XPP model

This model was converted from XPP ode format to SBML using sbmlutils-0.1.5a6.

# successor of model-fk-sk-na_7-1.ode, with changes:
# * new fast K model with 2 tauh
# * new slow K model with p=4
#
# conductances in nS  
# currents in pA  
# Voltages in mV  
# time in ms  
# capacitances in pF  
  
#dV/dt=-1/c*(gKs*mKs^4*(V-EK) + gKf*mKf^4*(fh*hKf+(1-fh)*hKf2)*(V-EK) + gNa*mNa^3*hNa*(V-ENa) + gleak*(V-Eleak)-I)  

dV/dt=-1/c*(Iks+Ikf+Ina+Inap+gleak*(V-Eleak)-I)
  
#slow K  
# orig = 5.1
par gKs=50
par EK=-80  
minfKs(V) = 1/(1+exp((V+12.85)/(-19.91)))  
mtauKs(V) = 2.03 + 1.96 /(1+exp((V-29.83)/3.32))  
dmKs/dt=(minfKs(V)-mKs)/mtauKs(V)  
Iks=gKs*mKs^4*(V-EK)  
aux Iks=Iks

#fast K with 2 inactivation time constants
dmKf/dt=(minfKf(V)-mKf)/mtauKf(V)  
dhKf/dt=(hinfK(V)-hKf)/htauK(V)  
dhKf2/dt=(hinfK2(V)-hKf)/116  
Ikf=gKf*mKf^4*(fh*hKf + (1-fh)*hKf2)*(V-EK)  
par gKf=24.1
par fh=.95
minfKf(V) = 1/(1+exp((V+17.55)/(-7.27)))  
mtauKf(V) = 1.94+2.66/(1+exp((V-8.12)/7.96))  
hinfK(V) = 1/(1+exp((V+45)/6))  
htauK(V) = 1.79+515.8/(1+exp((V+147.4)/(28.66)))  
# mistake; should be hinfK == hinfK2
hinfK2(V) = 1/(1+exp((V+44.2)/1.5))
aux Ikf=Ikf
  
#na  
# from O'Dowd and Aldrich (1988)
dmNa/dt=(minfNa(V)-mNa)/mtauNa(V)
dhNa/dt=(hinfNa(V)-hNa)/htauNa(V)
Ina=gNa*mNa^3*hNa*(V-ENa)
par ENa=45
# gNa reported as 500 pS/pF, multiply with C=20 pF
par gNa=100
minfNa(V) = 1/(1+exp((V+29.13)/(-8.922)))
mtauNa(V) = 3.861-3.434/(1+exp((V+51.35)/(-5.98)))
hinfNa(V) = 1/(1+exp((V+40)/6.048))
htauNa(V) = 2.834-2.371/(1+exp((V+21.9)/(-2.641)))
aux Ina=Ina

# NaP from DmNav10 of WHL oocyte #1
dmNaP/dt=(minfNaP(V)-mNaP)/mtauNaP(V)
Inap=gNaP*mNaP*(V-ENa)
par gNaP=.8
minfNap(V) = 1/(1+exp((V+48.77)/(-3.68)))
mtauNap(V) = 1
aux Inap=Inap

global 1 t {I=Ihold}    
global 1 t-10 {I=Ipulse}  
global 1 t-510 {I=Ihold}  

# initial conditions for settled at I=-12
# easiest way is to get this is to save "info" from File menu
init V=-54.56137733296305, MKS=0.1095841015345856, MKF=0.006114411948700807, HKF=0.831116786237579, HKF2=6.331878827270821, MNA=0.05466001581199555, HNA=0.9174076713170543, MNAP=0.1716833324516358

@ total=530,bounds=10000000000,meth=euler,dt=.001, nout=100, maxstor=10000000  

par I=0 c=4 Ipulse=0 Ihold=-12
par gleak=6.8 eleak=-55
done 

Terms of use