Metadata-Version: 2.1
Name: dspin
Version: 1.0.2
Summary: Python implementation of 'D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response'
Home-page: https://github.com/JialongJiang/DSPIN
Author: Jialong Jiang
Author-email: jiangjl@caltech.edu
License: Apache-2.0 license
Keywords: network inference,single cell,transcriptomics
Classifier: Development Status :: 4 - Beta
Classifier: Intended Audience :: Science/Research
Classifier: Operating System :: OS Independent
Classifier: Programming Language :: Python :: 3
Classifier: Programming Language :: Python :: 3.9
Classifier: License :: OSI Approved :: Apache Software License
Classifier: Topic :: Scientific/Engineering :: Bio-Informatics
Classifier: Topic :: Scientific/Engineering :: Information Analysis
Classifier: Topic :: Scientific/Engineering :: Physics
Requires-Python: >=3.6
Description-Content-Type: text/markdown
License-File: LICENSE
Requires-Dist: anndata
Requires-Dist: matplotlib
Requires-Dist: scanpy
Requires-Dist: tqdm
Requires-Dist: igraph
Requires-Dist: leidenalg

# D-SPIN: Constructing regulatory network models from scRNA-seq perturbation profiling  

D-SPIN is a computational framework for constructing regulatory network models of genes or gene programs from single-cell RNA-seq profiling of perturbation conditions. D-SPIN integrates information from multiple perturbation conditions for network inference with improved efficienty and accuracy. The regulatory network can be defined on single genes or gene programs (groups of coexpressed genes). The package includes implementation of gene program discovery, network inference, and network analysis. 

If D-SPIN is useful for your research, consider citing "D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response" ([bioRxiv](https://www.biorxiv.org/content/10.1101/2023.04.19.537364)).

## Contact 

For any questions and feedback regarding D-SPIN, please contact us at [jiangjl@caltech.edu](mailto:jiangjl@caltech.edu) or open an issue on GitHub.
