition "A chemical substance (often a mixture) processed for consumption for nutritional, medical or technical use." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OBI_0000047> .

biolink:ProteinIsoform a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "protein isoform" ;
    rdfs:subClassOf biolink:GeneProductIsoformMixin,
        biolink:Protein ;
    skos:altLabel "proteoform" ;
    skos:definition "Represents a protein that is a specific isoform of the canonical or reference protein. See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114032/" .

biolink:Quotient a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "quotient" ;
    rdfs:subClassOf linkml:Double .

biolink:RNAProductIsoform a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "RNA product isoform" ;
    rdfs:subClassOf biolink:GeneProductIsoformMixin,
        biolink:RNAProduct ;
    skos:definition "Represents a protein that is a specific isoform of the canonical or reference RNA" .

biolink:ReagentTargetedGene a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "reagent targeted gene" ;
    rdfs:subClassOf biolink:GenomicEntity ;
    skos:definition "A gene altered in its expression level in the context of some experiment as a result of being targeted by gene-knockdown reagent(s) such as a morpholino or RNAi." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000504> .

biolink:RelationshipType a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "relationship type" ;
    rdfs:subClassOf biolink:OntologyClass ;
    skos:definition "An OWL property used as an edge label" .

biolink:SensitivityQuantifier a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "sensitivity quantifier" ;
    rdfs:subClassOf biolink:RelationshipQuantifier,
        linkml:mixin .

biolink:SequenceVariantModulatesTreatmentAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "sequence variant modulates treatment association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Treatment ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "An association between a sequence variant and a treatment or health intervention. The treatment object itself encompasses both the disease and the drug used." ;
    skos:note "An alternate way to model the same information could be via a qualifier" .

biolink:Serial a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "serial" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:issue ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:iso_abbreviation ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty rdf:type ;
            owl:qualifiedCardinality 1 ],
        biolink:Publication ;
    skos:altLabel "journal" ;
    skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." .

biolink:SiRNA a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "siRNA" ;
    rdfs:subClassOf biolink:NoncodingRNAProduct ;
    skos:altLabel "RNAi",
        "small interfering RNA" ;
    skos:definition "A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. SRNAs trigger the cleavage of their target molecules." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000646>,
        WIKIDATA:Q203221 .

biolink:Snv a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "snv" ;
    rdfs:subClassOf biolink:SequenceVariant ;
    skos:altLabel "single nucleotide polymorphism",
        "single nucleotide variant",
        "snp" ;
    skos:definition "SNVs are single nucleotide positions in genomic DNA at which different sequence alternatives exist" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001483> .

biolink:SocioeconomicExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "socioeconomic exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Class ;
            owl:intersectionOf ( [ a owl:Restriction ;
                        owl:allValuesFrom biolink:SocioeconomicAttribute ;
                        owl:onProperty biolink:has_attribute ] [ a owl:Restriction ;
                        owl:onProperty biolink:has_attribute ;
                        owl:someValuesFrom biolink:SocioeconomicAttribute ] ) ],
        biolink:Behavior,
        biolink:ExposureEvent ;
    skos:definition "A socioeconomic exposure is a factor relating to social and financial status of an affected individual (e.g. poverty)." .

biolink:SocioeconomicOutcome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "socioeconomic outcome" ;
    rdfs:subClassOf biolink:Behavior,
        biolink:Outcome ;
    skos:definition "An general social or economic outcome, such as healthcare costs, utilization, etc., resulting from an exposure event" .

biolink:TranscriptToGeneRelationship a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "transcript to gene relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Transcript ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:SequenceFeatureRelationship ;
    skos:definition "A gene is a collection of transcripts" .

biolink:UnclassifiedOntologyClass a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "unclassified ontology class" ;
    rdfs:subClassOf biolink:OntologyClass,
        linkml:mixin ;
    skos:definition "this is used for nodes that are taken from an ontology but are not typed using an existing biolink class" .

biolink:VariantAsAModelOfDiseaseAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "variant as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin,
        biolink:VariantToDiseaseAssociation .

biolink:VariantToGeneExpressionAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "variant to gene expression association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:expression_site ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:phenotypic_state ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        biolink:GeneExpressionMixin,
        biolink:VariantToGeneAssociation ;
    skos:definition "An association between a variant and expression of a gene (i.e. e-QTL)" .

biolink:VariantToPhenotypicFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "variant to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:VariantToEntityAssociationMixin .

biolink:VariantToPopulationAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "variant to population association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        biolink:Association,
        biolink:FrequencyQualifierMixin,
        biolink:FrequencyQuantifier,
        biolink:VariantToEntityAssociationMixin ;
    skos:definition "An association between a variant and a population, where the variant has particular frequency in the population" .

biolink:Vitamin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "vitamin" ;
    rdfs:subClassOf biolink:Micronutrient ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_33229>,
        UMLSSC:T127,
        UMLSST:vita .

biolink:affects_expression_in a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects expression in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "Holds between a variant and an anatomical entity where the expression of the variant is located in." ;
    skos:exactMatch GTEx:affects_expression_in .

biolink:association_type a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "association type" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:CategoryType ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to the category of association (e.g. gene to phenotype)" .

biolink:author a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "author" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:contributor ;
    skos:definition "an instance of one (co-)creator primarily responsible for a written work" ;
    skos:exactMatch dct:creator,
        WIKIDATA_PROPERTY:P50 .

biolink:biological_role_mixin a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "biological role mixin" ;
    rdfs:range linkml:String ;
    skos:definition "A role played by the molecular entity or part thereof within a biological context." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_24432> .

biolink:capable_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "capable of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:actively_involved_in ;
    skos:definition "holds between a physical entity and process or function, where the continuant alone has the ability to carry out the process or function." ;
    skos:exactMatch RTXKG1:capable_of,
        RO:0002215 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R52>,
        RO:0002500 .

biolink:causes_adverse_event a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "causes adverse event" ;
    rdfs:domain biolink:Drug ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:causes ;
    skos:definition "holds between a drug and a disease or phenotype that can be caused by the drug" ;
    skos:exactMatch Aeolus:0000001 .

biolink:chemical_role_mixin a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "chemical role mixin" ;
    rdfs:range linkml:String ;
    skos:definition "A role played by the molecular entity or part thereof within a chemical context." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_51086> .

biolink:chemically_similar_to a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "chemically similar to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:similar_to ;
    skos:definition "holds between one chemical substances and another that it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CHEBI_has_functional_parent>,
        <http://purl.obolibrary.org/obo/CHEBI_has_parent_hydride>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_acid_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_base_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_enantiomer_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_tautomer_of>,
        <http://purl.obolibrary.org/obo/NCIT_has_salt_form> .

biolink:chi_squared_statistic a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "chi squared statistic" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "represents the chi-squared statistic computed from observations" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/STATO_0000030> .

biolink:clinical_modifier_qualifier a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "clinical modifier qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:ClinicalModifier ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects" .

biolink:coexpressed_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "coexpressed with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "holds between any two genes or gene products, in which both are generally expressed within a single defined experimental context." .

biolink:colocalizes_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "colocalizes with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:definition "holds between two entities that are observed to be located in the same place." ;
    skos:exactMatch RO:00002325 .

biolink:contraindicated_for a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "contraindicated for" ;
    rdfs:domain biolink:Drug ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "Holds between a drug and a disease or phenotype, such that a person with that disease should not be treated with the drug." ;
    skos:exactMatch RTXKG1:contraindicated_for,
        DrugCentral:0000001 .

biolink:created_with a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "created_with" ;
    rdfs:domain biolink:Dataset ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch pav:createdWith .

biolink:decreases_abundance_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases abundance of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_abundance_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the amount of the other within a system of interest" ;
    skos:exactMatch CTD:decreases_abundance_of ;
    skos:relatedMatch UBERGRAPH:is_decrease_of .

biolink:decreases_activity_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases activity of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_activity_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the activity of the other within a system of interest" ;
    skos:exactMatch CTD:decreases_activity_of ;
    skos:narrowMatch GAMMA:aggregation_inhibitor,
        GAMMA:allosteric_antagonist,
        GAMMA:antagonist,
        GAMMA:blocker,
        GAMMA:channel_blocker,
        GAMMA:conversion_inhibitor,
        GAMMA:downregulator,
        GAMMA:gating_inhibitor,
        GAMMA:inactivator,
        GAMMA:inhibitor,
        GAMMA:inhibitory_allosteric_modulator,
        GAMMA:inverse_agonist,
        GAMMA:negative_allosteric_modulator,
        GAMMA:negative_modulator,
        GAMMA:partial_antagonist,
        GAMMA:suppressor,
        GAMMA:weak_inhibitor,
        DGIdb:antagonist,
        DGIdb:blocker,
        DGIdb:channel_blocker,
        DGIdb:gating_inhibitor,
        DGIdb:inhibitor,
        DGIdb:inhibitory_allosteric_modulator,
        DGIdb:inverse_agonist,
        DGIdb:negative_modulator,
        CHEMBL.MECHANISM:allosteric_antagonist,
        CHEMBL.MECHANISM:antagonist,
        CHEMBL.MECHANISM:inverse_agonist ;
    skos:relatedMatch GAMMA:ic50,
        GAMMA:ki,
        DGIdb:vaccine .

biolink:decreases_degradation_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases degradation of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_degradation_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the rate of degradation of the other within a system of interest" ;
    skos:exactMatch CTD:decreases_degradation_of ;
    skos:narrowMatch CTD:decreases_cleavage,
        CTD:decreases_hydrolysis .

biolink:decreases_expression_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases expression of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:affects_expression_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the level of expression of the other within a system of interest" ;
    skos:exactMatch RO:0003002,
        CTD:decreases_expression_of ;
    skos:narrowMatch CHEMBL.MECHANISM:antisense_inhibitor ;
    skos:relatedMatch DGIdb:antisense,
        DGIdb:antisense_oligonucleotide .

biolink:decreases_folding_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases folding of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_folding_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the rate or quality of folding of the other" ;
    skos:exactMatch CTD:decreases_folding_of .

biolink:decreases_localization_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases localization of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_localization_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the proper localization of the other within a system of interest" ;
    skos:exactMatch CTD:decreases_localization_of .

biolink:decreases_metabolic_processing_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases metabolic processing of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_metabolic_processing_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the rate of metabolic processing of the other within a system of interest" ;
    skos:exactMatch CTD:decreases_metabolic_processing_of .

biolink:decreases_molecular_interaction a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases molecular interaction" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:molecularly_interacts_with ;
    skos:definition "indicates that the source decreases the molecular interaction between the target and some other molecular entity" ;
    skos:exactMatch CTD:decreases_molecular_interaction_with .

biolink:decreases_molecular_modification_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases molecular modification of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_molecular_modification_of ;
    skos:definition "holds between two molecular entities where the action or effect of one leads to decreased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)" ;
    skos:exactMatch CTD:decreases_molecular_modification_of ;
    skos:narrowMatch CTD:decreases_ADP-ribosylation,
        CTD:decreases_N-linked_glycosylation,
        CTD:decreases_O-linked_glycosylation,
        CTD:decreases_acetylation,
        CTD:decreases_acylation,
        CTD:decreases_alkylation,
        CTD:decreases_amination,
        CTD:decreases_carbamoylation,
        CTD:decreases_carboxylation,
        CTD:decreases_ethylation,
        CTD:decreases_farnesylation,
        CTD:decreases_geranoylation,
        CTD:decreases_glucuronidation,
        CTD:decreases_glutathionylation,
        CTD:decreases_glycation,
        CTD:decreases_glycosylation,
        CTD:decreases_hydroxylation,
        CTD:decreases_lipidation,
        CTD:decreases_methylation,
        CTD:decreases_myristoylation,
        CTD:decreases_nitrosation,
        CTD:decreases_nucleotidylation,
        CTD:decreases_oxidation,
        CTD:decreases_palmitoylation,
        CTD:decreases_phosphorylation,
        CTD:decreases_prenylation,
        CTD:decreases_reduction,
        CTD:decreases_ribosylation,
        CTD:decreases_sulfation,
        CTD:decreases_sumoylation,
        CTD:decreases_ubiquitination,
        GAMMA:deoxidizer .

biolink:decreases_mutation_rate_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases mutation rate of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:affects_mutation_rate_of ;
    skos:broadMatch CTD:decreases_mutagenesis ;
    skos:definition "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity decreases the rate of mutation of the genomic entity within a system of interest" ;
    skos:exactMatch CTD:decreases_mutation_rate_of .

biolink:decreases_response_to a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases response to" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_response_to ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" ;
    skos:exactMatch CTD:decreases_response_to ;
    skos:narrowMatch CTD:decreases_response_to_substance,
        GAMMA:desensitize_the_target .

biolink:decreases_secretion_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases secretion of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_secretion_of ;
    skos:broadMatch CTD:decreases_export ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the rate of secretion of the other out of a cell, gland, or organ" ;
    skos:exactMatch CTD:decreases_secretion_of .

biolink:decreases_splicing_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases splicing of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:Transcript ;
    rdfs:subPropertyOf biolink:affects_splicing_of ;
    skos:broadMatch CTD:decreases_splicing_of ;
    skos:definition "holds between a molecular entity and an mRNA where the action or effect of the molecular entity decreases the proper splicing of the mRNA" ;
    skos:exactMatch CTD:decreases_RNA_splicing .

biolink:decreases_stability_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases stability of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_stability_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the stability of the other within a system of interest" ;
    skos:exactMatch CTD:decreases_stability_of .

biolink:decreases_synthesis_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases synthesis of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_synthesis_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the rate of chemical synthesis of the other" ;
    skos:exactMatch CTD:decreases_synthesis_of,
        GAMMA:inhibition_of_synthesis .

biolink:decreases_transport_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases transport of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_transport_of ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the rate of transport of the other across some boundary in a system of interest" ;
    skos:exactMatch CTD:decreases_transport_of .

biolink:decreases_uptake_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "decreases uptake of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_uptake_of ;
    skos:broadMatch CTD:decreases_import ;
    skos:definition "holds between two molecular entities where the action or effect of one decreases the rate of uptake of the other into of a cell, gland, or organ" ;
    skos:exactMatch CTD:decreases_uptake_of .

biolink:develops_from a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "develops from" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:closeMatch <http://purl.obolibrary.org/obo/FMA_develops_into>,
        RO:0002203 ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BTO_develops_from>,
        <http://purl.obolibrary.org/obo/DDANAT_develops_from>,
        <http://purl.obolibrary.org/obo/FMA_develops_from>,
        RO:0002202 ;
    skos:narrowMatch RO:0002207,
        RO:0002225,
        RO:0002226 .

biolink:directly_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "directly interacts with" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:interacts_with ;
    skos:broadMatch SIO:000203 ;
    skos:definition "Holds between molecular entities that physically and directly interact with each other" ;
    skos:exactMatch CTD:interacts_with,
        chembio:interacts,
        GAMMA:interacts_with ;
    skos:narrowMatch <http://identifiers.org/drugbank/chelator>,
        PHAROS:drug_targets,
        CTD:affects_binding,
        GAMMA:adduct,
        GAMMA:antibody,
        GAMMA:antibody_binding,
        GAMMA:binder,
        GAMMA:binding,
        GAMMA:chaperone,
        GAMMA:cofactor,
        GAMMA:component,
        GAMMA:ligand,
        GAMMA:multitarget,
        GAMMA:pharmacological_chaperone,
        GAMMA:releasing_agent,
        DGIdb:binder,
        DGIdb:cofactor ;
    skos:relatedMatch GAMMA:kb,
        GAMMA:kd,
        GAMMA:potency .

biolink:disease_has_basis_in a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "disease has basis in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "A relation that holds between a disease and an entity where the state of the entity has contribution to the disease." ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/MONDO_disease_has_basis_in_accumulation_of>,
        <http://purl.obolibrary.org/obo/MONDO_disease_has_basis_in_development_of> .

biolink:editor a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "editor" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:contributor ;
    skos:definition "editor of a compiled work such as a book or a periodical (newspaper or an academic journal). Note that in the case of publications which have a containing \"published in\" node property, the editor association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the editorial agent of the encompassing publication (e.g. only from the Book referenced by the 'published_in' property of a book chapter Publication node)." ;
    skos:exactMatch WIKIDATA_PROPERTY:P98 .

biolink:enables a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "enables" ;
    rdfs:domain biolink:PhysicalEntity ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:enabled_by ;
    skos:definition "holds between a physical entity and a process, where the physical entity executes the process" ;
    skos:exactMatch RO:0002327 .

biolink:exacerbates a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "exacerbates" ;
    rdfs:domain biolink:BiologicalEntity ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." ;
    skos:exactMatch RO:0003309 .

biolink:filler a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "filler" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The value in a property-value tuple" .

biolink:full_name a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "full name" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "a long-form human readable name for a thing" .

biolink:genetically_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "genetically interacts with" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:interacts_with ;
    skos:definition "holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality." ;
    skos:exactMatch RO:0002435 .

biolink:has_chemical_formula a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has chemical formula" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalFormulaValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "description of chemical compound based on element symbols" ;
    skos:exactMatch WIKIDATA_PROPERTY:P274 .

biolink:has_completed a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has completed" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between an entity and a process that the entity is capable of and has completed" ;
    skos:exactMatch RTXKG1:has_completed,
        <http://purl.obolibrary.org/obo/CL_has_completed> .

biolink:has_confidence_level a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has confidence level" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:ConfidenceLevel ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to a qualitative term denoting the level of confidence" .

biolink:has_decreased_amount a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has decreased amount" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CL_has_low_plasma_membrane_amount> .

biolink:has_evidence a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has evidence" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:EvidenceType ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to an instance of supporting evidence" ;
    skos:exactMatch RO:0002558 .

biolink:has_increased_amount a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has increased amount" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CL_has_high_plasma_membrane_amount> .

biolink:has_molecular_consequence a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has molecular consequence" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "connects a sequence variant to a class describing the molecular consequence. E.g.  SO:0001583" ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_allele_has_activity> .

biolink:has_not_completed a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has not completed" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between an entity and a process that the entity is capable of, but has not completed" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CL_has_not_completed> .

biolink:has_receptor a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has receptor" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range biolink:OrganismalEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "the organism or organism part being exposed" ;
    skos:exactMatch ExO:0000001 .

biolink:has_route a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has route" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "the process that results in the stressor coming into direct contact with the receptor" ;
    skos:exactMatch ExO:0000055 ;
    skos:narrowMatch LOINC:has_pharmaceutical_route,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form_intended_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_route_of_administration> .

biolink:has_sequence_location a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has sequence location" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between two genomic entities when the subject can be localized in sequence coordinates on the object. For example, between an exon and a chromosome/contig." ;
    skos:exactMatch <http://biohackathon.org/resource/faldo#location> .

biolink:has_stressor a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has stressor" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "has stimulus" ;
    skos:definition "the process or entity that the receptor is being exposed to" ;
    skos:exactMatch ExO:0000000 .

biolink:has_topic a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has topic" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "descriptors",
        "topic" ;
    skos:definition "Connects a node to a vocabulary term or ontology class that describes some aspect of the entity. In general specific characterization is preferred. See https://github.com/biolink/biolink-model/issues/238" ;
    skos:exactMatch foaf:topic .

biolink:has_variant_part a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has variant part" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:has_part ;
    skos:definition "holds between a genomic entity and a genotypic entity that is a sub-component of it" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000382> .

biolink:in_cell_population_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "in cell population with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:definition "holds between two genes or gene products that are expressed in the same cell type or population" .

biolink:in_complex_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "in complex with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:broadMatch SIO:010285 ;
    skos:definition "holds between two genes or gene products that are part of (or code for products that are part of) in the same macromolecular complex mixin" ;
    skos:relatedMatch SIO:010497 .

biolink:in_linkage_disequilibrium_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "in linkage disequilibrium with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between two sequence variants, the presence of which are correlated in a population" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C16798> .

biolink:in_pathway_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "in pathway with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:definition "holds between two genes or gene products that are part of in the same biological pathway" ;
    skos:relatedMatch SIO:010532 .

biolink:increases_abundance_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases abundance of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_abundance_of ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the amount of the other within a system of interest" ;
    skos:exactMatch CTD:increases_abundance_of ;
    skos:relatedMatch UBERGRAPH:is_increase_of .

biolink:increases_activity_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases activity of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_activity_of ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the activity of the other within a system of interest" ;
    skos:exactMatch CTD:increases_activity_of ;
    skos:narrowMatch GAMMA:activator,
        GAMMA:agonist,
        GAMMA:inducer,
        GAMMA:opener,
        GAMMA:partial_agonist,
        GAMMA:positive_allosteric_modulator,
        GAMMA:positive_modulator,
        GAMMA:potentiator,
        GAMMA:stimulator,
        DGIdb:agonist,
        DGIdb:inducer,
        DGIdb:partial_agonist,
        DGIdb:positive_allosteric_modulator,
        DGIdb:stimulator,
        CHEMBL.MECHANISM:agonist,
        CHEMBL.MECHANISM:opener,
        CHEMBL.MECHANISM:partial_agonist,
        CHEMBL.MECHANISM:positive_allosteric_modulator,
        CHEMBL.MECHANISM:positive_modulator ;
    skos:relatedMatch GAMMA:ac50,
        GAMMA:ec50 .

biolink:increases_degradation_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases degradation of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_degradation_of ;
    skos:closeMatch CHEMBL.MECHANISM:degrader,
        CHEMBL.MECHANISM:hydrolytic_enzyme,
        CHEMBL.MECHANISM:proteolytic_enzyme ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the rate of degradation of the other within a system of interest" ;
    skos:exactMatch CTD:increases_degradation_of ;
    skos:narrowMatch GOREL:0002004,
        CTD:increases_cleavage,
        CTD:increases_hydrolysis ;
    skos:relatedMatch GAMMA:substrate,
        CHEMBL.MECHANISM:substrate .

biolink:increases_expression_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases expression of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:affects_expression_of ;
    skos:closeMatch CHEMBL.MECHANISM:releasing_agent ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the level of expression of the other within a system of interest" ;
    skos:exactMatch RO:0003003,
        CTD:increases_expression_of .

biolink:increases_folding_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases folding of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_folding_of ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the rate or quality of folding of the other" ;
    skos:exactMatch CTD:increases_folding_of .

biolink:increases_localization_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases localization of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_localization_of ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the proper localization of the other within a system of interest" ;
    skos:exactMatch CTD:increases_localization_of .

biolink:increases_metabolic_processing_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases metabolic processing of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_metabolic_processing_of ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the rate of metabolic processing of the other within a system of interest" ;
    skos:exactMatch CTD:increases_metabolic_processing_of ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_enzyme_metabolizes_chemical_or_drug> .

biolink:increases_molecular_interaction a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases molecular interaction" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:molecularly_interacts_with ;
    skos:definition "indicates that the source increases the molecular interaction between the target and some other molecular entity" ;
    skos:exactMatch CTD:increases_molecular_interaction_with .

biolink:increases_molecular_modification_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases molecular modification of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_molecular_modification_of ;
    skos:definition "holds between two molecular entities where the action or effect of one leads to increased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)" ;
    skos:exactMatch CTD:increases_molecular_modification_of ;
    skos:narrowMatch CTD:increases_ADP-ribosylation,
        CTD:increases_N-linked_glycosylation,
        CTD:increases_O-linked_glycosylation,
        CTD:increases_acetylation,
        CTD:increases_acylation,
        CTD:increases_alkylation,
        CTD:increases_amination,
        CTD:increases_carbamoylation,
        CTD:increases_carboxylation,
        CTD:increases_ethylation,
        CTD:increases_farnesylation,
        CTD:increases_geranoylation,
        CTD:increases_glucuronidation,
        CTD:increases_glutathionylation,
        CTD:increases_glycation,
        CTD:increases_glycosylation,
        CTD:increases_hydroxylation,
        CTD:increases_lipidation,
        CTD:increases_methylation,
        CTD:increases_myristoylation,
        CTD:increases_nitrosation,
        CTD:increases_nucleotidylation,
        CTD:increases_oxidation,
        CTD:increases_palmitoylation,
        CTD:increases_phosphorylation,
        CTD:increases_prenylation,
        CTD:increases_reduction,
        CTD:increases_ribosylation,
        CTD:increases_sulfation,
        CTD:increases_sumoylation,
        CTD:increases_ubiquitination,
        GAMMA:acetylation,
        GAMMA:oxidizer .

biolink:increases_mutation_rate_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases mutation rate of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:affects_mutation_rate_of ;
    skos:broadMatch CTD:increases_mutagenesis ;
    skos:definition "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity increases the rate of mutation of the genomic entity within a system of interest" ;
    skos:exactMatch CTD:increases_mutation_rate_of .

biolink:increases_response_to a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases response to" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_response_to ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" ;
    skos:exactMatch CTD:increases_response_to .

biolink:increases_secretion_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases secretion of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_secretion_of ;
    skos:broadMatch CTD:increases_export ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the rate of secretion of the other out of a cell, gland, or organ" ;
    skos:exactMatch CTD:increases_secretion_of .

biolink:increases_splicing_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases splicing of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:Transcript ;
    rdfs:subPropertyOf biolink:affects_splicing_of ;
    skos:broadMatch CTD:increases_splicing_of ;
    skos:definition "holds between a molecular entity and an mRNA where the action or effect of the molecular entity increases the proper splicing of the mRNA" ;
    skos:exactMatch CTD:increases_RNA_splicing .

biolink:increases_stability_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases stability of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_stability_of ;
    skos:closeMatch CHEMBL.MECHANISM:stabiliser ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the stability of the other within a system of interest" ;
    skos:exactMatch CTD:increases_stability_of .

biolink:increases_synthesis_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases synthesis of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_synthesis_of ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the rate of chemical synthesis of the other" ;
    skos:exactMatch CTD:increases_synthesis_of .

biolink:increases_transport_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases transport of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_transport_of ;
    skos:closeMatch GAMMA:carrier,
        GAMMA:transporter ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the rate of transport of the other across some boundary in a system of interest" ;
    skos:exactMatch CTD:increases_transport_of .

biolink:increases_uptake_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "increases uptake of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects_uptake_of ;
    skos:broadMatch CTD:increases_import ;
    skos:definition "holds between two molecular entities where the action or effect of one increases the rate of uptake of the other into of a cell, gland, or organ" ;
    skos:exactMatch CTD:increases_uptake_of .

biolink:is_frameshift_variant_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is frameshift variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001589>,
        SNPEFF:frameshift_variant ;
    skos:narrowMatch SNPEFF:start_lost,
        SNPEFF:stop_lost .

biolink:is_missense_variant_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is missense variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a gene  and a sequence variant, such the sequence variant results in a different amino acid sequence but where the length is preserved." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001583>,
        SNPEFF:missense_variant ;
    skos:narrowMatch SNPEFF:initiator_codon_variant,
        SNPEFF:structural_interaction_variant .

biolink:is_nearby_variant_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is nearby variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a sequence variant and a gene sequence that the variant is genomically close to." ;
    skos:exactMatch GAMMA:0000102 ;
    skos:narrowMatch SNPEFF:downstream_gene_variant,
        SNPEFF:upstream_gene_variant .

biolink:is_non_coding_variant_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is non coding variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a sequence variant and a gene, where the variant does not affect the coding sequence" ;
    skos:exactMatch GAMMA:0000103 ;
    skos:narrowMatch SNPEFF:3_prime_UTR_variant,
        SNPEFF:5_prime_UTR_premature_start_codon_gain_variant,
        SNPEFF:5_prime_UTR_variant,
        SNPEFF:intron_variant,
        SNPEFF:non_coding_transcript_exon_variant .

biolink:is_nonsense_variant_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is nonsense variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:broadMatch <http://purl.obolibrary.org/obo/SO_0002054> ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant results in a premature stop codon" ;
    skos:exactMatch SNPEFF:stop_gained .

biolink:is_splice_site_variant_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is splice site variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant is in the canonical splice site of one of the gene's exons." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001629> ;
    skos:narrowMatch SNPEFF:splice_acceptor_variant,
        SNPEFF:splice_donor_variant,
        SNPEFF:splice_region_variant .

biolink:is_synonymous_variant_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is synonymous variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant is in the coding sequence of the gene, but results in the same amino acid sequence" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001819>,
        SNPEFF:synonymous_variant ;
    skos:narrowMatch SNPEFF:start_retained,
        SNPEFF:stop_retained_variant .

biolink:lacks_part a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "lacks part" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:exactMatch RTXKG1:lacks_part,
        <http://purl.obolibrary.org/obo/CL_lacks_part>,
        <http://purl.obolibrary.org/obo/PR_lacks_part> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CL_lacks_plasma_membrane_part> .

biolink:logical_interpretation a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "logical interpretation" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:LogicalInterpretationEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:exactMatch os:LogicalInterpretation .

biolink:manifestation_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "manifestation of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Disease ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:broadMatch WIKIDATA_PROPERTY:P1557 ;
    skos:definition "that part of a phenomenon which is directly observable or visibly expressed, or which gives evidence to the underlying process; used in SemMedDB for linking things like dysfunctions and processes to some disease or syndrome" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OMIM_manifestation_of>,
        SEMMEDDB:MANIFESTATION_OF,
        SEMMEDDB:manifestation_of ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_has_definitional_manifestation> .

biolink:model_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "model of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:similar_to ;
    skos:definition "holds between a thing and some other thing it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." ;
    skos:exactMatch RO:0003301 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/FOODON_00001301> .

biolink:negatively_correlated_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "negatively correlated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "holds between any two named thing entities \"correlated with\" one another in a negative manner." ;
    skos:exactMatch CTD:negative_correlation .

biolink:occurs_in a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "occurs in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:closeMatch <http://purl.obolibrary.org/obo/BFO_0000067>,
        <http://purl.obolibrary.org/obo/SNOMED_has_occurrence>,
        <http://purl.obolibrary.org/obo/UBERON_site_of> ;
    skos:definition "holds between a process and a material entity or site within which the process occurs" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000066>,
        <http://purl.obolibrary.org/obo/SNOMED_occurs_in>,
        PathWhiz:has_location ;
    skos:narrowMatch LOINC:has_imaged_location,
        RO:0002231,
        RO:0002232,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_procedure_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_site>,
        UBERON_CORE:site_of,
        PathWhiz:in_species,
        SEMMEDDB:OCCURS_IN,
        SEMMEDDB:PROCESS_OF,
        SEMMEDDB:occurs_in,
        SEMMEDDB:process_of .

biolink:opposite_of a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "opposite of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:seeAlso "https://doi.org/10.1101/108977",
        "https://github.com/biolink/biolink-model/issues/657" ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x). (This description is from RO. Needs to be rephrased)." ;
    skos:exactMatch RO:0002604 .

biolink:orthologous_to a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "orthologous to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:homologous_to ;
    skos:definition "a homology relationship between entities (typically genes) that diverged after a speciation event." ;
    skos:exactMatch RO:HOM0000017,
        WIKIDATA_PROPERTY:P684 .

biolink:p_value a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "p value" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone." ;
    skos:exactMatch EDAM-DATA:1669,
        <http://purl.obolibrary.org/obo/NCIT_C44185>,
        <http://purl.obolibrary.org/obo/OBI_0000175> .

biolink:paralogous_to a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "paralogous to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:homologous_to ;
    skos:definition "a homology relationship that holds between entities (typically genes) that diverged after a duplication event." ;
    skos:exactMatch RO:HOM0000011 .

biolink:positively_correlated_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "positively correlated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "holds between any two named thing entities \"correlated with\" one another in a positive manner." ;
    skos:exactMatch CTD:positive_correlation .

biolink:predisposes a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "predisposes" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affects_risk_for ;
    skos:definition "holds between two entities where exposure to one entity increases the chance of developing the other" ;
    skos:exactMatch SEMMEDDB:PREDISPOSES,
        SEMMEDDB:predisposes .

biolink:provider a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "provider" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:contributor ;
    skos:definition "person, group, organization or project that provides a piece of information (e.g. a knowledge association)." .

biolink:publisher a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "publisher" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:contributor ;
    skos:definition "organization or person responsible for publishing books, periodicals, podcasts, games or software. Note that in the case of publications which have a containing \"published in\" node property, the publisher association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the publisher agent of the encompassing publication (e.g. only from the Journal referenced by the 'published_in' property of an journal article Publication node)." ;
    skos:exactMatch dct:publisher,
        WIKIDATA_PROPERTY:P123 .

biolink:related_condition a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "related condition" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000790> .

biolink:retrieved_on a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "retrieved on" ;
    rdfs:domain biolink:Dataset ;
    rdfs:range linkml:Date ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch pav:retrievedOn .

biolink:same_as a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "same as" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:exact_match ;
    skos:closeMatch owl:equivalentClass ;
    skos:definition "holds between two entities that are considered equivalent to each other" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MONDO_equivalentTo>,
        owl:sameAs,
        CHEMBL.MECHANISM:equivalent_to,
        <https://www.w3.org/TR/skos-reference/#exactMatch>,
        WIKIDATA_PROPERTY:P2888 ;
    skos:narrowMatch <http://identifiers.org/drugbank/external-identifier> .

biolink:superclass_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "superclass of" ;
    rdfs:domain biolink:OntologyClass ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:subclass_of ;
    skos:definition "holds between two classes where the domain class is a super class of the range class" ;
    skos:exactMatch <http://identifiers.org/mesh/inverse_isa>,
        RXNORM:inverse_isa,
        <http://purl.obolibrary.org/obo/GO_inverse_isa>,
        CHEMBL.MECHANISM:superset_of,
        VANDF:inverse_isa,
        WIKIDATA:Q66088480 ;
    skos:narrowMatch <http://identifiers.org/umls/RB>,
        <http://purl.obolibrary.org/obo/NCIT_cdrh_parent_of>,
        <http://purl.obolibrary.org/obo/NCIT_ctcae_5_parent_of>,
        <http://purl.obolibrary.org/obo/NCIT_subset_includes_concept>,
        <http://purl.obolibrary.org/obo/OMIM_has_manifestation>,
        <http://purl.obolibrary.org/obo/SNOMED_has_basic_dose_form> .

biolink:update_date a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "update date" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Date ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "date on which an entity was updated. This can be applied to nodes or edges" .

biolink:version a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "version" ;
    rdfs:domain biolink:Dataset ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:broadMatch pav:version,
        owl:versionInfo .

biolink:version_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "version of" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range biolink:DatasetSummary ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:isVersionOf .

biolink:xenologous_to a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "xenologous to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:homologous_to ;
    skos:definition "a homology relationship characterized by an interspecies (horizontal) transfer since the common ancestor." ;
    skos:exactMatch RO:HOM0000018 .

linkml:SubsetDefinition a owl:Class ;
    rdfs:label "subset_definition" ;
    skos:definition "the name and description of a subset" .

GOP:systematic_synonym a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "systematic synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "more commonly used for gene symbols in yeast" ;
    skos:exactMatch GOP:systematic_synonym .

dcat:downloadURL a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:AdministrativeEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "administrative entity" ;
    rdfs:subClassOf biolink:NamedThing .

biolink:BehavioralFeature a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "behavioral feature" ;
    rdfs:subClassOf biolink:PhenotypicFeature ;
    skos:definition "A phenotypic feature which is behavioral in nature." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NBO_0000243> .

biolink:BookChapter a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "book chapter" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:chapter ],
        [ a owl:Restriction ;
            owl:onClass linkml:Uriorcurie ;
            owl:onProperty biolink:published_in ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:volume ],
        biolink:Publication .

biolink:Case a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "case" ;
    rdfs:subClassOf biolink:IndividualOrganism ;
    skos:altLabel "patient",
        "proband" ;
    skos:definition "An individual (human) organism that has a patient role in some clinical context." .

biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "cell line to disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:CellLineToEntityAssociationMixin,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    skos:definition "An relationship between a cell line and a disease or a phenotype, where the cell line is derived from an individual with that disease or phenotype." .

biolink:CellularComponent a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "cellular component" ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    skos:broadMatch WIKIDATA:P681 ;
    skos:definition "A location in or around a cell" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0005575>,
        SIO:001400,
        UMLSSC:T026,
        UMLSST:celc,
        WIKIDATA:Q5058355 .

biolink:ChemicalExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "chemical exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:ChemicalSubstance,
        biolink:ExposureEvent ;
    skos:definition "A chemical exposure is an intake of a particular chemical substance, other than a drug." ;
    skos:exactMatch ECTO:9000000,
        SIO:001399 .

biolink:ChemicalFormulaValue a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "chemical formula value" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onDataRange xsd:string ;
            owl:onProperty linkml:topValue ;
            owl:qualifiedCardinality 1 ] ;
    skos:definition "A chemical formula" ;
    skos:editorialNote "Should be implemented as a stronger type" .

biolink:ChemicalToChemicalAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "chemical to chemical association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ChemicalSubstance ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:ChemicalToEntityAssociationMixin ;
    skos:definition "A relationship between two chemical entities. This can encompass actual interactions as well as temporal causal edges, e.g. one chemical converted to another." .

biolink:ClinicalCourse a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "clinical course" ;
    rdfs:subClassOf biolink:ClinicalAttribute ;
    skos:definition "The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/HP_0031797> .

biolink:ClinicalIntervention a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "clinical intervention" ;
    rdfs:subClassOf biolink:ClinicalEntity .

biolink:ClinicalModifier a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "clinical modifier" ;
    rdfs:subClassOf biolink:ClinicalAttribute ;
    skos:definition "Used to characterize and specify the phenotypic abnormalities defined in the phenotypic abnormality sub-ontology, with respect to severity, laterality, and other aspects" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/HP_0012823> .

biolink:CodingSequence a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "coding sequence" ;
    rdfs:subClassOf biolink:GenomicEntity ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000316>,
        SIO:001390 .

biolink:ConfidenceLevel a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "confidence level" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:closeMatch <http://purl.obolibrary.org/obo/SEPIO_0000167> ;
    skos:definition "Level of confidence in a statement" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CIO_0000028>,
        <http://purl.obolibrary.org/obo/SEPIO_0000187> .

biolink:Death a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "death" ;
    rdfs:subClassOf biolink:BiologicalProcess ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0016265> .

biolink:DrugExposure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "drug exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Drug,
        biolink:ExposureEvent ;
    skos:altLabel "drug dose",
        "drug intake",
        "medication intake" ;
    skos:broadMatch SIO:001005 ;
    skos:definition "A drug exposure is an intake of a particular drug." ;
    skos:exactMatch ECTO:0000509 .

biolink:DrugToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "drug to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Drug ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:MolecularEntityToEntityAssociationMixin,
        linkml:mixin ;
    skos:definition "An interaction between a drug and another entity" .

biolink:EnvironmentalProcess a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "environmental process" ;
    rdfs:subClassOf biolink:Occurrent,
        biolink:PlanetaryEntity ;
    skos:exactMatch <http://purl.obolibrary.org/obo/ENVO_02500000> .

biolink:EvidenceType a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "evidence type" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:altLabel "evidence code" ;
    skos:definition "Class of evidence that supports an association" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/ECO_0000000> .

biolink:Exon a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "exon" ;
    rdfs:subClassOf biolink:GenomicEntity ;
    skos:definition "A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000147>,
        SIO:010445,
        WIKIDATA:Q373027 .

biolink:FrequencyQuantifier a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "frequency quantifier" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        biolink:RelationshipQuantifier,
        linkml:mixin .

biolink:GenotypeToDiseaseAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genotype to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        biolink:Association,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:GenotypeToEntityAssociationMixin ;
    skos:note "TODO decide no how to model pathogenicity" .

biolink:Hospitalization a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "hospitalization" ;
    rdfs:subClassOf biolink:ClinicalIntervention ;
    skos:exactMatch <http://identifiers.org/snomedct/32485007>,
        WIKIDATA:Q3140971 .

biolink:IndividualOrganism a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "individual organism" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        biolink:OrganismalEntity,
        biolink:ThingWithTaxon ;
    skos:altLabel "organism" ;
    skos:definition "An instance of an organism. For example, Richard Nixon, Charles Darwin, my pet cat. Example ID: ORCID:0000-0002-5355-2576" ;
    skos:exactMatch SIO:010000,
        UMLSSC:T001,
        UMLSST:orgm ;
    skos:narrowMatch foaf:Person,
        WIKIDATA:Q795052 .

biolink:Micronutrient a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "micronutrient" ;
    rdfs:subClassOf biolink:Nutrient ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_27027> .

biolink:MolecularActivity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "molecular activity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:MacromolecularMachineMixin ;
            owl:onProperty biolink:enabled_by ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalSubstance ;
            owl:onProperty biolink:has_input ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalSubstance ;
            owl:onProperty biolink:has_output ],
        biolink:BiologicalProcessOrActivity,
        biolink:Occurrent,
        biolink:OntologyClass ;
    skos:altLabel "molecular event",
        "molecular function",
        "reaction" ;
    skos:definition "An execution of a molecular function carried out by a gene product or macromolecular complex." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0003674>,
        UMLSSC:T044,
        UMLSST:moft .

biolink:PairwiseGeneToGeneInteraction a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pairwise gene to gene interaction" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass linkml:Uriorcurie ;
            owl:onProperty biolink:relation ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:GeneToGeneAssociation ;
    skos:definition "An interaction between two genes or two gene products. May be physical (e.g. protein binding) or genetic (between genes). May be symmetric (e.g. protein interaction) or directed (e.g. phosphorylation)" .

biolink:Pathway a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pathway" ;
    rdfs:subClassOf biolink:BiologicalProcess,
        biolink:OntologyClass ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PW_0000001>,
        WIKIDATA:Q4915012 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/GO_0007165>,
        SIO:010526 .

biolink:SequenceAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "sequence association" ;
    rdfs:subClassOf biolink:Association ;
    skos:definition "An association between a sequence feature and a genomic entity it is localized to." .

biolink:SpecificityQuantifier a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "specificity quantifier" ;
    rdfs:subClassOf biolink:RelationshipQuantifier,
        linkml:mixin .

biolink:StudyPopulation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "study population" ;
    rdfs:subClassOf biolink:PopulationOfIndividualOrganisms ;
    skos:closeMatch WIKIDATA:Q7229825 ;
    skos:definition "A group of people banded together or treated as a group as participants in a research study." .

biolink:SymbolType a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "symbol type" ;
    rdfs:subClassOf linkml:String .

biolink:TaxonomicRank a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "taxonomic rank" ;
    rdfs:subClassOf biolink:OntologyClass ;
    skos:definition "A descriptor for the rank within a taxonomic classification. Example instance: TAXRANK:0000017 (kingdom)" ;
    skos:exactMatch WIKIDATA:Q427626 .

biolink:VariantToDiseaseAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "variant to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        biolink:Association,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:VariantToEntityAssociationMixin ;
    skos:note "TODO decide no how to model pathogenicity" .

biolink:VariantToGeneAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "variant to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:VariantToEntityAssociationMixin ;
    skos:definition "An association between a variant and a gene, where the variant has a genetic association with the gene (i.e. is in linkage disequilibrium)" .

biolink:actively_involved_in a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "actively involved in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:participates_in ;
    skos:broadMatch RTXKG1:involved_in ;
    skos:closeMatch <http://purl.obolibrary.org/obo/NCIT_biological_process_involves_chemical_or_drug> ;
    skos:definition "holds between a continuant and a process or function, where the continuant actively contributes to part or all of the process or function it realizes" ;
    skos:exactMatch RO:0002331,
        RO:0002432 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_gene_involved_in_molecular_abnormality>,
        RO:0002503,
        <http://purl.obolibrary.org/obo/nbo#by_means>,
        ORPHA:317348,
        ORPHA:317349,
        ORPHA:327767 .

biolink:address a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "address" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "the particulars of the place where someone or an organization is situated.  For now, this slot is a simple text \"blob\" containing all relevant details of the given location for fitness of purpose. For the moment, this \"address\" can include other contact details such as email and phone number(?)." .

biolink:affiliation a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affiliation" ;
    rdfs:domain biolink:Agent ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "a professional relationship between one provider (often a person) within another provider (often an organization). Target provider identity should be specified by a CURIE. Providers may have multiple affiliations." .

biolink:aggregate_statistic a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "aggregate statistic" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property .

biolink:ameliorates a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "ameliorates" ;
    rdfs:domain biolink:BiologicalEntity ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." ;
    skos:exactMatch RO:0003307,
        CTD:therapeutic .

biolink:approved_for_treatment_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "approved for treatment by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:Treatment ;
    rdfs:subPropertyOf biolink:treated_by ;
    owl:inverseOf biolink:approved_to_treat ;
    skos:definition "holds between a disease or phenotypic feature and a therapeutic process or chemical substance that is approved for treatment of the condition (or not, if negated) to some level of clinical trial" .

biolink:approved_to_treat a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "approved to treat" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:treats ;
    owl:inverseOf biolink:approved_for_treatment_by ;
    skos:definition "holds between a therapeutic procedure or chemical substance and a disease or phenotypic feature for which it is approved for treatment to some level of clinical trial. Note that in terms of REPODB narrow mappings, terms containing 'suspended', 'terminated' or 'withdrawn' should be mapped onto associations using this term for which 'negated: true' is asserted." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C172573> ;
    skos:narrowMatch REPODB:clinically_tested_approved_unknown_phase,
        REPODB:clinically_tested_suspended_phase_0,
        REPODB:clinically_tested_suspended_phase_1,
        REPODB:clinically_tested_suspended_phase_1_or_phase_2,
        REPODB:clinically_tested_suspended_phase_2,
        REPODB:clinically_tested_suspended_phase_2_or_phase_3,
        REPODB:clinically_tested_suspended_phase_3,
        REPODB:clinically_tested_terminated_phase_0,
        REPODB:clinically_tested_terminated_phase_1,
        REPODB:clinically_tested_terminated_phase_1_or_phase_2,
        REPODB:clinically_tested_terminated_phase_2,
        REPODB:clinically_tested_terminated_phase_2_or_phase_3,
        REPODB:clinically_tested_terminated_phase_3,
        REPODB:clinically_tested_withdrawn_phase_0,
        REPODB:clinically_tested_withdrawn_phase_1,
        REPODB:clinically_tested_withdrawn_phase_1_or_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2_or_phase_3,
        REPODB:clinically_tested_withdrawn_phase_3,
        <http://purl.obolibrary.org/obo/NCIT_R172>,
        <http://purl.obolibrary.org/obo/NCIT_regimen_has_accepted_use_for_disease> .

biolink:associated_environmental_context a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:authors a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "authors" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an publication to the list of authors who contributed to the publication. This property should be a comma-delimited list of author names. It is recommended that an author's name be formatted as \"surname, firstname initial.\".   Note that this property is a node annotation expressing the citation list of authorship which might typically otherwise be more completely documented in biolink:PublicationToProviderAssociation defined edges which point to full details about an author and possibly, some qualifiers which clarify the specific status of a given author in the publication." .

biolink:biomarker_for a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "biomarker for" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:correlated_with ;
    owl:inverseOf biolink:has_biomarker ;
    skos:broadMatch RO:0002607 ;
    skos:definition "holds between a measurable molecular entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_R39> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R47>,
        <http://purl.obolibrary.org/obo/NCIT_genetic_biomarker_related_to>,
        <http://purl.obolibrary.org/obo/NCIT_is_molecular_abnormality_of_disease>,
        ORPHA:465410,
        SEMMEDDB:diagnoses .

biolink:broad_match a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "broad match" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:narrow_match ;
    skos:definition "a list of terms from different schemas or terminology systems that have a broader, more general meaning. Broader terms are typically shown as parents in a hierarchy or tree." ;
    skos:exactMatch <https://www.w3.org/TR/skos-reference/#broadMatch>,
        WIKIDATA:Q39894595 .

biolink:catalyst_qualifier a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:caused_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "caused by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:causes ;
    skos:definition "holds between two entities where the occurrence, existence, or activity of one is caused by the occurrence or generation of the other" ;
    skos:exactMatch WIKIDATA_PROPERTY:P828 ;
    skos:narrowMatch RTXKG1:disease_caused_by_disruption_of,
        RTXKG1:disease_has_basis_in_dysfunction_of,
        RTXKG1:realized_in_response_to,
        RTXKG1:realized_in_response_to_stimulus,
        RO:0001022,
        RO:0002608,
        RO:0004019,
        RO:0004020,
        RO:0004028,
        RO:0009501 .

biolink:chapter a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "chapter" ;
    rdfs:domain biolink:BookChapter ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "chapter of a book" ;
    skos:exactMatch WIKIDATA:Q1980247 .

biolink:close_match a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "close match" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "a list of terms from different schemas or terminology systems that have a semantically similar but not strictly equivalent, broader, or narrower meaning. Such terms often describe the same general concept from different ontological perspectives (e.g. drug as a type of chemical entity versus drug as a type of role borne by a chemical entity)." ;
    skos:exactMatch SEMMEDDB:SAME_AS,
        SEMMEDDB:same_as,
        <https://www.w3.org/TR/skos-reference/#closeMatch> ;
    skos:narrowMatch <http://identifiers.org/meddra/classified_as>,
        <http://identifiers.org/umls/SY>,
        RXNORM:has_quantified_form,
        <http://purl.obolibrary.org/obo/CHEBI_is_enantiomer_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_tautomer_of>,
        <http://purl.obolibrary.org/obo/xref>,
        oboformat:xref .

biolink:condition_associated_with_gene a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "condition associated with gene" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:genetic_association ;
    owl:inverseOf biolink:gene_associated_with_condition ;
    skos:definition "holds between a gene and a disease or phenotypic feature that may be influenced, contribute to, or be correlated with the gene or its alleles/products" ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R176>,
        hetio:ASSOCIATES_DaG .

biolink:contributes_to a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "contributes to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:closeMatch <http://purl.obolibrary.org/obo/IDO_0000664> ;
    skos:definition "holds between two entities where the occurrence, existence, or activity of one causes or contributes to the occurrence or generation of the other" ;
    skos:exactMatch RO:0002326 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/MONDO_predisposes_towards>,
        RO:0002255,
        RO:0003304,
        CTD:marker_mechanism .

biolink:creation_date a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "creation date" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Date ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "publication date" ;
    skos:definition "date on which an entity was created. This can be applied to nodes or edges" ;
    skos:exactMatch dct:createdOn,
        WIKIDATA_PROPERTY:P577 .

biolink:disrupted_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "disrupted by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:disrupts ;
    skos:definition "describes a relationship where the structure, function, or occurrence of one entity is degraded or interfered with by another." .

biolink:disrupts a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "disrupts" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affects ;
    owl:inverseOf biolink:disrupted_by ;
    skos:definition "describes a relationship where one entity degrades or interferes with the structure, function, or occurrence of another." ;
    skos:exactMatch SEMMEDDB:DISRUPTS,
        SEMMEDDB:disrupts,
        CHEMBL.MECHANISM:disrupting_agent ;
    skos:narrowMatch RTXKG1:disease_causes_disruption_of,
        RO:0004024,
        RO:0004025 .

biolink:distribution_download_url a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "distribution download url" ;
    rdfs:domain biolink:DatasetDistribution ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dcat:downloadURL .

biolink:end_interbase_coordinate a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "end interbase coordinate" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:interbase_coordinate ;
    skos:definition "The position at which the subject genomic entity ends on the chromosome or other entity to which it is located on." .

biolink:entity_negatively_regulated_by_entity a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "entity negatively regulated by entity" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:entity_regulated_by_entity ;
    owl:inverseOf biolink:entity_negatively_regulates_entity .

biolink:entity_negatively_regulates_entity a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "entity negatively regulates entity" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:entity_regulates_entity,
        biolink:negatively_regulates ;
    owl:inverseOf biolink:entity_negatively_regulated_by_entity ;
    skos:altLabel "activity directly negatively regulates activity of" ;
    skos:exactMatch RO:0002449 ;
    skos:narrowMatch hetio:DOWNREGULATES_AdG,
        hetio:DOWNREGULATES_DdG,
        SEMMEDDB:INHIBITS,
        SEMMEDDB:inhibits .

biolink:entity_positively_regulated_by_entity a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "entity positively regulated by entity" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:entity_regulated_by_entity ;
    owl:inverseOf biolink:entity_positively_regulates_entity .

biolink:entity_positively_regulates_entity a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "entity positively regulates entity" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:entity_regulates_entity,
        biolink:positively_regulates ;
    owl:inverseOf biolink:entity_positively_regulated_by_entity ;
    skos:altLabel "activity directly positively regulates activity of" ;
    skos:broadMatch RO:0004034 ;
    skos:exactMatch RO:0002450 ;
    skos:narrowMatch hetio:UPREGULATES_AuG,
        hetio:UPREGULATES_DuG,
        SEMMEDDB:STIMULATES,
        SEMMEDDB:stimulates .

biolink:exact_match a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "exact match" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:close_match ;
    skos:definition "holds between two entities that have strictly equivalent meanings, with a high degree of confidence" ;
    skos:exactMatch <https://www.w3.org/TR/skos-reference/#exactMatch>,
        WIKIDATA:P2888,
        WIKIDATA:Q39893449 .

biolink:expressed_in a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "expressed in" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:AnatomicalEntity ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:expresses ;
    skos:definition "holds between a gene or gene product and an anatomical entity in which it is expressed" ;
    skos:exactMatch RO:0002206 ;
    skos:narrowMatch RTXKG1:expressed_in,
        <http://purl.obolibrary.org/obo/NCIT_R46>,
        <http://purl.obolibrary.org/obo/NCIT_R49> .

biolink:expresses a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "expresses" ;
    rdfs:domain biolink:AnatomicalEntity ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:expressed_in ;
    skos:definition "holds between an anatomical entity and gene or gene product that is expressed there" ;
    skos:exactMatch RO:0002292,
        hetio:EXPRESSES_AeG .

biolink:format a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "format" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:format,
        WIKIDATA_PROPERTY:P2701 .

biolink:gene_associated_with_condition a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "gene associated with condition" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:genetic_association ;
    owl:inverseOf biolink:condition_associated_with_gene ;
    skos:broadMatch <http://purl.obolibrary.org/obo/GENO_0000840>,
        <http://purl.obolibrary.org/obo/GENO_0000841> ;
    skos:definition "holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with" ;
    skos:exactMatch RTXKG1:gene_associated_with_condition ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R175>,
        <http://purl.obolibrary.org/obo/NCIT_R38>,
        <http://purl.obolibrary.org/obo/NCIT_R48> .

biolink:gene_product_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "gene product of" ;
    rdfs:domain biolink:GeneProductMixin ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:has_gene_product ;
    skos:definition "definition x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of thatf process is either y or something that is ribosomally translated from x" ;
    skos:exactMatch RO:0002204 .

biolink:genome_build a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "genome build" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "The version of the genome on which a feature is located. For example, GRCh38 for Homo sapiens." .

biolink:has_active_ingredient a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has active ingredient" ;
    rdfs:domain biolink:Drug ;
    rdfs:range biolink:ChemicalSubstance ;
    rdfs:subPropertyOf biolink:has_part ;
    owl:inverseOf biolink:is_active_ingredient_of ;
    skos:definition "holds between a drug and a chemical substance in which the latter is a part of the former, and is a biologically active component" ;
    skos:exactMatch RO:0002248 .

biolink:has_biomarker a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has biomarker" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:correlated_with ;
    owl:inverseOf biolink:biomarker_for ;
    skos:definition "holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature." ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_disease_has_finding>,
        <http://purl.obolibrary.org/obo/NCIT_disease_has_molecular_abnormality>,
        <http://purl.obolibrary.org/obo/NCIT_disease_is_marked_by_gene> .

biolink:has_device a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has device" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Device ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity to one or more (medical) devices" .

biolink:has_drug a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has drug" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity to one or more drugs" .

biolink:has_excipient a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has excipient" ;
    rdfs:domain biolink:Drug ;
    rdfs:range biolink:ChemicalSubstance ;
    rdfs:subPropertyOf biolink:has_part ;
    owl:inverseOf biolink:is_excipient_of ;
    skos:definition "holds between a drug and a chemical substances in which the latter is a part of the former, and is a biologically inactive component" ;
    skos:exactMatch WIKIDATA:Q902638 .

biolink:has_gene a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:has_gene_product a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has gene product" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:GeneProductMixin ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:gene_product_of ;
    skos:closeMatch <http://purl.obolibrary.org/obo/PR_has_gene_template> ;
    skos:definition "holds between a gene and a transcribed and/or translated product generated from it" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_gene_encodes_gene_product>,
        RO:0002205,
        WIKIDATA_PROPERTY:P688 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R178> .

biolink:has_metabolite a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has metabolite" ;
    rdfs:domain biolink:ChemicalSubstance ;
    rdfs:range biolink:ChemicalSubstance ;
    rdfs:subPropertyOf biolink:derives_into ;
    owl:inverseOf biolink:is_metabolite_of ;
    skos:definition "holds between two chemical substances in which the second one is derived from the first one as a product of metabolism" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> ;
    skos:note "The CHEBI ID represents a role rather than a predicate" .

biolink:has_numeric_value a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has numeric value" ;
    rdfs:domain biolink:QuantityValue ;
    rdfs:range linkml:Double ;
    skos:definition "connects a quantity value to a number" ;
    skos:exactMatch qud:quantityValue .

biolink:has_nutrient a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has nutrient" ;
    rdfs:domain biolink:ChemicalSubstance ;
    rdfs:range biolink:ChemicalSubstance ;
    rdfs:subPropertyOf biolink:has_food_component ;
    owl:inverseOf biolink:nutrient_of ;
    skos:definition "one or more nutrients which are growth factors for a living organism" ;
    skos:exactMatch WIKIDATA:Q181394 .

biolink:has_participant a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has participant" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:participates_in ;
    skos:closeMatch WIKIDATA_PROPERTY:P2283 ;
    skos:definition "holds between a process and a continuant, where the continuant is somehow involved in the process" ;
    skos:exactMatch RO:0000057,
        RO:has_participant ;
    skos:narrowMatch LOINC:has_subject,
        <http://purl.obolibrary.org/obo/BFO_0000167>,
        <http://purl.obolibrary.org/obo/NCIT_pathway_has_gene_element>,
        <http://purl.obolibrary.org/obo/NCIT_process_includes_biological_process>,
        <http://purl.obolibrary.org/obo/NCIT_process_involves_gene>,
        <http://purl.obolibrary.org/obo/OBI_0000293>,
        RO:0004007,
        RO:0004020,
        RO:0004021,
        <http://purl.obolibrary.org/obo/SNOMED_has_indirect_device>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_device>,
        <http://purl.obolibrary.org/obo/SNOMED_has_recipient_category>,
        <http://purl.obolibrary.org/obo/nbo#has_participant>,
        PathWhiz:has_bound,
        PathWhiz:has_compound,
        PathWhiz:has_element_collection,
        PathWhiz:has_enzyme,
        PathWhiz:has_nucleic_acid,
        PathWhiz:has_protein,
        PathWhiz:has_reaction .

biolink:has_phenotype a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has phenotype" ;
    rdfs:domain biolink:BiologicalEntity ;
    rdfs:range biolink:PhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:phenotype_of ;
    skos:broadMatch <http://purl.obolibrary.org/obo/NCIT_R115>,
        <http://purl.obolibrary.org/obo/OMIM_has_phenotype>,
        hetio:PRESENTS_DpS ;
    skos:closeMatch <http://purl.obolibrary.org/obo/OMIM_phenotype_of> ;
    skos:definition "holds between a biological entity and a phenotype, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature)." ;
    skos:editorialNote "check the range" ;
    skos:exactMatch RTXKG1:has_phenotype,
        RO:0002200,
        <http://purl.obolibrary.org/obo/SNOMED_characterized_by> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R89>,
        RO:0004022,
        <http://purl.obolibrary.org/obo/doid#has_symptom> .

biolink:has_population_context a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has population context" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:PopulationOfIndividualOrganisms ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a biological population (general, study, cohort, etc.) with a specific set of characteristics to constrain an association." .

biolink:has_procedure a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has procedure" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Procedure ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity to one or more (medical) procedures" .

biolink:has_qualitative_value a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has qualitative value" ;
    rdfs:domain biolink:Attribute ;
    rdfs:range biolink:NamedThing ;
    skos:definition "connects an attribute to a value" .

biolink:has_quantitative_value a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has quantitative value" ;
    rdfs:domain biolink:Attribute ;
    rdfs:range biolink:QuantityValue ;
    skos:definition "connects an attribute to a value" ;
    skos:exactMatch qud:quantityValue ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_has_concentration_strength_numerator_value>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_denominator_value>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_numerator_value> .

biolink:has_taxonomic_rank a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:has_temporal_context a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has temporal context" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:TimeType ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a constraint of time placed upon the truth value of an association." .

biolink:has_unit a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has unit" ;
    rdfs:domain biolink:QuantityValue ;
    rdfs:range biolink:Unit ;
    skos:closeMatch <http://purl.obolibrary.org/obo/uo#is_unit_of>,
        EFO:0001697 ;
    skos:definition "connects a quantity value to a unit" ;
    skos:exactMatch IAO:0000039,
        qud:unit ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_has_concentration_strength_denominator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_concentration_strength_numerator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_denominator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_numerator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_unit_of_presentation> .

biolink:has_zygosity a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has zygosity" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:Zygosity ;
    rdfs:subPropertyOf biolink:node_property .

biolink:interacting_molecules_category a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "interacting molecules category" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:exactMatch MI:1046 ;
    linkml:examples "Example(value='MI:1048', description='smallmolecule-protein')" .

biolink:is_active_ingredient_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is active ingredient of" ;
    rdfs:domain biolink:ChemicalSubstance ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_active_ingredient ;
    skos:definition "holds between a chemical substance and a drug, in which the former is a part of the latter, and is a biologically active component" ;
    skos:exactMatch RO:0002249 .

biolink:is_excipient_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is excipient of" ;
    rdfs:domain biolink:ChemicalSubstance ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_excipient ;
    skos:definition "holds between a chemical substance and a drug in which the former is a part of the latter, and is a biologically inactive component" ;
    skos:exactMatch WIKIDATA:Q902638 .

biolink:is_metabolite a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is metabolite" ;
    rdfs:domain biolink:ChemicalSubstance ;
    rdfs:range linkml:Boolean ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "indicates whether a chemical substance is a metabolite" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> .

biolink:is_metabolite_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is metabolite of" ;
    rdfs:domain biolink:ChemicalSubstance ;
    rdfs:range biolink:ChemicalSubstance ;
    rdfs:subPropertyOf biolink:derives_from ;
    owl:inverseOf biolink:has_metabolite ;
    skos:definition "holds between two chemical substances in which the first one is derived from the second one as a product of metabolism" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> ;
    skos:note "The CHEBI ID represents a role rather than a predicate" .

biolink:keywords a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "keywords" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "keywords tagging a publication" .

biolink:latitude a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "latitude" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "latitude" ;
    skos:exactMatch wgs:lat .

biolink:license a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "license" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:license ;
    skos:narrowMatch WIKIDATA_PROPERTY:P275 .

biolink:located_in a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "located in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:location_of ;
    skos:definition "holds between a material entity and a material entity or site within which it is located (but of which it is not considered a part)" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/FMA_has_location>,
        RO:0001025 ;
    skos:narrowMatch <http://identifiers.org/hmdb/at_cellular_location>,
        <http://identifiers.org/hmdb/at_tissue>,
        <http://identifiers.org/hmdb/in_biospecimen>,
        RTXKG1:disease_has_location,
        LOINC:has_imaging_focus,
        <http://purl.obolibrary.org/obo/BSPO_0000107>,
        <http://purl.obolibrary.org/obo/BSPO_0000108>,
        <http://purl.obolibrary.org/obo/BSPO_0000120>,
        <http://purl.obolibrary.org/obo/BSPO_0000121>,
        <http://purl.obolibrary.org/obo/BSPO_0000122>,
        <http://purl.obolibrary.org/obo/BSPO_0000123>,
        <http://purl.obolibrary.org/obo/BSPO_0000124>,
        <http://purl.obolibrary.org/obo/BSPO_0000125>,
        <http://purl.obolibrary.org/obo/BSPO_0000126>,
        <http://purl.obolibrary.org/obo/BSPO_0001100>,
        <http://purl.obolibrary.org/obo/BSPO_0001101>,
        <http://purl.obolibrary.org/obo/BSPO_0001107>,
        <http://purl.obolibrary.org/obo/BSPO_0015101>,
        <http://purl.obolibrary.org/obo/BSPO_0015102>,
        <http://purl.obolibrary.org/obo/BSPO_0015202>,
        <http://purl.obolibrary.org/obo/FMA_has_location>,
        GOREL:0001004,
        <http://purl.obolibrary.org/obo/NCIT_R100>,
        <http://purl.obolibrary.org/obo/NCIT_R145>,
        <http://purl.obolibrary.org/obo/NCIT_R155>,
        <http://purl.obolibrary.org/obo/NCIT_R156>,
        <http://purl.obolibrary.org/obo/NCIT_R165>,
        <http://purl.obolibrary.org/obo/NCIT_R166>,
        <http://purl.obolibrary.org/obo/NCIT_R167>,
        <http://purl.obolibrary.org/obo/NCIT_R168>,
        <http://purl.obolibrary.org/obo/NCIT_R169>,
        <http://purl.obolibrary.org/obo/NCIT_R170>,
        <http://purl.obolibrary.org/obo/NCIT_R171>,
        <http://purl.obolibrary.org/obo/NCIT_R40>,
        <http://purl.obolibrary.org/obo/NCIT_is_location_of_anatomic_structure>,
        RO:0002303,
        <http://purl.obolibrary.org/obo/SNOMED_has_finding_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_indirect_procedure_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_inherent_location>,
        UBERON_CORE:in_central_side_of,
        UBERON_CORE:in_innermost_side_of,
        UBERON_CORE:in_outermost_side_of,
        EFO:0000784 .

biolink:location_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "location of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:located_in ;
    skos:definition "holds between material entity or site and a material entity that is located within it (but not considered a part of it)" ;
    skos:exactMatch RTXKG1:site_of,
        <http://purl.obolibrary.org/obo/FMA_location_of>,
        RO:0001015,
        SEMMEDDB:LOCATION_OF,
        SEMMEDDB:location_of,
        WIKIDATA_PROPERTY:P276 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_inherent_location_of> .

biolink:longitude a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "longitude" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "longitude" ;
    skos:exactMatch wgs:long .

biolink:mesh_terms a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "mesh terms" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "mesh terms tagging a publication" .

biolink:narrow_match a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "narrow match" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:broad_match ;
    skos:definition "a list of terms from different schemas or terminology systems that have a narrower, more specific meaning. Narrower terms are typically shown as children in a hierarchy or tree." ;
    skos:exactMatch <https://www.w3.org/TR/skos-reference/#narrowMatch>,
        WIKIDATA:Q39893967 .

biolink:negated a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "negated" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Boolean ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "if set to true, then the association is negated i.e. is not true" .

biolink:negatively_regulated_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "negatively regulated by" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    rdfs:subPropertyOf biolink:regulated_by ;
    owl:inverseOf biolink:negatively_regulates .

biolink:nutrient_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "nutrient of" ;
    rdfs:domain biolink:ChemicalSubstance ;
    rdfs:range biolink:ChemicalSubstance ;
    rdfs:subPropertyOf biolink:food_component_of ;
    owl:inverseOf biolink:has_nutrient ;
    skos:definition "holds between a one or more chemical substances present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .

biolink:pages a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:phase a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "phase" ;
    rdfs:domain biolink:CodingSequence ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "The phase for a coding sequence entity. For example, phase of a CDS as represented in a GFF3 with a value of 0, 1 or 2." .

biolink:phenotype_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "phenotype of" ;
    rdfs:domain biolink:PhenotypicFeature ;
    rdfs:range biolink:BiologicalEntity ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:has_phenotype ;
    skos:definition "holds between a phenotype and a biological entity, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature)." ;
    skos:editorialNote "check the domain" .

biolink:physically_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "physically interacts with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:interacts_with ;
    skos:closeMatch <http://identifiers.org/drugbank/target>,
        CHEMBL.MECHANISM:binding_agent,
        CHEMBL.MECHANISM:chelating_agent,
        CHEMBL.MECHANISM:cross-linking_agent,
        CHEMBL.MECHANISM:oxidative_enzyme,
        CHEMBL.MECHANISM:sequestering_agent,
        CHEMBL.MECHANISM:substrate ;
    skos:definition "holds between two entities that make physical contact as part of some interaction" ;
    skos:exactMatch RTXKG1:physically_interacts_with,
        WIKIDATA_PROPERTY:P129 ;
    skos:narrowMatch <http://identifiers.org/drugbank/drug-interaction>,
        <http://purl.obolibrary.org/obo/FMA_adheres_to>,
        <http://purl.obolibrary.org/obo/NCIT_A7>,
        <http://purl.obolibrary.org/obo/PR_non-covalently_bound_to>,
        SEMMEDDB:INTERACTS_WITH,
        SEMMEDDB:interacts_with .

biolink:positively_regulated_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "positively regulated by" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    rdfs:subPropertyOf biolink:regulated_by ;
    owl:inverseOf biolink:positively_regulates .

biolink:preceded_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "preceded by" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:temporally_related_to ;
    owl:inverseOf biolink:precedes ;
    skos:broadMatch <http://purl.obolibrary.org/obo/GENEPIO_0001739> ;
    skos:definition "holds between two processes, where the other is completed before the one begins" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000062> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/FMA_transforms_from>,
        RO:0002087,
        RO:0002285 .

biolink:precedes a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "precedes" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:temporally_related_to ;
    owl:inverseOf biolink:preceded_by ;
    skos:broadMatch WIKIDATA_PROPERTY:P156 ;
    skos:closeMatch RO:0002263,
        RO:0002264 ;
    skos:definition "holds between two processes, where one completes before the other begins" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000063>,
        <http://purl.obolibrary.org/obo/SNOMED_occurs_before>,
        SEMMEDDB:PRECEDES,
        SEMMEDDB:precedes ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/FMA_transforms_into>,
        RO:0002090,
        RO:0002411,
        RO:0002412 .

biolink:prevented_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "prevented by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:prevents ;
    skos:definition "holds between a potential outcome of which the likelihood was reduced by the application or use of an entity." .

biolink:prevents a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "prevents" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affects_risk_for ;
    owl:inverseOf biolink:prevented_by ;
    skos:definition "holds between an entity whose application or use reduces the likelihood of a potential outcome. Typically used to associate a chemical substance, exposure, activity, or medical intervention that can prevent the onset a disease or phenotypic feature." ;
    skos:exactMatch SEMMEDDB:PREVENTS,
        SEMMEDDB:prevents ;
    skos:narrowMatch RO:0002599 .

biolink:process_negatively_regulated_by_process a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "process negatively regulated by process" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:process_regulated_by_process ;
    owl:inverseOf biolink:process_negatively_regulates_process .

biolink:process_negatively_regulates_process a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "process negatively regulates process" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:negatively_regulates,
        biolink:process_regulates_process ;
    owl:inverseOf biolink:process_negatively_regulated_by_process ;
    skos:exactMatch RO:0002212 .

biolink:process_positively_regulated_by_process a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "process positively regulated by process" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:process_regulated_by_process ;
    owl:inverseOf biolink:process_positively_regulates_process .

biolink:process_positively_regulates_process a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "process positively regulates process" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:positively_regulates,
        biolink:process_regulates_process ;
    owl:inverseOf biolink:process_positively_regulated_by_process ;
    skos:exactMatch RO:0002213 .

biolink:produced_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "produced by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:produces ;
    skos:exactMatch RO:0003001 .

biolink:produces a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "produces" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:produced_by ;
    skos:definition "holds between a material entity and a product that is generated through the intentional actions or functioning of the material entity" ;
    skos:exactMatch RO:0003000,
        SEMMEDDB:PRODUCES,
        SEMMEDDB:produces,
        WIKIDATA_PROPERTY:P1056 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R29>,
        <http://purl.obolibrary.org/obo/SNOMED_has_process_output>,
        <http://purl.obolibrary.org/obo/SNOMED_specimen_procedure_of> ;
    skos:relatedMatch GOREL:0001010 .

biolink:provided_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "provided by" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to the agent (person, organization or group) that provided it" ;
    skos:exactMatch pav:providedBy .

biolink:publications a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "publications" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:Publication ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to publications supporting the association" .

biolink:rights a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "rights" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:rights .

biolink:sequence_variant_qualifier a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "sequence variant qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a qualifier used in an association with the variant" .

biolink:source_web_page a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "source web page" ;
    rdfs:domain biolink:DatasetSummary ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:broadMatch dct:source .

biolink:start_interbase_coordinate a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "start interbase coordinate" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:interbase_coordinate ;
    skos:definition "The position at which the subject genomic entity starts on the chromosome or other entity to which it is located on." .

biolink:strand a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "strand" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "The strand on which a feature is located. Has a value of '+' (sense strand or forward strand) or '-' (anti-sense strand or reverse strand)." .

biolink:summary a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "summary" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "abstract" ;
    skos:definition "executive  summary of a publication" ;
    skos:exactMatch dct:abstract,
        WIKIDATA:Q333291 .

biolink:symbol a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "symbol" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Symbol for a particular thing" ;
    skos:exactMatch gpi:DB_Object_Symbol,
        alliancegenome:symbol .

biolink:transcribed_from a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "transcribed from" ;
    rdfs:domain biolink:Transcript ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:transcribed_to ;
    skos:definition "x is transcribed from y if and only if x is synthesized from template y" ;
    skos:exactMatch RO:0002510,
        SIO:010081 .

biolink:transcribed_to a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "transcribed to" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Transcript ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:transcribed_from ;
    skos:definition "inverse of transcribed from" ;
    skos:exactMatch RO:0002511,
        SIO:010080 .

biolink:translates_to a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "translates to" ;
    rdfs:domain biolink:Transcript ;
    rdfs:range biolink:Protein ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:translation_of ;
    skos:closeMatch RO:0002513,
        SIO:010082 ;
    skos:definition "x (amino acid chain/polypeptide) is the ribosomal translation of y (transcript) if and only if a ribosome reads y (transcript) through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces x (amino acid chain/polypeptide)" .

biolink:translation_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "translation of" ;
    rdfs:domain biolink:Protein ;
    rdfs:range biolink:Transcript ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:translates_to ;
    skos:closeMatch RO:0002512,
        SIO:010083 ;
    skos:definition "inverse of translates to" .

linkml:topValue a owl:DatatypeProperty ;
    rdfs:label "value" .

dct:description a owl:ObjectProperty,
        linkml:SlotDefinition .

dct:distribution a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has distribution" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range biolink:DatasetDistribution ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:distribution .

schema1:logo a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "source logo" ;
    rdfs:domain biolink:DatasetSummary ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch schema1:logo .

os:AllSomeInterpretation a owl:Class,
        biolink:LogicalInterpretationEnum ;
    rdfs:label "AllSome" ;
    skos:definition "A modifier on a triple that causes the triple to be interpreted as an all-some statement." .

os:SomeSomeInterpretation a owl:Class,
        biolink:LogicalInterpretationEnum ;
    rdfs:label "SomeSome" ;
    skos:definition "A modifier on a triple that causes the triple to be interpreted as a some-some statement" .

biolink:ActivityAndBehavior a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "activity and behavior" ;
    rdfs:subClassOf biolink:Occurrent,
        linkml:mixin ;
    skos:definition "Activity or behavior of any independent integral living, organization or mechanical actor in the world" ;
    skos:exactMatch UMLSSG:ACTI .

biolink:AnatomicalEntityToAnatomicalEntityAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "anatomical entity to anatomical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association .

biolink:BiologicalSequence a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "biological sequence" ;
    rdfs:subClassOf linkml:String .

biolink:CaseToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "case to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Case ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An abstract association for use where the case is the subject" .

biolink:CellLine a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "cell line" ;
    rdfs:subClassOf biolink:OrganismalEntity ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CLO_0000031> .

biolink:CellLineToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "cell line to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:CellLine ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An relationship between a cell line and another entity" .

biolink:ClinicalEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "clinical entity" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities" .

biolink:Device a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "device" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment" ;
    skos:narrowMatch UMLSSG:DEVI,
        UMLSSC:T074,
        UMLSSC:T075,
        UMLSSC:T203,
        UMLSST:drdd,
        UMLSST:medd,
        UMLSST:resd .

biolink:EntityToExposureEventAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "entity to exposure event association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ExposureEvent ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An association between some entity and an exposure event." .

biolink:EntityToFeatureOrDiseaseQualifiersMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "entity to feature or disease qualifiers mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        biolink:FrequencyQualifierMixin,
        linkml:mixin ;
    skos:definition "Qualifiers for entity to disease or phenotype associations." .

biolink:EntityToOutcomeAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "entity to outcome association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Outcome ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An association between some entity and an outcome" .

biolink:ExposureEventToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "exposure event to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ExposureEvent ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An association between some exposure event and some entity." .

biolink:GeneOntologyClass a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene ontology class" ;
    rdfs:subClassOf biolink:OntologyClass,
        linkml:mixin ;
    skos:definition "an ontology class that describes a functional aspect of a gene, gene prodoct or complex" .

biolink:GeneProductIsoformMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene product isoform mixin" ;
    rdfs:subClassOf biolink:GeneProductMixin,
        linkml:mixin ;
    skos:definition "This is an abstract class that can be mixed in with different kinds of gene products to indicate that the gene product is intended to represent a specific isoform rather than a canonical or reference or generic product. The designation of canonical or reference may be arbitrary, or it may represent the superclass of all isoforms." .

biolink:GeneToDiseaseAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        biolink:Association,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:GeneToEntityAssociationMixin ;
    skos:exactMatch SIO:000983 ;
    skos:note "NCIT:R176 refers to the inverse relationship" .

biolink:GeographicLocation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "geographic location" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Float ;
            owl:onProperty biolink:latitude ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Float ;
            owl:onProperty biolink:longitude ],
        biolink:PlanetaryEntity ;
    skos:definition "a location that can be described in lat/long coordinates" ;
    skos:exactMatch UMLSSG:GEOG,
        UMLSSC:T083,
        UMLSST:geoa .

<https://w3id.org/biolink/vocab/LogicalInterpretationEnum#InverseAllSome> a owl:Class,
        biolink:LogicalInterpretationEnum ;
    rdfs:label "InverseAllSome" .

biolink:MaterialSample a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "material sample" ;
    rdfs:subClassOf biolink:PhysicalEntity,
        biolink:SubjectOfInvestigation ;
    skos:altLabel "biosample",
        "biospecimen",
        "physical sample",
        "sample" ;
    skos:definition "A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a substance) to be used for testing, analysis, inspection, investigation, demonstration, or trial use. [SIO]" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OBI_0000747>,
        SIO:001050 .

biolink:MaterialSampleToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "material sample to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MaterialSample ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An association between a material sample and something." .

biolink:NarrativeText a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "narrative text" ;
    rdfs:subClassOf linkml:String ;
    skos:definition "A string that provides a human-readable description of something" .

biolink:NoncodingRNAProduct a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "noncoding RNA product" ;
    rdfs:subClassOf biolink:RNAProduct ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000655>,
        SIO:001235 .

biolink:Nutrient a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "nutrient" ;
    rdfs:subClassOf biolink:ChemicalSubstance ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_33284> .

biolink:OrganismAttribute a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "organism attribute" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "describes a characteristic of an organismal entity." ;
    skos:exactMatch UMLSSC:T032,
        UMLSST:orga .

biolink:OrganismTaxonToOrganismTaxonAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "organism taxon to organism taxon association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:OrganismTaxonToEntityAssociation ;
    skos:definition "A relationship between two organism taxon nodes" .

biolink:PathologicalAnatomicalStructure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pathological anatomical structure" ;
    rdfs:subClassOf biolink:AnatomicalEntity,
        biolink:PathologicalEntityMixin ;
    skos:definition "An anatomical structure with the potential of have an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level." .

biolink:PathologicalProcess a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pathological process" ;
    rdfs:subClassOf biolink:BiologicalProcess,
        biolink:PathologicalEntityMixin ;
    skos:definition "A biologic function or a process having an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C16956>,
        <http://purl.obolibrary.org/obo/OBI_1110122> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C19151>,
        EFO:0009708 .

biolink:Procedure a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "procedure" ;
    rdfs:subClassOf biolink:ActivityAndBehavior,
        biolink:NamedThing ;
    skos:definition "A series of actions conducted in a certain order or manner" ;
    skos:exactMatch UMLSSG:PROC ;
    skos:narrowMatch UMLSSC:T059,
        UMLSSC:T060,
        UMLSSC:T061,
        UMLSSC:T063,
        UMLSST:diap,
        UMLSST:lbpr,
        UMLSST:mbrt,
        UMLSST:topp .

biolink:RNAProduct a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "RNA product" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:IriType ;
            owl:onProperty biolink:xref ],
        biolink:GeneProductMixin,
        biolink:Transcript ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_33697>,
        WIKIDATA:Q11053 .

biolink:SocioeconomicAttribute a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "socioeconomic attribute" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "Attributes relating to a socioeconomic manifestation" .

biolink:SubjectOfInvestigation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "subject of investigation" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "An entity that has the role of being studied in an investigation, study, or experiment" .

biolink:Unit a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "unit" ;
    rdfs:subClassOf linkml:String .

biolink:Zygosity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "zygosity" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000133> .

biolink:affects_abundance_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects abundance of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one changes the amount of the other within a system of interest" ;
    skos:exactMatch CTD:affects_abundance_of .

biolink:affects_activity_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects activity of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one changes the activity of the other within a system of interest" ;
    skos:exactMatch CTD:affects_activity_of ;
    skos:narrowMatch GAMMA:allosteric_modulator,
        GAMMA:modulator,
        GAMMA:regulator,
        DGIdb:allosteric_modulator,
        DGIdb:modulator .

biolink:affects_degradation_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects degradation of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one impacts the rate of degradation of the other within a system of interest, where chemical degradation is defined act or process of simplifying or breaking down a molecule into smaller parts, either naturally or artificially (Oxford English Dictionary, UK, 1995)" ;
    skos:exactMatch CTD:affects_degradation_of ;
    skos:narrowMatch CTD:affects_cleavage,
        CTD:affects_hydrolysis .

biolink:affects_expression_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects expression of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one changes the level of expression of the other within a system of interest" ;
    skos:exactMatch CTD:affects_expression_of .

biolink:affects_folding_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects folding of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one changes the rate or quality of folding of the other" ;
    skos:exactMatch CTD:affects_folding_of .

biolink:affects_localization_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects localization of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one changes the localization of the other within a system of interest" ;
    skos:exactMatch GOREL:0002003,
        CTD:affects_localization_of ;
    skos:relatedMatch GAMMA:storage .

biolink:affects_metabolic_processing_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects metabolic processing of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one impacts the metabolic processing of the other within a system of interest" ;
    skos:exactMatch CTD:affects_metabolic_processing_of ;
    skos:relatedMatch GAMMA:catalytic_activity .

biolink:affects_molecular_modification_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects molecular modification of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one leads changes in the molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)" ;
    skos:exactMatch CTD:affects_molecular_modification_of ;
    skos:narrowMatch CTD:affects_ADP-ribosylation,
        CTD:affects_N-linked_glycosylation,
        CTD:affects_O-linked_glycosylation,
        CTD:affects_acetylation,
        CTD:affects_acylation,
        CTD:affects_alkylation,
        CTD:affects_amination,
        CTD:affects_carbamoylation,
        CTD:affects_carboxylation,
        CTD:affects_ethylation,
        CTD:affects_farnesylation,
        CTD:affects_geranoylation,
        CTD:affects_glucuronidation,
        CTD:affects_glutathionylation,
        CTD:affects_glycation,
        CTD:affects_glycosylation,
        CTD:affects_hydroxylation,
        CTD:affects_lipidation,
        CTD:affects_methylation,
        CTD:affects_myristoylation,
        CTD:affects_nitrosation,
        CTD:affects_nucleotidylation,
        CTD:affects_oxidation,
        CTD:affects_palmitoylation,
        CTD:affects_phosphorylation,
        CTD:affects_prenylation,
        CTD:affects_reduction,
        CTD:affects_ribosylation,
        CTD:affects_sulfation,
        CTD:affects_sumoylation,
        CTD:affects_ubiquitination .

biolink:affects_mutation_rate_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects mutation rate of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:broadMatch CTD:affects_mutagenesis ;
    skos:definition "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity impacts the rate of mutation of the genomic entity within a system of interest" ;
    skos:exactMatch CTD:affects_mutation_rate_of .

biolink:affects_response_to a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects response to" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one impacts the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" ;
    skos:exactMatch CTD:affects_response_to .

biolink:affects_risk_for a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects risk for" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between two entities where exposure to one entity alters the chance of developing the other" .

biolink:affects_secretion_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects secretion of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:broadMatch CTD:affects_export ;
    skos:definition "holds between two molecular entities where the action or effect of one impacts the rate of secretion of the other out of a cell, gland, or organ" ;
    skos:exactMatch CTD:affects_secretion_of .

biolink:affects_splicing_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects splicing of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:Transcript ;
    rdfs:subPropertyOf biolink:affects ;
    skos:broadMatch CTD:affects_splicing_of ;
    skos:definition "holds between a molecular entity and an mRNA where the action or effect of the molecular entity impacts the splicing of the mRNA" ;
    skos:exactMatch CTD:affects_RNA_splicing .

biolink:affects_stability_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects stability of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:closeMatch GAMMA:stabilization ;
    skos:definition "holds between two molecular entities where the action or effect of one impacts the stability of the other within a system of interest" ;
    skos:exactMatch CTD:affects_stability_of .

biolink:affects_synthesis_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects synthesis of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one impacts the rate of chemical synthesis of the other" ;
    skos:exactMatch CTD:affects_synthesis_of .

biolink:affects_transport_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects transport of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:definition "holds between two molecular entities where the action or effect of one impacts the rate of transport of the other across some boundary in a system of interest" ;
    skos:exactMatch CTD:affects_transport_of ;
    skos:narrowMatch RO:0002313,
        RO:0002340,
        RO:0002345 .

biolink:affects_uptake_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects uptake of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects ;
    skos:broadMatch CTD:affects_import ;
    skos:definition "holds between two molecular entities where the action or effect of one impacts the rate of uptake of the other into of a cell, gland, or organ" ;
    skos:exactMatch CTD:affects_uptake_of .

biolink:causes a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "causes" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:contributes_to ;
    owl:inverseOf biolink:caused_by ;
    skos:broadMatch RO:0002410 ;
    skos:definition "holds between two entities where the occurrence, existence, or activity of one causes the occurrence or generation of the other" ;
    skos:exactMatch RO:0002506,
        <http://purl.obolibrary.org/obo/SNOMED_cause_of>,
        SEMMEDDB:CAUSES,
        SEMMEDDB:causes,
        WIKIDATA_PROPERTY:P1542 ;
    skos:narrowMatch <http://identifiers.org/umls/has_physiologic_effect>,
        RTXKG1:capable_of_part_of,
        GOREL:0000040,
        <http://purl.obolibrary.org/obo/MONDO_disease_causes_feature>,
        <http://purl.obolibrary.org/obo/MONDO_disease_triggers>,
        <http://purl.obolibrary.org/obo/NCIT_allele_has_abnormality>,
        <http://purl.obolibrary.org/obo/NCIT_biological_process_has_result_biological_process>,
        <http://purl.obolibrary.org/obo/NCIT_chemical_or_drug_has_physiologic_effect>,
        <http://purl.obolibrary.org/obo/NCIT_chemical_or_drug_initiates_biological_process>,
        <http://purl.obolibrary.org/obo/NCIT_chromosome_mapped_to_disease>,
        <http://purl.obolibrary.org/obo/NCIT_disease_has_normal_tissue_origin>,
        <http://purl.obolibrary.org/obo/NCIT_process_initiates_biological_process>,
        RO:0002256,
        RO:0002315,
        RO:0002507,
        RO:0002509,
        RO:0004001,
        <http://purl.obolibrary.org/obo/SNOMED_causative_agent_of>,
        <http://purl.obolibrary.org/obo/SNOMED_has_realization>,
        <http://purl.obolibrary.org/obo/nbo#in_response_to>,
        ORPHA:317343,
        ORPHA:317344,
        ORPHA:317346,
        ORPHA:410295,
        ORPHA:410296 .

biolink:derives_from a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "derives from" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:derives_into ;
    skos:definition "holds between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/FMA_derives_from>,
        RO:0001000,
        <http://purl.obolibrary.org/obo/doid#derives_from> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CHEBI_has_functional_parent>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_source_topography> .

biolink:derives_into a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "derives into" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:derives_from ;
    skos:definition "holds between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/FMA_derives>,
        <http://purl.obolibrary.org/obo/NCIT_is_normal_cell_origin_of_disease>,
        <http://purl.obolibrary.org/obo/NCIT_may_be_normal_cell_origin_of_disease>,
        RO:0001001,
        SEMMEDDB:CONVERTS_TO,
        SEMMEDDB:converts_to .

biolink:food_component_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "food component of" ;
    rdfs:domain biolink:ChemicalSubstance ;
    rdfs:range biolink:ChemicalSubstance ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_food_component ;
    skos:definition "holds between a one or more chemical substances present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .

biolink:genetic_association a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "genetic association" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "Co-occurrence of a certain allele of a genetic marker and the phenotype of interest in the same individuals at above-chance level" ;
    skos:exactMatch WIKIDATA_PROPERTY:P2293 .

biolink:has_attribute_type a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:has_biological_sequence a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:has_count a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:has_food_component a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has food component" ;
    rdfs:domain biolink:ChemicalSubstance ;
    rdfs:range biolink:ChemicalSubstance ;
    rdfs:subPropertyOf biolink:has_part ;
    owl:inverseOf biolink:food_component_of ;
    skos:definition "holds between food and one or more chemical substances composing it, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .

biolink:has_input a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:has_output a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:has_percentage a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has percentage" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Double ;
    rdfs:subPropertyOf biolink:aggregate_statistic ;
    skos:definition "equivalent to has quotient multiplied by 100" .

biolink:has_quotient a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:has_total a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:interbase_coordinate a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "interbase coordinate" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "A position in interbase coordinates. This is applied to a sequence localization edge." .

biolink:iri a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "iri" ;
    rdfs:range biolink:IriType ;
    skos:definition "An IRI for an entity. This is determined by the id using expansion rules." ;
    skos:exactMatch WIKIDATA_PROPERTY:P854 .

biolink:iso_abbreviation a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:issue a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "issue" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "issue of a newspaper, a scientific journal or magazine for reference purpose" ;
    skos:exactMatch WIKIDATA_PROPERTY:P433 .

biolink:molecularly_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "molecularly interacts with" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:physically_interacts_with ;
    skos:exactMatch RTXKG1:targets,
        RO:0002436,
        CTD:molecularly_interacts_with ;
    skos:relatedMatch DGIdb:antibody .

biolink:overlaps a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "overlaps" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between entities that overlap in their extents (materials or processes)" ;
    skos:exactMatch RO:0002131 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/BSPO_0005001>,
        RO:0002100,
        RO:0002102,
        RO:0002433,
        CHEMBL.MECHANISM:overlaps_with .

biolink:published_in a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:qualifiers a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:source a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "source" ;
    rdfs:range biolink:LabelType ;
    skos:definition "a lightweight analog to the association class 'has provider' slot, which is the string name, or the authoritative (i.e. database) namespace, designating the origin of the entity to which the slot belongs." .

biolink:subclass_of a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:temporally_related_to a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "temporally related to" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between two entities with a temporal relationship" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SNOMED_temporally_related_to> ;
    skos:narrowMatch RO:0002082,
        RO:0002083,
        RO:0002092,
        RO:0002093,
        RO:0002223,
        RO:0002224,
        RO:0002229,
        RO:0002230,
        RO:0002488,
        RO:0002489,
        RO:0002492,
        RO:0002493,
        RO:0002496,
        RO:0002497 .

biolink:treated_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "treated by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:Treatment ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:treats ;
    skos:definition "holds between a disease or phenotypic feature and a therapeutic process or chemical substance that is used to treat the condition" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MONDO_disease_responds_to>,
        WIKIDATA_PROPERTY:P2176 ;
    skos:narrowMatch RO:0002302 .

biolink:treats a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "treats" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:ameliorates ;
    owl:inverseOf biolink:treated_by ;
    skos:altLabel "is substance that treats" ;
    skos:broadMatch RO:0003307 ;
    skos:definition "holds between a therapeutic procedure or chemical substance and a disease or phenotypic feature that it is used to treat" ;
    skos:exactMatch <http://identifiers.org/drugbank/treats>,
        SEMMEDDB:TREATS,
        SEMMEDDB:treats,
        WIKIDATA_PROPERTY:P2175 ;
    skos:narrowMatch REPODB:clinically_tested_approved_unknown_phase,
        REPODB:clinically_tested_suspended_phase_0,
        REPODB:clinically_tested_suspended_phase_1,
        REPODB:clinically_tested_suspended_phase_1_or_phase_2,
        REPODB:clinically_tested_suspended_phase_2,
        REPODB:clinically_tested_suspended_phase_2_or_phase_3,
        REPODB:clinically_tested_suspended_phase_3,
        REPODB:clinically_tested_terminated_phase_0,
        REPODB:clinically_tested_terminated_phase_1,
        REPODB:clinically_tested_terminated_phase_1_or_phase_2,
        REPODB:clinically_tested_terminated_phase_2,
        REPODB:clinically_tested_terminated_phase_2_or_phase_3,
        REPODB:clinically_tested_terminated_phase_3,
        REPODB:clinically_tested_withdrawn_phase_0,
        REPODB:clinically_tested_withdrawn_phase_1,
        REPODB:clinically_tested_withdrawn_phase_1_or_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2_or_phase_3,
        REPODB:clinically_tested_withdrawn_phase_3,
        RTXKG1:indicated_for,
        <http://purl.obolibrary.org/obo/NCIT_regimen_has_accepted_use_for_disease>,
        RO:0002606,
        <http://purl.obolibrary.org/obo/SNOMED_plays_role> ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/MONDO_disease_responds_to> .

dct:source a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has dataset" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range biolink:Dataset ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:source .

pav:version a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "ingest date" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch pav:version .

biolink:Annotation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "annotation" ;
    skos:definition "Biolink Model root class for entity annotations." .

biolink:BiologicalProcessOrActivity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "biological process or activity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:has_input ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:has_output ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PhysicalEntity ;
            owl:onProperty biolink:enabled_by ],
        biolink:BiologicalEntity,
        biolink:Occurrent,
        biolink:OntologyClass ;
    skos:definition "Either an individual molecular activity, or a collection of causally connected molecular activities in a biological system." .

biolink:CategoryType a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "category type" ;
    rdfs:subClassOf linkml:Uriorcurie ;
    skos:definition "A primitive type in which the value denotes a class within the biolink model. The value must be a URI or a CURIE. In a Neo4j representation, the value should be the CURIE for the biolink class, for example biolink:Gene. For an RDF representation, the value should be a URI such as https://w3id.org/biolink/vocab/Gene" .

biolink:DatasetDistribution a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "dataset distribution" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:distribution_download_url ],
        biolink:InformationContentEntity ;
    skos:definition "an item that holds distribution level information about a dataset." ;
    skos:exactMatch dcat:Distribution .

biolink:DatasetSummary a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "dataset summary" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty schema1:logo ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:source_web_page ],
        biolink:InformationContentEntity ;
    skos:definition "an item that holds summary level information about a dataset." .

biolink:Disease a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease" ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeature ;
    skos:altLabel "condition",
        "disorder",
        "medical condition" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/DOID_4>,
        <http://purl.obolibrary.org/obo/MONDO_0000001>,
        <http://purl.obolibrary.org/obo/NCIT_C2991>,
        SIO:010299,
        UMLSSG:DISO,
        UMLSSC:T047,
        UMLSST:dsyn,
        WIKIDATA:Q12136 ;
    skos:narrowMatch UMLSSC:T019,
        UMLSSC:T020,
        UMLSSC:T037,
        UMLSSC:T046,
        UMLSSC:T048,
        UMLSSC:T049,
        UMLSSC:T190,
        UMLSSC:T191,
        UMLSST:acab,
        UMLSST:anab,
        UMLSST:cgab,
        UMLSST:comd,
        UMLSST:inpo,
        UMLSST:mobd,
        UMLSST:neop,
        UMLSST:patf .

biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease or phenotypic feature to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:DiseaseToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Disease ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:Entity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:NarrativeText ;
            owl:onProperty dct:description ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:IriType ;
            owl:onProperty biolink:iri ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Agent ;
            owl:onProperty biolink:provided_by ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty rdf:type ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CategoryType ;
            owl:onProperty biolink:category ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty biolink:source ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Attribute ;
            owl:onProperty biolink:has_attribute ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty rdfs:label ] ;
    skos:definition "Root Biolink Model class for all things and informational relationships, real or imagined." .

biolink:FrequencyQualifierMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "frequency qualifier mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        linkml:mixin ;
    skos:definition "Qualifier for frequency type associations" .

biolink:GeneExpressionMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene expression mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:expression_site ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:phenotypic_state ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        linkml:mixin ;
    skos:definition "Observed gene expression intensity, context (site, stage) and associated phenotypic status within which the expression occurs." .

biolink:GeneToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:GeneToGeneAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:altLabel "molecular or genetic interaction" ;
    skos:definition "abstract parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction." .

biolink:GenotypeToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genotype to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:MolecularEntityToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "molecular entity to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MolecularEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An interaction between a molecular entity and another entity" .

biolink:OrganismTaxonToEntityAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "organism taxon to entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An association between an organism taxon and another entity" .

biolink:PhysicalEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "physical entity" ;
    rdfs:subClassOf biolink:NamedThing,
        biolink:PhysicalEssence ;
    skos:definition "An entity that has material reality (a.k.a. physical essence)." ;
    skos:exactMatch UMLSSC:T072,
        UMLSST:phob ;
    skos:narrowMatch UMLSSC:T073,
        UMLSST:mnob .

biolink:PhysicalEssence a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "physical essence" ;
    rdfs:subClassOf biolink:PhysicalEssenceOrOccurrent,
        linkml:mixin ;
    skos:definition "Semantic mixin concept.  Pertains to entities that have physical properties such as mass, volume, or charge." .

biolink:PlanetaryEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "planetary entity" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "Any entity or process that exists at the level of the whole planet" .

biolink:Protein a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "protein" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:IriType ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        biolink:GeneProductMixin,
        biolink:GenomicEntity ;
    skos:altLabel "polypeptide" ;
    skos:broadMatch UMLSSC:T116,
        UMLSST:aapp ;
    skos:definition "A gene product that is composed of a chain of amino acid sequences and is produced by ribosome-mediated translation of mRNA" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PR_000000001>,
        <http://purl.obolibrary.org/obo/SO_0000104>,
        SIO:010043,
        UMLSSC:T087,
        UMLSST:amas,
        WIKIDATA:Q8054 .

biolink:SequenceFeatureRelationship a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "sequence feature relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GenomicEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GenomicEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "For example, a particular exon is part of a particular transcript or gene" ;
    skos:exactMatch CHADO:feature_relationship .

biolink:Treatment a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "treatment" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Drug ;
            owl:onProperty biolink:has_drug ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Device ;
            owl:onProperty biolink:has_device ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Procedure ;
            owl:onProperty biolink:has_procedure ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:ChemicalOrDrugOrTreatment,
        biolink:ExposureEvent,
        biolink:NamedThing ;
    skos:altLabel "medical action",
        "medical intervention" ;
    skos:definition "A treatment is targeted at a disease or phenotype and may involve multiple drug 'exposures', medical devices and/or procedures" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OGMS_0000090>,
        SIO:001398 .

biolink:enabled_by a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:entity_regulated_by_entity a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "entity regulated by entity" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:entity_regulates_entity .

biolink:entity_regulates_entity a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "entity regulates entity" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:affects,
        biolink:regulates ;
    owl:inverseOf biolink:entity_regulated_by_entity ;
    skos:altLabel "activity directly regulates activity of" ;
    skos:exactMatch RO:0002448 ;
    skos:narrowMatch WIKIDATA_PROPERTY:P128 .

biolink:expression_site a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "expression site" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:AnatomicalEntity ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "location in which gene or protein expression takes place. May be cell, tissue, or organ." ;
    linkml:examples "Example(value='UBERON:0002037', description='cerebellum')" .

biolink:homologous_to a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "homologous to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:similar_to ;
    skos:altLabel "in homology relationship with" ;
    skos:definition "holds between two biological entities that have common evolutionary origin" ;
    skos:exactMatch RO:HOM0000001,
        SIO:010302 ;
    skos:narrowMatch UBERON_CORE:sexually_homologous_to ;
    skos:note "typically used to describe homology relationships between genes or gene products" .

biolink:interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "interacts with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between any two entities that directly or indirectly interact with each other" ;
    skos:exactMatch RO:0002434 ;
    skos:narrowMatch RO:0002103,
        RO:0002120,
        RO:0002130,
        SEMMEDDB:complicates .

biolink:negatively_regulates a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "negatively regulates" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    rdfs:subPropertyOf biolink:regulates ;
    owl:inverseOf biolink:negatively_regulated_by ;
    skos:broadMatch RO:0004033 ;
    skos:closeMatch RO:0002335 ;
    skos:exactMatch RO:0002212,
        RO:0004035 ;
    skos:narrowMatch RO:0002630,
        CHEMBL.MECHANISM:blocker,
        CHEMBL.MECHANISM:inhibitor,
        CHEMBL.MECHANISM:negative_allosteric_modulator,
        CHEMBL.MECHANISM:negative_modulator ;
    skos:note "This is a grouping for negative process-process and entity-entity regulation." .

biolink:participates_in a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "participates in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:has_participant ;
    skos:definition "holds between a continuant and a process, where the continuant is somehow involved in the process" ;
    skos:exactMatch RTXKG1:participates_in,
        <http://purl.obolibrary.org/obo/BFO_0000056>,
        RO:0000056 ;
    skos:narrowMatch <http://identifiers.org/drugbank/pathway>,
        <http://identifiers.org/hmdb/in_pathway>,
        LOINC:is_given_pharmaceutical_substance_for,
        <http://purl.obolibrary.org/obo/NCIT_R130>,
        <http://purl.obolibrary.org/obo/NCIT_R131>,
        <http://purl.obolibrary.org/obo/NCIT_R37>,
        <http://purl.obolibrary.org/obo/NCIT_R51>,
        <http://purl.obolibrary.org/obo/NCIT_R53>,
        <http://purl.obolibrary.org/obo/OBI_0000295>,
        RO:0002216,
        RO:0002505,
        RO:0002565,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_device> .

biolink:phenotypic_state a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "phenotypic state" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "in experiments (e.g. gene expression) assaying diseased or unhealthy tissue, the phenotypic state can be put here, e.g. MONDO ID. For healthy tissues, use XXX." .

biolink:positively_regulates a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "positively regulates" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    rdfs:subPropertyOf biolink:regulates ;
    owl:inverseOf biolink:positively_regulated_by ;
    skos:closeMatch RO:0002336 ;
    skos:exactMatch RO:0002213 ;
    skos:narrowMatch RO:0002629,
        RO:0004032,
        RO:0004034,
        SEMMEDDB:augments,
        DGIdb:activator,
        CHEMBL.MECHANISM:activator ;
    skos:note "This is a grouping for positive process-process and entity-entity regulation." .

biolink:process_regulated_by_process a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "process regulated by process" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:process_regulates_process .

biolink:process_regulates_process a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "process regulates process" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:affects,
        biolink:regulates ;
    owl:inverseOf biolink:process_regulated_by_process ;
    skos:exactMatch RO:0002211 .

biolink:regulated_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "regulated by" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    owl:inverseOf biolink:regulates .

biolink:relation a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:similar_to a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "similar to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between an entity and some other entity with similar features." ;
    skos:exactMatch RO:HOM0000000,
        <http://purl.obolibrary.org/obo/SO_similar_to> .

biolink:volume a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "volume" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "volume of a book or music release in a collection/series or a published collection of journal issues in a serial publication" ;
    skos:exactMatch WIKIDATA_PROPERTY:P478 .

rdf:type a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:ChemicalToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "chemical to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ChemicalSubstance ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:MolecularEntityToEntityAssociationMixin,
        linkml:mixin ;
    skos:definition "An interaction between a chemical entity and another entity" .

biolink:ClinicalAttribute a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "clinical attribute" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "Attributes relating to a clinical manifestation" ;
    skos:exactMatch UMLSSC:T201,
        UMLSST:clna .

biolink:DatasetVersion a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "dataset version" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Dataset ;
            owl:onProperty dct:source ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty pav:version ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DatasetDistribution ;
            owl:onProperty dct:distribution ],
        biolink:InformationContentEntity ;
    skos:definition "an item that holds version level information about a dataset." .

biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "entity to disease or phenotypic feature association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:FunctionalAssociation a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "functional association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOntologyClass ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:MacromolecularMachineMixin ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "An association between a macromolecular machine mixin (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed." .

biolink:GeneGroupingMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene grouping mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        linkml:mixin ;
    skos:definition "any grouping of multiple genes or gene products" .

biolink:LifeStage a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "life stage" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        biolink:OrganismalEntity,
        biolink:ThingWithTaxon ;
    skos:definition "A stage of development or growth of an organism, including post-natal adult stages" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/UBERON_0000105> ;
    skos:narrowMatch HsapDv:0000000 .

biolink:LogicalInterpretationEnum a owl:Class,
        linkml:EnumDefinition ;
    rdfs:label "logical_interpretation_enum" ;
    owl:unionOf ( os:SomeSomeInterpretation os:AllSomeInterpretation <https://w3id.org/biolink/vocab/LogicalInterpretationEnum#InverseAllSome> ) ;
    linkml:permissible_values os:AllSomeInterpretation,
        os:SomeSomeInterpretation,
        <https://w3id.org/biolink/vocab/LogicalInterpretationEnum#InverseAllSome> .

biolink:MacromolecularMachineToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "macromolecular machine to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "an association which has a macromolecular machine mixin as a subject" .

biolink:PathologicalEntityMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "pathological entity mixin" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "A pathological (abnormal) structure or process." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MPATH_0> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/HP_0000118> .

biolink:QuantityValue a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "quantity value" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Unit ;
            owl:onProperty biolink:has_unit ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_numeric_value ],
        biolink:Annotation ;
    skos:definition "A value of an attribute that is quantitative and measurable, expressed as a combination of a unit and a numeric value" .

biolink:RelationshipQuantifier a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "relationship quantifier" ;
    rdfs:subClassOf linkml:mixin .

biolink:affected_by a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affected by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:affects ;
    skos:definition "describes an entity of which the state or quality is affected by another existing entity." .

biolink:category a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:coexists_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "coexists with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between two entities that are co-located in the same aggregate object, process, or spatio-temporal region" ;
    skos:exactMatch SEMMEDDB:COEXISTS_WITH,
        SEMMEDDB:coexists_with ;
    skos:narrowMatch LOINC:has_lateral_anatomic_location,
        LOINC:has_lateral_location_presence,
        <http://purl.obolibrary.org/obo/BSPO_0000096>,
        <http://purl.obolibrary.org/obo/BSPO_0000097>,
        <http://purl.obolibrary.org/obo/BSPO_0000098>,
        <http://purl.obolibrary.org/obo/BSPO_0000099>,
        <http://purl.obolibrary.org/obo/BSPO_0000100>,
        <http://purl.obolibrary.org/obo/BSPO_0000102>,
        <http://purl.obolibrary.org/obo/BSPO_0000104>,
        <http://purl.obolibrary.org/obo/BSPO_0000110>,
        <http://purl.obolibrary.org/obo/BSPO_0000113>,
        <http://purl.obolibrary.org/obo/BSPO_0015001>,
        <http://purl.obolibrary.org/obo/BSPO_0015002>,
        <http://purl.obolibrary.org/obo/BSPO_0015003>,
        <http://purl.obolibrary.org/obo/BSPO_0015005>,
        <http://purl.obolibrary.org/obo/BSPO_0015006>,
        <http://purl.obolibrary.org/obo/BSPO_0015007>,
        <http://purl.obolibrary.org/obo/BSPO_0015008>,
        <http://purl.obolibrary.org/obo/BSPO_0015009>,
        <http://purl.obolibrary.org/obo/BSPO_0015012>,
        <http://purl.obolibrary.org/obo/BSPO_0015014>,
        <http://purl.obolibrary.org/obo/BSPO_parallel_to>,
        <http://purl.obolibrary.org/obo/ENVO_01001307>,
        <http://purl.obolibrary.org/obo/FMA_adjacent_to>,
        <http://purl.obolibrary.org/obo/FMA_afferent_to>,
        <http://purl.obolibrary.org/obo/FMA_anterior_to>,
        <http://purl.obolibrary.org/obo/FMA_anteroinferior_to>,
        <http://purl.obolibrary.org/obo/FMA_anterolateral_to>,
        <http://purl.obolibrary.org/obo/FMA_anteromedial_to>,
        <http://purl.obolibrary.org/obo/FMA_anterosuperior_to>,
        <http://purl.obolibrary.org/obo/FMA_arterial_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_articulates_with>,
        <http://purl.obolibrary.org/obo/FMA_attaches_to>,
        <http://purl.obolibrary.org/obo/FMA_bounded_by>,
        <http://purl.obolibrary.org/obo/FMA_bounds>,
        <http://purl.obolibrary.org/obo/FMA_branch_of>,
        <http://purl.obolibrary.org/obo/FMA_connection_type_of>,
        <http://purl.obolibrary.org/obo/FMA_continuation_branch_of>,
        <http://purl.obolibrary.org/obo/FMA_continuous_distally_with>,
        <http://purl.obolibrary.org/obo/FMA_continuous_proximally_with>,
        <http://purl.obolibrary.org/obo/FMA_corresponds_to>,
        <http://purl.obolibrary.org/obo/FMA_development_type_of>,
        <http://purl.obolibrary.org/obo/FMA_developmental_stage_of>,
        <http://purl.obolibrary.org/obo/FMA_direct_cell_shape_of>,
        <http://purl.obolibrary.org/obo/FMA_direct_left_of>,
        <http://purl.obolibrary.org/obo/FMA_direct_right_of>,
        <http://purl.obolibrary.org/obo/FMA_distal_to>,
        <http://purl.obolibrary.org/obo/FMA_drains_into>,
        <http://purl.obolibrary.org/obo/FMA_efferent_to>,
        <http://purl.obolibrary.org/obo/FMA_external_to>,
        <http://purl.obolibrary.org/obo/FMA_formed_by>,
        <http://purl.obolibrary.org/obo/FMA_forms>,
        <http://purl.obolibrary.org/obo/FMA_full_grown_phenotype_of>,
        <http://purl.obolibrary.org/obo/FMA_fuses_with>,
        <http://purl.obolibrary.org/obo/FMA_fusion_of>,
        <http://purl.obolibrary.org/obo/FMA_germ_origin_of>,
        <http://purl.obolibrary.org/obo/FMA_has_adherent>,
        <http://purl.obolibrary.org/obo/FMA_has_arterial_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_branch>,
        <http://purl.obolibrary.org/obo/FMA_has_connection_type>,
        <http://purl.obolibrary.org/obo/FMA_has_continuation_branch>,
        <http://purl.obolibrary.org/obo/FMA_has_development_type>,
        <http://purl.obolibrary.org/obo/FMA_has_developmental_stage>,
        <http://purl.obolibrary.org/obo/FMA_has_direct_cell_shape>,
        <http://purl.obolibrary.org/obo/FMA_has_full_grown_phenotype>,
        <http://purl.obolibrary.org/obo/FMA_has_fusion>,
        <http://purl.obolibrary.org/obo/FMA_has_germ_origin>,
        <http://purl.obolibrary.org/obo/FMA_has_inherent_3d_shape>,
        <http://purl.obolibrary.org/obo/FMA_has_insertion>,
        <http://purl.obolibrary.org/obo/FMA_has_lymphatic_drainage>,
        <http://purl.obolibrary.org/obo/FMA_has_nerve_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_observed_anatomical_entity>,
        <http://purl.obolibrary.org/obo/FMA_has_origin>,
        <http://purl.obolibrary.org/obo/FMA_has_primary_segmental_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_projection>,
        <http://purl.obolibrary.org/obo/FMA_has_regional_part>,
        <http://purl.obolibrary.org/obo/FMA_has_related_developmental_entity>,
        <http://purl.obolibrary.org/obo/FMA_has_secondary_segmental_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_segmental_composition>,
        <http://purl.obolibrary.org/obo/FMA_has_segmental_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_tributary>,
        <http://purl.obolibrary.org/obo/FMA_has_venous_drainage>,
        <http://purl.obolibrary.org/obo/FMA_inferior_to>,
        <http://purl.obolibrary.org/obo/FMA_inferolateral_to>,
        <http://purl.obolibrary.org/obo/FMA_inferomedial_to>,
        <http://purl.obolibrary.org/obo/FMA_inherent_3d_shape_of>,
        <http://purl.obolibrary.org/obo/FMA_insertion_of>,
        <http://purl.obolibrary.org/obo/FMA_internal_to>,
        <http://purl.obolibrary.org/obo/FMA_lateral_to>,
        <http://purl.obolibrary.org/obo/FMA_left_lateral_to>,
        <http://purl.obolibrary.org/obo/FMA_left_medial_to>,
        <http://purl.obolibrary.org/obo/FMA_lymphatic_drainage_of>,
        <http://purl.obolibrary.org/obo/FMA_matures_from>,
        <http://purl.obolibrary.org/obo/FMA_matures_into>,
        <http://purl.obolibrary.org/obo/FMA_medial_to>,
        <http://purl.obolibrary.org/obo/FMA_merges_with>,
        <http://purl.obolibrary.org/obo/FMA_nerve_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_origin_of>,
        <http://purl.obolibrary.org/obo/FMA_posterior_to>,
        <http://purl.obolibrary.org/obo/FMA_posteroinferior_to>,
        <http://purl.obolibrary.org/obo/FMA_posterolateral_to>,
        <http://purl.obolibrary.org/obo/FMA_posteromedial_to>,
        <http://purl.obolibrary.org/obo/FMA_posterosuperior_to>,
        <http://purl.obolibrary.org/obo/FMA_primary_segmental_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_projects_from>,
        <http://purl.obolibrary.org/obo/FMA_projects_to>,
        <http://purl.obolibrary.org/obo/FMA_proximal_to>,
        <http://purl.obolibrary.org/obo/FMA_receives_attachment_from>,
        <http://purl.obolibrary.org/obo/FMA_receives_drainage_from>,
        <http://purl.obolibrary.org/obo/FMA_receives_input_from>,
        <http://purl.obolibrary.org/obo/FMA_receives_projection>,
        <http://purl.obolibrary.org/obo/FMA_related_part>,
        <http://purl.obolibrary.org/obo/FMA_right_lateral_to>,
        <http://purl.obolibrary.org/obo/FMA_right_medial_to>,
        <http://purl.obolibrary.org/obo/FMA_secondary_segmental_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_segmental_composition_of>,
        <http://purl.obolibrary.org/obo/FMA_segmental_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_sends_output_to>,
        <http://purl.obolibrary.org/obo/FMA_superior_to>,
        <http://purl.obolibrary.org/obo/FMA_superolateral_to>,
        <http://purl.obolibrary.org/obo/FMA_superomedial_to>,
        <http://purl.obolibrary.org/obo/FMA_surrounded_by>,
        <http://purl.obolibrary.org/obo/FMA_surrounds>,
        <http://purl.obolibrary.org/obo/FMA_tributary_of>,
        <http://purl.obolibrary.org/obo/FMA_venous_drainage_of>,
        RO:0002219,
        RO:0002220,
        RO:0002221,
        <http://purl.obolibrary.org/obo/SO_has_origin>,
        <http://purl.obolibrary.org/obo/UBERON_anastomoses_with>,
        <http://purl.obolibrary.org/obo/UBERON_anteriorly_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_channel_for>,
        <http://purl.obolibrary.org/obo/UBERON_channels_from>,
        <http://purl.obolibrary.org/obo/UBERON_channels_into>,
        <http://purl.obolibrary.org/obo/UBERON_conduit_for>,
        <http://purl.obolibrary.org/obo/UBERON_distally_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_existence_starts_and_ends_during>,
        <http://purl.obolibrary.org/obo/UBERON_extends_fibers_into>,
        <http://purl.obolibrary.org/obo/UBERON_filtered_through>,
        <http://purl.obolibrary.org/obo/UBERON_in_central_side_of>,
        <http://purl.obolibrary.org/obo/UBERON_in_innermost_side_of>,
        <http://purl.obolibrary.org/obo/UBERON_in_outermost_side_of>,
        <http://purl.obolibrary.org/obo/UBERON_indirectly_supplies>,
        <http://purl.obolibrary.org/obo/UBERON_posteriorly_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_protects>,
        <http://purl.obolibrary.org/obo/UBERON_proximally_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_sexually_homologous_to>,
        <http://purl.obolibrary.org/obo/core#distally_connected_to>,
        <http://purl.obolibrary.org/obo/core#subdivision_of>,
        UBERON_CORE:anastomoses_with,
        UBERON_CORE:anteriorly_connected_to,
        UBERON_CORE:channel_for,
        UBERON_CORE:channels_from,
        UBERON_CORE:channels_into,
        UBERON_CORE:conduit_for,
        UBERON_CORE:distally_connected_to,
        UBERON_CORE:extends_fibers_into,
        UBERON_CORE:filtered_through,
        UBERON_CORE:indirectly_supplies,
        UBERON_CORE:posteriorly_connected_to,
        UBERON_CORE:proximally_connected_to,
        UBERON_CORE:synapsed_by,
        UBERON_CORE:transitively_anteriorly_connected_to,
        UBERON_CORE:transitively_connected_to,
        UBERON_CORE:transitively_distally_connected_to,
        UBERON_CORE:transitively_proximally_connected_to .

biolink:contributor a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "contributor" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:exactMatch dct:contributor ;
    skos:note "This is a grouping for predicates relating entities to their associated contributors realizing them" .

biolink:has_gene_or_gene_product a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has gene or gene product" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity with one or more gene or gene products" .

biolink:part_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "part of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:overlaps ;
    owl:inverseOf biolink:has_part ;
    skos:broadMatch RXNORM:contained_in,
        <http://purl.obolibrary.org/obo/FMA_contained_in>,
        RO:0001018 ;
    skos:definition "holds between parts and wholes (material entities or processes)" ;
    skos:exactMatch RXNORM:constitutes,
        RXNORM:part_of,
        <http://purl.obolibrary.org/obo/BFO_0000050>,
        <http://purl.obolibrary.org/obo/FMA_part_of>,
        SEMMEDDB:PART_OF,
        SEMMEDDB:part_of,
        WIKIDATA_PROPERTY:P361 ;
    skos:narrowMatch <http://identifiers.org/drugbank/component_of>,
        <http://identifiers.org/meddra/member_of>,
        <http://identifiers.org/umls/component_of>,
        <http://identifiers.org/umls/has_owning_affiliate>,
        <http://identifiers.org/umls/owning_subsection_of>,
        LOINC:component_of,
        LOINC:has_supersystem,
        LOINC:member_of,
        LOINC:multipart_of,
        NDDF:ingredient_of,
        RXNORM:ingredient_of,
        RXNORM:ingredients_of,
        RXNORM:precise_ingredient_of,
        <http://purl.obolibrary.org/obo/BSPO_0001106>,
        <http://purl.obolibrary.org/obo/BSPO_0001108>,
        <http://purl.obolibrary.org/obo/BSPO_0001113>,
        <http://purl.obolibrary.org/obo/BSPO_0001115>,
        <http://purl.obolibrary.org/obo/CHEBI_is_substituent_group_from>,
        <http://purl.obolibrary.org/obo/FMA_constitutional_part_of>,
        <http://purl.obolibrary.org/obo/FMA_member_of>,
        <http://purl.obolibrary.org/obo/FMA_regional_part_of>,
        <http://purl.obolibrary.org/obo/FMA_related_developmental_entity_of>,
        <http://purl.obolibrary.org/obo/MONDO_part_of_progression_of_disease>,
        <http://purl.obolibrary.org/obo/NCIT_R27>,
        <http://purl.obolibrary.org/obo/NCIT_R82>,
        <http://purl.obolibrary.org/obo/NCIT_is_component_of_chemotherapy_regimen>,
        RO:0002007,
        RO:0002350,
        RO:0002376,
        RO:0002380,
        RO:0002571,
        RO:0002572,
        RO:0002576,
        <http://purl.obolibrary.org/obo/SNOMED_active_ingredient_of>,
        <http://purl.obolibrary.org/obo/SNOMED_basis_of_strength_substance_of>,
        <http://purl.obolibrary.org/obo/SNOMED_component_of>,
        <http://purl.obolibrary.org/obo/SNOMED_direct_substance_of>,
        <http://purl.obolibrary.org/obo/SNOMED_during>,
        <http://purl.obolibrary.org/obo/SNOMED_focus_of>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dependent>,
        <http://purl.obolibrary.org/obo/SNOMED_part_anatomy_structure_of>,
        <http://purl.obolibrary.org/obo/SNOMED_precise_active_ingredient_of>,
        <http://purl.obolibrary.org/obo/UBERON_subdivision_of>,
        UBERON_CORE:layer_part_of,
        UBERON_CORE:subdivision_of,
        UBERON_CORE:trunk_part_of,
        CPT:panel_element_of,
        CPT:panel_element_of_possibly_included,
        PDQ:component_of,
        VANDF:ingredient_of .

biolink:quantifier_qualifier a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:sequence_localization_attribute a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "sequence localization attribute" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "An attribute that can be applied to a genome sequence localization edge. These edges connect a genomic entity such as an exon to an entity such as a chromosome. Edge properties are used to ascribe specific positional information and other metadata to the localization. In pragmatic terms this can be thought of as columns in a GFF3 line." .

biolink:stage_qualifier a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:synonym a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "alias" ;
    skos:definition "Alternate human-readable names for a thing" ;
    skos:narrowMatch RXNORM:has_tradename,
        IAO:0000136,
        HANCESTRO:0330,
        OIO:hasBroadSynonym,
        OIO:hasExactSynonym,
        OIO:hasNarrowSynonym,
        OIO:hasRelatedSynonym,
        gff3:Alias,
        gpi:DB_Object_Synonyms,
        alliancegenome:synonyms,
        <https://www.w3.org/TR/skos-reference/#altLabel> .

rdfs:label a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:Behavior a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "behavior" ;
    rdfs:subClassOf biolink:BiologicalProcess,
        biolink:OntologyClass ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0007610>,
        UMLSSC:T053,
        UMLSST:bhvr ;
    skos:narrowMatch UMLSSC:T041,
        UMLSSC:T054,
        UMLSSC:T055,
        UMLSST:inbe,
        UMLSST:menp,
        UMLSST:socb .

biolink:ChemicalOrDrugOrTreatment a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "chemical or drug or treatment" ;
    rdfs:subClassOf linkml:mixin .

biolink:Dataset a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "dataset" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:definition "an item that refers to a collection of data from a data source." ;
    skos:exactMatch IAO:0000100,
        dcmitype:Dataset,
        schema1:dataset .

biolink:Mixture a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "mixture" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalSubstance ;
            owl:onProperty biolink:has_constituent ],
        linkml:mixin ;
    skos:definition "The physical combination of two or more molecular entities in which the identities are retained and are mixed in the form of solutions, suspensions and colloids." .

biolink:PhenotypicFeature a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "phenotypic feature" ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeature ;
    skos:altLabel "endophenotype",
        "phenotype",
        "sign",
        "symptom",
        "trait" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/UPHENO_0001001>,
        SIO:010056,
        WIKIDATA:Q104053 ;
    skos:narrowMatch UMLSSC:T184,
        UMLSST:sosy,
        WIKIDATA:Q169872,
        WIKIDATA:Q25203551 .

biolink:VariantToEntityAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "variant to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:correlated_with a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "correlated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between any two named thing entities. For example, correlated_with holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_correlates_with>,
        RO:0002610 ;
    skos:narrowMatch RTXKG1:associated_with_disease,
        LOINC:associated_with,
        <http://purl.obolibrary.org/obo/NCIT_is_associated_disease_of>,
        <http://purl.obolibrary.org/obo/NCIT_is_cytogenetic_abnormality_of_disease>,
        RO:0004029,
        <http://purl.obolibrary.org/obo/SNOMED_associated_with>,
        <http://purl.obolibrary.org/obo/SNOMED_has_associated_finding>,
        ORPHA:317345,
        PDQ:associated_disease .

biolink:has_attribute a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:has_constituent a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has constituent" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalSubstance ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "one or more chemical substances within a mixture" .

biolink:has_part a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "has part" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:overlaps ;
    owl:inverseOf biolink:part_of ;
    skos:broadMatch RXNORM:contains,
        <http://purl.obolibrary.org/obo/FMA_contains>,
        RO:0001019 ;
    skos:definition "holds between wholes and their parts (material entities or processes)" ;
    skos:exactMatch RTXKG1:has_part,
        RXNORM:consists_of,
        RXNORM:has_part,
        <http://purl.obolibrary.org/obo/BFO_0000051>,
        <http://purl.obolibrary.org/obo/BFO_0000055>,
        RO:0001019,
        WIKIDATA_PROPERTY:P527 ;
    skos:narrowMatch <http://identifiers.org/meddra/has_member>,
        <http://identifiers.org/umls/has_component>,
        RTXKG1:composed_primarily_of,
        RTXKG1:contains_process,
        RTXKG1:has_plasma_membrane_part,
        LOINC:has_component,
        LOINC:has_member,
        NDDF:has_ingredient,
        RXNORM:has_ingredient,
        <http://purl.obolibrary.org/obo/BFO_0000117>,
        <http://purl.obolibrary.org/obo/FMA_has_constitutional_part>,
        <http://purl.obolibrary.org/obo/FMA_has_member>,
        <http://purl.obolibrary.org/obo/FMA_has_part>,
        <http://purl.obolibrary.org/obo/FOODON_00001563>,
        <http://purl.obolibrary.org/obo/FOODON_00002420>,
        <http://purl.obolibrary.org/obo/MONDO_disease_has_major_feature>,
        <http://purl.obolibrary.org/obo/NCIT_R50>,
        <http://purl.obolibrary.org/obo/NCIT_complex_has_physical_part>,
        RO:0002104,
        RO:0002180,
        RO:0002351,
        RO:0002473,
        RO:0002524,
        RO:0002551,
        <http://purl.obolibrary.org/obo/SNOMED_has_component>,
        PathWhiz:has_element_in_bound,
        PathWhiz:has_protein_in_complex,
        PDQ:has_component .

biolink:regulates a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "regulates" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    owl:inverseOf biolink:regulated_by ;
    skos:closeMatch RO:0002334 ;
    skos:exactMatch RO:0002211 ;
    skos:narrowMatch RTXKG1:regulates_activity_of,
        RTXKG1:regulates_expression_of,
        RO:0002295,
        RO:0002332,
        RO:0002578,
        CHEMBL.MECHANISM:modulator,
        WIKIDATA_PROPERTY:P128 ;
    skos:note "This is a grouping for process-process and entity-entity regulation." .

biolink:xref a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "xref" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:IriType ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "DbXref",
        "Dbxref",
        "dbxref" ;
    skos:definition "Alternate CURIEs for a thing" ;
    skos:narrowMatch gff3:Dbxref,
        gpi:DB_Xrefs .

biolink:BiologicalProcess a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "biological process" ;
    rdfs:subClassOf biolink:BiologicalProcessOrActivity,
        biolink:Occurrent,
        biolink:OntologyClass ;
    skos:broadMatch WIKIDATA:P682 ;
    skos:definition "One or more causally connected executions of molecular functions" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0008150>,
        SIO:000006,
        WIKIDATA:Q2996394 .

biolink:GeneProductMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene product mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:IriType ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        biolink:GeneOrGeneProduct,
        linkml:mixin ;
    skos:definition "The functional molecular product of a single gene locus. Gene products are either proteins or functional RNA molecules." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000907>,
        <http://purl.obolibrary.org/obo/NCIT_C26548>,
        WIKIDATA:Q424689 .

biolink:GenomicSequenceLocalization a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genomic sequence localization" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:genome_build ],
        [ a owl:Restriction ;
            owl:onClass biolink:GenomicEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GenomicEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:end_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:strand ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:start_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:phase ],
        biolink:SequenceAssociation ;
    skos:definition "A relationship between a sequence feature and a genomic entity it is localized to. The reference entity may be a chromosome, chromosome region or information entity such as a contig." .

biolink:MacromolecularMachineMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "macromolecular machine mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SymbolType ;
            owl:onProperty rdfs:label ],
        linkml:mixin ;
    skos:definition "A union of gene locus, gene product, and macromolecular complex mixin. These are the basic units of function in a cell. They either carry out individual biological activities, or they encode molecules which do this." .

biolink:ModelToDiseaseAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "model to disease association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "This mixin is used for any association class for which the subject (source node) plays the role of a 'model', in that it recapitulates some features of the disease in a way that is useful for studying the disease outside a patient carrying the disease" .

biolink:PopulationOfIndividualOrganisms a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "population of individual organisms" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        biolink:OrganismalEntity,
        biolink:ThingWithTaxon ;
    skos:definition "A collection of individuals from the same taxonomic class distinguished by one or more characteristics.  Characteristics can include, but are not limited to, shared geographic location, genetics, phenotypes [Alliance for Genome Resources]" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OBI_0000181>,
        <http://purl.obolibrary.org/obo/PCO_0000001>,
        SIO:001061,
        UMLSSC:T098,
        UMLSST:popg ;
    skos:narrowMatch UMLSSC:T099,
        UMLSSC:T100,
        UMLSSC:T101,
        UMLSST:aggp,
        UMLSST:famg,
        UMLSST:podg .

biolink:EntityToPhenotypicFeatureAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "entity to phenotypic feature association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:NarrativeText ;
            owl:onProperty dct:description ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PhenotypicFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToFeatureOrDiseaseQualifiersMixin,
        linkml:mixin .

biolink:Genotype a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genotype" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Zygosity ;
            owl:onProperty biolink:has_zygosity ],
        biolink:GenomicEntity ;
    skos:definition "An information content entity that describes a genome by specifying the total variation in genomic sequence and/or gene expression, relative to some established background" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000536>,
        SIO:001079 ;
    skos:note "Consider renaming as genotypic entity" .

biolink:OrganismalEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "organismal entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Attribute ;
            owl:onProperty biolink:has_attribute ],
        biolink:BiologicalEntity ;
    skos:definition "A named entity that is either a part of an organism, a whole organism, population or clade of organisms, excluding molecular entities" ;
    skos:exactMatch UMLSSG:LIVB,
        WIKIDATA:Q7239 .

biolink:id a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:in_taxon a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "in taxon" ;
    rdfs:domain biolink:ThingWithTaxon ;
    rdfs:range biolink:OrganismTaxon ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:altLabel "instance of" ;
    skos:closeMatch <http://purl.obolibrary.org/obo/NCIT_is_organism_source_of_gene_product>,
        <http://purl.obolibrary.org/obo/NCIT_organism_has_gene> ;
    skos:definition "connects an entity to its taxonomic classification. Only certain kinds of entities can be taxonomically classified; see 'thing with taxon'" ;
    skos:exactMatch WIKIDATA_PROPERTY:P703 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_gene_found_in_organism>,
        <http://purl.obolibrary.org/obo/NCIT_gene_product_has_organism_source>,
        RO:0002160 ;
    skos:relatedMatch RO:0002162 .

biolink:is_sequence_variant_of a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "is sequence variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "holds between a sequence variant and a genomic entity" ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_gene_product_sequence_variation_encoded_by_gene_mutant>,
        <http://purl.obolibrary.org/obo/NCIT_gene_product_variant_of_gene_product>,
        <http://purl.obolibrary.org/obo/OMIM_allelic_variant_of>,
        WIKIDATA:P3433 .

biolink:EntityToDiseaseAssociationMixin a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "entity to disease association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Disease ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToFeatureOrDiseaseQualifiersMixin,
        linkml:mixin ;
    skos:definition "mixin class for any association whose object (target node) is a disease" .

biolink:ThingWithTaxon a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "thing with taxon" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        linkml:mixin ;
    skos:definition "A mixin that can be used on any entity that can be taxonomically classified. This includes individual organisms; genes, their products and other molecular entities; body parts; biological processes" .

biolink:sex_qualifier a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "sex qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:BiologicalSex ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a qualifier used in a phenotypic association to state whether the association is specific to a particular sex." .

biolink:Agent a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "agent" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty rdfs:label ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:address ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:Uriorcurie ;
            owl:onProperty biolink:affiliation ],
        biolink:AdministrativeEntity ;
    skos:altLabel "group" ;
    skos:definition "person, group, organization or project that provides a piece of information (i.e. a knowledge association)" ;
    skos:exactMatch dct:Agent,
        prov:Agent ;
    skos:narrowMatch UMLSSG:ORGA,
        UMLSSC:T092,
        UMLSSC:T093,
        UMLSSC:T094,
        UMLSSC:T095,
        UMLSSC:T096,
        UMLSSC:T097,
        UMLSST:grup,
        UMLSST:hcro,
        UMLSST:orgt,
        UMLSST:prog,
        UMLSST:pros,
        UMLSST:shro .

biolink:BiologicalEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "biological entity" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:narrowMatch SIO:010046,
        UMLSSC:T050,
        UMLSST:emod,
        WIKIDATA:Q28845870 .

biolink:IriType a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "iri type" ;
    rdfs:subClassOf linkml:Uriorcurie ;
    skos:definition "An IRI" .

biolink:Attribute a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "attribute" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty biolink:source ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:IriType ;
            owl:onProperty biolink:iri ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty rdfs:label ],
        [ a owl:Restriction ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:has_attribute_type ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty biolink:has_qualitative_value ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:has_quantitative_value ],
        biolink:Annotation,
        biolink:OntologyClass ;
    skos:definition "A property or characteristic of an entity. For example, an apple may have properties such as color, shape, age, crispiness. An environmental sample may have attributes such as depth, lat, long, material." ;
    skos:exactMatch SIO:000614 .

biolink:Drug a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "drug" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalSubstance ;
            owl:onProperty biolink:has_constituent ],
        biolink:ChemicalOrDrugOrTreatment,
        biolink:Mixture,
        biolink:MolecularEntity,
        biolink:OntologyClass ;
    skos:broadMatch UMLSSC:T121,
        UMLSST:phsu ;
    skos:definition "A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_23888>,
        UMLSSC:T200,
        UMLSST:clnd,
        WIKIDATA:Q12140 ;
    skos:narrowMatch UMLSSC:T195,
        UMLSST:antb ;
    skos:note "The CHEBI ID represents a role rather than a substance" .

biolink:Outcome a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "outcome" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "An entity that has the role of being the consequence of an exposure event. This is an abstract mixin grouping of various categories of possible biological or non-biological (e.g. clinical) outcomes." .

biolink:Transcript a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "transcript" ;
    rdfs:subClassOf biolink:GenomicEntity ;
    skos:definition "An RNA synthesized on a DNA or RNA template by an RNA polymerase." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000673>,
        SIO:010450,
        WIKIDATA:Q7243183 .

biolink:BiologicalSex a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "biological sex" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0000047> .

biolink:InformationContentEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "information content entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:rights ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:format ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Date ;
            owl:onProperty biolink:creation_date ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:license ],
        biolink:NamedThing ;
    skos:altLabel "information",
        "information artefact",
        "information entity" ;
    skos:definition "a piece of information that typically describes some topic of discourse or is used as support." ;
    skos:exactMatch IAO:0000030 ;
    skos:narrowMatch UMLSSG:CONC,
        UMLSSC:T077,
        UMLSSC:T078,
        UMLSSC:T079,
        UMLSSC:T080,
        UMLSSC:T081,
        UMLSSC:T082,
        UMLSSC:T089,
        UMLSSC:T102,
        UMLSSC:T169,
        UMLSSC:T171,
        UMLSSC:T185,
        UMLSST:clas,
        UMLSST:cnce,
        UMLSST:ftcn,
        UMLSST:grpa,
        UMLSST:idcn,
        UMLSST:lang,
        UMLSST:qlco,
        UMLSST:qnco,
        UMLSST:rnlw,
        UMLSST:spco,
        UMLSST:tmco .

biolink:onset_qualifier a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "onset qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:Onset ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a qualifier used in a phenotypic association to state when the phenotype appears is in the subject" .

biolink:severity_qualifier a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "severity qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:SeverityValue ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a qualifier used in a phenotypic association to state how severe the phenotype is in the subject" .

linkml:TypeDefinition a owl:Class ;
    rdfs:label "type_definition" ;
    skos:definition "A data type definition." .

biolink:LabelType a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "label type" ;
    rdfs:subClassOf linkml:String ;
    skos:definition "A string that provides a human-readable name for an entity" .

biolink:Onset a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "onset" ;
    rdfs:subClassOf biolink:ClinicalCourse ;
    skos:definition "The age group in which (disease) symptom manifestations appear" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/HP_0003674> .

biolink:SeverityValue a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "severity value" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "describes the severity of a phenotypic feature or disease" .

biolink:frequency_qualifier a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "frequency qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:FrequencyValue ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a qualifier used in a phenotypic association to state how frequent the phenotype is observed in the subject" .

biolink:timepoint a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "timepoint" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:TimeType ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "a point in time" .

biolink:FrequencyValue a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "frequency value" ;
    rdfs:subClassOf linkml:String .

biolink:PhysicalEssenceOrOccurrent a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "physical essence or occurrent" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "Either a physical or processual entity." .

biolink:Publication a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "publication" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty dct:type ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:IriType ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty rdfs:label ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty biolink:keywords ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty biolink:authors ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:Uriorcurie ;
            owl:onProperty biolink:mesh_terms ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty biolink:pages ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:summary ],
        biolink:InformationContentEntity ;
    skos:definition "Any published piece of information. Can refer to a whole publication, its encompassing publication (i.e. journal or book) or to a part of a publication, if of significant knowledge scope (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web, as well as printed materials, either directly or in one of the Publication Biolink category subclasses." ;
    skos:exactMatch IAO:0000311 ;
    skos:narrowMatch IAO:0000013,
        UMLSSC:T170,
        UMLSST:inpr .

biolink:SequenceVariant a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "sequence variant" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        biolink:GenomicEntity ;
    skos:altLabel "allele" ;
    skos:broadMatch <http://purl.obolibrary.org/obo/SO_0001060> ;
    skos:definition "An allele that varies in its sequence from what is considered the reference allele at that locus." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000002>,
        <http://purl.obolibrary.org/obo/SO_0001059>,
        SIO:010277,
        VMC:Allele,
        WIKIDATA:Q15304597 ;
    skos:note "This class is for modeling the specific state at a locus. A single DBSNP rs ID could correspond to more than one sequence variants (e.g CIViC:1252 and CIViC:1253, two distinct BRCA2 alleles for rs28897743)" .

biolink:TimeType a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "time type" ;
    rdfs:subClassOf linkml:Time .

biolink:OrganismTaxon a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "organism taxon" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TaxonomicRank ;
            owl:onProperty biolink:has_taxonomic_rank ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:subclass_of ],
        biolink:NamedThing ;
    skos:altLabel "taxon",
        "taxonomic classification" ;
    skos:definition "A classification of a set of organisms. Example instances: NCBITaxon:9606 (Homo sapiens), NCBITaxon:2 (Bacteria). Can also be used to represent strains or subspecies." ;
    skos:exactMatch WIKIDATA:Q16521 ;
    skos:narrowMatch UMLSSC:T002,
        UMLSSC:T004,
        UMLSSC:T005,
        UMLSSC:T007,
        UMLSSC:T008,
        UMLSSC:T010,
        UMLSSC:T011,
        UMLSSC:T012,
        UMLSSC:T013,
        UMLSSC:T014,
        UMLSSC:T015,
        UMLSSC:T016,
        UMLSSC:T194,
        UMLSSC:T204,
        UMLSST:amph,
        UMLSST:anim,
        UMLSST:arch,
        UMLSST:bact,
        UMLSST:bird,
        UMLSST:euka,
        UMLSST:fish,
        UMLSST:fngs,
        UMLSST:humn,
        UMLSST:mamm,
        UMLSST:plnt,
        UMLSST:rept,
        UMLSST:virs,
        UMLSST:vtbt .

biolink:AnatomicalEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "anatomical entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        biolink:OrganismalEntity,
        biolink:PhysicalEssence,
        biolink:ThingWithTaxon ;
    skos:definition "A subcellular location, cell type or gross anatomical part" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/UBERON_0001062>,
        UMLSSG:ANAT,
        WIKIDATA:Q4936952 ;
    skos:narrowMatch UMLSSC:T022,
        UMLSSC:T029,
        UMLSSC:T030,
        UMLSSC:T031,
        UMLSST:bdsu,
        UMLSST:bdsy,
        UMLSST:blor,
        UMLSST:bsoj .

biolink:ExposureEvent a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "exposure event" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        linkml:mixin ;
    skos:altLabel "experimental condition",
        "exposure" ;
    skos:broadMatch UMLSSC:T051,
        UMLSST:evnt ;
    skos:definition "A (possibly time bounded) incidence of a feature of the environment of an organism that influences one or more phenotypic features of that organism, potentially mediated by genes" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/XCO_0000000> .

biolink:association_slot a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "association slot" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    skos:altLabel "edge property",
        "statement property" ;
    skos:definition "any slot that relates an association to another entity" .

biolink:affects a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "affects" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:affected_by ;
    skos:definition "describes an entity that has a direct affect on the state or quality of another existing entity. Use of the 'affects' predicate implies that the affected entity already exists, unlike predicates such as 'affects risk for' and 'prevents, where the outcome is something that may or may not come to be." ;
    skos:exactMatch RTXKG1:affects,
        SEMMEDDB:AFFECTS,
        SEMMEDDB:affects,
        DGIdb:affects ;
    skos:narrowMatch GOREL:0001006,
        <http://purl.obolibrary.org/obo/NCIT_R100>,
        <http://purl.obolibrary.org/obo/NCIT_R101>,
        <http://purl.obolibrary.org/obo/NCIT_R102>,
        <http://purl.obolibrary.org/obo/NCIT_R113>,
        <http://purl.obolibrary.org/obo/NCIT_R124>,
        <http://purl.obolibrary.org/obo/NCIT_R133>,
        <http://purl.obolibrary.org/obo/NCIT_R146>,
        <http://purl.obolibrary.org/obo/NCIT_R150>,
        <http://purl.obolibrary.org/obo/NCIT_R158>,
        <http://purl.obolibrary.org/obo/NCIT_R160>,
        <http://purl.obolibrary.org/obo/NCIT_R173>,
        <http://purl.obolibrary.org/obo/NCIT_R23>,
        <http://purl.obolibrary.org/obo/NCIT_R25>,
        <http://purl.obolibrary.org/obo/NCIT_R30>,
        <http://purl.obolibrary.org/obo/NCIT_R72>,
        <http://purl.obolibrary.org/obo/NCIT_gene_mapped_to_disease>,
        RO:0002263,
        RO:0002264,
        RO:0002343,
        RO:0002355,
        RO:0002591,
        RO:0002592,
        RO:0012003,
        <http://purl.obolibrary.org/obo/SNOMED_has_pathological_process>,
        <http://purl.obolibrary.org/obo/UPHENO_0000001>,
        CTD:inferred,
        CTD:prediction_hypothesis,
        SEMMEDDB:administered_to ;
    skos:relatedMatch <http://identifiers.org/drugbank/pathway> .

biolink:DiseaseOrPhenotypicFeature a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "disease or phenotypic feature" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        biolink:BiologicalEntity,
        biolink:ThingWithTaxon ;
    skos:altLabel "phenome" ;
    skos:definition "Either one of a disease or an individual phenotypic feature. Some knowledge resources such as Monarch treat these as distinct, others such as MESH conflate." ;
    skos:narrowMatch UMLSSC:T033,
        UMLSST:fndg .

biolink:GeneOrGeneProduct a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene or gene product" ;
    rdfs:subClassOf biolink:MacromolecularMachineMixin,
        linkml:mixin ;
    skos:definition "A union of gene loci or gene products. Frequently an identifier for one will be used as proxy for another" .

biolink:Gene a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "gene" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:IriType ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:symbol ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        biolink:GeneOrGeneProduct,
        biolink:GenomicEntity ;
    skos:altLabel "locus" ;
    skos:definition "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene locus may include regulatory regions, transcribed regions and/or other functional sequence regions." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000704>,
        SIO:010035,
        WIKIDATA:Q7187 .

biolink:GenomicEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "genomic entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        biolink:MolecularEntity ;
    skos:altLabel "sequence feature" ;
    skos:definition "an entity that can either be directly located on a genome (gene, transcript, exon, regulatory region) or is encoded in a genome (protein)" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000897>,
        <http://purl.obolibrary.org/obo/SO_0000110>,
        UMLSSG:GENE ;
    skos:narrowMatch UMLSSC:T028,
        UMLSSC:T086,
        UMLSST:gngm,
        UMLSST:nusq .

rdf:predicate a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:PredicateType a owl:Class,
        linkml:TypeDefinition ;
    rdfs:label "predicate type" ;
    rdfs:subClassOf linkml:Uriorcurie ;
    skos:definition "A CURIE from the biolink related_to hierarchy. For example, biolink:related_to, biolink:causes, biolink:treats." .

biolink:Occurrent a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "occurrent" ;
    rdfs:subClassOf biolink:PhysicalEssenceOrOccurrent,
        linkml:mixin ;
    skos:definition "A processual entity." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000003> .

biolink:OntologyClass a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "ontology class" ;
    rdfs:seeAlso "https://github.com/biolink/biolink-model/issues/486" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "a concept or class in an ontology, vocabulary or thesaurus. Note that nodes in a biolink compatible KG can be considered both instances of biolink classes, and OWL classes in their own right. In general you should not need to use this class directly. Instead, use the appropriate biolink class. For example, for the GO concept of endocytosis (GO:0006897), use bl:BiologicalProcess as the type." ;
    skos:exactMatch schema1:Class,
        owl:Class ;
    skos:note "Note that formally this is a metaclass. Instances of this class are instances in the graph, but can be the object of 'type' edges. For example, if we had a node in the graph representing a specific brain of a specific patient (e.g brain001), this could have  a category of bl:Sample, and by typed more specifically with an ontology class UBERON:nnn, which has as category bl:AnatomicalEntity",
        "This is modeled as a mixin. 'ontology class' should not be the primary type of a node in the KG. Instead you should use an informative bioloink category, such as AnatomicalEntity (for Uberon classes), ChemicalSubstance (for CHEBI or CHEMBL), etc" ;
    linkml:examples "Example(value='UBERON:0000955', description=\"the class 'brain' from the Uberon anatomy ontology\")" .

biolink:ChemicalSubstance a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "chemical substance" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Boolean ;
            owl:onProperty biolink:is_metabolite ],
        biolink:MolecularEntity,
        biolink:OntologyClass ;
    skos:broadMatch UMLSSC:T167,
        UMLSST:sbst ;
    skos:definition "May be a chemical entity or a formulation with a chemical entity as active ingredient, or a complex material with multiple chemical entities as part" ;
    skos:exactMatch SIO:010004,
        UMLSSC:T103,
        UMLSST:chem,
        WIKIDATA:Q79529 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CHEBI_24431>,
        UMLSSC:T104,
        UMLSSC:T109,
        UMLSSC:T114,
        UMLSSC:T120,
        UMLSSC:T122,
        UMLSSC:T130,
        UMLSSC:T131,
        UMLSSC:T196,
        UMLSSC:T197,
        UMLSST:bodm,
        UMLSST:chvf,
        UMLSST:chvs,
        UMLSST:elii,
        UMLSST:hops,
        UMLSST:inch,
        UMLSST:irda,
        UMLSST:nnon,
        UMLSST:orch .

biolink:node_property a owl:ObjectProperty,
        linkml:SlotDefinition ;
    rdfs:label "node property" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    skos:definition "A grouping for any property that holds between a node and a value" .

rdf:object a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:related_to a owl:ObjectProperty,
        owl:SymmetricProperty,
        linkml:SlotDefinition ;
    rdfs:label "related to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    skos:broadMatch owl:topObjectProperty ;
    skos:definition "A relationship that is asserted between two named things" ;
    skos:exactMatch <http://identifiers.org/umls/related_to>,
        SEMMEDDB:ASSOCIATED_WITH,
        SEMMEDDB:associated_with,
        <https://www.w3.org/TR/skos-reference/#relatedMatch> ;
    skos:narrowMatch <http://identifiers.org/hmdb/disease>,
        <http://identifiers.org/hmdb/has_protein_association>,
        <http://identifiers.org/mesh/RO>,
        <http://identifiers.org/mesh/has_mapping_qualifier>,
        <http://identifiers.org/mesh/mapped_to>,
        <http://identifiers.org/umls/RO>,
        <http://identifiers.org/umls/RQ>,
        <http://identifiers.org/umls/class_code_classified_by>,
        <http://identifiers.org/umls/exhibited_by>,
        <http://identifiers.org/umls/has_context_binding>,
        <http://identifiers.org/umls/has_form>,
        <http://identifiers.org/umls/has_mapping_qualifier>,
        <http://identifiers.org/umls/larger_than>,
        <http://identifiers.org/umls/mapped_to>,
        <http://identifiers.org/umls/owning_section_of>,
        RTXKG1:functionally_related_to,
        LOINC:has_answer,
        LOINC:has_challenge,
        LOINC:has_evaluation,
        LOINC:mapped_to,
        LOINC:mth_has_expanded_form,
        HCPCS:mapped_to,
        RXNORM:has_form,
        RXNORM:reformulated_to,
        <http://purl.obolibrary.org/obo/BFO_0000054>,
        <http://purl.obolibrary.org/obo/BFO_0000068>,
        <http://purl.obolibrary.org/obo/BFO_0000069>,
        <http://purl.obolibrary.org/obo/BTO_related_to>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_acid_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_base_of>,
        <http://purl.obolibrary.org/obo/FMA_connected_to>,
        <http://purl.obolibrary.org/obo/FMA_continuous_with>,
        <http://purl.obolibrary.org/obo/FMA_homonym_of>,
        <http://purl.obolibrary.org/obo/FMA_related_developmental_entity_of>,
        GOREL:0002005,
        GOREL:0012006,
        IAO:0000136,
        <http://purl.obolibrary.org/obo/MONDO_disease_shares_features_of>,
        <http://purl.obolibrary.org/obo/NCIT_disease_may_have_associated_disease>,
        <http://purl.obolibrary.org/obo/NCIT_human_disease_maps_to_eo_disease>,
        <http://purl.obolibrary.org/obo/NCIT_is_abnormal_cell_of_disease>,
        <http://purl.obolibrary.org/obo/NCIT_is_related_to_endogenous_product>,
        RO:0000052,
        RO:0000053,
        RO:0002001,
        RO:0002002,
        RO:0002003,
        RO:0002008,
        RO:0002084,
        RO:0002092,
        RO:0002093,
        RO:0002134,
        RO:0002150,
        RO:0002159,
        RO:0002176,
        RO:0002177,
        RO:0002178,
        RO:0002179,
        RO:0002314,
        RO:0002322,
        RO:0002328,
        RO:0002332,
        RO:0002338,
        RO:0002339,
        RO:0002341,
        RO:0002342,
        RO:0002344,
        RO:0002348,
        RO:0002349,
        RO:0002356,
        RO:0002371,
        RO:0002372,
        RO:0002373,
        RO:0002374,
        RO:0002385,
        RO:0002387,
        RO:0002451,
        RO:0002494,
        RO:0002495,
        RO:0002568,
        RO:0002573,
        RO:0004026,
        RO:0004027,
        RO:0009001,
        RO:0009004,
        <http://purl.obolibrary.org/obo/SNOMED_has_associated_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_associated_procedure>,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_disposition>,
        <http://purl.obolibrary.org/obo/SNOMED_has_indirect_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_modification>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_source_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_inheres_in>,
        <http://purl.obolibrary.org/obo/SNOMED_is_interpreted_by>,
        <http://purl.obolibrary.org/obo/SNOMED_relative_to_part_of>,
        <http://purl.obolibrary.org/obo/UBERON_synapsed_by>,
        <http://purl.obolibrary.org/obo/core#connected_to>,
        <http://purl.obolibrary.org/obo/core#innervated_by>,
        <http://purl.obolibrary.org/obo/envo#has_increased_levels_of>,
        <http://purl.obolibrary.org/obo/has_role>,
        <http://purl.obolibrary.org/obo/nbo#is_about>,
        PATO-PROPERTY:decreased_in_magnitude_relative_to,
        PATO-PROPERTY:has_cross_section,
        PATO-PROPERTY:has_relative_magnitude,
        PATO-PROPERTY:increased_in_magnitude_relative_to,
        PATO-PROPERTY:reciprocal_of,
        UBERON_CORE:protects,
        EFO:0006351,
        SEMMEDDB:compared_with,
        SEMMEDDB:higher_than,
        SEMMEDDB:lower_than,
        CPT:has_add_on_code,
        CPT:mapped_to .

rdf:subject a owl:ObjectProperty,
        linkml:SlotDefinition .

biolink:Association a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:qualifiers ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty rdf:type ],
        [ a owl:Restriction ;
            owl:onClass linkml:Uriorcurie ;
            owl:onProperty biolink:relation ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Publication ;
            owl:onProperty biolink:publications ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Boolean ;
            owl:onProperty biolink:negated ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CategoryType ;
            owl:onProperty biolink:category ],
        biolink:Entity ;
    skos:definition "A typed association between two entities, supported by evidence" ;
    skos:exactMatch OBAN:association,
        rdf:Statement,
        owl:Axiom ;
    skos:note "This is roughly the model used by biolink and ontobio at the moment" .

biolink:MolecularEntity a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "molecular entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        biolink:BiologicalEntity,
        biolink:OntologyClass,
        biolink:PhysicalEssence,
        biolink:ThingWithTaxon ;
    skos:altLabel "bioentity" ;
    skos:definition "A gene, gene product, small molecule or macromolecule (including protein complex)\"" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_24431> ;
    skos:narrowMatch SIO:010341,
        UMLSSG:CHEM,
        UMLSSC:T085,
        UMLSSC:T123,
        UMLSSC:T125,
        UMLSSC:T126,
        UMLSSC:T129,
        UMLSSC:T192,
        UMLSST:bacs,
        UMLSST:enzy,
        UMLSST:horm,
        UMLSST:imft,
        UMLSST:mosq,
        UMLSST:rcpt,
        WIKIDATA:Q43460564 .

biolink:NamedThing a owl:Class,
        linkml:ClassDefinition ;
    rdfs:label "named thing" ;
    rdfs:subClassOf [ a owl:Class ;
            owl:intersectionOf ( [ a owl:Restriction ;
                        owl:allValuesFrom biolink:NamedThing ;
                        owl:onProperty biolink:category ] [ a owl:Restriction ;
                        owl:onProperty biolink:category ;
                        owl:someValuesFrom biolink:NamedThing ] ) ],
        biolink:Entity ;
    skos:definition "a databased entity or concept/class" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000001>,
        UMLSSG:OBJC,
        UMLSSC:T071,
        UMLSST:enty,
        WIKIDATA:Q35120 .

linkml:ClassDefinition a owl:Class ;
    rdfs:label "class_definition" ;
    skos:definition "the definition of a class or interface" .

linkml:SlotDefinition a owl:Class ;
    rdfs:label "slot_definition" ;
    skos:definition "the definition of a property or a slot" .


