@prefix : <https://w3id.org/linkml/> .
@prefix CHADO: <http://gmod.org/wiki/Chado/> .
@prefix CHEMBL.MECHANISM: <https://www.ebi.ac.uk/chembl/mechanism/inspect/> .
@prefix CID: <http://pubchem.ncbi.nlm.nih.gov/compound/> .
@prefix COAR_RESOURCE: <http://purl.org/coar/resource_type/> .
@prefix CPT: <https://www.ama-assn.org/practice-management/cpt/> .
@prefix DRUGBANK: <http://identifiers.org/drugbank/> .
@prefix GOP: <http://purl.obolibrary.org/obo/go#> .
@prefix GTEx: <https://www.gtexportal.org/home/gene/> .
@prefix HCPCS: <http://purl.bioontology.org/ontology/HCPCS/> .
@prefix HMDB: <http://identifiers.org/hmdb/> .
@prefix KEGG.RCLASS: <http://www.kegg.jp/entry/> .
@prefix LOINC: <http://loinc.org/rdf/> .
@prefix MEDDRA: <http://identifiers.org/meddra/> .
@prefix MESH: <http://identifiers.org/mesh/> .
@prefix MSigDB: <https://www.gsea-msigdb.org/gsea/msigdb/> .
@prefix NDDF: <http://purl.bioontology.org/ontology/NDDF/> .
@prefix OBAN: <http://purl.org/oban/> .
@prefix OBO: <http://purl.obolibrary.org/obo/> .
@prefix ORCID: <https://orcid.org/> .
@prefix PATO-PROPERTY: <http://purl.obolibrary.org/obo/pato#> .
@prefix PDQ: <https://www.cancer.gov/publications/pdq#> .
@prefix PathWhiz: <http://smpdb.ca/pathways/#> .
@prefix REPODB: <http://apps.chiragjpgroup.org/repoDB/> .
@prefix RTXKG1: <http://kg1endpoint.rtx.ai/> .
@prefix RXNORM: <http://purl.bioontology.org/ontology/RXNORM/> .
@prefix ResearchID: <https://publons.com/researcher/> .
@prefix SNOMEDCT: <http://identifiers.org/snomedct/> .
@prefix UBERGRAPH: <http://translator.renci.org/ubergraph-axioms.ofn#> .
@prefix UBERON_CORE: <http://purl.obolibrary.org/obo/uberon/core#> .
@prefix UMLS: <http://identifiers.org/umls/> .
@prefix UMLSSC: <https://metamap.nlm.nih.gov/Docs/SemanticTypes_2018AB.txt/code#> .
@prefix UMLSSG: <https://metamap.nlm.nih.gov/Docs/SemGroups_2018.txt/group#> .
@prefix UMLSST: <https://metamap.nlm.nih.gov/Docs/SemanticTypes_2018AB.txt/type#> .
@prefix VANDF: <https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/VANDF/> .
@prefix VMC: <https://github.com/ga4gh/vr-spec/> .
@prefix WIKIDATA: <https://www.wikidata.org/wiki/> .
@prefix WIKIDATA_PROPERTY: <https://www.wikidata.org/wiki/Property:> .
@prefix alliancegenome: <https://www.alliancegenome.org/> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dctypes: <http://purl.org/dc/dcmitype/> .
@prefix doi: <https://doi.org/> .
@prefix fabio: <http://purl.org/spar/fabio/> .
@prefix faldo: <http://biohackathon.org/resource/faldo#> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix foodb.compound: <http://foodb.ca/compounds/> .
@prefix gff3: <https://github.com/The-Sequence-Ontology/Specifications/blob/master/gff3.md#> .
@prefix gpi: <https://github.com/geneontology/go-annotation/blob/master/specs/gpad-gpi-2-0.md#> .
@prefix gtpo: <https://rdf.guidetopharmacology.org/ns/gtpo#> .
@prefix interpro: <https://www.ebi.ac.uk/interpro/entry/> .
@prefix isbn: <https://www.isbn-international.org/identifier/> .
@prefix isni: <https://isni.org/isni/> .
@prefix issn: <https://portal.issn.org/resource/ISSN/> .
@prefix linkml: <https://w3id.org/linkml/> .
@prefix medgen: <https://www.ncbi.nlm.nih.gov/medgen/> .
@prefix ns1: <http://www.w3.org/2004/02/skos/core#> .
@prefix oboInOwl: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix oboformat: <http://www.geneontology.org/formats/oboInOWL#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix qud: <http://qudt.org/1.1/schema/qudt#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <http://schema.org/> .
@prefix shex: <http://www.w3.org/ns/shex#> .
@prefix skos: <https://www.w3.org/TR/skos-reference/#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

biolink:Biolink-Model a linkml:SchemaDefinition ;
    dct:description "Entity and association taxonomy and datamodel for life-sciences data" ;
    dct:license "https://creativecommons.org/publicdomain/zero/1.0/" ;
    pav:version "1.8.2" ;
    linkml:classes biolink:Activity,
        biolink:ActivityAndBehavior,
        biolink:AdministrativeEntity,
        biolink:Agent,
        biolink:AnatomicalEntity,
        biolink:AnatomicalEntityToAnatomicalEntityAssociation,
        biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation,
        biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation,
        biolink:Annotation,
        biolink:Article,
        biolink:Association,
        biolink:Attribute,
        biolink:Behavior,
        biolink:BehaviorToBehavioralFeatureAssociation,
        biolink:BehavioralExposure,
        biolink:BehavioralFeature,
        biolink:BehavioralOutcome,
        biolink:BiologicalEntity,
        biolink:BiologicalProcess,
        biolink:BiologicalProcessOrActivity,
        biolink:BiologicalSex,
        biolink:BioticExposure,
        biolink:Book,
        biolink:BookChapter,
        biolink:Carbohydrate,
        biolink:Case,
        biolink:CaseToEntityAssociationMixin,
        biolink:CaseToPhenotypicFeatureAssociation,
        biolink:Cell,
        biolink:CellLine,
        biolink:CellLineAsAModelOfDiseaseAssociation,
        biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation,
        biolink:CellLineToEntityAssociationMixin,
        biolink:CellularComponent,
        biolink:ChemicalExposure,
        biolink:ChemicalOrDrugOrTreatment,
        biolink:ChemicalSubstance,
        biolink:ChemicalToChemicalAssociation,
        biolink:ChemicalToChemicalDerivationAssociation,
        biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation,
        biolink:ChemicalToEntityAssociationMixin,
        biolink:ChemicalToGeneAssociation,
        biolink:ChemicalToPathwayAssociation,
        biolink:ClinicalAttribute,
        biolink:ClinicalCourse,
        biolink:ClinicalEntity,
        biolink:ClinicalFinding,
        biolink:ClinicalIntervention,
        biolink:ClinicalMeasurement,
        biolink:ClinicalModifier,
        biolink:ClinicalTrial,
        biolink:CodingSequence,
        biolink:Cohort,
        biolink:ComplexChemicalExposure,
        biolink:ConfidenceLevel,
        biolink:ContributorAssociation,
        biolink:Dataset,
        biolink:DatasetDistribution,
        biolink:DatasetSummary,
        biolink:DatasetVersion,
        biolink:Death,
        biolink:Device,
        biolink:Disease,
        biolink:DiseaseOrPhenotypicFeature,
        biolink:DiseaseOrPhenotypicFeatureAssociationToLocationAssociation,
        biolink:DiseaseOrPhenotypicFeatureExposure,
        biolink:DiseaseOrPhenotypicFeatureOutcome,
        biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin,
        biolink:DiseaseOrPhenotypicFeatureToLocationAssociation,
        biolink:DiseaseToEntityAssociationMixin,
        biolink:DiseaseToExposureEventAssociation,
        biolink:DiseaseToPhenotypicFeatureAssociation,
        biolink:Drug,
        biolink:DrugExposure,
        biolink:DrugToEntityAssociationMixin,
        biolink:DrugToGeneAssociation,
        biolink:DrugToGeneInteractionExposure,
        biolink:Entity,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin,
        biolink:EntityToExposureEventAssociationMixin,
        biolink:EntityToFeatureOrDiseaseQualifiersMixin,
        biolink:EntityToOutcomeAssociationMixin,
        biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:EnvironmentalExposure,
        biolink:EnvironmentalFeature,
        biolink:EnvironmentalFoodContaminant,
        biolink:EnvironmentalProcess,
        biolink:EpidemiologicalOutcome,
        biolink:EvidenceType,
        biolink:Exon,
        biolink:ExonToTranscriptRelationship,
        biolink:ExposureEvent,
        biolink:ExposureEventToEntityAssociationMixin,
        biolink:ExposureEventToOutcomeAssociation,
        biolink:ExposureEventToPhenotypicFeatureAssociation,
        biolink:Food,
        biolink:FoodAdditive,
        biolink:FoodComponent,
        biolink:FrequencyQualifierMixin,
        biolink:FrequencyQuantifier,
        biolink:FunctionalAssociation,
        biolink:Gene,
        biolink:GeneAsAModelOfDiseaseAssociation,
        biolink:GeneExpressionMixin,
        biolink:GeneFamily,
        biolink:GeneGroupingMixin,
        biolink:GeneHasVariantThatContributesToDiseaseAssociation,
        biolink:GeneOntologyClass,
        biolink:GeneOrGeneProduct,
        biolink:GeneProductIsoformMixin,
        biolink:GeneProductMixin,
        biolink:GeneRegulatoryRelationship,
        biolink:GeneToDiseaseAssociation,
        biolink:GeneToEntityAssociationMixin,
        biolink:GeneToExpressionSiteAssociation,
        biolink:GeneToGeneAssociation,
        biolink:GeneToGeneCoexpressionAssociation,
        biolink:GeneToGeneHomologyAssociation,
        biolink:GeneToGeneProductRelationship,
        biolink:GeneToGoTermAssociation,
        biolink:GeneToPhenotypicFeatureAssociation,
        biolink:Genome,
        biolink:GenomicBackgroundExposure,
        biolink:GenomicEntity,
        biolink:GenomicSequenceLocalization,
        biolink:Genotype,
        biolink:GenotypeAsAModelOfDiseaseAssociation,
        biolink:GenotypeToDiseaseAssociation,
        biolink:GenotypeToEntityAssociationMixin,
        biolink:GenotypeToGeneAssociation,
        biolink:GenotypeToGenotypePartAssociation,
        biolink:GenotypeToPhenotypicFeatureAssociation,
        biolink:GenotypeToVariantAssociation,
        biolink:GenotypicSex,
        biolink:GeographicExposure,
        biolink:GeographicLocation,
        biolink:GeographicLocationAtTime,
        biolink:GrossAnatomicalStructure,
        biolink:Haplotype,
        biolink:Hospitalization,
        biolink:HospitalizationOutcome,
        biolink:IndividualOrganism,
        biolink:InformationContentEntity,
        biolink:Inheritance,
        biolink:LifeStage,
        biolink:MacromolecularComplexMixin,
        biolink:MacromolecularMachineMixin,
        biolink:MacromolecularMachineToBiologicalProcessAssociation,
        biolink:MacromolecularMachineToCellularComponentAssociation,
        biolink:MacromolecularMachineToEntityAssociationMixin,
        biolink:MacromolecularMachineToMolecularActivityAssociation,
        biolink:Macronutrient,
        biolink:MaterialSample,
        biolink:MaterialSampleDerivationAssociation,
        biolink:MaterialSampleToDiseaseOrPhenotypicFeatureAssociation,
        biolink:MaterialSampleToEntityAssociationMixin,
        biolink:Metabolite,
        biolink:MicroRNA,
        biolink:Micronutrient,
        biolink:Mixture,
        biolink:ModelToDiseaseAssociationMixin,
        biolink:MolecularActivity,
        biolink:MolecularEntity,
        biolink:MolecularEntityToEntityAssociationMixin,
        biolink:MortalityOutcome,
        biolink:NamedThing,
        biolink:NoncodingRNAProduct,
        biolink:Nutrient,
        biolink:Occurrent,
        biolink:Onset,
        biolink:OntologyClass,
        biolink:OrganismAttribute,
        biolink:OrganismTaxon,
        biolink:OrganismTaxonToEntityAssociation,
        biolink:OrganismTaxonToEnvironmentAssociation,
        biolink:OrganismTaxonToOrganismTaxonAssociation,
        biolink:OrganismTaxonToOrganismTaxonInteraction,
        biolink:OrganismTaxonToOrganismTaxonSpecialization,
        biolink:OrganismalEntity,
        biolink:OrganismalEntityAsAModelOfDiseaseAssociation,
        biolink:Outcome,
        biolink:PairwiseGeneToGeneInteraction,
        biolink:PairwiseMolecularInteraction,
        biolink:PathognomonicityQuantifier,
        biolink:PathologicalAnatomicalExposure,
        biolink:PathologicalAnatomicalOutcome,
        biolink:PathologicalAnatomicalStructure,
        biolink:PathologicalEntityMixin,
        biolink:PathologicalProcess,
        biolink:PathologicalProcessExposure,
        biolink:PathologicalProcessOutcome,
        biolink:Pathway,
        biolink:Phenomenon,
        biolink:PhenotypicFeature,
        biolink:PhenotypicQuality,
        biolink:PhenotypicSex,
        biolink:PhysicalEntity,
        biolink:PhysicalEssence,
        biolink:PhysicalEssenceOrOccurrent,
        biolink:PhysiologicalProcess,
        biolink:PlanetaryEntity,
        biolink:PopulationOfIndividualOrganisms,
        biolink:PopulationToPopulationAssociation,
        biolink:Procedure,
        biolink:ProcessedMaterial,
        biolink:Protein,
        biolink:ProteinIsoform,
        biolink:Publication,
        biolink:QuantityValue,
        biolink:RNAProduct,
        biolink:RNAProductIsoform,
        biolink:ReagentTargetedGene,
        biolink:RelationshipQuantifier,
        biolink:RelationshipType,
        biolink:SensitivityQuantifier,
        biolink:SequenceAssociation,
        biolink:SequenceFeatureRelationship,
        biolink:SequenceVariant,
        biolink:SequenceVariantModulatesTreatmentAssociation,
        biolink:Serial,
        biolink:SeverityValue,
        biolink:SiRNA,
        biolink:Snv,
        biolink:SocioeconomicAttribute,
        biolink:SocioeconomicExposure,
        biolink:SocioeconomicOutcome,
        biolink:SpecificityQuantifier,
        biolink:StudyPopulation,
        biolink:SubjectOfInvestigation,
        biolink:TaxonomicRank,
        biolink:ThingWithTaxon,
        biolink:Transcript,
        biolink:TranscriptToGeneRelationship,
        biolink:Treatment,
        biolink:UnclassifiedOntologyClass,
        biolink:VariantAsAModelOfDiseaseAssociation,
        biolink:VariantToDiseaseAssociation,
        biolink:VariantToEntityAssociationMixin,
        biolink:VariantToGeneAssociation,
        biolink:VariantToGeneExpressionAssociation,
        biolink:VariantToPhenotypicFeatureAssociation,
        biolink:VariantToPopulationAssociation,
        biolink:Vitamin,
        biolink:Zygosity ;
    linkml:default_curi_maps "idot_context",
        "monarch_context",
        "obo_context",
        "semweb_context" ;
    linkml:default_prefix "biolink" ;
    linkml:default_range biolink:string ;
    linkml:emit_prefixes "BIOGRID",
        "OIO",
        "rdf",
        "rdfs",
        "skos",
        "xsd" ;
    linkml:enums biolink:logical_interpretation_enum ;
    linkml:generation_date "2021-10-18 01:24"^^xsd:dateTime ;
    linkml:imports linkml:types ;
    linkml:metamodel_version "1.7.0" ;
    linkml:prefixes [ linkml:prefix_prefix "oboformat" ;
            linkml:prefix_reference oboformat: ],
        [ linkml:prefix_prefix "wgs" ;
            linkml:prefix_reference <http://www.w3.org/2003/01/geo/wgs84_pos> ],
        [ linkml:prefix_prefix "CHEMBL.MECHANISM" ;
            linkml:prefix_reference CHEMBL.MECHANISM: ],
        [ linkml:prefix_prefix "gff3" ;
            linkml:prefix_reference gff3: ],
        [ linkml:prefix_prefix "CID" ;
            linkml:prefix_reference CID: ],
        [ linkml:prefix_prefix "CAID" ;
            linkml:prefix_reference <http://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_caid?caid=> ],
        [ linkml:prefix_prefix "ExO" ;
            linkml:prefix_reference OBO:ExO_ ],
        [ linkml:prefix_prefix "EDAM-DATA" ;
            linkml:prefix_reference <http://edamontology.org/data_> ],
        [ linkml:prefix_prefix "pav" ;
            linkml:prefix_reference pav: ],
        [ linkml:prefix_prefix "KEGG.RCLASS" ;
            linkml:prefix_reference KEGG.RCLASS: ],
        [ linkml:prefix_prefix "RO" ;
            linkml:prefix_reference OBO:RO_ ],
        [ linkml:prefix_prefix "hetio" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/hetio_> ],
        [ linkml:prefix_prefix "ICD0" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/ICD0_> ],
        [ linkml:prefix_prefix "ORCID" ;
            linkml:prefix_reference ORCID: ],
        [ linkml:prefix_prefix "fabio" ;
            linkml:prefix_reference fabio: ],
        [ linkml:prefix_prefix "foodb.compound" ;
            linkml:prefix_reference foodb.compound: ],
        [ linkml:prefix_prefix "gpi" ;
            linkml:prefix_reference gpi: ],
        [ linkml:prefix_prefix "OBOREL" ;
            linkml:prefix_reference OBO:RO_ ],
        [ linkml:prefix_prefix "UMLSSG" ;
            linkml:prefix_reference UMLSSG: ],
        [ linkml:prefix_prefix "EDAM-TOPIC" ;
            linkml:prefix_reference <http://edamontology.org/topic_> ],
        [ linkml:prefix_prefix "HsapDv" ;
            linkml:prefix_reference OBO:HsapDv_ ],
        [ linkml:prefix_prefix "GSID" ;
            linkml:prefix_reference <https://scholar.google.com/citations?user=> ],
        [ linkml:prefix_prefix "UBERON_CORE" ;
            linkml:prefix_reference UBERON_CORE: ],
        [ linkml:prefix_prefix "GTOPDB" ;
            linkml:prefix_reference <https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=> ],
        [ linkml:prefix_prefix "doi" ;
            linkml:prefix_reference doi: ],
        [ linkml:prefix_prefix "foaf" ;
            linkml:prefix_reference foaf: ],
        [ linkml:prefix_prefix "KEGG.BRITE" ;
            linkml:prefix_reference KEGG.RCLASS: ],
        [ linkml:prefix_prefix "PHAROS" ;
            linkml:prefix_reference <http://pharos.nih.gov/> ],
        [ linkml:prefix_prefix "isbn" ;
            linkml:prefix_reference isbn: ],
        [ linkml:prefix_prefix "GOP" ;
            linkml:prefix_reference GOP: ],
        [ linkml:prefix_prefix "isni" ;
            linkml:prefix_reference isni: ],
        [ linkml:prefix_prefix "MetaCyc" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/MetaCyc_> ],
        [ linkml:prefix_prefix "UMLSSC" ;
            linkml:prefix_reference UMLSSC: ],
        [ linkml:prefix_prefix "NDDF" ;
            linkml:prefix_reference NDDF: ],
        [ linkml:prefix_prefix "DrugCentral" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/DrugCentral_> ],
        [ linkml:prefix_prefix "SEMMEDDB" ;
            linkml:prefix_reference <https://skr3.nlm.nih.gov/SemMedDB> ],
        [ linkml:prefix_prefix "os" ;
            linkml:prefix_reference <https://github.com/cmungall/owlstar/blob/master/owlstar.ttl> ],
        [ linkml:prefix_prefix "KEGG.GENE" ;
            linkml:prefix_reference KEGG.RCLASS: ],
        [ linkml:prefix_prefix "RXCUI" ;
            linkml:prefix_reference <https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=> ],
        [ linkml:prefix_prefix "CHADO" ;
            linkml:prefix_reference CHADO: ],
        [ linkml:prefix_prefix "biolink" ;
            linkml:prefix_reference biolink: ],
        [ linkml:prefix_prefix "prov" ;
            linkml:prefix_reference prov: ],
        [ linkml:prefix_prefix "MSigDB" ;
            linkml:prefix_reference MSigDB: ],
        [ linkml:prefix_prefix "RTXKG1" ;
            linkml:prefix_reference RTXKG1: ],
        [ linkml:prefix_prefix "EFO" ;
            linkml:prefix_reference <http://www.ebi.ac.uk/efo/EFO_> ],
        [ linkml:prefix_prefix "VANDF" ;
            linkml:prefix_reference VANDF: ],
        [ linkml:prefix_prefix "EDAM-FORMAT" ;
            linkml:prefix_reference <http://edamontology.org/format_> ],
        [ linkml:prefix_prefix "Aeolus" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/Aeolus_> ],
        [ linkml:prefix_prefix "ICD9" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/ICD9_> ],
        [ linkml:prefix_prefix "CTD" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/CTD_> ],
        [ linkml:prefix_prefix "SNPEFF" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/SNPEFF_> ],
        [ linkml:prefix_prefix "HANCESTRO" ;
            linkml:prefix_reference <http://www.ebi.ac.uk/ancestro/ancestro_> ],
        [ linkml:prefix_prefix "NLMID" ;
            linkml:prefix_reference <https://www.ncbi.nlm.nih.gov/nlmcatalog/?term=> ],
        [ linkml:prefix_prefix "KEGG.DGROUP" ;
            linkml:prefix_reference KEGG.RCLASS: ],
        [ linkml:prefix_prefix "DGIdb" ;
            linkml:prefix_reference <https://www.dgidb.org/interaction_types> ],
        [ linkml:prefix_prefix "gtpo" ;
            linkml:prefix_reference gtpo: ],
        [ linkml:prefix_prefix "LOINC" ;
            linkml:prefix_reference LOINC: ],
        [ linkml:prefix_prefix "WBVocab" ;
            linkml:prefix_reference <http://bio2rdf.org/wormbase_vocabulary> ],
        [ linkml:prefix_prefix "RXNORM" ;
            linkml:prefix_reference RXNORM: ],
        [ linkml:prefix_prefix "schema" ;
            linkml:prefix_reference schema: ],
        [ linkml:prefix_prefix "ECTO" ;
            linkml:prefix_reference OBO:ECTO_ ],
        [ linkml:prefix_prefix "PATO-PROPERTY" ;
            linkml:prefix_reference PATO-PROPERTY: ],
        [ linkml:prefix_prefix "ICD10" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/ICD10_> ],
        [ linkml:prefix_prefix "linkml" ;
            linkml:prefix_reference linkml: ],
        [ linkml:prefix_prefix "INO" ;
            linkml:prefix_reference OBO:INO_ ],
        [ linkml:prefix_prefix "GAMMA" ;
            linkml:prefix_reference <http://translator.renci.org/GAMMA_> ],
        [ linkml:prefix_prefix "UBERGRAPH" ;
            linkml:prefix_reference UBERGRAPH: ],
        [ linkml:prefix_prefix "GTEx" ;
            linkml:prefix_reference GTEx: ],
        [ linkml:prefix_prefix "UMLSST" ;
            linkml:prefix_reference UMLSST: ],
        [ linkml:prefix_prefix "PDQ" ;
            linkml:prefix_reference PDQ: ],
        [ linkml:prefix_prefix "OBAN" ;
            linkml:prefix_reference OBAN: ],
        [ linkml:prefix_prefix "ChemBank" ;
            linkml:prefix_reference <http://chembank.broadinstitute.org/chemistry/viewMolecule.htm?cbid=> ],
        [ linkml:prefix_prefix "COAR_RESOURCE" ;
            linkml:prefix_reference COAR_RESOURCE: ],
        [ linkml:prefix_prefix "medgen" ;
            linkml:prefix_reference medgen: ],
        [ linkml:prefix_prefix "ResearchID" ;
            linkml:prefix_reference ResearchID: ],
        [ linkml:prefix_prefix "qud" ;
            linkml:prefix_reference qud: ],
        [ linkml:prefix_prefix "dct" ;
            linkml:prefix_reference dct: ],
        [ linkml:prefix_prefix "ScopusID" ;
            linkml:prefix_reference <https://www.scopus.com/authid/detail.uri?authorId=> ],
        [ linkml:prefix_prefix "REPODB" ;
            linkml:prefix_reference REPODB: ],
        [ linkml:prefix_prefix "KEGG.ENZYME" ;
            linkml:prefix_reference KEGG.RCLASS: ],
        [ linkml:prefix_prefix "chembio" ;
            linkml:prefix_reference <http://translator.ncats.nih.gov/chembio_> ],
        [ linkml:prefix_prefix "dcat" ;
            linkml:prefix_reference dcat: ],
        [ linkml:prefix_prefix "WIKIDATA" ;
            linkml:prefix_reference WIKIDATA: ],
        [ linkml:prefix_prefix "alliancegenome" ;
            linkml:prefix_reference alliancegenome: ],
        [ linkml:prefix_prefix "HCPCS" ;
            linkml:prefix_reference HCPCS: ],
        [ linkml:prefix_prefix "MI" ;
            linkml:prefix_reference OBO:MI_ ],
        [ linkml:prefix_prefix "ORPHA" ;
            linkml:prefix_reference <http://www.orpha.net/ORDO/Orphanet_> ],
        [ linkml:prefix_prefix "EDAM-OPERATION" ;
            linkml:prefix_reference <http://edamontology.org/operation_> ],
        [ linkml:prefix_prefix "GOREL" ;
            linkml:prefix_reference OBO:GOREL_ ],
        [ linkml:prefix_prefix "WIKIDATA_PROPERTY" ;
            linkml:prefix_reference WIKIDATA_PROPERTY: ],
        [ linkml:prefix_prefix "CPT" ;
            linkml:prefix_reference CPT: ],
        [ linkml:prefix_prefix "SIO" ;
            linkml:prefix_reference <http://semanticscience.org/resource/SIO_> ],
        [ linkml:prefix_prefix "PathWhiz" ;
            linkml:prefix_reference PathWhiz: ],
        [ linkml:prefix_prefix "VMC" ;
            linkml:prefix_reference VMC: ],
        [ linkml:prefix_prefix "interpro" ;
            linkml:prefix_reference interpro: ],
        [ linkml:prefix_prefix "issn" ;
            linkml:prefix_reference issn: ] ;
    linkml:slots biolink:actively_involved_in,
        biolink:address,
        biolink:affected_by,
        biolink:affects,
        biolink:affects_abundance_of,
        biolink:affects_activity_of,
        biolink:affects_degradation_of,
        biolink:affects_expression_in,
        biolink:affects_expression_of,
        biolink:affects_folding_of,
        biolink:affects_localization_of,
        biolink:affects_metabolic_processing_of,
        biolink:affects_molecular_modification_of,
        biolink:affects_mutation_rate_of,
        biolink:affects_response_to,
        biolink:affects_risk_for,
        biolink:affects_secretion_of,
        biolink:affects_splicing_of,
        biolink:affects_stability_of,
        biolink:affects_synthesis_of,
        biolink:affects_transport_of,
        biolink:affects_uptake_of,
        biolink:affiliation,
        biolink:agent_id,
        biolink:agent_name,
        biolink:aggregate_statistic,
        biolink:ameliorates,
        biolink:anatomical_entity_to_anatomical_entity_association_object,
        biolink:anatomical_entity_to_anatomical_entity_association_subject,
        biolink:anatomical_entity_to_anatomical_entity_ontogenic_association_object,
        biolink:anatomical_entity_to_anatomical_entity_ontogenic_association_predicate,
        biolink:anatomical_entity_to_anatomical_entity_ontogenic_association_subject,
        biolink:anatomical_entity_to_anatomical_entity_part_of_association_object,
        biolink:anatomical_entity_to_anatomical_entity_part_of_association_predicate,
        biolink:anatomical_entity_to_anatomical_entity_part_of_association_subject,
        biolink:approved_for_treatment_by,
        biolink:approved_to_treat,
        biolink:article_iso_abbreviation,
        biolink:article_published_in,
        biolink:associated_environmental_context,
        biolink:association_category,
        biolink:association_id,
        biolink:association_slot,
        biolink:association_type,
        biolink:attribute_name,
        biolink:author,
        biolink:authors,
        biolink:behavior_to_behavioral_feature_association_object,
        biolink:behavior_to_behavioral_feature_association_subject,
        biolink:biological_role_mixin,
        biolink:biomarker_for,
        biolink:book_chapter_published_in,
        biolink:book_id,
        biolink:book_type,
        biolink:broad_match,
        biolink:capable_of,
        biolink:case_to_entity_association_mixin_subject,
        biolink:catalyst_qualifier,
        biolink:category,
        biolink:caused_by,
        biolink:causes,
        biolink:causes_adverse_event,
        biolink:cell_line_as_a_model_of_disease_association_subject,
        biolink:cell_line_to_disease_or_phenotypic_feature_association_subject,
        biolink:cell_line_to_entity_association_mixin_subject,
        biolink:chapter,
        biolink:chemical_role_mixin,
        biolink:chemical_to_chemical_association_object,
        biolink:chemical_to_chemical_derivation_association_catalyst_qualifier,
        biolink:chemical_to_chemical_derivation_association_object,
        biolink:chemical_to_chemical_derivation_association_predicate,
        biolink:chemical_to_chemical_derivation_association_subject,
        biolink:chemical_to_disease_or_phenotypic_feature_association_object,
        biolink:chemical_to_entity_association_mixin_subject,
        biolink:chemical_to_gene_association_object,
        biolink:chemical_to_pathway_association_object,
        biolink:chemically_similar_to,
        biolink:chi_squared_statistic,
        biolink:clinical_finding_has_attribute,
        biolink:clinical_measurement_has_attribute_type,
        biolink:clinical_modifier_qualifier,
        biolink:close_match,
        biolink:coexists_with,
        biolink:coexpressed_with,
        biolink:colocalizes_with,
        biolink:condition_associated_with_gene,
        biolink:contraindicated_for,
        biolink:contributes_to,
        biolink:contributor,
        biolink:contributor_association_object,
        biolink:contributor_association_predicate,
        biolink:contributor_association_qualifiers,
        biolink:contributor_association_subject,
        biolink:correlated_with,
        biolink:created_with,
        biolink:creation_date,
        biolink:dataset_download_url,
        biolink:decreases_abundance_of,
        biolink:decreases_activity_of,
        biolink:decreases_degradation_of,
        biolink:decreases_expression_of,
        biolink:decreases_folding_of,
        biolink:decreases_localization_of,
        biolink:decreases_metabolic_processing_of,
        biolink:decreases_molecular_interaction,
        biolink:decreases_molecular_modification_of,
        biolink:decreases_mutation_rate_of,
        biolink:decreases_response_to,
        biolink:decreases_secretion_of,
        biolink:decreases_splicing_of,
        biolink:decreases_stability_of,
        biolink:decreases_synthesis_of,
        biolink:decreases_transport_of,
        biolink:decreases_uptake_of,
        biolink:derives_from,
        biolink:derives_into,
        biolink:description,
        biolink:develops_from,
        biolink:directly_interacts_with,
        biolink:disease_has_basis_in,
        biolink:disease_or_phenotypic_feature_association_to_location_association_object,
        biolink:disease_or_phenotypic_feature_to_entity_association_mixin_subject,
        biolink:disease_or_phenotypic_feature_to_location_association_object,
        biolink:disease_to_entity_association_mixin_subject,
        biolink:disrupted_by,
        biolink:disrupts,
        biolink:distribution_download_url,
        biolink:download_url,
        biolink:drug_to_entity_association_mixin_subject,
        biolink:drug_to_gene_association_object,
        biolink:edge_label,
        biolink:editor,
        biolink:enabled_by,
        biolink:enables,
        biolink:end_interbase_coordinate,
        biolink:entity_negatively_regulated_by_entity,
        biolink:entity_negatively_regulates_entity,
        biolink:entity_positively_regulated_by_entity,
        biolink:entity_positively_regulates_entity,
        biolink:entity_regulated_by_entity,
        biolink:entity_regulates_entity,
        biolink:entity_to_disease_association_mixin_object,
        biolink:entity_to_disease_or_phenotypic_feature_association_mixin_object,
        biolink:entity_to_exposure_event_association_mixin_object,
        biolink:entity_to_outcome_association_mixin_object,
        biolink:entity_to_phenotypic_feature_association_mixin_description,
        biolink:entity_to_phenotypic_feature_association_mixin_object,
        biolink:exacerbates,
        biolink:exact_match,
        biolink:exon_to_transcript_relationship_object,
        biolink:exon_to_transcript_relationship_subject,
        biolink:exposure_event_to_entity_association_mixin_subject,
        biolink:exposure_event_to_phenotypic_feature_association_subject,
        biolink:expressed_in,
        biolink:expresses,
        biolink:expression_site,
        biolink:filler,
        biolink:food_component_of,
        biolink:format,
        biolink:frequency_qualifier,
        biolink:full_name,
        biolink:functional_association_object,
        biolink:functional_association_subject,
        biolink:gene_as_a_model_of_disease_association_subject,
        biolink:gene_associated_with_condition,
        biolink:gene_expression_mixin_quantifier_qualifier,
        biolink:gene_has_variant_that_contributes_to_disease_association_subject,
        biolink:gene_product_of,
        biolink:gene_regulatory_relationship_object,
        biolink:gene_regulatory_relationship_predicate,
        biolink:gene_regulatory_relationship_subject,
        biolink:gene_to_disease_association_subject,
        biolink:gene_to_entity_association_mixin_subject,
        biolink:gene_to_expression_site_association_object,
        biolink:gene_to_expression_site_association_predicate,
        biolink:gene_to_expression_site_association_quantifier_qualifier,
        biolink:gene_to_expression_site_association_stage_qualifier,
        biolink:gene_to_expression_site_association_subject,
        biolink:gene_to_gene_association_object,
        biolink:gene_to_gene_association_subject,
        biolink:gene_to_gene_coexpression_association_predicate,
        biolink:gene_to_gene_homology_association_predicate,
        biolink:gene_to_gene_product_relationship_object,
        biolink:gene_to_gene_product_relationship_predicate,
        biolink:gene_to_gene_product_relationship_subject,
        biolink:gene_to_go_term_association_object,
        biolink:gene_to_go_term_association_subject,
        biolink:gene_to_phenotypic_feature_association_subject,
        biolink:genetic_association,
        biolink:genetically_interacts_with,
        biolink:genome_build,
        biolink:genomic_sequence_localization_object,
        biolink:genomic_sequence_localization_predicate,
        biolink:genomic_sequence_localization_subject,
        biolink:genotype_as_a_model_of_disease_association_subject,
        biolink:genotype_to_disease_association_object,
        biolink:genotype_to_disease_association_predicate,
        biolink:genotype_to_disease_association_subject,
        biolink:genotype_to_entity_association_mixin_subject,
        biolink:genotype_to_gene_association_object,
        biolink:genotype_to_gene_association_predicate,
        biolink:genotype_to_gene_association_subject,
        biolink:genotype_to_genotype_part_association_object,
        biolink:genotype_to_genotype_part_association_predicate,
        biolink:genotype_to_genotype_part_association_subject,
        biolink:genotype_to_phenotypic_feature_association_predicate,
        biolink:genotype_to_phenotypic_feature_association_subject,
        biolink:genotype_to_variant_association_object,
        biolink:genotype_to_variant_association_predicate,
        biolink:genotype_to_variant_association_subject,
        biolink:has_active_ingredient,
        biolink:has_attribute,
        biolink:has_attribute_type,
        biolink:has_biological_sequence,
        biolink:has_biomarker,
        biolink:has_chemical_formula,
        biolink:has_completed,
        biolink:has_confidence_level,
        biolink:has_constituent,
        biolink:has_count,
        biolink:has_dataset,
        biolink:has_decreased_amount,
        biolink:has_device,
        biolink:has_distribution,
        biolink:has_drug,
        biolink:has_evidence,
        biolink:has_excipient,
        biolink:has_food_component,
        biolink:has_gene,
        biolink:has_gene_or_gene_product,
        biolink:has_gene_product,
        biolink:has_increased_amount,
        biolink:has_input,
        biolink:has_metabolite,
        biolink:has_molecular_consequence,
        biolink:has_not_completed,
        biolink:has_numeric_value,
        biolink:has_nutrient,
        biolink:has_output,
        biolink:has_part,
        biolink:has_participant,
        biolink:has_percentage,
        biolink:has_phenotype,
        biolink:has_population_context,
        biolink:has_procedure,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:has_quotient,
        biolink:has_receptor,
        biolink:has_route,
        biolink:has_sequence_location,
        biolink:has_stressor,
        biolink:has_taxonomic_rank,
        biolink:has_temporal_context,
        biolink:has_topic,
        biolink:has_total,
        biolink:has_unit,
        biolink:has_variant_part,
        biolink:has_zygosity,
        biolink:homologous_to,
        biolink:id,
        biolink:in_cell_population_with,
        biolink:in_complex_with,
        biolink:in_linkage_disequilibrium_with,
        biolink:in_pathway_with,
        biolink:in_taxon,
        biolink:increases_abundance_of,
        biolink:increases_activity_of,
        biolink:increases_degradation_of,
        biolink:increases_expression_of,
        biolink:increases_folding_of,
        biolink:increases_localization_of,
        biolink:increases_metabolic_processing_of,
        biolink:increases_molecular_interaction,
        biolink:increases_molecular_modification_of,
        biolink:increases_mutation_rate_of,
        biolink:increases_response_to,
        biolink:increases_secretion_of,
        biolink:increases_splicing_of,
        biolink:increases_stability_of,
        biolink:increases_synthesis_of,
        biolink:increases_transport_of,
        biolink:increases_uptake_of,
        biolink:ingest_date,
        biolink:interacting_molecules_category,
        biolink:interacts_with,
        biolink:interbase_coordinate,
        biolink:iri,
        biolink:is_active_ingredient_of,
        biolink:is_excipient_of,
        biolink:is_frameshift_variant_of,
        biolink:is_metabolite,
        biolink:is_metabolite_of,
        biolink:is_missense_variant_of,
        biolink:is_nearby_variant_of,
        biolink:is_non_coding_variant_of,
        biolink:is_nonsense_variant_of,
        biolink:is_sequence_variant_of,
        biolink:is_splice_site_variant_of,
        biolink:is_synonymous_variant_of,
        biolink:iso_abbreviation,
        biolink:issue,
        biolink:keywords,
        biolink:lacks_part,
        biolink:latitude,
        biolink:license,
        biolink:located_in,
        biolink:location_of,
        biolink:logical_interpretation,
        biolink:longitude,
        biolink:macromolecular_machine_mixin_name,
        biolink:macromolecular_machine_to_biological_process_association_object,
        biolink:macromolecular_machine_to_cellular_component_association_object,
        biolink:macromolecular_machine_to_entity_association_mixin_subject,
        biolink:macromolecular_machine_to_molecular_activity_association_object,
        biolink:manifestation_of,
        biolink:material_sample_derivation_association_object,
        biolink:material_sample_derivation_association_predicate,
        biolink:material_sample_derivation_association_subject,
        biolink:material_sample_to_entity_association_mixin_subject,
        biolink:mesh_terms,
        biolink:model_of,
        biolink:model_to_disease_association_mixin_predicate,
        biolink:model_to_disease_association_mixin_subject,
        biolink:molecular_activity_enabled_by,
        biolink:molecular_activity_has_input,
        biolink:molecular_activity_has_output,
        biolink:molecular_entity_to_entity_association_mixin_subject,
        biolink:molecularly_interacts_with,
        biolink:name,
        biolink:named_thing_category,
        biolink:narrow_match,
        biolink:negated,
        biolink:negatively_correlated_with,
        biolink:negatively_regulated_by,
        biolink:negatively_regulates,
        biolink:node_property,
        biolink:nutrient_of,
        biolink:object,
        biolink:occurs_in,
        biolink:onset_qualifier,
        biolink:opposite_of,
        biolink:organism_taxon_has_taxonomic_rank,
        biolink:organism_taxon_subclass_of,
        biolink:organism_taxon_to_entity_association_subject,
        biolink:organism_taxon_to_environment_association_object,
        biolink:organism_taxon_to_environment_association_predicate,
        biolink:organism_taxon_to_environment_association_subject,
        biolink:organism_taxon_to_organism_taxon_association_object,
        biolink:organism_taxon_to_organism_taxon_association_subject,
        biolink:organism_taxon_to_organism_taxon_interaction_associated_environmental_context,
        biolink:organism_taxon_to_organism_taxon_interaction_object,
        biolink:organism_taxon_to_organism_taxon_interaction_predicate,
        biolink:organism_taxon_to_organism_taxon_interaction_subject,
        biolink:organism_taxon_to_organism_taxon_specialization_object,
        biolink:organism_taxon_to_organism_taxon_specialization_predicate,
        biolink:organism_taxon_to_organism_taxon_specialization_subject,
        biolink:organismal_entity_as_a_model_of_disease_association_subject,
        biolink:organismal_entity_has_attribute,
        biolink:orthologous_to,
        biolink:overlaps,
        biolink:p_value,
        biolink:pages,
        biolink:pairwise_gene_to_gene_interaction_predicate,
        biolink:pairwise_gene_to_gene_interaction_relation,
        biolink:pairwise_molecular_interaction_id,
        biolink:pairwise_molecular_interaction_object,
        biolink:pairwise_molecular_interaction_predicate,
        biolink:pairwise_molecular_interaction_relation,
        biolink:pairwise_molecular_interaction_subject,
        biolink:paralogous_to,
        biolink:part_of,
        biolink:participates_in,
        biolink:phase,
        biolink:phenotype_of,
        biolink:phenotypic_state,
        biolink:physically_interacts_with,
        biolink:population_to_population_association_object,
        biolink:population_to_population_association_predicate,
        biolink:population_to_population_association_subject,
        biolink:positively_correlated_with,
        biolink:positively_regulated_by,
        biolink:positively_regulates,
        biolink:preceded_by,
        biolink:precedes,
        biolink:predicate,
        biolink:predisposes,
        biolink:prevented_by,
        biolink:prevents,
        biolink:process_negatively_regulated_by_process,
        biolink:process_negatively_regulates_process,
        biolink:process_positively_regulated_by_process,
        biolink:process_positively_regulates_process,
        biolink:process_regulated_by_process,
        biolink:process_regulates_process,
        biolink:produced_by,
        biolink:produces,
        biolink:provided_by,
        biolink:provider,
        biolink:publication_id,
        biolink:publication_name,
        biolink:publication_pages,
        biolink:publication_type,
        biolink:publications,
        biolink:published_in,
        biolink:publisher,
        biolink:qualifiers,
        biolink:quantifier_qualifier,
        biolink:regulated_by,
        biolink:regulates,
        biolink:related_condition,
        biolink:related_to,
        biolink:relation,
        biolink:retrieved_on,
        biolink:rights,
        biolink:same_as,
        biolink:sequence_feature_relationship_object,
        biolink:sequence_feature_relationship_subject,
        biolink:sequence_localization_attribute,
        biolink:sequence_variant_has_biological_sequence,
        biolink:sequence_variant_has_gene,
        biolink:sequence_variant_id,
        biolink:sequence_variant_modulates_treatment_association_object,
        biolink:sequence_variant_modulates_treatment_association_subject,
        biolink:sequence_variant_qualifier,
        biolink:serial_id,
        biolink:serial_type,
        biolink:severity_qualifier,
        biolink:sex_qualifier,
        biolink:similar_to,
        biolink:socioeconomic_exposure_has_attribute,
        biolink:source,
        biolink:source_logo,
        biolink:source_web_page,
        biolink:stage_qualifier,
        biolink:start_interbase_coordinate,
        biolink:strand,
        biolink:subclass_of,
        biolink:subject,
        biolink:summary,
        biolink:superclass_of,
        biolink:symbol,
        biolink:synonym,
        biolink:systematic_synonym,
        biolink:temporally_related_to,
        biolink:timepoint,
        biolink:transcribed_from,
        biolink:transcribed_to,
        biolink:transcript_to_gene_relationship_object,
        biolink:transcript_to_gene_relationship_subject,
        biolink:translates_to,
        biolink:translation_of,
        biolink:treated_by,
        biolink:treats,
        biolink:type,
        biolink:update_date,
        biolink:variant_as_a_model_of_disease_association_subject,
        biolink:variant_to_disease_association_object,
        biolink:variant_to_disease_association_predicate,
        biolink:variant_to_disease_association_subject,
        biolink:variant_to_entity_association_mixin_subject,
        biolink:variant_to_gene_association_object,
        biolink:variant_to_gene_association_predicate,
        biolink:variant_to_gene_expression_association_predicate,
        biolink:variant_to_phenotypic_feature_association_subject,
        biolink:variant_to_population_association_has_count,
        biolink:variant_to_population_association_has_quotient,
        biolink:variant_to_population_association_has_total,
        biolink:variant_to_population_association_object,
        biolink:variant_to_population_association_subject,
        biolink:version,
        biolink:version_of,
        biolink:volume,
        biolink:xenologous_to,
        biolink:xref ;
    linkml:source_file "biolink-model.yaml" ;
    linkml:source_file_date "Mon Oct 18 01:20:49 2021"^^xsd:dateTime ;
    linkml:source_file_size 267853 ;
    linkml:subsets biolink:model_organism_database,
        biolink:samples,
        biolink:testing,
        biolink:translator_minimal ;
    linkml:types biolink:biological_sequence,
        biolink:boolean,
        biolink:category_type,
        biolink:chemical_formula_value,
        biolink:date,
        biolink:datetime,
        biolink:decimal,
        biolink:double,
        biolink:float,
        biolink:frequency_value,
        biolink:integer,
        biolink:iri_type,
        biolink:label_type,
        biolink:narrative_text,
        biolink:ncname,
        biolink:nodeidentifier,
        biolink:objectidentifier,
        biolink:percentage_frequency_value,
        biolink:predicate_type,
        biolink:quotient,
        biolink:string,
        biolink:symbol_type,
        biolink:time,
        biolink:time_type,
        biolink:unit,
        biolink:uri,
        biolink:uriorcurie .

biolink:AllSome dct:description "A modifier on a triple that causes the triple to be interpreted as an all-some statement." ;
    linkml:meaning <https://github.com/cmungall/owlstar/blob/master/owlstar.ttlAllSomeInterpretation> .

biolink:SomeSome dct:description "A modifier on a triple that causes the triple to be interpreted as a some-some statement" ;
    linkml:meaning <https://github.com/cmungall/owlstar/blob/master/owlstar.ttlSomeSomeInterpretation> .

biolink:datetime a linkml:TypeDefinition ;
    dct:description "The combination of a date and time" ;
    ns1:inScheme linkml:types ;
    linkml:base "XSDDateTime" ;
    linkml:definition_uri linkml:Datetime ;
    linkml:imported_from "linkml:types" ;
    linkml:repr "str" ;
    linkml:uri xsd:dateTime .

biolink:decimal a linkml:TypeDefinition ;
    dct:description "A real number with arbitrary precision that conforms to the xsd:decimal specification" ;
    ns1:inScheme linkml:types ;
    linkml:base "Decimal" ;
    linkml:definition_uri linkml:Decimal ;
    linkml:imported_from "linkml:types" ;
    linkml:uri xsd:decimal .

biolink:ncname a linkml:TypeDefinition ;
    dct:description "Prefix part of CURIE" ;
    ns1:inScheme linkml:types ;
    linkml:base "NCName" ;
    linkml:definition_uri linkml:Ncname ;
    linkml:imported_from "linkml:types" ;
    linkml:repr "str" ;
    linkml:uri xsd:string .

biolink:nodeidentifier a linkml:TypeDefinition ;
    dct:description "A URI, CURIE or BNODE that represents a node in a model." ;
    ns1:inScheme linkml:types ;
    linkml:base "NodeIdentifier" ;
    linkml:definition_uri linkml:Nodeidentifier ;
    linkml:imported_from "linkml:types" ;
    linkml:repr "str" ;
    linkml:uri shex:nonLiteral .

biolink:objectidentifier a linkml:TypeDefinition ;
    dct:description "A URI or CURIE that represents an object in the model." ;
    ns1:inScheme linkml:types ;
    ns1:note "Used for inheritence and type checking" ;
    linkml:base "ElementIdentifier" ;
    linkml:definition_uri linkml:Objectidentifier ;
    linkml:imported_from "linkml:types" ;
    linkml:repr "str" ;
    linkml:uri shex:iri .

biolink:percentage_frequency_value a linkml:TypeDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "float" ;
    linkml:definition_uri biolink:PercentageFrequencyValue ;
    linkml:typeof biolink:double ;
    linkml:uri OBO:UO_0000187 .

biolink:quotient a linkml:TypeDefinition ;
    ns1:altLabel "ratio" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "float" ;
    linkml:definition_uri biolink:Quotient ;
    linkml:typeof biolink:double ;
    linkml:uri OBO:UO_0010006 .

biolink:uri a linkml:TypeDefinition ;
    dct:description "a complete URI" ;
    ns1:inScheme linkml:types ;
    linkml:base "URI" ;
    linkml:definition_uri linkml:Uri ;
    linkml:imported_from "linkml:types" ;
    linkml:repr "str" ;
    linkml:uri xsd:anyURI .

biolink:agent_id a linkml:SlotDefinition ;
    dct:description "Different classes of agents have distinct preferred identifiers. For publishers, use the ISBN publisher code. See https://grp.isbn-international.org/ for publisher code lookups. For editors, authors and  individual providers, use the individual's ORCID if available; Otherwise, a ScopusID, ResearchID or Google Scholar ID ('GSID') may be used if the author ORCID is unknown. Institutional agents could be identified by an International Standard Name Identifier ('ISNI') code." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch gff3:ID,
        gpi:DB_Object_ID,
        alliancegenome:primaryId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "id" ;
    linkml:definition_uri biolink:id ;
    linkml:domain biolink:Agent ;
    linkml:domain_of biolink:Agent ;
    linkml:identifier true ;
    linkml:is_a biolink:id ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Agent ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri biolink:id ;
    linkml:usage_slot_name "id" ;
    linkml:values_from biolink:GSID,
        biolink:ORCID,
        biolink:ResearchID,
        biolink:ScopusID,
        biolink:isbn,
        biolink:isni .

biolink:agent_name a linkml:SlotDefinition ;
    dct:description "it is recommended that an author's 'name' property be formatted as \"surname, firstname initial.\"" ;
    oboInOwl:inSubset biolink:samples,
        biolink:translator_minimal ;
    ns1:altLabel "display name",
        "label",
        "title" ;
    ns1:exactMatch gff3:Name,
        gpi:DB_Object_Name ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdfs:label ;
    ns1:narrowMatch dct:title,
        WIKIDATA_PROPERTY:P1476 ;
    ns1:prefLabel "name" ;
    linkml:definition_uri biolink:name ;
    linkml:domain biolink:Agent ;
    linkml:domain_of biolink:Agent ;
    linkml:is_a biolink:name ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Agent ;
    linkml:range biolink:label_type ;
    linkml:slot_uri rdfs:label ;
    linkml:usage_slot_name "name" .

biolink:anatomical_entity_to_anatomical_entity_ontogenic_association_object a linkml:SlotDefinition ;
    dct:description "the structure at an earlier time" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:domain_of biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:is_a biolink:anatomical_entity_to_anatomical_entity_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:anatomical_entity_to_anatomical_entity_ontogenic_association_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:develops_from ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:domain_of biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:anatomical_entity_to_anatomical_entity_ontogenic_association_subject a linkml:SlotDefinition ;
    dct:description "the structure at a later time" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:domain_of biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:is_a biolink:anatomical_entity_to_anatomical_entity_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:anatomical_entity_to_anatomical_entity_part_of_association_object a linkml:SlotDefinition ;
    dct:description "the whole" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:domain_of biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:is_a biolink:anatomical_entity_to_anatomical_entity_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:anatomical_entity_to_anatomical_entity_part_of_association_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:part_of ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:domain_of biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:anatomical_entity_to_anatomical_entity_part_of_association_subject a linkml:SlotDefinition ;
    dct:description "the part" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:domain_of biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:is_a biolink:anatomical_entity_to_anatomical_entity_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:article_iso_abbreviation a linkml:SlotDefinition ;
    dct:description "Optional value, if used locally as a convenience, is set to the iso abbreviation of the 'published in' parent." ;
    ns1:exactMatch WIKIDATA_PROPERTY:P1160 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "iso abbreviation" ;
    linkml:definition_uri biolink:iso_abbreviation ;
    linkml:domain biolink:Article ;
    linkml:domain_of biolink:Article ;
    linkml:is_a biolink:iso_abbreviation ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Article ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:iso_abbreviation ;
    linkml:usage_slot_name "iso abbreviation" .

biolink:article_published_in a linkml:SlotDefinition ;
    dct:description "The enclosing parent serial containing the article should have industry-standard identifier from ISSN." ;
    ns1:exactMatch WIKIDATA_PROPERTY:P1433 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "published in" ;
    linkml:definition_uri biolink:published_in ;
    linkml:domain biolink:Article ;
    linkml:domain_of biolink:Article ;
    linkml:is_a biolink:published_in ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Article ;
    linkml:range biolink:uriorcurie ;
    linkml:required true ;
    linkml:slot_uri biolink:published_in ;
    linkml:usage_slot_name "published in" ;
    linkml:values_from biolink:NLMID,
        biolink:isbn,
        biolink:issn .

biolink:behavior_to_behavioral_feature_association_object a linkml:SlotDefinition ;
    dct:description "behavioral feature that is the object of the association" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:BehaviorToBehavioralFeatureAssociation ;
    linkml:domain_of biolink:BehaviorToBehavioralFeatureAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:BehaviorToBehavioralFeatureAssociation ;
    linkml:range biolink:BehavioralFeature ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:behavior_to_behavioral_feature_association_subject a linkml:SlotDefinition ;
    dct:description "behavior that is the subject of the association" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:BehaviorToBehavioralFeatureAssociation ;
    linkml:domain_of biolink:BehaviorToBehavioralFeatureAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:BehaviorToBehavioralFeatureAssociation ;
    linkml:range biolink:Behavior ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:book_chapter_published_in a linkml:SlotDefinition ;
    dct:description "The enclosing parent book containing the chapter should have industry-standard identifier from ISBN." ;
    ns1:exactMatch WIKIDATA_PROPERTY:P1433 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "published in" ;
    linkml:definition_uri biolink:published_in ;
    linkml:domain biolink:BookChapter ;
    linkml:domain_of biolink:BookChapter ;
    linkml:is_a biolink:published_in ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:BookChapter ;
    linkml:range biolink:uriorcurie ;
    linkml:required true ;
    linkml:slot_uri biolink:published_in ;
    linkml:usage_slot_name "published in" ;
    linkml:values_from biolink:NLMID,
        biolink:isbn,
        biolink:issn .

biolink:book_id a linkml:SlotDefinition ;
    dct:description "Books should have industry-standard identifier such as from ISBN." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch gff3:ID,
        gpi:DB_Object_ID,
        alliancegenome:primaryId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "id" ;
    linkml:definition_uri biolink:id ;
    linkml:domain biolink:Book ;
    linkml:domain_of biolink:Book ;
    linkml:identifier true ;
    linkml:is_a biolink:publication_id ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Book ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri biolink:id ;
    linkml:usage_slot_name "id" .

biolink:book_type a linkml:SlotDefinition ;
    dct:description "Should generally be set to an ontology class defined term for 'book'." ;
    ns1:exactMatch gff3:type,
        gpi:DB_Object_Type,
        alliancegenome:soTermId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:type ;
    ns1:prefLabel "type" ;
    linkml:definition_uri biolink:type ;
    linkml:domain biolink:Book ;
    linkml:domain_of biolink:Book ;
    linkml:is_a biolink:publication_type ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Book ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri rdf:type ;
    linkml:usage_slot_name "type" .

biolink:case_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "the case (e.g. patient) that has the property" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:CaseToEntityAssociationMixin ;
    linkml:domain_of biolink:CaseToEntityAssociationMixin ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:CaseToEntityAssociationMixin ;
    linkml:range biolink:Case ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:cell_line_as_a_model_of_disease_association_subject a linkml:SlotDefinition ;
    dct:description "A cell line derived from an organismal entity with a disease state that is used as a model of that disease." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:CellLineAsAModelOfDiseaseAssociation ;
    linkml:domain_of biolink:CellLineAsAModelOfDiseaseAssociation ;
    linkml:is_a biolink:cell_line_to_disease_or_phenotypic_feature_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:CellLineAsAModelOfDiseaseAssociation ;
    linkml:range biolink:CellLine ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:cell_line_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:CellLineToEntityAssociationMixin ;
    linkml:domain_of biolink:CellLineToEntityAssociationMixin ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:CellLineToEntityAssociationMixin ;
    linkml:range biolink:CellLine ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:chemical_formula_value a linkml:TypeDefinition ;
    dct:description "A chemical formula" ;
    ns1:editorialNote "Should be implemented as a stronger type" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "str" ;
    linkml:definition_uri biolink:ChemicalFormulaValue ;
    linkml:uri xsd:string .

biolink:chemical_to_chemical_derivation_association_catalyst_qualifier a linkml:SlotDefinition ;
    dct:description "this connects the derivation edge to the molecular entity that catalyzes the reaction that causes the subject chemical to transform into the object chemical." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "catalyst qualifier" ;
    linkml:definition_uri biolink:catalyst_qualifier ;
    linkml:domain biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:domain_of biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:catalyst_qualifier ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:range biolink:MacromolecularMachineMixin ;
    linkml:slot_uri biolink:catalyst_qualifier ;
    linkml:usage_slot_name "catalyst qualifier" .

biolink:chemical_to_chemical_derivation_association_object a linkml:SlotDefinition ;
    dct:description "the downstream chemical entity" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:domain_of biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:is_a biolink:chemical_to_chemical_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:chemical_to_chemical_derivation_association_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:derives_into ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:domain_of biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:chemical_to_chemical_derivation_association_subject a linkml:SlotDefinition ;
    dct:description "the upstream chemical entity" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:domain_of biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:chemical_to_disease_or_phenotypic_feature_association_object a linkml:SlotDefinition ;
    dct:description "the disease or phenotype that is affected by the chemical" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:domain_of biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:chemical_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "the chemical substance or entity that is an interactor" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:ChemicalToEntityAssociationMixin ;
    linkml:domain_of biolink:ChemicalToEntityAssociationMixin ;
    linkml:is_a biolink:molecular_entity_to_entity_association_mixin_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ChemicalToEntityAssociationMixin ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:chemical_to_gene_association_object a linkml:SlotDefinition ;
    dct:description "the gene or gene product that is affected by the chemical." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:ChemicalToGeneAssociation ;
    linkml:domain_of biolink:ChemicalToGeneAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ChemicalToGeneAssociation ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:chemical_to_pathway_association_object a linkml:SlotDefinition ;
    dct:description "the pathway that is affected by the chemical" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:ChemicalToPathwayAssociation ;
    linkml:domain_of biolink:ChemicalToPathwayAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ChemicalToPathwayAssociation ;
    linkml:range biolink:Pathway ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:clinical_finding_has_attribute a linkml:SlotDefinition ;
    dct:description "connects any entity to an attribute" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:closeMatch OBO:OBI_0001927 ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_000008> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch DRUGBANK:category,
        UMLS:has_structural_class,
        UMLS:has_supported_concept_property,
        UMLS:has_supported_concept_relationship,
        UMLS:may_be_qualified_by,
        LOINC:has_action_guidance,
        LOINC:has_adjustment,
        LOINC:has_aggregation_view,
        LOINC:has_approach_guidance,
        LOINC:has_divisor,
        LOINC:has_exam,
        LOINC:has_method,
        LOINC:has_modality_subtype,
        LOINC:has_object_guidance,
        LOINC:has_scale,
        LOINC:has_suffix,
        LOINC:has_time_aspect,
        LOINC:has_time_modifier,
        LOINC:has_timing_of,
        OBO:INO_0000154,
        OBO:NCIT_disease_is_grade,
        OBO:NCIT_disease_is_stage,
        OBO:NCIT_eo_disease_has_property_or_attribute,
        OBO:NCIT_has_data_element,
        OBO:NCIT_has_pharmaceutical_administration_method,
        OBO:NCIT_has_pharmaceutical_basic_dose_form,
        OBO:NCIT_has_pharmaceutical_intended_site,
        OBO:NCIT_has_pharmaceutical_release_characteristics,
        OBO:NCIT_has_pharmaceutical_state_of_matter,
        OBO:NCIT_has_pharmaceutical_transformation,
        OBO:NCIT_is_qualified_by,
        OBO:NCIT_qualifier_applies_to,
        OBO:NCIT_role_has_domain,
        OBO:NCIT_role_has_range,
        OBO:OMIM_has_inheritance_type,
        OBO:RO_0000053,
        OBO:RO_0000086,
        OBO:RO_0000087,
        OBO:SNOMED_has_access,
        OBO:SNOMED_has_clinical_course,
        OBO:SNOMED_has_count_of_base_of_active_ingredient,
        OBO:SNOMED_has_dose_form_administration_method,
        OBO:SNOMED_has_dose_form_release_characteristic,
        OBO:SNOMED_has_dose_form_transformation,
        OBO:SNOMED_has_finding_context,
        OBO:SNOMED_has_finding_informer,
        OBO:SNOMED_has_inherent_attribute,
        OBO:SNOMED_has_intent,
        OBO:SNOMED_has_interpretation,
        OBO:SNOMED_has_laterality,
        OBO:SNOMED_has_measurement_method,
        OBO:SNOMED_has_method,
        OBO:SNOMED_has_priority,
        OBO:SNOMED_has_procedure_context,
        OBO:SNOMED_has_process_duration,
        OBO:SNOMED_has_property,
        OBO:SNOMED_has_revision_status,
        OBO:SNOMED_has_scale_type,
        OBO:SNOMED_has_severity,
        OBO:SNOMED_has_specimen,
        OBO:SNOMED_has_state_of_matter,
        OBO:SNOMED_has_subject_relationship_context,
        OBO:SNOMED_has_surgical_approach,
        OBO:SNOMED_has_technique,
        OBO:SNOMED_has_temporal_context,
        OBO:SNOMED_has_time_aspect,
        OBO:SNOMED_has_units,
        OBAN:association_has_object_property,
        OBAN:association_has_subject_property,
        <http://www.ebi.ac.uk/ancestro/ancestro_0301>,
        <http://www.ebi.ac.uk/ancestro/ancestro_0308>,
        <http://www.ebi.ac.uk/efo/EFO_is_executed_in>,
        <http://www.orpha.net/ORDO/Orphanet_C016>,
        <http://www.orpha.net/ORDO/Orphanet_C017>,
        CPT:has_possibly_included_panel_element ;
    ns1:prefLabel "has attribute" ;
    linkml:definition_uri biolink:has_attribute ;
    linkml:domain biolink:ClinicalFinding ;
    linkml:domain_of biolink:ClinicalFinding ;
    linkml:inlined true ;
    linkml:is_a biolink:has_attribute ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:ClinicalFinding ;
    linkml:range biolink:ClinicalAttribute ;
    linkml:slot_uri biolink:has_attribute ;
    linkml:usage_slot_name "has attribute" .

biolink:clinical_measurement_has_attribute_type a linkml:SlotDefinition ;
    dct:description "connects an attribute to a class that describes it" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_modality_type,
        LOINC:has_view_type ;
    ns1:prefLabel "has attribute type" ;
    linkml:definition_uri biolink:has_attribute_type ;
    linkml:domain biolink:ClinicalMeasurement ;
    linkml:domain_of biolink:ClinicalMeasurement ;
    linkml:inlined true ;
    linkml:is_a biolink:has_attribute_type ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:ClinicalMeasurement ;
    linkml:range biolink:OntologyClass ;
    linkml:required true ;
    linkml:slot_uri biolink:has_attribute_type ;
    linkml:usage_slot_name "has attribute type" ;
    linkml:values_from biolink:EFO,
        biolink:LOINC .

biolink:contributor_association_object a linkml:SlotDefinition ;
    dct:description "agent helping to realise the given entity (e.g. such as a publication)" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:ContributorAssociation ;
    linkml:domain_of biolink:ContributorAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ContributorAssociation ;
    linkml:range biolink:Agent ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:contributor_association_predicate a linkml:SlotDefinition ;
    dct:description "generally one of the predicate values 'provider', 'publisher', 'editor' or 'author'" ;
    rdfs:subPropertyOf biolink:contributor ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:ContributorAssociation ;
    linkml:domain_of biolink:ContributorAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:ContributorAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:contributor_association_qualifiers a linkml:SlotDefinition ;
    dct:description "this field can be used to annotate special characteristics of an agent relationship, such as the fact that a given author agent of a publication is the 'corresponding author'" ;
    ns1:altLabel "qualifier" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "qualifiers" ;
    linkml:definition_uri biolink:qualifiers ;
    linkml:domain biolink:ContributorAssociation ;
    linkml:domain_of biolink:ContributorAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:qualifiers ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation qualifier" ;
                    linkml:local_name_source "ga4gh" ] ] ;
    linkml:multivalued true ;
    linkml:owner biolink:ContributorAssociation ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:qualifiers ;
    linkml:usage_slot_name "qualifiers" .

biolink:contributor_association_subject a linkml:SlotDefinition ;
    dct:description "information content entity which an agent has helped realise" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:ContributorAssociation ;
    linkml:domain_of biolink:ContributorAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ContributorAssociation ;
    linkml:range biolink:InformationContentEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:disease_or_phenotypic_feature_association_to_location_association_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:DiseaseOrPhenotypicFeatureAssociationToLocationAssociation ;
    linkml:domain_of biolink:DiseaseOrPhenotypicFeatureAssociationToLocationAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:DiseaseOrPhenotypicFeatureAssociationToLocationAssociation ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:disease_or_phenotypic_feature_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "disease or phenotype" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    linkml:domain_of biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    linkml:examples [ a linkml:Example ;
            dct:description "Ehlers-Danlos syndrome, vascular type" ;
            ns1:example "MONDO:0017314" ],
        [ a linkml:Example ;
            dct:description "abnormal brain ventricle size" ;
            ns1:example "MP:0013229" ] ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:disease_or_phenotypic_feature_to_location_association_object a linkml:SlotDefinition ;
    dct:description "anatomical entity in which the disease or feature is found." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:DiseaseOrPhenotypicFeatureToLocationAssociation ;
    linkml:domain_of biolink:DiseaseOrPhenotypicFeatureToLocationAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "lung" ;
            ns1:example "UBERON:0002048" ] ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:DiseaseOrPhenotypicFeatureToLocationAssociation ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:disease_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "disease class" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:DiseaseToEntityAssociationMixin ;
    linkml:domain_of biolink:DiseaseToEntityAssociationMixin ;
    linkml:examples [ a linkml:Example ;
            dct:description "Ehlers-Danlos syndrome, vascular type" ;
            ns1:example "MONDO:0017314" ] ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:DiseaseToEntityAssociationMixin ;
    linkml:range biolink:Disease ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" ;
    linkml:values_from biolink:doid,
        biolink:mondo,
        biolink:ncit,
        biolink:omim,
        biolink:orphanet .

biolink:drug_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "the drug that is an interactor" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:DrugToEntityAssociationMixin ;
    linkml:domain_of biolink:DrugToEntityAssociationMixin ;
    linkml:is_a biolink:molecular_entity_to_entity_association_mixin_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:DrugToEntityAssociationMixin ;
    linkml:range biolink:Drug ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:drug_to_gene_association_object a linkml:SlotDefinition ;
    dct:description "the gene or gene product that is affected by the drug" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:DrugToGeneAssociation ;
    linkml:domain_of biolink:DrugToGeneAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:DrugToGeneAssociation ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:entity_to_disease_association_mixin_object a linkml:SlotDefinition ;
    dct:description "disease" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:EntityToDiseaseAssociationMixin ;
    linkml:domain_of biolink:EntityToDiseaseAssociationMixin ;
    linkml:examples [ a linkml:Example ;
            dct:description "Ehlers-Danlos syndrome" ;
            ns1:example "MONDO:0020066" ] ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:EntityToDiseaseAssociationMixin ;
    linkml:range biolink:Disease ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:entity_to_disease_or_phenotypic_feature_association_mixin_object a linkml:SlotDefinition ;
    dct:description "disease or phenotype" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    linkml:domain_of biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    linkml:examples [ a linkml:Example ;
            dct:description "abnormal brain ventricle size" ;
            ns1:example "MP:0013229" ],
        [ a linkml:Example ;
            dct:description "Ehlers-Danlos syndrome, vascular type" ;
            ns1:example "MONDO:0017314" ] ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:entity_to_exposure_event_association_mixin_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:EntityToExposureEventAssociationMixin ;
    linkml:domain_of biolink:EntityToExposureEventAssociationMixin ;
    linkml:inlined true ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:EntityToExposureEventAssociationMixin ;
    linkml:range biolink:ExposureEvent ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:entity_to_outcome_association_mixin_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:EntityToOutcomeAssociationMixin ;
    linkml:domain_of biolink:EntityToOutcomeAssociationMixin ;
    linkml:inlined true ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:EntityToOutcomeAssociationMixin ;
    linkml:range biolink:Outcome ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:entity_to_phenotypic_feature_association_mixin_description a linkml:SlotDefinition ;
    dct:description "A description of specific aspects of this phenotype, not otherwise covered by the phenotype ontology class" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:altLabel "definition" ;
    ns1:exactMatch OBO:IAO_0000115,
        skos:definitions ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation dct:description ;
    ns1:narrowMatch gff3:Description ;
    ns1:prefLabel "description" ;
    linkml:definition_uri biolink:description ;
    linkml:domain biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:domain_of biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:is_a biolink:description ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:range biolink:narrative_text ;
    linkml:slot_uri dct:description ;
    linkml:usage_slot_name "description" .

biolink:entity_to_phenotypic_feature_association_mixin_object a linkml:SlotDefinition ;
    dct:description "phenotypic class" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:domain_of biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:examples [ a linkml:Example ;
            dct:description "Hyperkinesis" ;
            ns1:example "HP:0002487" ],
        [ a linkml:Example ;
            dct:description "abnormal circulating bilirubin level" ;
            ns1:example "MP:0001569" ],
        [ a linkml:Example ;
            dct:description "axon morphology variant" ;
            ns1:example "WBPhenotype:0000180" ] ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:range biolink:PhenotypicFeature ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" ;
    linkml:values_from biolink:hp,
        biolink:mp,
        biolink:upheno,
        biolink:wbphenotype .

biolink:exon_to_transcript_relationship_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:ExonToTranscriptRelationship ;
    linkml:domain_of biolink:ExonToTranscriptRelationship ;
    linkml:is_a biolink:sequence_feature_relationship_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ExonToTranscriptRelationship ;
    linkml:range biolink:Transcript ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:exon_to_transcript_relationship_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:ExonToTranscriptRelationship ;
    linkml:domain_of biolink:ExonToTranscriptRelationship ;
    linkml:is_a biolink:sequence_feature_relationship_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ExonToTranscriptRelationship ;
    linkml:range biolink:Exon ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:exposure_event_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:ExposureEventToEntityAssociationMixin ;
    linkml:domain_of biolink:ExposureEventToEntityAssociationMixin ;
    linkml:inlined true ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ExposureEventToEntityAssociationMixin ;
    linkml:range biolink:ExposureEvent ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:exposure_event_to_phenotypic_feature_association_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:ExposureEventToPhenotypicFeatureAssociation ;
    linkml:domain_of biolink:ExposureEventToPhenotypicFeatureAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ExposureEventToPhenotypicFeatureAssociation ;
    linkml:range biolink:ExposureEvent ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:frequency_value a linkml:TypeDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "str" ;
    linkml:definition_uri biolink:FrequencyValue ;
    linkml:typeof biolink:string ;
    linkml:uri OBO:UO_0000105 .

biolink:gene_as_a_model_of_disease_association_subject a linkml:SlotDefinition ;
    dct:description "A gene that has a role in modeling the disease. This may be a model organism ortholog of a known disease gene, or it may be a gene whose mutants recapitulate core features of the disease." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneAsAModelOfDiseaseAssociation ;
    linkml:domain_of biolink:GeneAsAModelOfDiseaseAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:gene_to_disease_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneAsAModelOfDiseaseAssociation ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:gene_has_variant_that_contributes_to_disease_association_subject a linkml:SlotDefinition ;
    dct:description "A gene that has a role in modeling the disease. This may be a model organism ortholog of a known disease gene, or it may be a gene whose mutants recapitulate core features of the disease." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneHasVariantThatContributesToDiseaseAssociation ;
    linkml:domain_of biolink:GeneHasVariantThatContributesToDiseaseAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:gene_to_disease_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneHasVariantThatContributesToDiseaseAssociation ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:gene_regulatory_relationship_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GeneRegulatoryRelationship ;
    linkml:domain_of biolink:GeneRegulatoryRelationship ;
    linkml:inlined true ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneRegulatoryRelationship ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:role "regulated gene" ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:gene_regulatory_relationship_predicate a linkml:SlotDefinition ;
    dct:description "the direction is always from regulator to regulated" ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GeneRegulatoryRelationship ;
    linkml:domain_of biolink:GeneRegulatoryRelationship ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GeneRegulatoryRelationship ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:gene_regulatory_relationship_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneRegulatoryRelationship ;
    linkml:domain_of biolink:GeneRegulatoryRelationship ;
    linkml:inlined true ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneRegulatoryRelationship ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:role "regulatory gene" ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:gene_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "gene that is the subject of the association" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneToEntityAssociationMixin ;
    linkml:domain_of biolink:GeneToEntityAssociationMixin ;
    linkml:inlined true ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToEntityAssociationMixin ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:gene_to_expression_site_association_object a linkml:SlotDefinition ;
    dct:description "location in which the gene is expressed" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GeneToExpressionSiteAssociation ;
    linkml:domain_of biolink:GeneToExpressionSiteAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "cerebellum" ;
            ns1:example "UBERON:0002037" ] ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToExpressionSiteAssociation ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:gene_to_expression_site_association_predicate a linkml:SlotDefinition ;
    dct:description "expression relationship" ;
    rdfs:subPropertyOf biolink:expressed_in ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GeneToExpressionSiteAssociation ;
    linkml:domain_of biolink:GeneToExpressionSiteAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GeneToExpressionSiteAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:gene_to_expression_site_association_quantifier_qualifier a linkml:SlotDefinition ;
    dct:description "can be used to indicate magnitude, or also ranking" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLS:measures,
        LOINC:analyzes,
        LOINC:measured_by,
        LOINC:property_of,
        <https://skr3.nlm.nih.gov/SemMedDBmeasures> ;
    ns1:prefLabel "quantifier qualifier" ;
    linkml:definition_uri biolink:quantifier_qualifier ;
    linkml:domain biolink:GeneToExpressionSiteAssociation ;
    linkml:domain_of biolink:GeneToExpressionSiteAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:quantifier_qualifier ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:GeneToExpressionSiteAssociation ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:quantifier_qualifier ;
    linkml:usage_slot_name "quantifier qualifier" .

biolink:gene_to_expression_site_association_stage_qualifier a linkml:SlotDefinition ;
    dct:description "stage at which the gene is expressed in the site" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "stage qualifier" ;
    linkml:definition_uri biolink:stage_qualifier ;
    linkml:domain biolink:GeneToExpressionSiteAssociation ;
    linkml:domain_of biolink:GeneToExpressionSiteAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "larval stage" ;
            ns1:example "UBERON:0000069" ] ;
    linkml:is_a biolink:stage_qualifier ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:GeneToExpressionSiteAssociation ;
    linkml:range biolink:LifeStage ;
    linkml:slot_uri biolink:stage_qualifier ;
    linkml:usage_slot_name "stage qualifier" .

biolink:gene_to_expression_site_association_subject a linkml:SlotDefinition ;
    dct:description "gene in which variation is correlated with the phenotypic feature" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneToExpressionSiteAssociation ;
    linkml:domain_of biolink:GeneToExpressionSiteAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToExpressionSiteAssociation ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:gene_to_gene_coexpression_association_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:coexpressed_with ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GeneToGeneCoexpressionAssociation ;
    linkml:domain_of biolink:GeneToGeneCoexpressionAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GeneToGeneCoexpressionAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:symmetric true ;
    linkml:usage_slot_name "predicate" .

biolink:gene_to_gene_homology_association_predicate a linkml:SlotDefinition ;
    dct:description "homology relationship type" ;
    rdfs:subPropertyOf biolink:homologous_to ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GeneToGeneHomologyAssociation ;
    linkml:domain_of biolink:GeneToGeneHomologyAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GeneToGeneHomologyAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:symmetric true ;
    linkml:usage_slot_name "predicate" .

biolink:gene_to_gene_product_relationship_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GeneToGeneProductRelationship ;
    linkml:domain_of biolink:GeneToGeneProductRelationship ;
    linkml:inlined true ;
    linkml:is_a biolink:sequence_feature_relationship_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToGeneProductRelationship ;
    linkml:range biolink:GeneProductMixin ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:gene_to_gene_product_relationship_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:has_gene_product ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GeneToGeneProductRelationship ;
    linkml:domain_of biolink:GeneToGeneProductRelationship ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GeneToGeneProductRelationship ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:gene_to_gene_product_relationship_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneToGeneProductRelationship ;
    linkml:domain_of biolink:GeneToGeneProductRelationship ;
    linkml:is_a biolink:sequence_feature_relationship_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToGeneProductRelationship ;
    linkml:range biolink:Gene ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:gene_to_go_term_association_object a linkml:SlotDefinition ;
    dct:description "class describing the activity, process or localization of the gene product" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GeneToGoTermAssociation ;
    linkml:domain_of biolink:GeneToGoTermAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "kinase activity" ;
            ns1:example "GO:0016301" ] ;
    linkml:inlined true ;
    linkml:is_a biolink:functional_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToGoTermAssociation ;
    linkml:range biolink:GeneOntologyClass ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" ;
    linkml:values_from biolink:go .

biolink:gene_to_go_term_association_subject a linkml:SlotDefinition ;
    dct:description "gene, product or macromolecular complex that has the function associated with the GO term" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneToGoTermAssociation ;
    linkml:domain_of biolink:GeneToGoTermAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "twist1b" ;
            ns1:example "ZFIN:ZDB-GENE-050417-357" ] ;
    linkml:is_a biolink:functional_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToGoTermAssociation ;
    linkml:range biolink:MolecularEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:gene_to_phenotypic_feature_association_subject a linkml:SlotDefinition ;
    dct:description "gene in which variation is correlated with the phenotypic feature" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneToPhenotypicFeatureAssociation ;
    linkml:domain_of biolink:GeneToPhenotypicFeatureAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "COL1A1 (Human)" ;
            ns1:example "HGNC:2197" ] ;
    linkml:inlined true ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToPhenotypicFeatureAssociation ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:genomic_sequence_localization_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:altLabel "reference" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GenomicSequenceLocalization ;
    linkml:domain_of biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenomicSequenceLocalization ;
    linkml:range biolink:GenomicEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:genomic_sequence_localization_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:has_sequence_location ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GenomicSequenceLocalization ;
    linkml:domain_of biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GenomicSequenceLocalization ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:genomic_sequence_localization_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:altLabel "sequence feature" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GenomicSequenceLocalization ;
    linkml:domain_of biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenomicSequenceLocalization ;
    linkml:range biolink:GenomicEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:genotype_as_a_model_of_disease_association_subject a linkml:SlotDefinition ;
    dct:description "A genotype that has a role in modeling the disease." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GenotypeAsAModelOfDiseaseAssociation ;
    linkml:domain_of biolink:GenotypeAsAModelOfDiseaseAssociation ;
    linkml:is_a biolink:genotype_to_disease_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeAsAModelOfDiseaseAssociation ;
    linkml:range biolink:Genotype ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:genotype_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "genotype that is the subject of the association" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GenotypeToEntityAssociationMixin ;
    linkml:domain_of biolink:GenotypeToEntityAssociationMixin ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToEntityAssociationMixin ;
    linkml:range biolink:Genotype ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:genotype_to_gene_association_object a linkml:SlotDefinition ;
    dct:description "gene implicated in genotype" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GenotypeToGeneAssociation ;
    linkml:domain_of biolink:GenotypeToGeneAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToGeneAssociation ;
    linkml:range biolink:Gene ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:genotype_to_gene_association_predicate a linkml:SlotDefinition ;
    dct:description "the relationship type used to connect genotype to gene" ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GenotypeToGeneAssociation ;
    linkml:domain_of biolink:GenotypeToGeneAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GenotypeToGeneAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:genotype_to_gene_association_subject a linkml:SlotDefinition ;
    dct:description "parent genotype" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GenotypeToGeneAssociation ;
    linkml:domain_of biolink:GenotypeToGeneAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToGeneAssociation ;
    linkml:range biolink:Genotype ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:genotype_to_genotype_part_association_object a linkml:SlotDefinition ;
    dct:description "child genotype" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GenotypeToGenotypePartAssociation ;
    linkml:domain_of biolink:GenotypeToGenotypePartAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToGenotypePartAssociation ;
    linkml:range biolink:Genotype ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:genotype_to_genotype_part_association_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:has_variant_part ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GenotypeToGenotypePartAssociation ;
    linkml:domain_of biolink:GenotypeToGenotypePartAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GenotypeToGenotypePartAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:genotype_to_genotype_part_association_subject a linkml:SlotDefinition ;
    dct:description "parent genotype" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GenotypeToGenotypePartAssociation ;
    linkml:domain_of biolink:GenotypeToGenotypePartAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToGenotypePartAssociation ;
    linkml:range biolink:Genotype ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:genotype_to_phenotypic_feature_association_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:has_phenotype ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GenotypeToPhenotypicFeatureAssociation ;
    linkml:domain_of biolink:GenotypeToPhenotypicFeatureAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GenotypeToPhenotypicFeatureAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:genotype_to_phenotypic_feature_association_subject a linkml:SlotDefinition ;
    dct:description "genotype that is associated with the phenotypic feature" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GenotypeToPhenotypicFeatureAssociation ;
    linkml:domain_of biolink:GenotypeToPhenotypicFeatureAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToPhenotypicFeatureAssociation ;
    linkml:range biolink:Genotype ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:genotype_to_variant_association_object a linkml:SlotDefinition ;
    dct:description "gene implicated in genotype" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GenotypeToVariantAssociation ;
    linkml:domain_of biolink:GenotypeToVariantAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToVariantAssociation ;
    linkml:range biolink:SequenceVariant ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:genotype_to_variant_association_predicate a linkml:SlotDefinition ;
    dct:description "the relationship type used to connect genotype to gene" ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GenotypeToVariantAssociation ;
    linkml:domain_of biolink:GenotypeToVariantAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GenotypeToVariantAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:genotype_to_variant_association_subject a linkml:SlotDefinition ;
    dct:description "parent genotype" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GenotypeToVariantAssociation ;
    linkml:domain_of biolink:GenotypeToVariantAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToVariantAssociation ;
    linkml:range biolink:Genotype ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:logical_interpretation_enum ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:LogicalInterpretationEnum ;
    linkml:permissible_values biolink:AllSome,
        biolink:InverseAllSome,
        biolink:SomeSome .

biolink:macromolecular_machine_to_biological_process_association_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:MacromolecularMachineToBiologicalProcessAssociation ;
    linkml:domain_of biolink:MacromolecularMachineToBiologicalProcessAssociation ;
    linkml:is_a biolink:functional_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:MacromolecularMachineToBiologicalProcessAssociation ;
    linkml:range biolink:BiologicalProcess ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:macromolecular_machine_to_cellular_component_association_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:MacromolecularMachineToCellularComponentAssociation ;
    linkml:domain_of biolink:MacromolecularMachineToCellularComponentAssociation ;
    linkml:is_a biolink:functional_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:MacromolecularMachineToCellularComponentAssociation ;
    linkml:range biolink:CellularComponent ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:macromolecular_machine_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:MacromolecularMachineToEntityAssociationMixin ;
    linkml:domain_of biolink:MacromolecularMachineToEntityAssociationMixin ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:MacromolecularMachineToEntityAssociationMixin ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:macromolecular_machine_to_molecular_activity_association_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:MacromolecularMachineToMolecularActivityAssociation ;
    linkml:domain_of biolink:MacromolecularMachineToMolecularActivityAssociation ;
    linkml:is_a biolink:functional_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:MacromolecularMachineToMolecularActivityAssociation ;
    linkml:range biolink:MolecularActivity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:material_sample_derivation_association_object a linkml:SlotDefinition ;
    dct:description "the material entity the sample was derived from. This may be another material sample, or any other material entity, including for example an organism, a geographic feature, or some environmental material." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:MaterialSampleDerivationAssociation ;
    linkml:domain_of biolink:MaterialSampleDerivationAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:MaterialSampleDerivationAssociation ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:material_sample_derivation_association_predicate a linkml:SlotDefinition ;
    dct:description "derivation relationship" ;
    rdfs:subPropertyOf biolink:derives_from ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:MaterialSampleDerivationAssociation ;
    linkml:domain_of biolink:MaterialSampleDerivationAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:MaterialSampleDerivationAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:material_sample_derivation_association_subject a linkml:SlotDefinition ;
    dct:description "the material sample being described" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:MaterialSampleDerivationAssociation ;
    linkml:domain_of biolink:MaterialSampleDerivationAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:MaterialSampleDerivationAssociation ;
    linkml:range biolink:MaterialSample ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:material_sample_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "the material sample being described" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:MaterialSampleToEntityAssociationMixin ;
    linkml:domain_of biolink:MaterialSampleToEntityAssociationMixin ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:MaterialSampleToEntityAssociationMixin ;
    linkml:range biolink:MaterialSample ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:model_to_disease_association_mixin_predicate a linkml:SlotDefinition ;
    dct:description "The relationship to the disease" ;
    rdfs:subPropertyOf biolink:model_of ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:ModelToDiseaseAssociationMixin ;
    linkml:domain_of biolink:ModelToDiseaseAssociationMixin ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:ModelToDiseaseAssociationMixin ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:model_to_disease_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "The entity that serves as the model of the disease. This may be an organism, a strain of organism, a genotype or variant that exhibits similar features, or a gene that when mutated exhibits features of the disease" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:ModelToDiseaseAssociationMixin ;
    linkml:domain_of biolink:ModelToDiseaseAssociationMixin ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ModelToDiseaseAssociationMixin ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:molecular_activity_enabled_by a linkml:SlotDefinition ;
    dct:description "The gene product, gene, or complex that catalyzes the reaction" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_0002333 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "enabled by" ;
    linkml:definition_uri biolink:enabled_by ;
    linkml:domain biolink:MolecularActivity ;
    linkml:domain_of biolink:MolecularActivity ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:enabled_by ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:MolecularActivity ;
    linkml:range biolink:MacromolecularMachineMixin ;
    linkml:slot_uri biolink:enabled_by ;
    linkml:usage_slot_name "enabled by" .

biolink:molecular_activity_has_input a linkml:SlotDefinition ;
    dct:description "A chemical entity that is the input for the reaction" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch OBO:RO_0002352 ;
    ns1:exactMatch OBO:RO_0002233,
        <https://skr3.nlm.nih.gov/SemMedDBUSES>,
        <https://skr3.nlm.nih.gov/SemMedDBuses> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_fragments_for_synonyms,
        LOINC:has_system,
        OBO:RO_0002590,
        OBO:RO_0004009,
        OBO:SNOMED_has_finding_method,
        OBO:SNOMED_has_precondition,
        OBO:SNOMED_has_specimen_source_identity,
        OBO:SNOMED_has_specimen_substance,
        OBO:SNOMED_uses_access_device,
        OBO:SNOMED_uses_device,
        OBO:SNOMED_uses_energy,
        OBO:SNOMED_uses_substance,
        PathWhiz:has_left_element ;
    ns1:prefLabel "has input" ;
    linkml:definition_uri biolink:has_input ;
    linkml:domain biolink:MolecularActivity ;
    linkml:domain_of biolink:MolecularActivity ;
    linkml:inherited true ;
    linkml:is_a biolink:has_input ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:MolecularActivity ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:has_input ;
    linkml:usage_slot_name "has input" .

biolink:molecular_activity_has_output a linkml:SlotDefinition ;
    dct:description "A chemical entity that is the output for the reaction" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch RTXKG1:output_of,
        OBO:RO_0002353,
        OBO:RO_0002354 ;
    ns1:exactMatch OBO:RO_0002234 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_R31,
        OBO:OBI_0000299,
        OBO:RO_0002296,
        OBO:RO_0002297,
        OBO:RO_0002298,
        OBO:RO_0002299,
        OBO:RO_0002588,
        OBO:RO_0004008,
        PathWhiz:has_right_element ;
    ns1:prefLabel "has output" ;
    linkml:definition_uri biolink:has_output ;
    linkml:domain biolink:MolecularActivity ;
    linkml:domain_of biolink:MolecularActivity ;
    linkml:inherited true ;
    linkml:is_a biolink:has_output ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:MolecularActivity ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:has_output ;
    linkml:usage_slot_name "has output" .

biolink:organism_taxon_to_entity_association_subject a linkml:SlotDefinition ;
    dct:description "organism taxon that is the subject of the association" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:OrganismTaxonToEntityAssociation ;
    linkml:domain_of biolink:OrganismTaxonToEntityAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismTaxonToEntityAssociation ;
    linkml:range biolink:OrganismTaxon ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:organism_taxon_to_environment_association_object a linkml:SlotDefinition ;
    dct:description "the environment in which the organism occurs" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:domain_of biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:role "environmental context" ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:organism_taxon_to_environment_association_predicate a linkml:SlotDefinition ;
    dct:description """predicate describing the relationship between the taxon and the environment
 """ ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:domain_of biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:organism_taxon_to_environment_association_subject a linkml:SlotDefinition ;
    dct:description "the taxon that is the subject of the association" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:domain_of biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:range biolink:OrganismTaxon ;
    linkml:required true ;
    linkml:role "interactor taxon" ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:organism_taxon_to_organism_taxon_interaction_associated_environmental_context a linkml:SlotDefinition ;
    dct:description "the environment in which the two taxa interact" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "associated environmental context" ;
    linkml:definition_uri biolink:associated_environmental_context ;
    linkml:domain biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:is_a biolink:associated_environmental_context ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:associated_environmental_context ;
    linkml:usage_slot_name "associated environmental context" .

biolink:organism_taxon_to_organism_taxon_interaction_object a linkml:SlotDefinition ;
    dct:description "the taxon that is the subject of the association" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:is_a biolink:organism_taxon_to_organism_taxon_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:range biolink:OrganismTaxon ;
    linkml:required true ;
    linkml:role "interactee taxon" ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:organism_taxon_to_organism_taxon_interaction_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:interacts_with ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:organism_taxon_to_organism_taxon_interaction_subject a linkml:SlotDefinition ;
    dct:description "the taxon that is the subject of the association" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:is_a biolink:organism_taxon_to_organism_taxon_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:range biolink:OrganismTaxon ;
    linkml:required true ;
    linkml:role "interactor taxon" ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:organism_taxon_to_organism_taxon_specialization_object a linkml:SlotDefinition ;
    dct:description "the more general taxon" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:is_a biolink:organism_taxon_to_organism_taxon_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:range biolink:OrganismTaxon ;
    linkml:required true ;
    linkml:role "parent taxon" ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:organism_taxon_to_organism_taxon_specialization_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:subclass_of ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:organism_taxon_to_organism_taxon_specialization_subject a linkml:SlotDefinition ;
    dct:description "the more specific taxon" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:is_a biolink:organism_taxon_to_organism_taxon_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:range biolink:OrganismTaxon ;
    linkml:required true ;
    linkml:role "child taxon" ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:organismal_entity_as_a_model_of_disease_association_subject a linkml:SlotDefinition ;
    dct:description "A organismal entity (strain, breed) with a predisposition to a disease, or bred/created specifically to model a disease." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:OrganismalEntityAsAModelOfDiseaseAssociation ;
    linkml:domain_of biolink:OrganismalEntityAsAModelOfDiseaseAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismalEntityAsAModelOfDiseaseAssociation ;
    linkml:range biolink:OrganismalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:pairwise_molecular_interaction_id a linkml:SlotDefinition ;
    dct:description "identifier for the interaction. This may come from an interaction database such as IMEX." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch gff3:ID,
        gpi:DB_Object_ID,
        alliancegenome:primaryId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "id" ;
    linkml:definition_uri biolink:id ;
    linkml:domain biolink:PairwiseMolecularInteraction ;
    linkml:domain_of biolink:PairwiseMolecularInteraction ;
    linkml:examples [ a linkml:Example ;
            ns1:example "WB:WBInteraction000538741" ] ;
    linkml:identifier true ;
    linkml:is_a biolink:id ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:PairwiseMolecularInteraction ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri biolink:id ;
    linkml:usage_slot_name "id" ;
    linkml:values_from biolink:BioGRID,
        biolink:IMEX .

biolink:pairwise_molecular_interaction_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:PairwiseMolecularInteraction ;
    linkml:domain_of biolink:PairwiseMolecularInteraction ;
    linkml:is_a biolink:gene_to_gene_association_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:PairwiseMolecularInteraction ;
    linkml:range biolink:MolecularEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:pairwise_molecular_interaction_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:molecularly_interacts_with ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:PairwiseMolecularInteraction ;
    linkml:domain_of biolink:PairwiseMolecularInteraction ;
    linkml:is_a biolink:pairwise_gene_to_gene_interaction_predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:PairwiseMolecularInteraction ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:pairwise_molecular_interaction_relation a linkml:SlotDefinition ;
    dct:description "interaction relationship type" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "relation" ;
    linkml:definition_uri biolink:relation ;
    linkml:domain biolink:PairwiseMolecularInteraction ;
    linkml:domain_of biolink:PairwiseMolecularInteraction ;
    linkml:examples [ a linkml:Example ;
            dct:description "the subject molecular phosphorylates the object molecule" ;
            ns1:example "RO:0002447" ] ;
    linkml:id_prefixes "BSPO",
        "RO",
        "SIO" ;
    linkml:is_a biolink:pairwise_gene_to_gene_interaction_relation ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:PairwiseMolecularInteraction ;
    linkml:range biolink:uriorcurie ;
    linkml:required true ;
    linkml:slot_uri biolink:relation ;
    linkml:usage_slot_name "relation" ;
    linkml:values_from biolink:mi,
        biolink:ro .

biolink:pairwise_molecular_interaction_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:PairwiseMolecularInteraction ;
    linkml:domain_of biolink:PairwiseMolecularInteraction ;
    linkml:is_a biolink:gene_to_gene_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:PairwiseMolecularInteraction ;
    linkml:range biolink:MolecularEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:population_to_population_association_object a linkml:SlotDefinition ;
    dct:description "the population that form the object of the association" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:PopulationToPopulationAssociation ;
    linkml:domain_of biolink:PopulationToPopulationAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:PopulationToPopulationAssociation ;
    linkml:range biolink:PopulationOfIndividualOrganisms ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:population_to_population_association_predicate a linkml:SlotDefinition ;
    dct:description "A relationship type that holds between the subject and object populations. Standard mereological relations can be used. E.g. subject part-of object, subject overlaps object. Derivation relationships can also be used" ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:PopulationToPopulationAssociation ;
    linkml:domain_of biolink:PopulationToPopulationAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:PopulationToPopulationAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:population_to_population_association_subject a linkml:SlotDefinition ;
    dct:description "the population that form the subject of the association" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:PopulationToPopulationAssociation ;
    linkml:domain_of biolink:PopulationToPopulationAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:PopulationToPopulationAssociation ;
    linkml:range biolink:PopulationOfIndividualOrganisms ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:sequence_variant_modulates_treatment_association_object a linkml:SlotDefinition ;
    dct:description "treatment whose efficacy is modulated by the subject variant" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:SequenceVariantModulatesTreatmentAssociation ;
    linkml:domain_of biolink:SequenceVariantModulatesTreatmentAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:SequenceVariantModulatesTreatmentAssociation ;
    linkml:range biolink:Treatment ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:sequence_variant_modulates_treatment_association_subject a linkml:SlotDefinition ;
    dct:description "variant that modulates the treatment of some disease" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:SequenceVariantModulatesTreatmentAssociation ;
    linkml:domain_of biolink:SequenceVariantModulatesTreatmentAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:SequenceVariantModulatesTreatmentAssociation ;
    linkml:range biolink:SequenceVariant ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:serial_id a linkml:SlotDefinition ;
    dct:description "Serials (journals) should have industry-standard identifier such as from ISSN." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch gff3:ID,
        gpi:DB_Object_ID,
        alliancegenome:primaryId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "id" ;
    linkml:definition_uri biolink:id ;
    linkml:domain biolink:Serial ;
    linkml:domain_of biolink:Serial ;
    linkml:identifier true ;
    linkml:is_a biolink:publication_id ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Serial ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri biolink:id ;
    linkml:usage_slot_name "id" .

biolink:serial_type a linkml:SlotDefinition ;
    dct:description "Should generally be set to an ontology class defined term for 'serial' or 'journal'." ;
    ns1:exactMatch gff3:type,
        gpi:DB_Object_Type,
        alliancegenome:soTermId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:type ;
    ns1:prefLabel "type" ;
    linkml:definition_uri biolink:type ;
    linkml:domain biolink:Serial ;
    linkml:domain_of biolink:Serial ;
    linkml:is_a biolink:publication_type ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Serial ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri rdf:type ;
    linkml:usage_slot_name "type" .

biolink:socioeconomic_exposure_has_attribute a linkml:SlotDefinition ;
    dct:description "connects any entity to an attribute" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:closeMatch OBO:OBI_0001927 ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_000008> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch DRUGBANK:category,
        UMLS:has_structural_class,
        UMLS:has_supported_concept_property,
        UMLS:has_supported_concept_relationship,
        UMLS:may_be_qualified_by,
        LOINC:has_action_guidance,
        LOINC:has_adjustment,
        LOINC:has_aggregation_view,
        LOINC:has_approach_guidance,
        LOINC:has_divisor,
        LOINC:has_exam,
        LOINC:has_method,
        LOINC:has_modality_subtype,
        LOINC:has_object_guidance,
        LOINC:has_scale,
        LOINC:has_suffix,
        LOINC:has_time_aspect,
        LOINC:has_time_modifier,
        LOINC:has_timing_of,
        OBO:INO_0000154,
        OBO:NCIT_disease_is_grade,
        OBO:NCIT_disease_is_stage,
        OBO:NCIT_eo_disease_has_property_or_attribute,
        OBO:NCIT_has_data_element,
        OBO:NCIT_has_pharmaceutical_administration_method,
        OBO:NCIT_has_pharmaceutical_basic_dose_form,
        OBO:NCIT_has_pharmaceutical_intended_site,
        OBO:NCIT_has_pharmaceutical_release_characteristics,
        OBO:NCIT_has_pharmaceutical_state_of_matter,
        OBO:NCIT_has_pharmaceutical_transformation,
        OBO:NCIT_is_qualified_by,
        OBO:NCIT_qualifier_applies_to,
        OBO:NCIT_role_has_domain,
        OBO:NCIT_role_has_range,
        OBO:OMIM_has_inheritance_type,
        OBO:RO_0000053,
        OBO:RO_0000086,
        OBO:RO_0000087,
        OBO:SNOMED_has_access,
        OBO:SNOMED_has_clinical_course,
        OBO:SNOMED_has_count_of_base_of_active_ingredient,
        OBO:SNOMED_has_dose_form_administration_method,
        OBO:SNOMED_has_dose_form_release_characteristic,
        OBO:SNOMED_has_dose_form_transformation,
        OBO:SNOMED_has_finding_context,
        OBO:SNOMED_has_finding_informer,
        OBO:SNOMED_has_inherent_attribute,
        OBO:SNOMED_has_intent,
        OBO:SNOMED_has_interpretation,
        OBO:SNOMED_has_laterality,
        OBO:SNOMED_has_measurement_method,
        OBO:SNOMED_has_method,
        OBO:SNOMED_has_priority,
        OBO:SNOMED_has_procedure_context,
        OBO:SNOMED_has_process_duration,
        OBO:SNOMED_has_property,
        OBO:SNOMED_has_revision_status,
        OBO:SNOMED_has_scale_type,
        OBO:SNOMED_has_severity,
        OBO:SNOMED_has_specimen,
        OBO:SNOMED_has_state_of_matter,
        OBO:SNOMED_has_subject_relationship_context,
        OBO:SNOMED_has_surgical_approach,
        OBO:SNOMED_has_technique,
        OBO:SNOMED_has_temporal_context,
        OBO:SNOMED_has_time_aspect,
        OBO:SNOMED_has_units,
        OBAN:association_has_object_property,
        OBAN:association_has_subject_property,
        <http://www.ebi.ac.uk/ancestro/ancestro_0301>,
        <http://www.ebi.ac.uk/ancestro/ancestro_0308>,
        <http://www.ebi.ac.uk/efo/EFO_is_executed_in>,
        <http://www.orpha.net/ORDO/Orphanet_C016>,
        <http://www.orpha.net/ORDO/Orphanet_C017>,
        CPT:has_possibly_included_panel_element ;
    ns1:prefLabel "has attribute" ;
    linkml:definition_uri biolink:has_attribute ;
    linkml:domain biolink:SocioeconomicExposure ;
    linkml:domain_of biolink:SocioeconomicExposure ;
    linkml:inlined true ;
    linkml:is_a biolink:has_attribute ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:SocioeconomicExposure ;
    linkml:range biolink:SocioeconomicAttribute ;
    linkml:required true ;
    linkml:slot_uri biolink:has_attribute ;
    linkml:usage_slot_name "has attribute" .

biolink:symbol_type a linkml:TypeDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "str" ;
    linkml:definition_uri biolink:SymbolType ;
    linkml:typeof biolink:string ;
    linkml:uri xsd:string .

biolink:time a linkml:TypeDefinition ;
    dct:description "A time object represents a (local) time of day, independent of any particular day" ;
    ns1:editorialNote "URI is dateTime because OWL reasoners don't work with straight date or time" ;
    ns1:inScheme linkml:types ;
    linkml:base "XSDTime" ;
    linkml:definition_uri linkml:Time ;
    linkml:imported_from "linkml:types" ;
    linkml:repr "str" ;
    linkml:uri xsd:dateTime .

biolink:transcript_to_gene_relationship_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:TranscriptToGeneRelationship ;
    linkml:domain_of biolink:TranscriptToGeneRelationship ;
    linkml:is_a biolink:sequence_feature_relationship_object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:TranscriptToGeneRelationship ;
    linkml:range biolink:Gene ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:transcript_to_gene_relationship_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:TranscriptToGeneRelationship ;
    linkml:domain_of biolink:TranscriptToGeneRelationship ;
    linkml:is_a biolink:sequence_feature_relationship_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:TranscriptToGeneRelationship ;
    linkml:range biolink:Transcript ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:unit a linkml:TypeDefinition ;
    ns1:exactMatch qud:Unit ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "str" ;
    linkml:definition_uri biolink:Unit ;
    linkml:id_prefixes "UO" ;
    linkml:typeof biolink:string ;
    linkml:uri OBO:UO_0000000 .

biolink:variant_as_a_model_of_disease_association_subject a linkml:SlotDefinition ;
    dct:description "A variant that has a role in modeling the disease." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:VariantAsAModelOfDiseaseAssociation ;
    linkml:domain_of biolink:VariantAsAModelOfDiseaseAssociation ;
    linkml:is_a biolink:variant_to_disease_association_subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:VariantAsAModelOfDiseaseAssociation ;
    linkml:range biolink:SequenceVariant ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:variant_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "a sequence variant in which the allele state is associated with some other entity" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:VariantToEntityAssociationMixin ;
    linkml:domain_of biolink:VariantToEntityAssociationMixin ;
    linkml:examples [ a linkml:Example ;
            dct:description "ClinVar representation of NM_000059.3(BRCA2):c.7007G>A (p.Arg2336His)" ;
            ns1:example "ClinVar:38077" ],
        [ a linkml:Example ;
            dct:description "chr13:g.32921033G>C (hg19) in ClinGen" ;
            ns1:example "ClinGen:CA024716" ] ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:VariantToEntityAssociationMixin ;
    linkml:range biolink:SequenceVariant ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:variant_to_gene_expression_association_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:affects_expression_of ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:VariantToGeneExpressionAssociation ;
    linkml:domain_of biolink:VariantToGeneExpressionAssociation ;
    linkml:is_a biolink:variant_to_gene_association_predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:VariantToGeneExpressionAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:variant_to_phenotypic_feature_association_subject a linkml:SlotDefinition ;
    dct:description "a sequence variant in which the allele state is associated in some way with the phenotype state" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:VariantToPhenotypicFeatureAssociation ;
    linkml:domain_of biolink:VariantToPhenotypicFeatureAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:VariantToPhenotypicFeatureAssociation ;
    linkml:range biolink:SequenceVariant ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:variant_to_population_association_has_count a linkml:SlotDefinition ;
    dct:description "number in object population that carry a particular allele, aka allele count" ;
    ns1:exactMatch LOINC:has_count ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "has count" ;
    linkml:definition_uri biolink:has_count ;
    linkml:domain biolink:VariantToPopulationAssociation ;
    linkml:domain_of biolink:VariantToPopulationAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "4 individuals in gnomad set" ;
            ns1:example "4" ] ;
    linkml:is_a biolink:has_count ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:VariantToPopulationAssociation ;
    linkml:range biolink:integer ;
    linkml:slot_uri biolink:has_count ;
    linkml:usage_slot_name "has count" .

biolink:variant_to_population_association_has_quotient a linkml:SlotDefinition ;
    dct:description "frequency of allele in population, expressed as a number with allele divided by number in reference population, aka allele frequency" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "has quotient" ;
    linkml:definition_uri biolink:has_quotient ;
    linkml:domain biolink:VariantToPopulationAssociation ;
    linkml:domain_of biolink:VariantToPopulationAssociation ;
    linkml:examples [ a linkml:Example ;
            ns1:example "0.0001666" ] ;
    linkml:is_a biolink:has_quotient ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:VariantToPopulationAssociation ;
    linkml:range biolink:double ;
    linkml:slot_uri biolink:has_quotient ;
    linkml:usage_slot_name "has quotient" .

biolink:variant_to_population_association_has_total a linkml:SlotDefinition ;
    dct:description "number all populations that carry a particular allele, aka allele number" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "has total" ;
    linkml:definition_uri biolink:has_total ;
    linkml:domain biolink:VariantToPopulationAssociation ;
    linkml:domain_of biolink:VariantToPopulationAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "24014 individuals in gnomad set" ;
            ns1:example "24014" ] ;
    linkml:is_a biolink:has_total ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:VariantToPopulationAssociation ;
    linkml:range biolink:integer ;
    linkml:slot_uri biolink:has_total ;
    linkml:usage_slot_name "has total" .

biolink:variant_to_population_association_object a linkml:SlotDefinition ;
    dct:description "the population that is observed to have the frequency" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:VariantToPopulationAssociation ;
    linkml:domain_of biolink:VariantToPopulationAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "African" ;
            ns1:example "HANCESTRO:0010" ] ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:VariantToPopulationAssociation ;
    linkml:range biolink:PopulationOfIndividualOrganisms ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:variant_to_population_association_subject a linkml:SlotDefinition ;
    dct:description "an allele that has a certain frequency in a given population" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:VariantToPopulationAssociation ;
    linkml:domain_of biolink:VariantToPopulationAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "17:41203088 A/C in gnomad" ;
            ns1:example "NC_000017.11:g.43051071A>T" ] ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:VariantToPopulationAssociation ;
    linkml:range biolink:SequenceVariant ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:Activity a linkml:ClassDefinition ;
    dct:description "An activity is something that occurs over a period of time and acts upon or with entities; it may include consuming, processing, transforming, modifying, relocating, using, or generating entities." ;
    ns1:exactMatch OBO:NCIT_C43431,
        prov:Activity,
        UMLSSC:T052,
        UMLSST:acty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T056,
        UMLSSC:T057,
        UMLSSC:T058,
        UMLSSC:T062,
        UMLSSC:T064,
        UMLSSC:T065,
        UMLSSC:T066,
        UMLSST:dora,
        UMLSST:edac,
        UMLSST:gora,
        UMLSST:hlca,
        UMLSST:mcha,
        UMLSST:ocac,
        UMLSST:resa ;
    linkml:class_uri biolink:Activity ;
    linkml:definition_uri biolink:Activity ;
    linkml:is_a biolink:NamedThing ;
    linkml:mixins biolink:ActivityAndBehavior ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:BehavioralExposure a linkml:ClassDefinition ;
    dct:description "A behavioral exposure is a factor relating to behavior impacting an individual." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:BehavioralExposure ;
    linkml:definition_uri biolink:BehavioralExposure ;
    linkml:is_a biolink:Behavior ;
    linkml:mixins biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:BehavioralOutcome a linkml:ClassDefinition ;
    dct:description "An outcome resulting from an exposure event which is the manifestation of human behavior." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:BehavioralOutcome ;
    linkml:definition_uri biolink:BehavioralOutcome ;
    linkml:is_a biolink:Behavior ;
    linkml:mixins biolink:Outcome ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:BioticExposure a linkml:ClassDefinition ;
    dct:description "An external biotic exposure is an intake of (sometimes pathological) biological organisms (including viruses)." ;
    ns1:altLabel "bacterial exposure",
        "viral exposure" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:BioticExposure ;
    linkml:definition_uri biolink:BioticExposure ;
    linkml:is_a biolink:OrganismTaxon ;
    linkml:mixins biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organism_taxon_has_taxonomic_rank,
        biolink:organism_taxon_subclass_of,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:Carbohydrate a linkml:ClassDefinition ;
    ns1:exactMatch UMLSSC:T088,
        UMLSST:crbs ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Carbohydrate ;
    linkml:definition_uri biolink:Carbohydrate ;
    linkml:deprecated "This class will be removed from the Biolink model" ;
    linkml:id_prefixes "PUBCHEM.SUBSTANCE" ;
    linkml:is_a biolink:ChemicalSubstance ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:CaseToPhenotypicFeatureAssociation a linkml:ClassDefinition ;
    dct:description "An association between a case (e.g. individual patient) and a phenotypic feature in which the individual has or has had the phenotype." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:CaseToPhenotypicFeatureAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:CaseToPhenotypicFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:CaseToEntityAssociationMixin,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:sex_qualifier,
        biolink:source,
        biolink:subject .

biolink:Cell a linkml:ClassDefinition ;
    ns1:exactMatch OBO:CL_0000000,
        OBO:GO_0005623,
        <http://semanticscience.org/resource/SIO_010001>,
        UMLSSC:T025,
        UMLSST:cell,
        WIKIDATA:Q7868 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Cell ;
    linkml:definition_uri biolink:Cell ;
    linkml:id_prefixes "CL",
        "MESH",
        "NCIT",
        "PO",
        "SNOMEDCT",
        "UBERON",
        "UMLS" ;
    linkml:is_a biolink:AnatomicalEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:ClinicalTrial a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ClinicalTrial ;
    linkml:definition_uri biolink:ClinicalTrial ;
    linkml:is_a biolink:ClinicalEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Cohort a linkml:ClassDefinition ;
    dct:description "A group of people banded together or treated as a group who share common characteristics. A cohort 'study' is a particular form of longitudinal study that samples a cohort, performing a cross-section at intervals through time." ;
    ns1:exactMatch WIKIDATA:Q1303415 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T097,
        UMLSSC:T099,
        UMLSSC:T100,
        UMLSSC:T101,
        UMLSST:aggp,
        UMLSST:famg,
        UMLSST:podg,
        UMLSST:prog ;
    linkml:class_uri biolink:Cohort ;
    linkml:definition_uri biolink:Cohort ;
    linkml:is_a biolink:StudyPopulation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:ComplexChemicalExposure a linkml:ClassDefinition ;
    dct:description "A complex chemical exposure is an intake of a chemical mixture (e.g. gasoline), other than a drug." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ComplexChemicalExposure ;
    linkml:definition_uri biolink:ComplexChemicalExposure ;
    linkml:is_a biolink:ChemicalExposure ;
    linkml:mixins biolink:Mixture ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_constituent,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:DiseaseOrPhenotypicFeatureExposure a linkml:ClassDefinition ;
    dct:description "A disease or phenotypic feature state, when viewed as an exposure, represents an precondition, leading to or influencing an outcome, e.g. HIV predisposing an individual to infections; a relative deficiency of skin pigmentation predisposing an individual to skin cancer." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DiseaseOrPhenotypicFeatureExposure ;
    linkml:definition_uri biolink:DiseaseOrPhenotypicFeatureExposure ;
    linkml:is_a biolink:DiseaseOrPhenotypicFeature ;
    linkml:mixins biolink:ExposureEvent,
        biolink:PathologicalEntityMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:DiseaseOrPhenotypicFeatureOutcome a linkml:ClassDefinition ;
    dct:description "Physiological outcomes resulting from an exposure event which is the manifestation of a disease or other characteristic phenotype." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DiseaseOrPhenotypicFeatureOutcome ;
    linkml:definition_uri biolink:DiseaseOrPhenotypicFeatureOutcome ;
    linkml:is_a biolink:DiseaseOrPhenotypicFeature ;
    linkml:mixins biolink:Outcome ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:DiseaseToExposureEventAssociation a linkml:ClassDefinition ;
    dct:description "An association between an exposure event and a disease." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DiseaseToExposureEventAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:DiseaseToExposureEventAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:DiseaseToEntityAssociationMixin,
        biolink:EntityToExposureEventAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:DiseaseToPhenotypicFeatureAssociation a linkml:ClassDefinition ;
    dct:description "An association between a disease and a phenotypic feature in which the phenotypic feature is associated with the disease in some way." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DiseaseToPhenotypicFeatureAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:DiseaseToPhenotypicFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:DiseaseToEntityAssociationMixin,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:sex_qualifier,
        biolink:source,
        biolink:subject .

biolink:DrugToGeneInteractionExposure a linkml:ClassDefinition ;
    dct:description "drug to gene interaction exposure is a drug exposure is where the interactions of the drug with specific genes are known to constitute an 'exposure' to the organism, leading to or influencing an outcome." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DrugToGeneInteractionExposure ;
    linkml:definition_uri biolink:DrugToGeneInteractionExposure ;
    linkml:is_a biolink:DrugExposure ;
    linkml:mixins biolink:GeneGroupingMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_constituent,
        biolink:has_gene_or_gene_product,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:EnvironmentalExposure a linkml:ClassDefinition ;
    dct:description "A environmental exposure is a factor relating to abiotic processes in the environment including sunlight (UV-B), atmospheric (heat, cold, general pollution) and water-born contaminants." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EnvironmentalExposure ;
    linkml:definition_uri biolink:EnvironmentalExposure ;
    linkml:is_a biolink:EnvironmentalProcess ;
    linkml:mixins biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:EnvironmentalFeature a linkml:ClassDefinition ;
    ns1:exactMatch OBO:ENVO_01000254 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EnvironmentalFeature ;
    linkml:definition_uri biolink:EnvironmentalFeature ;
    linkml:is_a biolink:PlanetaryEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:EnvironmentalFoodContaminant a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch OBO:CHEBI_78299 ;
    linkml:class_uri biolink:EnvironmentalFoodContaminant ;
    linkml:definition_uri biolink:EnvironmentalFoodContaminant ;
    linkml:is_a biolink:ChemicalSubstance ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:EpidemiologicalOutcome a linkml:ClassDefinition ;
    dct:description "An epidemiological outcome, such as societal disease burden, resulting from an exposure event." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch OBO:NCIT_C19291 ;
    linkml:class_uri biolink:EpidemiologicalOutcome ;
    linkml:definition_uri biolink:EpidemiologicalOutcome ;
    linkml:is_a biolink:BiologicalEntity ;
    linkml:mixins biolink:Outcome ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Food a linkml:ClassDefinition ;
    dct:description "A substance consumed by a living organism as a source of nutrition" ;
    ns1:exactMatch UMLSSC:T168,
        UMLSST:food ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Food ;
    linkml:definition_uri biolink:Food ;
    linkml:id_prefixes "foodb.compound" ;
    linkml:is_a biolink:MolecularEntity ;
    linkml:mixins biolink:Mixture ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_constituent,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:FoodAdditive a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch OBO:CHEBI_64047 ;
    linkml:class_uri biolink:FoodAdditive ;
    linkml:definition_uri biolink:FoodAdditive ;
    linkml:is_a biolink:ChemicalSubstance ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:FoodComponent a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch OBO:CHEBI_78295 ;
    linkml:class_uri biolink:FoodComponent ;
    linkml:definition_uri biolink:FoodComponent ;
    linkml:deprecated "Food component is replaced by a slot/role of chemical substance and will be removed from the Biolink model." ;
    linkml:is_a biolink:ChemicalSubstance ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:GeneFamily a linkml:ClassDefinition ;
    dct:description "any grouping of multiple genes or gene products related by common descent" ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "orthogroup",
        "protein family" ;
    ns1:exactMatch OBO:NCIT_C26004,
        WIKIDATA:Q2278983 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_C20130,
        <http://semanticscience.org/resource/SIO_001380>,
        WIKIDATA:Q417841 ;
    linkml:class_uri biolink:GeneFamily ;
    linkml:definition_uri biolink:GeneFamily ;
    linkml:id_prefixes "CATH",
        "CATH.SUPERFAMILY",
        "CDD",
        "EGGNOG",
        "FB",
        "HAMAP",
        "HGNC.FAMILY",
        "KEGG.ORTHOLOGY",
        "PANTHER.FAMILY",
        "PFAM",
        "PIRSF",
        "PRINTS",
        "PRODOM",
        "PROSITE",
        "RFAM",
        "SMART",
        "SUPFAM",
        "TIGRFAM",
        "interpro" ;
    linkml:is_a biolink:MolecularEntity ;
    linkml:mixins biolink:GeneGroupingMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_gene_or_gene_product,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Genome a linkml:ClassDefinition ;
    dct:description "A genome is the sum of genetic material within a cell or virion." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:exactMatch OBO:SO_0001026,
        <http://semanticscience.org/resource/SIO_000984>,
        WIKIDATA:Q7020 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Genome ;
    linkml:definition_uri biolink:Genome ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:GenomicBackgroundExposure a linkml:ClassDefinition ;
    dct:description "A genomic background exposure is where an individual's specific genomic background of genes, sequence variants or other pre-existing genomic conditions constitute a kind of 'exposure' to the organism, leading to or influencing an outcome." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GenomicBackgroundExposure ;
    linkml:definition_uri biolink:GenomicBackgroundExposure ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:mixins biolink:ExposureEvent,
        biolink:GeneGroupingMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:has_gene_or_gene_product,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:GenotypicSex a linkml:ClassDefinition ;
    dct:description "An attribute corresponding to the genotypic sex of the individual, based upon genotypic composition of sex chromosomes." ;
    ns1:exactMatch OBO:PATO_0020000 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GenotypicSex ;
    linkml:definition_uri biolink:GenotypicSex ;
    linkml:is_a biolink:BiologicalSex ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:GeographicExposure a linkml:ClassDefinition ;
    dct:description "A geographic exposure is a factor relating to geographic proximity to some impactful entity." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeographicExposure ;
    linkml:definition_uri biolink:GeographicExposure ;
    linkml:is_a biolink:GeographicLocation ;
    linkml:mixins biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:latitude,
        biolink:longitude,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:GrossAnatomicalStructure a linkml:ClassDefinition ;
    ns1:altLabel "organ",
        "tissue" ;
    ns1:exactMatch OBO:UBERON_0010000,
        UMLSSC:T017,
        UMLSSC:T021,
        UMLSST:anst,
        UMLSST:ffas,
        WIKIDATA:Q4936952 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T018,
        UMLSSC:T023,
        UMLSSC:T024,
        UMLSST:bpoc,
        UMLSST:emst,
        UMLSST:tisu ;
    linkml:class_uri biolink:GrossAnatomicalStructure ;
    linkml:definition_uri biolink:GrossAnatomicalStructure ;
    linkml:id_prefixes "FAO",
        "MESH",
        "NCIT",
        "PO",
        "UBERON",
        "UMLS" ;
    linkml:is_a biolink:AnatomicalEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Haplotype a linkml:ClassDefinition ;
    dct:description "A set of zero or more Alleles on a single instance of a Sequence[VMC]" ;
    ns1:exactMatch OBO:GENO_0000871,
        OBO:SO_0001024,
        VMC:Haplotype ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Haplotype ;
    linkml:definition_uri biolink:Haplotype ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:HospitalizationOutcome a linkml:ClassDefinition ;
    dct:description "An outcome resulting from an exposure event which is the increased manifestation of acute (e.g. emergency room visit) or chronic (inpatient) hospitalization." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:HospitalizationOutcome ;
    linkml:definition_uri biolink:HospitalizationOutcome ;
    linkml:is_a biolink:Hospitalization ;
    linkml:mixins biolink:Outcome ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Inheritance a linkml:ClassDefinition ;
    dct:description "The pattern or 'mode' in which a particular genetic trait or disorder is passed from one generation to the next, e.g. autosomal dominant, autosomal recessive, etc." ;
    ns1:exactMatch OBO:GENO_0000141,
        OBO:HP_0000005,
        OBO:NCIT_C45827 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Inheritance ;
    linkml:definition_uri biolink:Inheritance ;
    linkml:is_a biolink:OrganismAttribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:MacromolecularComplexMixin a linkml:ClassDefinition ;
    dct:description "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:exactMatch OBO:GO_0032991,
        WIKIDATA:Q22325163 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MacromolecularComplexMixin ;
    linkml:definition_uri biolink:MacromolecularComplexMixin ;
    linkml:id_prefixes "GO",
        "INTACT",
        "PR",
        "REACT" ;
    linkml:is_a biolink:MacromolecularMachineMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:macromolecular_machine_mixin_name .

biolink:Macronutrient a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch OBO:CHEBI_33937 ;
    linkml:class_uri biolink:Macronutrient ;
    linkml:definition_uri biolink:Macronutrient ;
    linkml:is_a biolink:Nutrient ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:MaterialSampleToDiseaseOrPhenotypicFeatureAssociation a linkml:ClassDefinition ;
    dct:description "An association between a material sample and a disease or phenotype." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MaterialSampleToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:MaterialSampleToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin,
        biolink:MaterialSampleToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:Metabolite a linkml:ClassDefinition ;
    dct:description "Any intermediate or product resulting from metabolism. Includes primary and secondary metabolites." ;
    ns1:exactMatch OBO:CHEBI_25212 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "The CHEBI ID represents a role rather than a substance" ;
    linkml:class_uri biolink:Metabolite ;
    linkml:definition_uri biolink:Metabolite ;
    linkml:deprecated "Metabolite is replaced by a slot/role of chemical substance and will be removed  from the Biolink model." ;
    linkml:is_a biolink:ChemicalSubstance ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:MicroRNA a linkml:ClassDefinition ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:exactMatch OBO:SO_0000276,
        <http://semanticscience.org/resource/SIO_001397>,
        WIKIDATA:Q310899 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MicroRNA ;
    linkml:definition_uri biolink:MicroRNA ;
    linkml:id_prefixes "HGNC",
        "MIR",
        "WormBase" ;
    linkml:is_a biolink:NoncodingRNAProduct ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:synonym,
        biolink:type,
        biolink:xref .

biolink:MortalityOutcome a linkml:ClassDefinition ;
    dct:description "An outcome of death from resulting from an exposure event." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MortalityOutcome ;
    linkml:definition_uri biolink:MortalityOutcome ;
    linkml:is_a biolink:Death ;
    linkml:mixins biolink:Outcome ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:PathognomonicityQuantifier a linkml:ClassDefinition ;
    dct:description "A relationship quantifier between a variant or symptom and a disease, which is high when the presence of the feature implies the existence of the disease" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PathognomonicityQuantifier ;
    linkml:definition_uri biolink:PathognomonicityQuantifier ;
    linkml:is_a biolink:SpecificityQuantifier ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:PathologicalAnatomicalExposure a linkml:ClassDefinition ;
    dct:description "An abnormal anatomical structure, when viewed as an exposure, representing an precondition, leading to or influencing an outcome, e.g. thrombosis leading to an ischemic disease outcome." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PathologicalAnatomicalExposure ;
    linkml:definition_uri biolink:PathologicalAnatomicalExposure ;
    linkml:is_a biolink:PathologicalAnatomicalStructure ;
    linkml:mixins biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:PathologicalAnatomicalOutcome a linkml:ClassDefinition ;
    dct:description "An outcome resulting from an exposure event which is the manifestation of an abnormal anatomical structure." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PathologicalAnatomicalOutcome ;
    linkml:definition_uri biolink:PathologicalAnatomicalOutcome ;
    linkml:is_a biolink:PathologicalAnatomicalStructure ;
    linkml:mixins biolink:Outcome ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:PathologicalProcessExposure a linkml:ClassDefinition ;
    dct:description "A pathological process, when viewed as an exposure, representing an precondition, leading to or influencing an outcome, e.g. autoimmunity leading to disease." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PathologicalProcessExposure ;
    linkml:definition_uri biolink:PathologicalProcessExposure ;
    linkml:is_a biolink:PathologicalProcess ;
    linkml:mixins biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:PathologicalProcessOutcome a linkml:ClassDefinition ;
    dct:description "An outcome resulting from an exposure event which is the manifestation of a pathological process." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PathologicalProcessOutcome ;
    linkml:definition_uri biolink:PathologicalProcessOutcome ;
    linkml:is_a biolink:PathologicalProcess ;
    linkml:mixins biolink:Outcome ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Phenomenon a linkml:ClassDefinition ;
    dct:description "a fact or situation that is observed to exist or happen, especially one whose cause or explanation is in question" ;
    ns1:broadMatch UMLSSC:T067,
        UMLSSC:T068,
        UMLSSC:T070,
        UMLSST:hcpp,
        UMLSST:npop,
        UMLSST:phpr ;
    ns1:exactMatch UMLSSG:PHEN ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T034,
        UMLSSC:T038,
        UMLSSC:T069,
        UMLSST:biof,
        UMLSST:eehu,
        UMLSST:lbtr ;
    linkml:class_uri biolink:Phenomenon ;
    linkml:definition_uri biolink:Phenomenon ;
    linkml:is_a biolink:NamedThing ;
    linkml:mixins biolink:Occurrent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:PhenotypicQuality a linkml:ClassDefinition ;
    dct:description "A property of a phenotype" ;
    ns1:altLabel "phenotypic properties" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation OBO:PATO_0000001 ;
    linkml:class_uri biolink:PhenotypicQuality ;
    linkml:definition_uri biolink:PhenotypicQuality ;
    linkml:is_a biolink:OrganismAttribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:PhenotypicSex a linkml:ClassDefinition ;
    dct:description "An attribute corresponding to the phenotypic sex of the individual, based upon the reproductive organs present." ;
    ns1:exactMatch OBO:PATO_0001894 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PhenotypicSex ;
    linkml:definition_uri biolink:PhenotypicSex ;
    linkml:is_a biolink:BiologicalSex ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:PhysiologicalProcess a linkml:ClassDefinition ;
    ns1:altLabel "physiology" ;
    ns1:closeMatch UMLSSG:PHYS ;
    ns1:exactMatch UMLSSC:T039,
        UMLSST:phsf,
        WIKIDATA:Q30892994 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T040,
        UMLSSC:T042,
        UMLSSC:T043,
        UMLSSC:T045,
        UMLSST:celf,
        UMLSST:genf,
        UMLSST:orgf,
        UMLSST:ortf ;
    linkml:class_uri biolink:PhysiologicalProcess ;
    linkml:definition_uri biolink:PhysiologicalProcess ;
    linkml:id_prefixes "GO",
        "REACT" ;
    linkml:is_a biolink:BiologicalProcess ;
    linkml:mixins biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:ProcessedMaterial a linkml:ClassDefinition ;
    dct:description "A chemical substance (often a mixture) processed for consumption for nutritional, medical or technical use." ;
    ns1:exactMatch OBO:OBI_0000047 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ProcessedMaterial ;
    linkml:definition_uri biolink:ProcessedMaterial ;
    linkml:is_a biolink:ChemicalSubstance ;
    linkml:mixins biolink:Mixture,
        biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_constituent,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:ProteinIsoform a linkml:ClassDefinition ;
    dct:description "Represents a protein that is a specific isoform of the canonical or reference protein. See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114032/" ;
    ns1:altLabel "proteoform" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ProteinIsoform ;
    linkml:definition_uri biolink:ProteinIsoform ;
    linkml:id_prefixes "ENSEMBL",
        "PR",
        "UNIPROT.ISOFORM",
        "UniProtKB" ;
    linkml:is_a biolink:Protein ;
    linkml:mixins biolink:GeneProductIsoformMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:synonym,
        biolink:type,
        biolink:xref .

biolink:RNAProductIsoform a linkml:ClassDefinition ;
    dct:description "Represents a protein that is a specific isoform of the canonical or reference RNA" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:RNAProductIsoform ;
    linkml:definition_uri biolink:RNAProductIsoform ;
    linkml:id_prefixes "RNACENTRAL" ;
    linkml:is_a biolink:RNAProduct ;
    linkml:mixins biolink:GeneProductIsoformMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:synonym,
        biolink:type,
        biolink:xref .

biolink:ReagentTargetedGene a linkml:ClassDefinition ;
    dct:description "A gene altered in its expression level in the context of some experiment as a result of being targeted by gene-knockdown reagent(s) such as a morpholino or RNAi." ;
    ns1:exactMatch OBO:GENO_0000504 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ReagentTargetedGene ;
    linkml:definition_uri biolink:ReagentTargetedGene ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:RelationshipType a linkml:ClassDefinition ;
    dct:description "An OWL property used as an edge label" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:RelationshipType ;
    linkml:definition_uri biolink:RelationshipType ;
    linkml:is_a biolink:OntologyClass ;
    linkml:slot_usage [ ] .

biolink:SensitivityQuantifier a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SensitivityQuantifier ;
    linkml:definition_uri biolink:SensitivityQuantifier ;
    linkml:is_a biolink:RelationshipQuantifier ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:SiRNA a linkml:ClassDefinition ;
    dct:description "A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. SRNAs trigger the cleavage of their target molecules." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "RNAi",
        "small interfering RNA" ;
    ns1:exactMatch OBO:SO_0000646,
        WIKIDATA:Q203221 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SiRNA ;
    linkml:definition_uri biolink:SiRNA ;
    linkml:id_prefixes "HGNC",
        "MIR",
        "WormBase" ;
    linkml:is_a biolink:NoncodingRNAProduct ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:synonym,
        biolink:type,
        biolink:xref .

biolink:Snv a linkml:ClassDefinition ;
    dct:description "SNVs are single nucleotide positions in genomic DNA at which different sequence alternatives exist" ;
    ns1:altLabel "single nucleotide polymorphism",
        "single nucleotide variant",
        "snp" ;
    ns1:exactMatch OBO:SO_0001483 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Snv ;
    linkml:definition_uri biolink:Snv ;
    linkml:is_a biolink:SequenceVariant ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:sequence_variant_has_biological_sequence,
        biolink:sequence_variant_has_gene,
        biolink:sequence_variant_id,
        biolink:source,
        biolink:type .

biolink:SocioeconomicOutcome a linkml:ClassDefinition ;
    dct:description "An general social or economic outcome, such as healthcare costs, utilization, etc., resulting from an exposure event" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SocioeconomicOutcome ;
    linkml:definition_uri biolink:SocioeconomicOutcome ;
    linkml:is_a biolink:Behavior ;
    linkml:mixins biolink:Outcome ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:UnclassifiedOntologyClass a linkml:ClassDefinition ;
    dct:description "this is used for nodes that are taken from an ontology but are not typed using an existing biolink class" ;
    oboInOwl:inSubset biolink:testing ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:UnclassifiedOntologyClass ;
    linkml:definition_uri biolink:UnclassifiedOntologyClass ;
    linkml:is_a biolink:OntologyClass ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:Vitamin a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch OBO:CHEBI_33229,
        UMLSSC:T127,
        UMLSST:vita ;
    linkml:class_uri biolink:Vitamin ;
    linkml:definition_uri biolink:Vitamin ;
    linkml:is_a biolink:Micronutrient ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:association_id a linkml:SlotDefinition ;
    dct:description "A unique identifier for an association" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "id" ;
    linkml:definition_uri biolink:association_id ;
    linkml:deprecated "This slot is deprecated in favor of 'id' slot." ;
    linkml:deprecated_element_has_exact_replacement biolink:id ;
    linkml:domain biolink:Association ;
    linkml:identifier true ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:association_id ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri biolink:id .

biolink:biological_role_mixin a linkml:SlotDefinition ;
    dct:description "A role played by the molecular entity or part thereof within a biological context." ;
    ns1:exactMatch OBO:CHEBI_24432 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:biological_role_mixin ;
    linkml:mixin true ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:biological_role_mixin .

biolink:biological_sequence a linkml:TypeDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "str" ;
    linkml:definition_uri biolink:BiologicalSequence ;
    linkml:typeof biolink:string ;
    linkml:uri xsd:string .

biolink:boolean a linkml:TypeDefinition ;
    dct:description "A binary (true or false) value" ;
    ns1:inScheme linkml:types ;
    linkml:base "Bool" ;
    linkml:definition_uri linkml:Boolean ;
    linkml:imported_from "linkml:types" ;
    linkml:repr "bool" ;
    linkml:uri xsd:boolean .

biolink:cell_line_to_disease_or_phenotypic_feature_association_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:domain_of biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:chemical_role_mixin a linkml:SlotDefinition ;
    dct:description "A role played by the molecular entity or part thereof within a chemical context." ;
    ns1:exactMatch OBO:CHEBI_51086 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:chemical_role_mixin ;
    linkml:mixin true ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:chemical_role_mixin .

biolink:chemical_to_chemical_association_object a linkml:SlotDefinition ;
    dct:description "the chemical element that is the target of the statement" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:ChemicalToChemicalAssociation ;
    linkml:domain_of biolink:ChemicalToChemicalAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:ChemicalToChemicalAssociation ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:dataset_download_url a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation dcat:downloadURL ;
    linkml:definition_uri biolink:dataset_download_url ;
    linkml:domain biolink:Dataset ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:dataset_download_url ;
    linkml:range biolink:string ;
    linkml:slot_uri dcat:downloadURL .

biolink:download_url a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation dcat:downloadURL ;
    linkml:definition_uri biolink:download_url ;
    linkml:domain biolink:InformationContentEntity ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:download_url ;
    linkml:range biolink:string ;
    linkml:slot_uri dcat:downloadURL .

biolink:edge_label a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    linkml:definition_uri biolink:edge_label ;
    linkml:deprecated "This slot is deprecated in favor of 'predicate' slot." ;
    linkml:deprecated_element_has_exact_replacement biolink:predicate ;
    linkml:domain biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "predicate" ;
            linkml:local_name_source "translator" ],
        [ a linkml:LocalName ;
            ns1:altLabel "annotation predicate" ;
            linkml:local_name_source "ga4gh" ] ;
    linkml:owner biolink:edge_label ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate .

biolink:genotype_to_disease_association_object a linkml:SlotDefinition ;
    dct:description "a disease that is associated with that genotype" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GenotypeToDiseaseAssociation ;
    linkml:domain_of biolink:GenotypeToDiseaseAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "hereditary breast cancer" ;
            ns1:example "MONDO:0016419" ] ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToDiseaseAssociation ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:genotype_to_disease_association_predicate a linkml:SlotDefinition ;
    dct:description "E.g. is pathogenic for" ;
    rdfs:subPropertyOf biolink:related_condition ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:GenotypeToDiseaseAssociation ;
    linkml:domain_of biolink:GenotypeToDiseaseAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:GenotypeToDiseaseAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:genotype_to_disease_association_subject a linkml:SlotDefinition ;
    dct:description "a genotype that is associated in some way with a disease state" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GenotypeToDiseaseAssociation ;
    linkml:domain_of biolink:GenotypeToDiseaseAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GenotypeToDiseaseAssociation ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:has_dataset a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation dct:source ;
    linkml:definition_uri biolink:has_dataset ;
    linkml:domain biolink:DatasetVersion ;
    linkml:domain_of biolink:DatasetVersion ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:DatasetVersion ;
    linkml:range biolink:Dataset ;
    linkml:slot_uri dct:source .

biolink:has_distribution a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation dct:distribution ;
    linkml:definition_uri biolink:has_distribution ;
    linkml:domain biolink:DatasetVersion ;
    linkml:domain_of biolink:DatasetVersion ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:DatasetVersion ;
    linkml:range biolink:DatasetDistribution ;
    linkml:slot_uri dct:distribution .

biolink:ingest_date a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation pav:version ;
    linkml:definition_uri biolink:ingest_date ;
    linkml:domain biolink:DatasetVersion ;
    linkml:domain_of biolink:DatasetVersion ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:DatasetVersion ;
    linkml:range biolink:string ;
    linkml:slot_uri pav:version .

biolink:iri_type a linkml:TypeDefinition ;
    dct:description "An IRI" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "URIorCURIE" ;
    linkml:definition_uri biolink:IriType ;
    linkml:repr "str" ;
    linkml:typeof biolink:uriorcurie ;
    linkml:uri xsd:anyURI .

biolink:narrative_text a linkml:TypeDefinition ;
    dct:description "A string that provides a human-readable description of something" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "str" ;
    linkml:definition_uri biolink:NarrativeText ;
    linkml:typeof biolink:string ;
    linkml:uri xsd:string .

biolink:organism_taxon_has_taxonomic_rank a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation WIKIDATA:P105 ;
    ns1:prefLabel "has taxonomic rank" ;
    linkml:domain biolink:OrganismTaxon ;
    linkml:domain_of biolink:OrganismTaxon ;
    linkml:inlined true ;
    linkml:is_a biolink:has_taxonomic_rank ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:OrganismTaxon ;
    linkml:range biolink:TaxonomicRank ;
    linkml:slot_uri biolink:has_taxonomic_rank ;
    linkml:usage_slot_name "has taxonomic rank" .

biolink:organism_taxon_subclass_of a linkml:SlotDefinition ;
    dct:description "subclass of holds between two taxa, e.g. human subclass of mammal" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch LOINC:class_of,
        LOINC:has_class ;
    ns1:exactMatch MESH:isa,
        RTXKG1:subclass_of,
        RXNORM:isa,
        OBO:GO_isa,
        rdfs:subClassOf,
        <https://skr3.nlm.nih.gov/SemMedDBIS_A>,
        <https://skr3.nlm.nih.gov/SemMedDBisa>,
        CHEMBL.MECHANISM:subset_of,
        VANDF:isa,
        WIKIDATA_PROPERTY:P279 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_archetype,
        LOINC:has_parent_group,
        LOINC:is_presence_guidance_for,
        NDDF:has_dose_form,
        RXNORM:has_dose_form,
        RXNORM:has_doseformgroup,
        OBO:CHEBI_has_parent_hydride,
        OBO:NCIT_A11,
        OBO:NCIT_A14,
        OBO:NCIT_A16,
        OBO:NCIT_A3,
        OBO:NCIT_R36,
        OBO:NCIT_R42,
        OBO:NCIT_gene_product_has_chemical_classification,
        OBO:SNOMED_entire_anatomy_structure_of,
        OBO:SNOMED_has_dose_form,
        OBO:intersection_of,
        rdfs:subPropertyOf ;
    ns1:prefLabel "subclass of" ;
    linkml:definition_uri biolink:subclass_of ;
    linkml:domain biolink:OrganismTaxon ;
    linkml:domain_of biolink:OrganismTaxon ;
    linkml:inherited true ;
    linkml:is_a biolink:subclass_of ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:OrganismTaxon ;
    linkml:range biolink:OrganismTaxon ;
    linkml:slot_uri biolink:subclass_of ;
    linkml:usage_slot_name "subclass of" .

biolink:pairwise_gene_to_gene_interaction_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:interacts_with ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:PairwiseGeneToGeneInteraction ;
    linkml:domain_of biolink:PairwiseGeneToGeneInteraction ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:PairwiseGeneToGeneInteraction ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:symmetric true ;
    linkml:usage_slot_name "predicate" .

biolink:pairwise_gene_to_gene_interaction_relation a linkml:SlotDefinition ;
    dct:description "interaction relationship type" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "relation" ;
    linkml:definition_uri biolink:relation ;
    linkml:domain biolink:PairwiseGeneToGeneInteraction ;
    linkml:domain_of biolink:PairwiseGeneToGeneInteraction ;
    linkml:id_prefixes "BSPO",
        "RO",
        "SIO" ;
    linkml:is_a biolink:relation ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:PairwiseGeneToGeneInteraction ;
    linkml:range biolink:uriorcurie ;
    linkml:required true ;
    linkml:slot_uri biolink:relation ;
    linkml:usage_slot_name "relation" ;
    linkml:values_from biolink:mi,
        biolink:ro .

biolink:sequence_variant_has_biological_sequence a linkml:SlotDefinition ;
    dct:description "The state of the sequence w.r.t a reference sequence" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "has biological sequence" ;
    linkml:definition_uri biolink:has_biological_sequence ;
    linkml:domain biolink:SequenceVariant ;
    linkml:domain_of biolink:SequenceVariant ;
    linkml:is_a biolink:has_biological_sequence ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:SequenceVariant ;
    linkml:range biolink:biological_sequence ;
    linkml:slot_uri biolink:has_biological_sequence ;
    linkml:usage_slot_name "has biological sequence" .

biolink:sequence_variant_has_gene a linkml:SlotDefinition ;
    dct:description "Each allele can be associated with any number of genes" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "has gene" ;
    linkml:definition_uri biolink:has_gene ;
    linkml:domain biolink:SequenceVariant ;
    linkml:domain_of biolink:SequenceVariant ;
    linkml:is_a biolink:has_gene ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:SequenceVariant ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:has_gene ;
    linkml:usage_slot_name "has gene" .

biolink:sequence_variant_id a linkml:SlotDefinition ;
    dct:description "A unique identifier for an entity. Must be either a CURIE shorthand for a URI or a complete URI" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch gff3:ID,
        gpi:DB_Object_ID,
        alliancegenome:primaryId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "id" ;
    linkml:definition_uri biolink:id ;
    linkml:domain biolink:SequenceVariant ;
    linkml:domain_of biolink:SequenceVariant ;
    linkml:examples [ a linkml:Example ;
            dct:description "NM_007294.3(BRCA1):c.2521C>T (p.Arg841Trp)" ;
            ns1:example "ClinVarVariant:17681" ],
        [ a linkml:Example ;
            dct:description "ti282a allele from ZFIN" ;
            ns1:example "ZFIN:ZDB-ALT-980203-1091" ] ;
    linkml:identifier true ;
    linkml:is_a biolink:id ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:SequenceVariant ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri biolink:id ;
    linkml:usage_slot_name "id" .

biolink:source_logo a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation schema:logo ;
    linkml:definition_uri biolink:source_logo ;
    linkml:domain biolink:DatasetSummary ;
    linkml:domain_of biolink:DatasetSummary ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:DatasetSummary ;
    linkml:range biolink:string ;
    linkml:slot_uri schema:logo .

biolink:systematic_synonym a linkml:SlotDefinition ;
    dct:description "more commonly used for gene symbols in yeast" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation GOP:systematic_synonym ;
    linkml:definition_uri biolink:systematic_synonym ;
    linkml:domain biolink:NamedThing ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:systematic_synonym ;
    linkml:range biolink:label_type ;
    linkml:slot_uri GOP:systematic_synonym .

biolink:testing a linkml:SubsetDefinition ;
    dct:description "TBD" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:Testing .

biolink:time_type a linkml:TypeDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "XSDTime" ;
    linkml:definition_uri biolink:TimeType ;
    linkml:repr "str" ;
    linkml:typeof biolink:time ;
    linkml:uri xsd:dateTime .

biolink:variant_to_disease_association_object a linkml:SlotDefinition ;
    dct:description "a disease that is associated with that variant" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:VariantToDiseaseAssociation ;
    linkml:domain_of biolink:VariantToDiseaseAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "hereditary breast cancer" ;
            ns1:example "MONDO:0016419" ] ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:VariantToDiseaseAssociation ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:variant_to_disease_association_predicate a linkml:SlotDefinition ;
    dct:description "E.g. is pathogenic for" ;
    rdfs:subPropertyOf biolink:related_condition ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:VariantToDiseaseAssociation ;
    linkml:domain_of biolink:VariantToDiseaseAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:VariantToDiseaseAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:variant_to_disease_association_subject a linkml:SlotDefinition ;
    dct:description "a sequence variant in which the allele state is associated in some way with the disease state" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:VariantToDiseaseAssociation ;
    linkml:domain_of biolink:VariantToDiseaseAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "NM_000059.3(BRCA2):c.7007G>C (p.Arg2336Pro)" ;
            ns1:example "ClinVar:52241" ] ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:VariantToDiseaseAssociation ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:variant_to_gene_association_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:VariantToGeneAssociation ;
    linkml:domain_of biolink:VariantToGeneAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:VariantToGeneAssociation ;
    linkml:range biolink:Gene ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:variant_to_gene_association_predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    rdfs:subPropertyOf biolink:genetic_association ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    ns1:prefLabel "predicate" ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:VariantToGeneAssociation ;
    linkml:domain_of biolink:VariantToGeneAssociation ;
    linkml:is_a biolink:predicate ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation predicate" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:translator [ ns1:altLabel "predicate" ;
                    linkml:local_name_source "translator" ] ] ;
    linkml:owner biolink:VariantToGeneAssociation ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate ;
    linkml:usage_slot_name "predicate" .

biolink:AdministrativeEntity a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:class_uri biolink:AdministrativeEntity ;
    linkml:definition_uri biolink:AdministrativeEntity ;
    linkml:is_a biolink:NamedThing ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:BehavioralFeature a linkml:ClassDefinition ;
    dct:description "A phenotypic feature which is behavioral in nature." ;
    ns1:exactMatch OBO:NBO_0000243 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:BehavioralFeature ;
    linkml:definition_uri biolink:BehavioralFeature ;
    linkml:is_a biolink:PhenotypicFeature ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Case a linkml:ClassDefinition ;
    dct:description "An individual (human) organism that has a patient role in some clinical context." ;
    ns1:altLabel "patient",
        "proband" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Case ;
    linkml:definition_uri biolink:Case ;
    linkml:is_a biolink:IndividualOrganism ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:CellularComponent a linkml:ClassDefinition ;
    dct:description "A location in or around a cell" ;
    ns1:broadMatch WIKIDATA:P681 ;
    ns1:exactMatch OBO:GO_0005575,
        <http://semanticscience.org/resource/SIO_001400>,
        UMLSSC:T026,
        UMLSST:celc,
        WIKIDATA:Q5058355 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:CellularComponent ;
    linkml:definition_uri biolink:CellularComponent ;
    linkml:id_prefixes "CL",
        "GO",
        "MESH",
        "NCIT",
        "SNOMEDCT",
        "UBERON",
        "UMLS" ;
    linkml:is_a biolink:AnatomicalEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:ChemicalExposure a linkml:ClassDefinition ;
    dct:description "A chemical exposure is an intake of a particular chemical substance, other than a drug." ;
    ns1:exactMatch OBO:ECTO_9000000,
        <http://semanticscience.org/resource/SIO_001399> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ChemicalExposure ;
    linkml:definition_uri biolink:ChemicalExposure ;
    linkml:is_a biolink:ChemicalSubstance ;
    linkml:mixins biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:ClinicalCourse a linkml:ClassDefinition ;
    dct:description "The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual" ;
    ns1:exactMatch OBO:HP_0031797 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ClinicalCourse ;
    linkml:definition_uri biolink:ClinicalCourse ;
    linkml:is_a biolink:ClinicalAttribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:ClinicalIntervention a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ClinicalIntervention ;
    linkml:definition_uri biolink:ClinicalIntervention ;
    linkml:is_a biolink:ClinicalEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:ClinicalModifier a linkml:ClassDefinition ;
    dct:description "Used to characterize and specify the phenotypic abnormalities defined in the phenotypic abnormality sub-ontology, with respect to severity, laterality, and other aspects" ;
    ns1:exactMatch OBO:HP_0012823 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ClinicalModifier ;
    linkml:definition_uri biolink:ClinicalModifier ;
    linkml:is_a biolink:ClinicalAttribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:CodingSequence a linkml:ClassDefinition ;
    ns1:exactMatch OBO:SO_0000316,
        <http://semanticscience.org/resource/SIO_001390> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:CodingSequence ;
    linkml:definition_uri biolink:CodingSequence ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:ConfidenceLevel a linkml:ClassDefinition ;
    dct:description "Level of confidence in a statement" ;
    ns1:closeMatch OBO:SEPIO_0000167 ;
    ns1:exactMatch OBO:CIO_0000028,
        OBO:SEPIO_0000187 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ConfidenceLevel ;
    linkml:definition_uri biolink:ConfidenceLevel ;
    linkml:is_a biolink:InformationContentEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:license,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:rights,
        biolink:source,
        biolink:type ;
    linkml:values_from biolink:cio .

biolink:Death a linkml:ClassDefinition ;
    ns1:exactMatch OBO:GO_0016265 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Death ;
    linkml:definition_uri biolink:Death ;
    linkml:is_a biolink:BiologicalProcess ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Device a linkml:ClassDefinition ;
    dct:description "A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSG:DEVI,
        UMLSSC:T074,
        UMLSSC:T075,
        UMLSSC:T203,
        UMLSST:drdd,
        UMLSST:medd,
        UMLSST:resd ;
    linkml:class_uri biolink:Device ;
    linkml:definition_uri biolink:Device ;
    linkml:is_a biolink:NamedThing ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:DrugExposure a linkml:ClassDefinition ;
    dct:description "A drug exposure is an intake of a particular drug." ;
    ns1:altLabel "drug dose",
        "drug intake",
        "medication intake" ;
    ns1:broadMatch <http://semanticscience.org/resource/SIO_001005> ;
    ns1:exactMatch OBO:ECTO_0000509 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DrugExposure ;
    linkml:definition_uri biolink:DrugExposure ;
    linkml:is_a biolink:Drug ;
    linkml:mixins biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_constituent,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:EnvironmentalProcess a linkml:ClassDefinition ;
    ns1:exactMatch OBO:ENVO_02500000 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EnvironmentalProcess ;
    linkml:definition_uri biolink:EnvironmentalProcess ;
    linkml:is_a biolink:PlanetaryEntity ;
    linkml:mixins biolink:Occurrent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:EvidenceType a linkml:ClassDefinition ;
    dct:description "Class of evidence that supports an association" ;
    ns1:altLabel "evidence code" ;
    ns1:exactMatch OBO:ECO_0000000 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EvidenceType ;
    linkml:definition_uri biolink:EvidenceType ;
    linkml:is_a biolink:InformationContentEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:license,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:rights,
        biolink:source,
        biolink:type ;
    linkml:values_from biolink:eco .

biolink:Exon a linkml:ClassDefinition ;
    dct:description "A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing." ;
    ns1:exactMatch OBO:SO_0000147,
        <http://semanticscience.org/resource/SIO_010445>,
        WIKIDATA:Q373027 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Exon ;
    linkml:definition_uri biolink:Exon ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:GeographicLocationAtTime a linkml:ClassDefinition ;
    dct:description "a location that can be described in lat/long coordinates, for a particular time" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeographicLocationAtTime ;
    linkml:definition_uri biolink:GeographicLocationAtTime ;
    linkml:is_a biolink:GeographicLocation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:latitude,
        biolink:longitude,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:Hospitalization a linkml:ClassDefinition ;
    ns1:exactMatch SNOMEDCT:32485007,
        WIKIDATA:Q3140971 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Hospitalization ;
    linkml:definition_uri biolink:Hospitalization ;
    linkml:is_a biolink:ClinicalIntervention ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:IndividualOrganism a linkml:ClassDefinition ;
    dct:description "An instance of an organism. For example, Richard Nixon, Charles Darwin, my pet cat. Example ID: ORCID:0000-0002-5355-2576" ;
    ns1:altLabel "organism" ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_010000>,
        UMLSSC:T001,
        UMLSST:orgm ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch foaf:Person,
        WIKIDATA:Q795052 ;
    linkml:class_uri biolink:IndividualOrganism ;
    linkml:definition_uri biolink:IndividualOrganism ;
    linkml:id_prefixes "ORCID" ;
    linkml:is_a biolink:OrganismalEntity ;
    linkml:mixins biolink:ThingWithTaxon ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Micronutrient a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch OBO:CHEBI_27027 ;
    linkml:class_uri biolink:Micronutrient ;
    linkml:definition_uri biolink:Micronutrient ;
    linkml:is_a biolink:Nutrient ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Onset a linkml:ClassDefinition ;
    dct:description "The age group in which (disease) symptom manifestations appear" ;
    ns1:exactMatch OBO:HP_0003674 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Onset ;
    linkml:definition_uri biolink:Onset ;
    linkml:is_a biolink:ClinicalCourse ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:Pathway a linkml:ClassDefinition ;
    ns1:exactMatch OBO:PW_0000001,
        WIKIDATA:Q4915012 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:GO_0007165,
        <http://semanticscience.org/resource/SIO_010526> ;
    linkml:class_uri biolink:Pathway ;
    linkml:definition_uri biolink:Pathway ;
    linkml:id_prefixes "FB",
        "GO",
        "KEGG",
        "MSigDB",
        "PANTHER.PATHWAY",
        "PHARMGKB.PATHWAYS",
        "REACT",
        "SMPDB",
        "WIKIPATHWAYS" ;
    linkml:is_a biolink:BiologicalProcess ;
    linkml:mixins biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Procedure a linkml:ClassDefinition ;
    dct:description "A series of actions conducted in a certain order or manner" ;
    ns1:exactMatch UMLSSG:PROC ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T059,
        UMLSSC:T060,
        UMLSSC:T061,
        UMLSSC:T063,
        UMLSST:diap,
        UMLSST:lbpr,
        UMLSST:mbrt,
        UMLSST:topp ;
    linkml:class_uri biolink:Procedure ;
    linkml:definition_uri biolink:Procedure ;
    linkml:is_a biolink:NamedThing ;
    linkml:mixins biolink:ActivityAndBehavior ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:SequenceAssociation a linkml:ClassDefinition ;
    dct:description "An association between a sequence feature and a genomic entity it is localized to." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SequenceAssociation ;
    linkml:definition_uri biolink:SequenceAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:SeverityValue a linkml:ClassDefinition ;
    dct:description "describes the severity of a phenotypic feature or disease" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SeverityValue ;
    linkml:definition_uri biolink:SeverityValue ;
    linkml:is_a biolink:Attribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:SocioeconomicAttribute a linkml:ClassDefinition ;
    dct:description "Attributes relating to a socioeconomic manifestation" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SocioeconomicAttribute ;
    linkml:definition_uri biolink:SocioeconomicAttribute ;
    linkml:is_a biolink:Attribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:SpecificityQuantifier a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SpecificityQuantifier ;
    linkml:definition_uri biolink:SpecificityQuantifier ;
    linkml:is_a biolink:RelationshipQuantifier ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:StudyPopulation a linkml:ClassDefinition ;
    dct:description "A group of people banded together or treated as a group as participants in a research study." ;
    ns1:closeMatch WIKIDATA:Q7229825 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:StudyPopulation ;
    linkml:definition_uri biolink:StudyPopulation ;
    linkml:is_a biolink:PopulationOfIndividualOrganisms ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:SubjectOfInvestigation a linkml:ClassDefinition ;
    dct:description "An entity that has the role of being studied in an investigation, study, or experiment" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SubjectOfInvestigation ;
    linkml:definition_uri biolink:SubjectOfInvestigation ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:Zygosity a linkml:ClassDefinition ;
    ns1:exactMatch OBO:GENO_0000133 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Zygosity ;
    linkml:definition_uri biolink:Zygosity ;
    linkml:is_a biolink:Attribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:address a linkml:SlotDefinition ;
    dct:description "the particulars of the place where someone or an organization is situated.  For now, this slot is a simple text \"blob\" containing all relevant details of the given location for fitness of purpose. For the moment, this \"address\" can include other contact details such as email and phone number(?)." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:address ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:Agent ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:Agent ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:address .

biolink:affects_expression_in a linkml:SlotDefinition ;
    dct:description "Holds between a variant and an anatomical entity where the expression of the variant is located in." ;
    ns1:exactMatch GTEx:affects_expression_in ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_expression_in ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_expression_in ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:affects_expression_in .

biolink:affiliation a linkml:SlotDefinition ;
    dct:description "a professional relationship between one provider (often a person) within another provider (often an organization). Target provider identity should be specified by a CURIE. Providers may have multiple affiliations." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affiliation ;
    linkml:domain biolink:Agent ;
    linkml:domain_of biolink:Agent ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:Agent ;
    linkml:range biolink:uriorcurie ;
    linkml:slot_uri biolink:affiliation .

biolink:anatomical_entity_to_anatomical_entity_association_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:domain_of biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:anatomical_entity_to_anatomical_entity_association_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:domain_of biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:author a linkml:SlotDefinition ;
    dct:description "an instance of one (co-)creator primarily responsible for a written work" ;
    ns1:exactMatch dct:creator,
        WIKIDATA_PROPERTY:P50 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:author ;
    linkml:domain biolink:Publication ;
    linkml:inherited true ;
    linkml:is_a biolink:contributor ;
    linkml:multivalued true ;
    linkml:owner biolink:author ;
    linkml:range biolink:Agent ;
    linkml:slot_uri biolink:author .

biolink:capable_of a linkml:SlotDefinition ;
    dct:description "holds between a physical entity and process or function, where the continuant alone has the ability to carry out the process or function." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch RTXKG1:capable_of,
        OBO:RO_0002215 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_R52,
        OBO:RO_0002500 ;
    linkml:definition_uri biolink:capable_of ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:actively_involved_in ;
    linkml:multivalued true ;
    linkml:owner biolink:capable_of ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:capable_of .

biolink:category_type a linkml:TypeDefinition ;
    dct:description "A primitive type in which the value denotes a class within the biolink model. The value must be a URI or a CURIE. In a Neo4j representation, the value should be the CURIE for the biolink class, for example biolink:Gene. For an RDF representation, the value should be a URI such as https://w3id.org/biolink/vocab/Gene" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "URIorCURIE" ;
    linkml:definition_uri biolink:CategoryType ;
    linkml:repr "str" ;
    linkml:typeof biolink:uriorcurie ;
    linkml:uri xsd:anyURI .

biolink:causes_adverse_event a linkml:SlotDefinition ;
    dct:description "holds between a drug and a disease or phenotype that can be caused by the drug" ;
    ns1:exactMatch <http://translator.ncats.nih.gov/Aeolus_0000001> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:causes_adverse_event ;
    linkml:domain biolink:Drug ;
    linkml:inherited true ;
    linkml:is_a biolink:causes ;
    linkml:multivalued true ;
    linkml:owner biolink:causes_adverse_event ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_uri biolink:causes_adverse_event .

biolink:chapter a linkml:SlotDefinition ;
    dct:description "chapter of a book" ;
    ns1:exactMatch WIKIDATA:Q1980247 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:chapter ;
    linkml:domain biolink:BookChapter ;
    linkml:domain_of biolink:BookChapter ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:BookChapter ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:chapter .

biolink:chemically_similar_to a linkml:SlotDefinition ;
    dct:description "holds between one chemical substances and another that it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:CHEBI_has_functional_parent,
        OBO:CHEBI_has_parent_hydride,
        OBO:CHEBI_is_conjugate_acid_of,
        OBO:CHEBI_is_conjugate_base_of,
        OBO:CHEBI_is_enantiomer_of,
        OBO:CHEBI_is_tautomer_of,
        OBO:NCIT_has_salt_form ;
    linkml:definition_uri biolink:chemically_similar_to ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:similar_to ;
    linkml:multivalued true ;
    linkml:owner biolink:chemically_similar_to ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:chemically_similar_to ;
    linkml:symmetric true .

biolink:chi_squared_statistic a linkml:SlotDefinition ;
    dct:description "represents the chi-squared statistic computed from observations" ;
    ns1:exactMatch OBO:STATO_0000030 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:chi_squared_statistic ;
    linkml:domain biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:chi_squared_statistic ;
    linkml:range biolink:float ;
    linkml:slot_uri biolink:chi_squared_statistic .

biolink:clinical_modifier_qualifier a linkml:SlotDefinition ;
    dct:description "Used to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:clinical_modifier_qualifier ;
    linkml:domain biolink:Association ;
    linkml:inlined true ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:clinical_modifier_qualifier ;
    linkml:range biolink:ClinicalModifier ;
    linkml:slot_uri biolink:clinical_modifier_qualifier .

biolink:colocalizes_with a linkml:SlotDefinition ;
    dct:description "holds between two entities that are observed to be located in the same place." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_00002325 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:colocalizes_with ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:coexists_with ;
    linkml:multivalued true ;
    linkml:owner biolink:colocalizes_with ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:colocalizes_with ;
    linkml:symmetric true .

biolink:contraindicated_for a linkml:SlotDefinition ;
    dct:description "Holds between a drug and a disease or phenotype, such that a person with that disease should not be treated with the drug." ;
    ns1:exactMatch RTXKG1:contraindicated_for,
        <http://translator.ncats.nih.gov/DrugCentral_0000001> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:contraindicated_for ;
    linkml:domain biolink:Drug ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:contraindicated_for ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_uri biolink:contraindicated_for .

biolink:created_with a linkml:SlotDefinition ;
    ns1:exactMatch pav:createdWith ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:created_with ;
    linkml:domain biolink:Dataset ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:created_with ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:created_with .

biolink:date a linkml:TypeDefinition ;
    dct:description "a date (year, month and day) in an idealized calendar" ;
    ns1:editorialNote "URI is dateTime because OWL reasoners don't work with straight date or time" ;
    ns1:inScheme linkml:types ;
    linkml:base "XSDDate" ;
    linkml:definition_uri linkml:Date ;
    linkml:imported_from "linkml:types" ;
    linkml:repr "str" ;
    linkml:uri xsd:date .

biolink:decreases_abundance_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the amount of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_abundance_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch UBERGRAPH:is_decrease_of ;
    linkml:definition_uri biolink:decreases_abundance_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_abundance_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_abundance_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_abundance_of .

biolink:decreases_activity_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the activity of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_activity_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.renci.org/GAMMA_aggregation_inhibitor>,
        <http://translator.renci.org/GAMMA_allosteric_antagonist>,
        <http://translator.renci.org/GAMMA_antagonist>,
        <http://translator.renci.org/GAMMA_blocker>,
        <http://translator.renci.org/GAMMA_channel_blocker>,
        <http://translator.renci.org/GAMMA_conversion_inhibitor>,
        <http://translator.renci.org/GAMMA_downregulator>,
        <http://translator.renci.org/GAMMA_gating_inhibitor>,
        <http://translator.renci.org/GAMMA_inactivator>,
        <http://translator.renci.org/GAMMA_inhibitor>,
        <http://translator.renci.org/GAMMA_inhibitory_allosteric_modulator>,
        <http://translator.renci.org/GAMMA_inverse_agonist>,
        <http://translator.renci.org/GAMMA_negative_allosteric_modulator>,
        <http://translator.renci.org/GAMMA_negative_modulator>,
        <http://translator.renci.org/GAMMA_partial_antagonist>,
        <http://translator.renci.org/GAMMA_suppressor>,
        <http://translator.renci.org/GAMMA_weak_inhibitor>,
        <https://www.dgidb.org/interaction_typesantagonist>,
        <https://www.dgidb.org/interaction_typesblocker>,
        <https://www.dgidb.org/interaction_typeschannel_blocker>,
        <https://www.dgidb.org/interaction_typesgating_inhibitor>,
        <https://www.dgidb.org/interaction_typesinhibitor>,
        <https://www.dgidb.org/interaction_typesinhibitory_allosteric_modulator>,
        <https://www.dgidb.org/interaction_typesinverse_agonist>,
        <https://www.dgidb.org/interaction_typesnegative_modulator>,
        CHEMBL.MECHANISM:allosteric_antagonist,
        CHEMBL.MECHANISM:antagonist,
        CHEMBL.MECHANISM:inverse_agonist ;
    ns1:relatedMatch <http://translator.renci.org/GAMMA_ic50>,
        <http://translator.renci.org/GAMMA_ki>,
        <https://www.dgidb.org/interaction_typesvaccine> ;
    linkml:definition_uri biolink:decreases_activity_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_activity_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_activity_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_activity_of .

biolink:decreases_degradation_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the rate of degradation of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_degradation_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/CTD_decreases_cleavage>,
        <http://translator.ncats.nih.gov/CTD_decreases_hydrolysis> ;
    linkml:definition_uri biolink:decreases_degradation_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_degradation_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_degradation_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_degradation_of .

biolink:decreases_expression_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the level of expression of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_0003002,
        <http://translator.ncats.nih.gov/CTD_decreases_expression_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch CHEMBL.MECHANISM:antisense_inhibitor ;
    ns1:relatedMatch <https://www.dgidb.org/interaction_typesantisense>,
        <https://www.dgidb.org/interaction_typesantisense_oligonucleotide> ;
    linkml:definition_uri biolink:decreases_expression_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_expression_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_expression_of ;
    linkml:range biolink:GenomicEntity ;
    linkml:slot_uri biolink:decreases_expression_of .

biolink:decreases_folding_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the rate or quality of folding of the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_folding_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_folding_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_folding_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_folding_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_folding_of .

biolink:decreases_localization_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the proper localization of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_localization_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_localization_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_localization_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_localization_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_localization_of .

biolink:decreases_metabolic_processing_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the rate of metabolic processing of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_metabolic_processing_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_metabolic_processing_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_metabolic_processing_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_metabolic_processing_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_metabolic_processing_of .

biolink:decreases_molecular_interaction a linkml:SlotDefinition ;
    dct:description "indicates that the source decreases the molecular interaction between the target and some other molecular entity" ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_molecular_interaction_with> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_molecular_interaction ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:molecularly_interacts_with ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_molecular_interaction ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_molecular_interaction .

biolink:decreases_molecular_modification_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one leads to decreased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_molecular_modification_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/CTD_decreases_ADP-ribosylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_N-linked_glycosylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_O-linked_glycosylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_acetylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_acylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_alkylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_amination>,
        <http://translator.ncats.nih.gov/CTD_decreases_carbamoylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_carboxylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_ethylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_farnesylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_geranoylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_glucuronidation>,
        <http://translator.ncats.nih.gov/CTD_decreases_glutathionylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_glycation>,
        <http://translator.ncats.nih.gov/CTD_decreases_glycosylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_hydroxylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_lipidation>,
        <http://translator.ncats.nih.gov/CTD_decreases_methylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_myristoylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_nitrosation>,
        <http://translator.ncats.nih.gov/CTD_decreases_nucleotidylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_oxidation>,
        <http://translator.ncats.nih.gov/CTD_decreases_palmitoylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_phosphorylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_prenylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_reduction>,
        <http://translator.ncats.nih.gov/CTD_decreases_ribosylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_sulfation>,
        <http://translator.ncats.nih.gov/CTD_decreases_sumoylation>,
        <http://translator.ncats.nih.gov/CTD_decreases_ubiquitination>,
        <http://translator.renci.org/GAMMA_deoxidizer> ;
    linkml:definition_uri biolink:decreases_molecular_modification_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_molecular_modification_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_molecular_modification_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_molecular_modification_of .

biolink:decreases_mutation_rate_of a linkml:SlotDefinition ;
    dct:description "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity decreases the rate of mutation of the genomic entity within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_decreases_mutagenesis> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_mutation_rate_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_mutation_rate_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_mutation_rate_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_mutation_rate_of ;
    linkml:range biolink:GenomicEntity ;
    linkml:slot_uri biolink:decreases_mutation_rate_of .

biolink:decreases_response_to a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_response_to> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/CTD_decreases_response_to_substance>,
        <http://translator.renci.org/GAMMA_desensitize_the_target> ;
    linkml:definition_uri biolink:decreases_response_to ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_response_to ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_response_to ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_response_to .

biolink:decreases_secretion_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the rate of secretion of the other out of a cell, gland, or organ" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_decreases_export> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_secretion_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_secretion_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_secretion_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_secretion_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_secretion_of .

biolink:decreases_splicing_of a linkml:SlotDefinition ;
    dct:description "holds between a molecular entity and an mRNA where the action or effect of the molecular entity decreases the proper splicing of the mRNA" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_decreases_splicing_of> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_RNA_splicing> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_splicing_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_splicing_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_splicing_of ;
    linkml:range biolink:Transcript ;
    linkml:slot_uri biolink:decreases_splicing_of .

biolink:decreases_stability_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the stability of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_stability_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_stability_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_stability_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_stability_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_stability_of .

biolink:decreases_synthesis_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the rate of chemical synthesis of the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_synthesis_of>,
        <http://translator.renci.org/GAMMA_inhibition_of_synthesis> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_synthesis_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_synthesis_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_synthesis_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_synthesis_of .

biolink:decreases_transport_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the rate of transport of the other across some boundary in a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_transport_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_transport_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_transport_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_transport_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_transport_of .

biolink:decreases_uptake_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one decreases the rate of uptake of the other into of a cell, gland, or organ" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_decreases_import> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_decreases_uptake_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:decreases_uptake_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_uptake_of ;
    linkml:multivalued true ;
    linkml:owner biolink:decreases_uptake_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:decreases_uptake_of .

biolink:directly_interacts_with a linkml:SlotDefinition ;
    dct:description "Holds between molecular entities that physically and directly interact with each other" ;
    ns1:broadMatch <http://semanticscience.org/resource/SIO_000203> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_interacts_with>,
        <http://translator.ncats.nih.gov/chembio_interacts>,
        <http://translator.renci.org/GAMMA_interacts_with> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch DRUGBANK:chelator,
        <http://pharos.nih.govdrug_targets/>,
        <http://translator.ncats.nih.gov/CTD_affects_binding>,
        <http://translator.renci.org/GAMMA_adduct>,
        <http://translator.renci.org/GAMMA_antibody>,
        <http://translator.renci.org/GAMMA_antibody_binding>,
        <http://translator.renci.org/GAMMA_binder>,
        <http://translator.renci.org/GAMMA_binding>,
        <http://translator.renci.org/GAMMA_chaperone>,
        <http://translator.renci.org/GAMMA_cofactor>,
        <http://translator.renci.org/GAMMA_component>,
        <http://translator.renci.org/GAMMA_ligand>,
        <http://translator.renci.org/GAMMA_multitarget>,
        <http://translator.renci.org/GAMMA_pharmacological_chaperone>,
        <http://translator.renci.org/GAMMA_releasing_agent>,
        <https://www.dgidb.org/interaction_typesbinder>,
        <https://www.dgidb.org/interaction_typescofactor> ;
    ns1:relatedMatch <http://translator.renci.org/GAMMA_kb>,
        <http://translator.renci.org/GAMMA_kd>,
        <http://translator.renci.org/GAMMA_potency> ;
    linkml:definition_uri biolink:directly_interacts_with ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:interacts_with ;
    linkml:multivalued true ;
    linkml:owner biolink:directly_interacts_with ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:directly_interacts_with ;
    linkml:symmetric true .

biolink:disease_has_basis_in a linkml:SlotDefinition ;
    dct:description "A relation that holds between a disease and an entity where the state of the entity has contribution to the disease." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:MONDO_disease_has_basis_in_accumulation_of,
        OBO:MONDO_disease_has_basis_in_development_of ;
    linkml:definition_uri biolink:disease_has_basis_in ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:disease_has_basis_in ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:disease_has_basis_in .

biolink:distribution_download_url a linkml:SlotDefinition ;
    ns1:exactMatch dcat:downloadURL ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:distribution_download_url ;
    linkml:domain biolink:DatasetDistribution ;
    linkml:domain_of biolink:DatasetDistribution ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:DatasetDistribution ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:distribution_download_url .

biolink:editor a linkml:SlotDefinition ;
    dct:description "editor of a compiled work such as a book or a periodical (newspaper or an academic journal). Note that in the case of publications which have a containing \"published in\" node property, the editor association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the editorial agent of the encompassing publication (e.g. only from the Book referenced by the 'published_in' property of a book chapter Publication node)." ;
    ns1:exactMatch WIKIDATA_PROPERTY:P98 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:editor ;
    linkml:domain biolink:Publication ;
    linkml:inherited true ;
    linkml:is_a biolink:contributor ;
    linkml:multivalued true ;
    linkml:owner biolink:editor ;
    linkml:range biolink:Agent ;
    linkml:slot_uri biolink:editor .

biolink:end_interbase_coordinate a linkml:SlotDefinition ;
    dct:description "The position at which the subject genomic entity ends on the chromosome or other entity to which it is located on." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:end_interbase_coordinate ;
    linkml:domain biolink:GenomicSequenceLocalization ;
    linkml:domain_of biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:interbase_coordinate ;
    linkml:owner biolink:GenomicSequenceLocalization ;
    linkml:range biolink:integer ;
    linkml:slot_uri biolink:end_interbase_coordinate .

biolink:exacerbates a linkml:SlotDefinition ;
    dct:description "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." ;
    ns1:exactMatch OBO:RO_0003309 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:exacerbates ;
    linkml:domain biolink:BiologicalEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:exacerbates ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_uri biolink:exacerbates .

biolink:filler a linkml:SlotDefinition ;
    dct:description "The value in a property-value tuple" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:filler ;
    linkml:domain biolink:NamedThing ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:filler ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:filler .

biolink:full_name a linkml:SlotDefinition ;
    dct:description "a long-form human readable name for a thing" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:full_name ;
    linkml:domain biolink:NamedThing ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:full_name ;
    linkml:range biolink:label_type ;
    linkml:slot_uri biolink:full_name .

biolink:gene_expression_mixin_quantifier_qualifier a linkml:SlotDefinition ;
    dct:description "Optional quantitative value indicating degree of expression." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLS:measures,
        LOINC:analyzes,
        LOINC:measured_by,
        LOINC:property_of,
        <https://skr3.nlm.nih.gov/SemMedDBmeasures> ;
    ns1:prefLabel "quantifier qualifier" ;
    linkml:definition_uri biolink:quantifier_qualifier ;
    linkml:domain biolink:GeneExpressionMixin ;
    linkml:domain_of biolink:GeneExpressionMixin ;
    linkml:inlined true ;
    linkml:is_a biolink:quantifier_qualifier ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:GeneExpressionMixin ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:quantifier_qualifier ;
    linkml:usage_slot_name "quantifier qualifier" .

biolink:gene_to_disease_association_subject a linkml:SlotDefinition ;
    dct:description "gene in which variation is correlated with the disease, may be protective or causative or associative, or as a model" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneToDiseaseAssociation ;
    linkml:domain_of biolink:GeneToDiseaseAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToDiseaseAssociation ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:genetically_interacts_with a linkml:SlotDefinition ;
    dct:description "holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_0002435 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:genetically_interacts_with ;
    linkml:domain biolink:Gene ;
    linkml:inherited true ;
    linkml:is_a biolink:interacts_with ;
    linkml:multivalued true ;
    linkml:owner biolink:genetically_interacts_with ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:genetically_interacts_with ;
    linkml:symmetric true .

biolink:genome_build a linkml:SlotDefinition ;
    dct:description "The version of the genome on which a feature is located. For example, GRCh38 for Homo sapiens." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:genome_build ;
    linkml:domain biolink:GenomicSequenceLocalization ;
    linkml:domain_of biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:sequence_localization_attribute ;
    linkml:owner biolink:GenomicSequenceLocalization ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:genome_build .

biolink:has_chemical_formula a linkml:SlotDefinition ;
    dct:description "description of chemical compound based on element symbols" ;
    ns1:exactMatch WIKIDATA_PROPERTY:P274 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_chemical_formula ;
    linkml:domain biolink:NamedThing ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:has_chemical_formula ;
    linkml:range biolink:chemical_formula_value ;
    linkml:slot_uri biolink:has_chemical_formula .

biolink:has_completed a linkml:SlotDefinition ;
    dct:description "holds between an entity and a process that the entity is capable of and has completed" ;
    ns1:exactMatch RTXKG1:has_completed,
        OBO:CL_has_completed ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_completed ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:has_completed ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_completed .

biolink:has_confidence_level a linkml:SlotDefinition ;
    dct:description "connects an association to a qualitative term denoting the level of confidence" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_confidence_level ;
    linkml:domain biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:has_confidence_level ;
    linkml:range biolink:ConfidenceLevel ;
    linkml:slot_uri biolink:has_confidence_level .

biolink:has_decreased_amount a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:CL_has_low_plasma_membrane_amount ;
    linkml:definition_uri biolink:has_decreased_amount ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:has_decreased_amount ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_decreased_amount .

biolink:has_device a linkml:SlotDefinition ;
    dct:description "connects an entity to one or more (medical) devices" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_device ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:Treatment ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:Treatment ;
    linkml:range biolink:Device ;
    linkml:slot_uri biolink:has_device .

biolink:has_drug a linkml:SlotDefinition ;
    dct:description "connects an entity to one or more drugs" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_drug ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:Treatment ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:Treatment ;
    linkml:range biolink:Drug ;
    linkml:slot_uri biolink:has_drug .

biolink:has_evidence a linkml:SlotDefinition ;
    dct:description "connects an association to an instance of supporting evidence" ;
    ns1:exactMatch OBO:RO_0002558 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_evidence ;
    linkml:domain biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:has_evidence ;
    linkml:range biolink:EvidenceType ;
    linkml:slot_uri biolink:has_evidence .

biolink:has_increased_amount a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:CL_has_high_plasma_membrane_amount ;
    linkml:definition_uri biolink:has_increased_amount ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:has_increased_amount ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_increased_amount .

biolink:has_molecular_consequence a linkml:SlotDefinition ;
    dct:description "connects a sequence variant to a class describing the molecular consequence. E.g.  SO:0001583" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_allele_has_activity ;
    linkml:definition_uri biolink:has_molecular_consequence ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:has_molecular_consequence ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:has_molecular_consequence .

biolink:has_not_completed a linkml:SlotDefinition ;
    dct:description "holds between an entity and a process that the entity is capable of, but has not completed" ;
    ns1:exactMatch OBO:CL_has_not_completed ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_not_completed ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:has_not_completed ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_not_completed .

biolink:has_numeric_value a linkml:SlotDefinition ;
    dct:description "connects a quantity value to a number" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:exactMatch qud:quantityValue ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_numeric_value ;
    linkml:domain biolink:QuantityValue ;
    linkml:domain_of biolink:QuantityValue ;
    linkml:owner biolink:QuantityValue ;
    linkml:range biolink:double ;
    linkml:slot_uri biolink:has_numeric_value .

biolink:has_population_context a linkml:SlotDefinition ;
    dct:description "a biological population (general, study, cohort, etc.) with a specific set of characteristics to constrain an association." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_population_context ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:ExposureEventToOutcomeAssociation ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:ExposureEventToOutcomeAssociation ;
    linkml:range biolink:PopulationOfIndividualOrganisms ;
    linkml:slot_uri biolink:has_population_context .

biolink:has_procedure a linkml:SlotDefinition ;
    dct:description "connects an entity to one or more (medical) procedures" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_procedure ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:Treatment ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:Treatment ;
    linkml:range biolink:Procedure ;
    linkml:slot_uri biolink:has_procedure .

biolink:has_receptor a linkml:SlotDefinition ;
    dct:description "the organism or organism part being exposed" ;
    ns1:exactMatch OBO:ExO_0000001 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_receptor ;
    linkml:domain biolink:ExposureEvent ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:has_receptor ;
    linkml:range biolink:OrganismalEntity ;
    linkml:slot_uri biolink:has_receptor .

biolink:has_route a linkml:SlotDefinition ;
    dct:description "the process that results in the stressor coming into direct contact with the receptor" ;
    ns1:exactMatch OBO:ExO_0000055 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_pharmaceutical_route,
        OBO:SNOMED_has_dose_form_intended_site,
        OBO:SNOMED_has_route_of_administration ;
    linkml:definition_uri biolink:has_route ;
    linkml:domain biolink:ExposureEvent ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:has_route ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:has_route .

biolink:has_stressor a linkml:SlotDefinition ;
    dct:description "the process or entity that the receptor is being exposed to" ;
    ns1:altLabel "has stimulus" ;
    ns1:exactMatch OBO:ExO_0000000 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_stressor ;
    linkml:domain biolink:ExposureEvent ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:has_stressor ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:has_stressor .

biolink:has_taxonomic_rank a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation WIKIDATA:P105 ;
    linkml:inlined true ;
    linkml:range biolink:TaxonomicRank ;
    linkml:slot_uri biolink:has_taxonomic_rank .

biolink:has_temporal_context a linkml:SlotDefinition ;
    dct:description "a constraint of time placed upon the truth value of an association." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_temporal_context ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:ExposureEventToOutcomeAssociation ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:ExposureEventToOutcomeAssociation ;
    linkml:range biolink:time_type ;
    linkml:slot_uri biolink:has_temporal_context .

biolink:has_topic a linkml:SlotDefinition ;
    dct:description "Connects a node to a vocabulary term or ontology class that describes some aspect of the entity. In general specific characterization is preferred. See https://github.com/biolink/biolink-model/issues/238" ;
    ns1:altLabel "descriptors",
        "topic" ;
    ns1:exactMatch foaf:topic ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_topic ;
    linkml:domain biolink:NamedThing ;
    linkml:inlined true ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:has_topic ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:has_topic .

biolink:has_unit a linkml:SlotDefinition ;
    dct:description "connects a quantity value to a unit" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:closeMatch <http://purl.obolibrary.org/obo/uo#is_unit_of>,
        <http://www.ebi.ac.uk/efo/EFO_0001697> ;
    ns1:exactMatch OBO:IAO_0000039,
        qud:unit ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:SNOMED_has_concentration_strength_denominator_unit,
        OBO:SNOMED_has_concentration_strength_numerator_unit,
        OBO:SNOMED_has_presentation_strength_denominator_unit,
        OBO:SNOMED_has_presentation_strength_numerator_unit,
        OBO:SNOMED_has_unit_of_presentation ;
    linkml:definition_uri biolink:has_unit ;
    linkml:domain biolink:QuantityValue ;
    linkml:domain_of biolink:QuantityValue ;
    linkml:owner biolink:QuantityValue ;
    linkml:range biolink:unit ;
    linkml:slot_uri biolink:has_unit .

biolink:in_cell_population_with a linkml:SlotDefinition ;
    dct:description "holds between two genes or gene products that are expressed in the same cell type or population" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:in_cell_population_with ;
    linkml:domain biolink:GeneOrGeneProduct ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:coexists_with ;
    linkml:multivalued true ;
    linkml:owner biolink:in_cell_population_with ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:slot_uri biolink:in_cell_population_with ;
    linkml:symmetric true .

biolink:in_complex_with a linkml:SlotDefinition ;
    dct:description "holds between two genes or gene products that are part of (or code for products that are part of) in the same macromolecular complex mixin" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://semanticscience.org/resource/SIO_010285> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch <http://semanticscience.org/resource/SIO_010497> ;
    linkml:definition_uri biolink:in_complex_with ;
    linkml:domain biolink:GeneOrGeneProduct ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:coexists_with ;
    linkml:multivalued true ;
    linkml:owner biolink:in_complex_with ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:slot_uri biolink:in_complex_with ;
    linkml:symmetric true .

biolink:in_linkage_disequilibrium_with a linkml:SlotDefinition ;
    dct:description "holds between two sequence variants, the presence of which are correlated in a population" ;
    ns1:exactMatch OBO:NCIT_C16798 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:in_linkage_disequilibrium_with ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:in_linkage_disequilibrium_with ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:in_linkage_disequilibrium_with ;
    linkml:symmetric true .

biolink:in_pathway_with a linkml:SlotDefinition ;
    dct:description "holds between two genes or gene products that are part of in the same biological pathway" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch <http://semanticscience.org/resource/SIO_010532> ;
    linkml:definition_uri biolink:in_pathway_with ;
    linkml:domain biolink:GeneOrGeneProduct ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:coexists_with ;
    linkml:multivalued true ;
    linkml:owner biolink:in_pathway_with ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:slot_uri biolink:in_pathway_with ;
    linkml:symmetric true .

biolink:increases_abundance_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the amount of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_abundance_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch UBERGRAPH:is_increase_of ;
    linkml:definition_uri biolink:increases_abundance_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_abundance_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_abundance_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_abundance_of .

biolink:increases_activity_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the activity of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_activity_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.renci.org/GAMMA_activator>,
        <http://translator.renci.org/GAMMA_agonist>,
        <http://translator.renci.org/GAMMA_inducer>,
        <http://translator.renci.org/GAMMA_opener>,
        <http://translator.renci.org/GAMMA_partial_agonist>,
        <http://translator.renci.org/GAMMA_positive_allosteric_modulator>,
        <http://translator.renci.org/GAMMA_positive_modulator>,
        <http://translator.renci.org/GAMMA_potentiator>,
        <http://translator.renci.org/GAMMA_stimulator>,
        <https://www.dgidb.org/interaction_typesagonist>,
        <https://www.dgidb.org/interaction_typesinducer>,
        <https://www.dgidb.org/interaction_typespartial_agonist>,
        <https://www.dgidb.org/interaction_typespositive_allosteric_modulator>,
        <https://www.dgidb.org/interaction_typesstimulator>,
        CHEMBL.MECHANISM:agonist,
        CHEMBL.MECHANISM:opener,
        CHEMBL.MECHANISM:partial_agonist,
        CHEMBL.MECHANISM:positive_allosteric_modulator,
        CHEMBL.MECHANISM:positive_modulator ;
    ns1:relatedMatch <http://translator.renci.org/GAMMA_ac50>,
        <http://translator.renci.org/GAMMA_ec50> ;
    linkml:definition_uri biolink:increases_activity_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_activity_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_activity_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_activity_of .

biolink:increases_degradation_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the rate of degradation of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch CHEMBL.MECHANISM:degrader,
        CHEMBL.MECHANISM:hydrolytic_enzyme,
        CHEMBL.MECHANISM:proteolytic_enzyme ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_degradation_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:GOREL_0002004,
        <http://translator.ncats.nih.gov/CTD_increases_cleavage>,
        <http://translator.ncats.nih.gov/CTD_increases_hydrolysis> ;
    ns1:relatedMatch <http://translator.renci.org/GAMMA_substrate>,
        CHEMBL.MECHANISM:substrate ;
    linkml:definition_uri biolink:increases_degradation_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_degradation_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_degradation_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_degradation_of .

biolink:increases_expression_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the level of expression of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch CHEMBL.MECHANISM:releasing_agent ;
    ns1:exactMatch OBO:RO_0003003,
        <http://translator.ncats.nih.gov/CTD_increases_expression_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_expression_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_expression_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_expression_of ;
    linkml:range biolink:GenomicEntity ;
    linkml:slot_uri biolink:increases_expression_of .

biolink:increases_folding_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the rate or quality of folding of the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_folding_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_folding_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_folding_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_folding_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_folding_of .

biolink:increases_localization_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the proper localization of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_localization_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_localization_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_localization_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_localization_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_localization_of .

biolink:increases_metabolic_processing_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the rate of metabolic processing of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_metabolic_processing_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_enzyme_metabolizes_chemical_or_drug ;
    linkml:definition_uri biolink:increases_metabolic_processing_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_metabolic_processing_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_metabolic_processing_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_metabolic_processing_of .

biolink:increases_molecular_interaction a linkml:SlotDefinition ;
    dct:description "indicates that the source increases the molecular interaction between the target and some other molecular entity" ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_molecular_interaction_with> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_molecular_interaction ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:molecularly_interacts_with ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_molecular_interaction ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_molecular_interaction .

biolink:increases_molecular_modification_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one leads to increased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_molecular_modification_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/CTD_increases_ADP-ribosylation>,
        <http://translator.ncats.nih.gov/CTD_increases_N-linked_glycosylation>,
        <http://translator.ncats.nih.gov/CTD_increases_O-linked_glycosylation>,
        <http://translator.ncats.nih.gov/CTD_increases_acetylation>,
        <http://translator.ncats.nih.gov/CTD_increases_acylation>,
        <http://translator.ncats.nih.gov/CTD_increases_alkylation>,
        <http://translator.ncats.nih.gov/CTD_increases_amination>,
        <http://translator.ncats.nih.gov/CTD_increases_carbamoylation>,
        <http://translator.ncats.nih.gov/CTD_increases_carboxylation>,
        <http://translator.ncats.nih.gov/CTD_increases_ethylation>,
        <http://translator.ncats.nih.gov/CTD_increases_farnesylation>,
        <http://translator.ncats.nih.gov/CTD_increases_geranoylation>,
        <http://translator.ncats.nih.gov/CTD_increases_glucuronidation>,
        <http://translator.ncats.nih.gov/CTD_increases_glutathionylation>,
        <http://translator.ncats.nih.gov/CTD_increases_glycation>,
        <http://translator.ncats.nih.gov/CTD_increases_glycosylation>,
        <http://translator.ncats.nih.gov/CTD_increases_hydroxylation>,
        <http://translator.ncats.nih.gov/CTD_increases_lipidation>,
        <http://translator.ncats.nih.gov/CTD_increases_methylation>,
        <http://translator.ncats.nih.gov/CTD_increases_myristoylation>,
        <http://translator.ncats.nih.gov/CTD_increases_nitrosation>,
        <http://translator.ncats.nih.gov/CTD_increases_nucleotidylation>,
        <http://translator.ncats.nih.gov/CTD_increases_oxidation>,
        <http://translator.ncats.nih.gov/CTD_increases_palmitoylation>,
        <http://translator.ncats.nih.gov/CTD_increases_phosphorylation>,
        <http://translator.ncats.nih.gov/CTD_increases_prenylation>,
        <http://translator.ncats.nih.gov/CTD_increases_reduction>,
        <http://translator.ncats.nih.gov/CTD_increases_ribosylation>,
        <http://translator.ncats.nih.gov/CTD_increases_sulfation>,
        <http://translator.ncats.nih.gov/CTD_increases_sumoylation>,
        <http://translator.ncats.nih.gov/CTD_increases_ubiquitination>,
        <http://translator.renci.org/GAMMA_acetylation>,
        <http://translator.renci.org/GAMMA_oxidizer> ;
    linkml:definition_uri biolink:increases_molecular_modification_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_molecular_modification_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_molecular_modification_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_molecular_modification_of .

biolink:increases_mutation_rate_of a linkml:SlotDefinition ;
    dct:description "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity increases the rate of mutation of the genomic entity within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_increases_mutagenesis> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_mutation_rate_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_mutation_rate_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_mutation_rate_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_mutation_rate_of ;
    linkml:range biolink:GenomicEntity ;
    linkml:slot_uri biolink:increases_mutation_rate_of .

biolink:increases_response_to a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_response_to> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_response_to ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_response_to ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_response_to ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_response_to .

biolink:increases_secretion_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the rate of secretion of the other out of a cell, gland, or organ" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_increases_export> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_secretion_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_secretion_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_secretion_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_secretion_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_secretion_of .

biolink:increases_splicing_of a linkml:SlotDefinition ;
    dct:description "holds between a molecular entity and an mRNA where the action or effect of the molecular entity increases the proper splicing of the mRNA" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_increases_splicing_of> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_RNA_splicing> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_splicing_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_splicing_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_splicing_of ;
    linkml:range biolink:Transcript ;
    linkml:slot_uri biolink:increases_splicing_of .

biolink:increases_stability_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the stability of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch CHEMBL.MECHANISM:stabiliser ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_stability_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_stability_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_stability_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_stability_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_stability_of .

biolink:increases_synthesis_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the rate of chemical synthesis of the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_synthesis_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_synthesis_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_synthesis_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_synthesis_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_synthesis_of .

biolink:increases_transport_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the rate of transport of the other across some boundary in a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch <http://translator.renci.org/GAMMA_carrier>,
        <http://translator.renci.org/GAMMA_transporter> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_transport_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_transport_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_transport_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_transport_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_transport_of .

biolink:increases_uptake_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one increases the rate of uptake of the other into of a cell, gland, or organ" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_increases_import> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_increases_uptake_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:increases_uptake_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_uptake_of ;
    linkml:multivalued true ;
    linkml:owner biolink:increases_uptake_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:increases_uptake_of .

biolink:interacting_molecules_category a linkml:SlotDefinition ;
    ns1:exactMatch OBO:MI_1046 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:interacting_molecules_category ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:PairwiseMolecularInteraction ;
    linkml:examples [ a linkml:Example ;
            dct:description "smallmolecule-protein" ;
            ns1:example "MI:1048" ] ;
    linkml:inlined true ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:PairwiseMolecularInteraction ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:interacting_molecules_category ;
    linkml:values_from biolink:MI .

biolink:is_frameshift_variant_of a linkml:SlotDefinition ;
    dct:description "holds between a sequence variant and a gene, such the sequence variant causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three." ;
    ns1:exactMatch OBO:SO_0001589,
        <http://translator.ncats.nih.gov/SNPEFF_frameshift_variant> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/SNPEFF_start_lost>,
        <http://translator.ncats.nih.gov/SNPEFF_stop_lost> ;
    linkml:definition_uri biolink:is_frameshift_variant_of ;
    linkml:domain biolink:SequenceVariant ;
    linkml:inherited true ;
    linkml:is_a biolink:is_sequence_variant_of ;
    linkml:multivalued true ;
    linkml:owner biolink:is_frameshift_variant_of ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:is_frameshift_variant_of .

biolink:is_missense_variant_of a linkml:SlotDefinition ;
    dct:description "holds between a gene  and a sequence variant, such the sequence variant results in a different amino acid sequence but where the length is preserved." ;
    ns1:exactMatch OBO:SO_0001583,
        <http://translator.ncats.nih.gov/SNPEFF_missense_variant> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/SNPEFF_initiator_codon_variant>,
        <http://translator.ncats.nih.gov/SNPEFF_structural_interaction_variant> ;
    linkml:definition_uri biolink:is_missense_variant_of ;
    linkml:domain biolink:SequenceVariant ;
    linkml:inherited true ;
    linkml:is_a biolink:is_sequence_variant_of ;
    linkml:multivalued true ;
    linkml:owner biolink:is_missense_variant_of ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:is_missense_variant_of .

biolink:is_nearby_variant_of a linkml:SlotDefinition ;
    dct:description "holds between a sequence variant and a gene sequence that the variant is genomically close to." ;
    ns1:exactMatch <http://translator.renci.org/GAMMA_0000102> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/SNPEFF_downstream_gene_variant>,
        <http://translator.ncats.nih.gov/SNPEFF_upstream_gene_variant> ;
    linkml:definition_uri biolink:is_nearby_variant_of ;
    linkml:domain biolink:SequenceVariant ;
    linkml:inherited true ;
    linkml:is_a biolink:is_sequence_variant_of ;
    linkml:multivalued true ;
    linkml:owner biolink:is_nearby_variant_of ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:is_nearby_variant_of .

biolink:is_non_coding_variant_of a linkml:SlotDefinition ;
    dct:description "holds between a sequence variant and a gene, where the variant does not affect the coding sequence" ;
    ns1:exactMatch <http://translator.renci.org/GAMMA_0000103> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/SNPEFF_3_prime_UTR_variant>,
        <http://translator.ncats.nih.gov/SNPEFF_5_prime_UTR_premature_start_codon_gain_variant>,
        <http://translator.ncats.nih.gov/SNPEFF_5_prime_UTR_variant>,
        <http://translator.ncats.nih.gov/SNPEFF_intron_variant>,
        <http://translator.ncats.nih.gov/SNPEFF_non_coding_transcript_exon_variant> ;
    linkml:definition_uri biolink:is_non_coding_variant_of ;
    linkml:domain biolink:SequenceVariant ;
    linkml:inherited true ;
    linkml:is_a biolink:is_sequence_variant_of ;
    linkml:multivalued true ;
    linkml:owner biolink:is_non_coding_variant_of ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:is_non_coding_variant_of .

biolink:is_nonsense_variant_of a linkml:SlotDefinition ;
    dct:description "holds between a sequence variant and a gene, such the sequence variant results in a premature stop codon" ;
    ns1:broadMatch OBO:SO_0002054 ;
    ns1:exactMatch <http://translator.ncats.nih.gov/SNPEFF_stop_gained> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:is_nonsense_variant_of ;
    linkml:domain biolink:SequenceVariant ;
    linkml:inherited true ;
    linkml:is_a biolink:is_sequence_variant_of ;
    linkml:multivalued true ;
    linkml:owner biolink:is_nonsense_variant_of ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:is_nonsense_variant_of .

biolink:is_splice_site_variant_of a linkml:SlotDefinition ;
    dct:description "holds between a sequence variant and a gene, such the sequence variant is in the canonical splice site of one of the gene's exons." ;
    ns1:exactMatch OBO:SO_0001629 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/SNPEFF_splice_acceptor_variant>,
        <http://translator.ncats.nih.gov/SNPEFF_splice_donor_variant>,
        <http://translator.ncats.nih.gov/SNPEFF_splice_region_variant> ;
    linkml:definition_uri biolink:is_splice_site_variant_of ;
    linkml:domain biolink:SequenceVariant ;
    linkml:inherited true ;
    linkml:is_a biolink:is_sequence_variant_of ;
    linkml:multivalued true ;
    linkml:owner biolink:is_splice_site_variant_of ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:is_splice_site_variant_of .

biolink:is_synonymous_variant_of a linkml:SlotDefinition ;
    dct:description "holds between a sequence variant and a gene, such the sequence variant is in the coding sequence of the gene, but results in the same amino acid sequence" ;
    ns1:exactMatch OBO:SO_0001819,
        <http://translator.ncats.nih.gov/SNPEFF_synonymous_variant> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/SNPEFF_start_retained>,
        <http://translator.ncats.nih.gov/SNPEFF_stop_retained_variant> ;
    linkml:definition_uri biolink:is_synonymous_variant_of ;
    linkml:domain biolink:SequenceVariant ;
    linkml:inherited true ;
    linkml:is_a biolink:is_sequence_variant_of ;
    linkml:multivalued true ;
    linkml:owner biolink:is_synonymous_variant_of ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:is_synonymous_variant_of .

biolink:lacks_part a linkml:SlotDefinition ;
    ns1:exactMatch RTXKG1:lacks_part,
        OBO:CL_lacks_part,
        OBO:PR_lacks_part ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:CL_lacks_plasma_membrane_part ;
    linkml:definition_uri biolink:lacks_part ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:lacks_part ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:lacks_part .

biolink:logical_interpretation a linkml:SlotDefinition ;
    ns1:exactMatch <https://github.com/cmungall/owlstar/blob/master/owlstar.ttlLogicalInterpretation> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:logical_interpretation ;
    linkml:domain biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:logical_interpretation ;
    linkml:range biolink:logical_interpretation_enum ;
    linkml:slot_uri biolink:logical_interpretation .

biolink:manifestation_of a linkml:SlotDefinition ;
    dct:description "that part of a phenomenon which is directly observable or visibly expressed, or which gives evidence to the underlying process; used in SemMedDB for linking things like dysfunctions and processes to some disease or syndrome" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch WIKIDATA_PROPERTY:P1557 ;
    ns1:exactMatch OBO:OMIM_manifestation_of,
        <https://skr3.nlm.nih.gov/SemMedDBMANIFESTATION_OF>,
        <https://skr3.nlm.nih.gov/SemMedDBmanifestation_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:SNOMED_has_definitional_manifestation ;
    linkml:definition_uri biolink:manifestation_of ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:manifestation_of ;
    linkml:range biolink:Disease ;
    linkml:slot_uri biolink:manifestation_of .

biolink:molecular_entity_to_entity_association_mixin_subject a linkml:SlotDefinition ;
    dct:description "the molecular entity that is an interactor" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:MolecularEntityToEntityAssociationMixin ;
    linkml:domain_of biolink:MolecularEntityToEntityAssociationMixin ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:MolecularEntityToEntityAssociationMixin ;
    linkml:range biolink:MolecularEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:negatively_correlated_with a linkml:SlotDefinition ;
    dct:description "holds between any two named thing entities \"correlated with\" one another in a negative manner." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_negative_correlation> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:negatively_correlated_with ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:correlated_with ;
    linkml:multivalued true ;
    linkml:owner biolink:negatively_correlated_with ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:negatively_correlated_with ;
    linkml:symmetric true .

biolink:occurs_in a linkml:SlotDefinition ;
    dct:description "holds between a process and a material entity or site within which the process occurs" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch OBO:BFO_0000067,
        OBO:SNOMED_has_occurrence,
        OBO:UBERON_site_of ;
    ns1:exactMatch OBO:BFO_0000066,
        OBO:SNOMED_occurs_in,
        PathWhiz:has_location ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_imaged_location,
        OBO:RO_0002231,
        OBO:RO_0002232,
        OBO:SNOMED_has_direct_procedure_site,
        OBO:SNOMED_has_direct_site,
        OBO:SNOMED_has_procedure_site,
        UBERON_CORE:site_of,
        PathWhiz:in_species,
        <https://skr3.nlm.nih.gov/SemMedDBOCCURS_IN>,
        <https://skr3.nlm.nih.gov/SemMedDBPROCESS_OF>,
        <https://skr3.nlm.nih.gov/SemMedDBoccurs_in>,
        <https://skr3.nlm.nih.gov/SemMedDBprocess_of> ;
    linkml:definition_uri biolink:occurs_in ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:occurs_in ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:occurs_in .

biolink:opposite_of a linkml:SlotDefinition ;
    dct:description "x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x). (This description is from RO. Needs to be rephrased)." ;
    rdfs:seeAlso <https://doi.org/10.1101/108977>,
        <https://github.com/biolink/biolink-model/issues/657> ;
    ns1:exactMatch OBO:RO_0002604 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:opposite_of ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:opposite_of ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:opposite_of ;
    linkml:symmetric true .

biolink:organism_taxon_to_organism_taxon_association_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:range biolink:OrganismTaxon ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:organism_taxon_to_organism_taxon_association_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:range biolink:OrganismTaxon ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:orthologous_to a linkml:SlotDefinition ;
    dct:description "a homology relationship between entities (typically genes) that diverged after a speciation event." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_HOM0000017,
        WIKIDATA_PROPERTY:P684 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:orthologous_to ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:homologous_to ;
    linkml:multivalued true ;
    linkml:owner biolink:orthologous_to ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:orthologous_to ;
    linkml:symmetric true .

biolink:p_value a linkml:SlotDefinition ;
    dct:description "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone." ;
    ns1:exactMatch <http://edamontology.org/data_1669>,
        OBO:NCIT_C44185,
        OBO:OBI_0000175 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:p_value ;
    linkml:domain biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:p_value ;
    linkml:range biolink:float ;
    linkml:slot_uri biolink:p_value .

biolink:paralogous_to a linkml:SlotDefinition ;
    dct:description "a homology relationship that holds between entities (typically genes) that diverged after a duplication event." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_HOM0000011 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:paralogous_to ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:homologous_to ;
    linkml:multivalued true ;
    linkml:owner biolink:paralogous_to ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:paralogous_to ;
    linkml:symmetric true .

biolink:positively_correlated_with a linkml:SlotDefinition ;
    dct:description "holds between any two named thing entities \"correlated with\" one another in a positive manner." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_positive_correlation> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:positively_correlated_with ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:correlated_with ;
    linkml:multivalued true ;
    linkml:owner biolink:positively_correlated_with ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:positively_correlated_with ;
    linkml:symmetric true .

biolink:predisposes a linkml:SlotDefinition ;
    dct:description "holds between two entities where exposure to one entity increases the chance of developing the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <https://skr3.nlm.nih.gov/SemMedDBPREDISPOSES>,
        <https://skr3.nlm.nih.gov/SemMedDBpredisposes> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:predisposes ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_risk_for ;
    linkml:multivalued true ;
    linkml:owner biolink:predisposes ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:predisposes .

biolink:provider a linkml:SlotDefinition ;
    dct:description "person, group, organization or project that provides a piece of information (e.g. a knowledge association)." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:provider ;
    linkml:domain biolink:InformationContentEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:contributor ;
    linkml:multivalued true ;
    linkml:owner biolink:provider ;
    linkml:range biolink:Agent ;
    linkml:slot_uri biolink:provider .

biolink:publisher a linkml:SlotDefinition ;
    dct:description "organization or person responsible for publishing books, periodicals, podcasts, games or software. Note that in the case of publications which have a containing \"published in\" node property, the publisher association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the publisher agent of the encompassing publication (e.g. only from the Journal referenced by the 'published_in' property of an journal article Publication node)." ;
    ns1:exactMatch dct:publisher,
        WIKIDATA_PROPERTY:P123 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:publisher ;
    linkml:domain biolink:Publication ;
    linkml:inherited true ;
    linkml:is_a biolink:contributor ;
    linkml:multivalued true ;
    linkml:owner biolink:publisher ;
    linkml:range biolink:Agent ;
    linkml:slot_uri biolink:publisher .

biolink:retrieved_on a linkml:SlotDefinition ;
    ns1:exactMatch pav:retrievedOn ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:retrieved_on ;
    linkml:domain biolink:Dataset ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:retrieved_on ;
    linkml:range biolink:date ;
    linkml:slot_uri biolink:retrieved_on .

biolink:same_as a linkml:SlotDefinition ;
    dct:description "holds between two entities that are considered equivalent to each other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch owl:equivalentClass ;
    ns1:exactMatch OBO:MONDO_equivalentTo,
        owl:sameAs,
        CHEMBL.MECHANISM:equivalent_to,
        skos:exactMatch,
        WIKIDATA_PROPERTY:P2888 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch DRUGBANK:external-identifier ;
    linkml:definition_uri biolink:same_as ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:exact_match ;
    linkml:multivalued true ;
    linkml:owner biolink:same_as ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:same_as ;
    linkml:symmetric true .

biolink:sequence_variant_qualifier a linkml:SlotDefinition ;
    dct:description "a qualifier used in an association with the variant" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:sequence_variant_qualifier ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:GeneHasVariantThatContributesToDiseaseAssociation ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:GeneHasVariantThatContributesToDiseaseAssociation ;
    linkml:range biolink:SequenceVariant ;
    linkml:slot_uri biolink:sequence_variant_qualifier .

biolink:source_web_page a linkml:SlotDefinition ;
    ns1:broadMatch dct:source ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:source_web_page ;
    linkml:domain biolink:DatasetSummary ;
    linkml:domain_of biolink:DatasetSummary ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:DatasetSummary ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:source_web_page .

biolink:start_interbase_coordinate a linkml:SlotDefinition ;
    dct:description "The position at which the subject genomic entity starts on the chromosome or other entity to which it is located on." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:start_interbase_coordinate ;
    linkml:domain biolink:GenomicSequenceLocalization ;
    linkml:domain_of biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:interbase_coordinate ;
    linkml:owner biolink:GenomicSequenceLocalization ;
    linkml:range biolink:integer ;
    linkml:slot_uri biolink:start_interbase_coordinate .

biolink:strand a linkml:SlotDefinition ;
    dct:description "The strand on which a feature is located. Has a value of '+' (sense strand or forward strand) or '-' (anti-sense strand or reverse strand)." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:strand ;
    linkml:domain biolink:GenomicSequenceLocalization ;
    linkml:domain_of biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:sequence_localization_attribute ;
    linkml:owner biolink:GenomicSequenceLocalization ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:strand .

biolink:update_date a linkml:SlotDefinition ;
    dct:description "date on which an entity was updated. This can be applied to nodes or edges" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:update_date ;
    linkml:domain biolink:NamedThing ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:update_date ;
    linkml:range biolink:date ;
    linkml:slot_uri biolink:update_date .

biolink:version a linkml:SlotDefinition ;
    ns1:broadMatch pav:version,
        owl:versionInfo ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:version ;
    linkml:domain biolink:Dataset ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:version ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:version .

biolink:version_of a linkml:SlotDefinition ;
    ns1:exactMatch dct:isVersionOf ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:version_of ;
    linkml:domain biolink:DatasetVersion ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:version_of ;
    linkml:range biolink:DatasetSummary ;
    linkml:slot_uri biolink:version_of .

biolink:xenologous_to a linkml:SlotDefinition ;
    dct:description "a homology relationship characterized by an interspecies (horizontal) transfer since the common ancestor." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_HOM0000018 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:xenologous_to ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:homologous_to ;
    linkml:multivalued true ;
    linkml:owner biolink:xenologous_to ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:xenologous_to ;
    linkml:symmetric true .

biolink:ActivityAndBehavior a linkml:ClassDefinition ;
    dct:description "Activity or behavior of any independent integral living, organization or mechanical actor in the world" ;
    ns1:exactMatch UMLSSG:ACTI ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ActivityAndBehavior ;
    linkml:definition_uri biolink:ActivityAndBehavior ;
    linkml:is_a biolink:Occurrent ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:Annotation a linkml:ClassDefinition ;
    dct:description "Biolink Model root class for entity annotations." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:class_uri biolink:Annotation ;
    linkml:definition_uri biolink:Annotation ;
    linkml:slot_usage [ ] .

biolink:CellLine a linkml:ClassDefinition ;
    ns1:exactMatch OBO:CLO_0000031 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:CellLine ;
    linkml:definition_uri biolink:CellLine ;
    linkml:id_prefixes "CLO" ;
    linkml:is_a biolink:OrganismalEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:ClinicalEntity a linkml:ClassDefinition ;
    dct:description "Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ClinicalEntity ;
    linkml:definition_uri biolink:ClinicalEntity ;
    linkml:is_a biolink:NamedThing ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:GeneOntologyClass a linkml:ClassDefinition ;
    dct:description "an ontology class that describes a functional aspect of a gene, gene prodoct or complex" ;
    oboInOwl:inSubset biolink:testing ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneOntologyClass ;
    linkml:definition_uri biolink:GeneOntologyClass ;
    linkml:is_a biolink:OntologyClass ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:GeneProductIsoformMixin a linkml:ClassDefinition ;
    dct:description "This is an abstract class that can be mixed in with different kinds of gene products to indicate that the gene product is intended to represent a specific isoform rather than a canonical or reference or generic product. The designation of canonical or reference may be arbitrary, or it may represent the superclass of all isoforms." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneProductIsoformMixin ;
    linkml:definition_uri biolink:GeneProductIsoformMixin ;
    linkml:is_a biolink:GeneProductMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:macromolecular_machine_mixin_name,
        biolink:synonym,
        biolink:xref .

biolink:LifeStage a linkml:ClassDefinition ;
    dct:description "A stage of development or growth of an organism, including post-natal adult stages" ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:exactMatch OBO:UBERON_0000105 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:HsapDv_0000000 ;
    linkml:class_uri biolink:LifeStage ;
    linkml:definition_uri biolink:LifeStage ;
    linkml:is_a biolink:OrganismalEntity ;
    linkml:mixins biolink:ThingWithTaxon ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:MaterialSample a linkml:ClassDefinition ;
    dct:description "A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a substance) to be used for testing, analysis, inspection, investigation, demonstration, or trial use. [SIO]" ;
    ns1:altLabel "biosample",
        "biospecimen",
        "physical sample",
        "sample" ;
    ns1:exactMatch OBO:OBI_0000747,
        <http://semanticscience.org/resource/SIO_001050> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MaterialSample ;
    linkml:definition_uri biolink:MaterialSample ;
    linkml:id_prefixes "BIOSAMPLE",
        "GOLD.META" ;
    linkml:is_a biolink:PhysicalEntity ;
    linkml:mixins biolink:SubjectOfInvestigation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:NoncodingRNAProduct a linkml:ClassDefinition ;
    ns1:exactMatch OBO:SO_0000655,
        <http://semanticscience.org/resource/SIO_001235> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:NoncodingRNAProduct ;
    linkml:definition_uri biolink:NoncodingRNAProduct ;
    linkml:id_prefixes "ENSEMBL",
        "NCBIGene",
        "RNACENTRAL" ;
    linkml:is_a biolink:RNAProduct ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:synonym,
        biolink:type,
        biolink:xref .

biolink:Nutrient a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch OBO:CHEBI_33284 ;
    linkml:class_uri biolink:Nutrient ;
    linkml:definition_uri biolink:Nutrient ;
    linkml:is_a biolink:ChemicalSubstance ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:OrganismAttribute a linkml:ClassDefinition ;
    dct:description "describes a characteristic of an organismal entity." ;
    ns1:exactMatch UMLSSC:T032,
        UMLSST:orga ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:OrganismAttribute ;
    linkml:definition_uri biolink:OrganismAttribute ;
    linkml:is_a biolink:Attribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:PathologicalAnatomicalStructure a linkml:ClassDefinition ;
    dct:description "An anatomical structure with the potential of have an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PathologicalAnatomicalStructure ;
    linkml:definition_uri biolink:PathologicalAnatomicalStructure ;
    linkml:is_a biolink:AnatomicalEntity ;
    linkml:mixins biolink:PathologicalEntityMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:PathologicalProcess a linkml:ClassDefinition ;
    dct:description "A biologic function or a process having an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level." ;
    ns1:exactMatch OBO:NCIT_C16956,
        OBO:OBI_1110122 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_C19151,
        <http://www.ebi.ac.uk/efo/EFO_0009708> ;
    linkml:class_uri biolink:PathologicalProcess ;
    linkml:definition_uri biolink:PathologicalProcess ;
    linkml:is_a biolink:BiologicalProcess ;
    linkml:mixins biolink:PathologicalEntityMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:RNAProduct a linkml:ClassDefinition ;
    ns1:exactMatch OBO:CHEBI_33697,
        WIKIDATA:Q11053 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:RNAProduct ;
    linkml:definition_uri biolink:RNAProduct ;
    linkml:id_prefixes "RNACENTRAL" ;
    linkml:is_a biolink:Transcript ;
    linkml:mixins biolink:GeneProductMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:synonym,
        biolink:type,
        biolink:xref .

biolink:TaxonomicRank a linkml:ClassDefinition ;
    dct:description "A descriptor for the rank within a taxonomic classification. Example instance: TAXRANK:0000017 (kingdom)" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation WIKIDATA:Q427626 ;
    linkml:class_uri biolink:TaxonomicRank ;
    linkml:definition_uri biolink:TaxonomicRank ;
    linkml:id_prefixes "TAXRANK" ;
    linkml:is_a biolink:OntologyClass ;
    linkml:slot_usage [ ] .

biolink:actively_involved_in a linkml:SlotDefinition ;
    dct:description "holds between a continuant and a process or function, where the continuant actively contributes to part or all of the process or function it realizes" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch RTXKG1:involved_in ;
    ns1:closeMatch OBO:NCIT_biological_process_involves_chemical_or_drug ;
    ns1:exactMatch OBO:RO_0002331,
        OBO:RO_0002432 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_gene_involved_in_molecular_abnormality,
        OBO:RO_0002503,
        <http://purl.obolibrary.org/obo/nbo#by_means>,
        <http://www.orpha.net/ORDO/Orphanet_317348>,
        <http://www.orpha.net/ORDO/Orphanet_317349>,
        <http://www.orpha.net/ORDO/Orphanet_327767> ;
    linkml:definition_uri biolink:actively_involved_in ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:participates_in ;
    linkml:multivalued true ;
    linkml:owner biolink:actively_involved_in ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:actively_involved_in .

biolink:ameliorates a linkml:SlotDefinition ;
    dct:description "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." ;
    ns1:exactMatch OBO:RO_0003307,
        <http://translator.ncats.nih.gov/CTD_therapeutic> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:ameliorates ;
    linkml:domain biolink:BiologicalEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:ameliorates ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_uri biolink:ameliorates .

biolink:approved_for_treatment_by a linkml:SlotDefinition ;
    dct:description "holds between a disease or phenotypic feature and a therapeutic process or chemical substance that is approved for treatment of the condition (or not, if negated) to some level of clinical trial" ;
    owl:inverseOf biolink:approved_to_treat ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:approved_for_treatment_by ;
    linkml:domain biolink:DiseaseOrPhenotypicFeature ;
    linkml:inherited true ;
    linkml:is_a biolink:treated_by ;
    linkml:multivalued true ;
    linkml:owner biolink:approved_for_treatment_by ;
    linkml:range biolink:Treatment ;
    linkml:slot_uri biolink:approved_for_treatment_by .

biolink:approved_to_treat a linkml:SlotDefinition ;
    dct:description "holds between a therapeutic procedure or chemical substance and a disease or phenotypic feature for which it is approved for treatment to some level of clinical trial. Note that in terms of REPODB narrow mappings, terms containing 'suspended', 'terminated' or 'withdrawn' should be mapped onto associations using this term for which 'negated: true' is asserted." ;
    owl:inverseOf biolink:approved_for_treatment_by ;
    ns1:exactMatch OBO:NCIT_C172573 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch REPODB:clinically_tested_approved_unknown_phase,
        REPODB:clinically_tested_suspended_phase_0,
        REPODB:clinically_tested_suspended_phase_1,
        REPODB:clinically_tested_suspended_phase_1_or_phase_2,
        REPODB:clinically_tested_suspended_phase_2,
        REPODB:clinically_tested_suspended_phase_2_or_phase_3,
        REPODB:clinically_tested_suspended_phase_3,
        REPODB:clinically_tested_terminated_phase_0,
        REPODB:clinically_tested_terminated_phase_1,
        REPODB:clinically_tested_terminated_phase_1_or_phase_2,
        REPODB:clinically_tested_terminated_phase_2,
        REPODB:clinically_tested_terminated_phase_2_or_phase_3,
        REPODB:clinically_tested_terminated_phase_3,
        REPODB:clinically_tested_withdrawn_phase_0,
        REPODB:clinically_tested_withdrawn_phase_1,
        REPODB:clinically_tested_withdrawn_phase_1_or_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2_or_phase_3,
        REPODB:clinically_tested_withdrawn_phase_3,
        OBO:NCIT_R172,
        OBO:NCIT_regimen_has_accepted_use_for_disease ;
    linkml:definition_uri biolink:approved_to_treat ;
    linkml:domain biolink:ChemicalOrDrugOrTreatment ;
    linkml:inherited true ;
    linkml:is_a biolink:treats ;
    linkml:multivalued true ;
    linkml:owner biolink:approved_to_treat ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_uri biolink:approved_to_treat .

biolink:biomarker_for a linkml:SlotDefinition ;
    dct:description "holds between a measurable molecular entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_biomarker ;
    ns1:broadMatch OBO:RO_0002607 ;
    ns1:exactMatch OBO:NCIT_R39 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_R47,
        OBO:NCIT_genetic_biomarker_related_to,
        OBO:NCIT_is_molecular_abnormality_of_disease,
        <http://www.orpha.net/ORDO/Orphanet_465410>,
        <https://skr3.nlm.nih.gov/SemMedDBdiagnoses> ;
    linkml:definition_uri biolink:biomarker_for ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:correlated_with ;
    linkml:multivalued true ;
    linkml:owner biolink:biomarker_for ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_uri biolink:biomarker_for .

biolink:broad_match a linkml:SlotDefinition ;
    dct:description "a list of terms from different schemas or terminology systems that have a broader, more general meaning. Broader terms are typically shown as parents in a hierarchy or tree." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:narrow_match ;
    ns1:exactMatch skos:broadMatch,
        WIKIDATA:Q39894595 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:broad_match ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:broad_match ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:broad_match .

biolink:caused_by a linkml:SlotDefinition ;
    dct:description "holds between two entities where the occurrence, existence, or activity of one is caused by the occurrence or generation of the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:causes ;
    ns1:exactMatch WIKIDATA_PROPERTY:P828 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch RTXKG1:disease_caused_by_disruption_of,
        RTXKG1:disease_has_basis_in_dysfunction_of,
        RTXKG1:realized_in_response_to,
        RTXKG1:realized_in_response_to_stimulus,
        OBO:RO_0001022,
        OBO:RO_0002608,
        OBO:RO_0004019,
        OBO:RO_0004020,
        OBO:RO_0004028,
        OBO:RO_0009501 ;
    linkml:definition_uri biolink:caused_by ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:caused_by ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:caused_by .

biolink:close_match a linkml:SlotDefinition ;
    dct:description "a list of terms from different schemas or terminology systems that have a semantically similar but not strictly equivalent, broader, or narrower meaning. Such terms often describe the same general concept from different ontological perspectives (e.g. drug as a type of chemical entity versus drug as a type of role borne by a chemical entity)." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <https://skr3.nlm.nih.gov/SemMedDBSAME_AS>,
        <https://skr3.nlm.nih.gov/SemMedDBsame_as>,
        skos:closeMatch ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch MEDDRA:classified_as,
        UMLS:SY,
        RXNORM:has_quantified_form,
        OBO:CHEBI_is_enantiomer_of,
        OBO:CHEBI_is_tautomer_of,
        OBO:xref,
        oboformat:xref ;
    linkml:definition_uri biolink:close_match ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:close_match ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:close_match ;
    linkml:symmetric true .

biolink:coexpressed_with a linkml:SlotDefinition ;
    dct:description "holds between any two genes or gene products, in which both are generally expressed within a single defined experimental context." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:coexpressed_with ;
    linkml:domain biolink:GeneOrGeneProduct ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:correlated_with ;
    linkml:multivalued true ;
    linkml:owner biolink:coexpressed_with ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:slot_uri biolink:coexpressed_with ;
    linkml:symmetric true .

biolink:condition_associated_with_gene a linkml:SlotDefinition ;
    dct:description "holds between a gene and a disease or phenotypic feature that may be influenced, contribute to, or be correlated with the gene or its alleles/products" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:gene_associated_with_condition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_R176,
        <http://translator.ncats.nih.gov/hetio_ASSOCIATES_DaG> ;
    linkml:definition_uri biolink:condition_associated_with_gene ;
    linkml:domain biolink:DiseaseOrPhenotypicFeature ;
    linkml:inherited true ;
    linkml:is_a biolink:genetic_association ;
    linkml:multivalued true ;
    linkml:owner biolink:condition_associated_with_gene ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:condition_associated_with_gene .

biolink:contributes_to a linkml:SlotDefinition ;
    dct:description "holds between two entities where the occurrence, existence, or activity of one causes or contributes to the occurrence or generation of the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch OBO:IDO_0000664 ;
    ns1:exactMatch OBO:RO_0002326 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:MONDO_predisposes_towards,
        OBO:RO_0002255,
        OBO:RO_0003304,
        <http://translator.ncats.nih.gov/CTD_marker_mechanism> ;
    linkml:definition_uri biolink:contributes_to ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:contributes_to ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:contributes_to .

biolink:develops_from a linkml:SlotDefinition ;
    ns1:closeMatch OBO:FMA_develops_into,
        OBO:RO_0002203 ;
    ns1:exactMatch OBO:BTO_develops_from,
        OBO:DDANAT_develops_from,
        OBO:FMA_develops_from,
        OBO:RO_0002202 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:RO_0002207,
        OBO:RO_0002225,
        OBO:RO_0002226 ;
    linkml:definition_uri biolink:develops_from ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:develops_from ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:develops_from .

biolink:disrupted_by a linkml:SlotDefinition ;
    dct:description "describes a relationship where the structure, function, or occurrence of one entity is degraded or interfered with by another." ;
    owl:inverseOf biolink:disrupts ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:disrupted_by ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:affected_by ;
    linkml:multivalued true ;
    linkml:owner biolink:disrupted_by ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:disrupted_by .

biolink:disrupts a linkml:SlotDefinition ;
    dct:description "describes a relationship where one entity degrades or interferes with the structure, function, or occurrence of another." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:disrupted_by ;
    ns1:exactMatch <https://skr3.nlm.nih.gov/SemMedDBDISRUPTS>,
        <https://skr3.nlm.nih.gov/SemMedDBdisrupts>,
        CHEMBL.MECHANISM:disrupting_agent ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch RTXKG1:disease_causes_disruption_of,
        OBO:RO_0004024,
        OBO:RO_0004025 ;
    linkml:definition_uri biolink:disrupts ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:disrupts ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:disrupts .

biolink:enables a linkml:SlotDefinition ;
    dct:description "holds between a physical entity and a process, where the physical entity executes the process" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:enabled_by ;
    ns1:exactMatch OBO:RO_0002327 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:enables ;
    linkml:domain biolink:PhysicalEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:participates_in ;
    linkml:multivalued true ;
    linkml:owner biolink:enables ;
    linkml:range biolink:BiologicalProcessOrActivity ;
    linkml:slot_uri biolink:enables .

biolink:entity_negatively_regulated_by_entity a linkml:SlotDefinition ;
    owl:inverseOf biolink:entity_negatively_regulates_entity ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:entity_negatively_regulated_by_entity ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:entity_regulated_by_entity ;
    linkml:multivalued true ;
    linkml:owner biolink:entity_negatively_regulated_by_entity ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:entity_negatively_regulated_by_entity .

biolink:entity_negatively_regulates_entity a linkml:SlotDefinition ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:entity_negatively_regulated_by_entity ;
    ns1:altLabel "activity directly negatively regulates activity of" ;
    ns1:exactMatch OBO:RO_0002449 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/hetio_DOWNREGULATES_AdG>,
        <http://translator.ncats.nih.gov/hetio_DOWNREGULATES_DdG>,
        <https://skr3.nlm.nih.gov/SemMedDBINHIBITS>,
        <https://skr3.nlm.nih.gov/SemMedDBinhibits> ;
    linkml:definition_uri biolink:entity_negatively_regulates_entity ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:entity_regulates_entity ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "negatively regulates" ;
            linkml:local_name_source "translator" ],
        [ a linkml:LocalName ;
            ns1:altLabel "activity directly negatively regulates activity of" ;
            linkml:local_name_source "ro" ] ;
    linkml:mixins biolink:negatively_regulates ;
    linkml:multivalued true ;
    linkml:owner biolink:entity_negatively_regulates_entity ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:entity_negatively_regulates_entity .

biolink:entity_positively_regulated_by_entity a linkml:SlotDefinition ;
    owl:inverseOf biolink:entity_positively_regulates_entity ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:entity_positively_regulated_by_entity ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:entity_regulated_by_entity ;
    linkml:multivalued true ;
    linkml:owner biolink:entity_positively_regulated_by_entity ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:entity_positively_regulated_by_entity .

biolink:entity_positively_regulates_entity a linkml:SlotDefinition ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:entity_positively_regulated_by_entity ;
    ns1:altLabel "activity directly positively regulates activity of" ;
    ns1:broadMatch OBO:RO_0004034 ;
    ns1:exactMatch OBO:RO_0002450 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/hetio_UPREGULATES_AuG>,
        <http://translator.ncats.nih.gov/hetio_UPREGULATES_DuG>,
        <https://skr3.nlm.nih.gov/SemMedDBSTIMULATES>,
        <https://skr3.nlm.nih.gov/SemMedDBstimulates> ;
    linkml:definition_uri biolink:entity_positively_regulates_entity ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:entity_regulates_entity ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "positively regulates" ;
            linkml:local_name_source "translator" ],
        [ a linkml:LocalName ;
            ns1:altLabel "activity directly positively regulates activity of" ;
            linkml:local_name_source "ro" ] ;
    linkml:mixins biolink:positively_regulates ;
    linkml:multivalued true ;
    linkml:owner biolink:entity_positively_regulates_entity ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:entity_positively_regulates_entity .

biolink:exact_match a linkml:SlotDefinition ;
    dct:description "holds between two entities that have strictly equivalent meanings, with a high degree of confidence" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch skos:exactMatch,
        WIKIDATA:P2888,
        WIKIDATA:Q39893449 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:exact_match ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:close_match ;
    linkml:multivalued true ;
    linkml:owner biolink:exact_match ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:exact_match ;
    linkml:symmetric true .

biolink:expresses a linkml:SlotDefinition ;
    dct:description "holds between an anatomical entity and gene or gene product that is expressed there" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:expressed_in ;
    ns1:exactMatch OBO:RO_0002292,
        <http://translator.ncats.nih.gov/hetio_EXPRESSES_AeG> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:expresses ;
    linkml:domain biolink:AnatomicalEntity ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:expresses ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:slot_uri biolink:expresses .

biolink:float a linkml:TypeDefinition ;
    dct:description "A real number that conforms to the xsd:float specification" ;
    ns1:inScheme linkml:types ;
    linkml:base "float" ;
    linkml:definition_uri linkml:Float ;
    linkml:imported_from "linkml:types" ;
    linkml:uri xsd:float .

biolink:gene_associated_with_condition a linkml:SlotDefinition ;
    dct:description "holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:condition_associated_with_gene ;
    ns1:broadMatch OBO:GENO_0000840,
        OBO:GENO_0000841 ;
    ns1:exactMatch RTXKG1:gene_associated_with_condition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_R175,
        OBO:NCIT_R38,
        OBO:NCIT_R48 ;
    linkml:definition_uri biolink:gene_associated_with_condition ;
    linkml:domain biolink:Gene ;
    linkml:inherited true ;
    linkml:is_a biolink:genetic_association ;
    linkml:multivalued true ;
    linkml:owner biolink:gene_associated_with_condition ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_uri biolink:gene_associated_with_condition .

biolink:gene_product_of a linkml:SlotDefinition ;
    dct:description "definition x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of thatf process is either y or something that is ribosomally translated from x" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_gene_product ;
    ns1:exactMatch OBO:RO_0002204 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:gene_product_of ;
    linkml:domain biolink:GeneProductMixin ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:gene_product_of ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:gene_product_of .

biolink:has_active_ingredient a linkml:SlotDefinition ;
    dct:description "holds between a drug and a chemical substance in which the latter is a part of the former, and is a biologically active component" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:is_active_ingredient_of ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation OBO:RO_0002248 ;
    linkml:definition_uri biolink:has_active_ingredient ;
    linkml:domain biolink:Drug ;
    linkml:inherited true ;
    linkml:is_a biolink:has_part ;
    linkml:multivalued true ;
    linkml:owner biolink:has_active_ingredient ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:has_active_ingredient .

biolink:has_biomarker a linkml:SlotDefinition ;
    dct:description "holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:biomarker_for ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_disease_has_finding,
        OBO:NCIT_disease_has_molecular_abnormality,
        OBO:NCIT_disease_is_marked_by_gene ;
    linkml:definition_uri biolink:has_biomarker ;
    linkml:domain biolink:DiseaseOrPhenotypicFeature ;
    linkml:inherited true ;
    linkml:is_a biolink:correlated_with ;
    linkml:multivalued true ;
    linkml:owner biolink:has_biomarker ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:has_biomarker .

biolink:has_excipient a linkml:SlotDefinition ;
    dct:description "holds between a drug and a chemical substances in which the latter is a part of the former, and is a biologically inactive component" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:is_excipient_of ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation WIKIDATA:Q902638 ;
    linkml:definition_uri biolink:has_excipient ;
    linkml:domain biolink:Drug ;
    linkml:inherited true ;
    linkml:is_a biolink:has_part ;
    linkml:multivalued true ;
    linkml:owner biolink:has_excipient ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:has_excipient .

biolink:has_metabolite a linkml:SlotDefinition ;
    dct:description "holds between two chemical substances in which the second one is derived from the first one as a product of metabolism" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:is_metabolite_of ;
    ns1:exactMatch OBO:CHEBI_25212 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "The CHEBI ID represents a role rather than a predicate" ;
    linkml:definition_uri biolink:has_metabolite ;
    linkml:domain biolink:ChemicalSubstance ;
    linkml:inherited true ;
    linkml:is_a biolink:derives_into ;
    linkml:multivalued true ;
    linkml:owner biolink:has_metabolite ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:has_metabolite .

biolink:has_nutrient a linkml:SlotDefinition ;
    dct:description "one or more nutrients which are growth factors for a living organism" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:nutrient_of ;
    ns1:exactMatch WIKIDATA:Q181394 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_nutrient ;
    linkml:domain biolink:ChemicalSubstance ;
    linkml:inherited true ;
    linkml:is_a biolink:has_food_component ;
    linkml:multivalued true ;
    linkml:owner biolink:has_nutrient ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:has_nutrient .

biolink:has_percentage a linkml:SlotDefinition ;
    dct:description "equivalent to has quotient multiplied by 100" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_percentage ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:FrequencyQuantifier ;
    linkml:is_a biolink:aggregate_statistic ;
    linkml:owner biolink:FrequencyQuantifier ;
    linkml:range biolink:double ;
    linkml:slot_uri biolink:has_percentage .

biolink:has_sequence_location a linkml:SlotDefinition ;
    dct:description "holds between two genomic entities when the subject can be localized in sequence coordinates on the object. For example, between an exon and a chromosome/contig." ;
    ns1:exactMatch faldo:location ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_sequence_location ;
    linkml:domain biolink:GenomicEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:has_sequence_location ;
    linkml:range biolink:GenomicEntity ;
    linkml:slot_uri biolink:has_sequence_location .

biolink:has_variant_part a linkml:SlotDefinition ;
    dct:description "holds between a genomic entity and a genotypic entity that is a sub-component of it" ;
    ns1:exactMatch OBO:GENO_0000382 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_variant_part ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:has_part ;
    linkml:multivalued true ;
    linkml:owner biolink:has_variant_part ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_variant_part .

biolink:has_zygosity a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_zygosity ;
    linkml:domain biolink:GenomicEntity ;
    linkml:domain_of biolink:Genotype ;
    linkml:inlined true ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:has_zygosity ;
    linkml:range biolink:Zygosity ;
    linkml:slot_uri biolink:has_zygosity .

biolink:is_active_ingredient_of a linkml:SlotDefinition ;
    dct:description "holds between a chemical substance and a drug, in which the former is a part of the latter, and is a biologically active component" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_active_ingredient ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation OBO:RO_0002249 ;
    linkml:definition_uri biolink:is_active_ingredient_of ;
    linkml:domain biolink:ChemicalSubstance ;
    linkml:inherited true ;
    linkml:is_a biolink:part_of ;
    linkml:multivalued true ;
    linkml:owner biolink:is_active_ingredient_of ;
    linkml:range biolink:Drug ;
    linkml:slot_uri biolink:is_active_ingredient_of .

biolink:is_excipient_of a linkml:SlotDefinition ;
    dct:description "holds between a chemical substance and a drug in which the former is a part of the latter, and is a biologically inactive component" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_excipient ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation WIKIDATA:Q902638 ;
    linkml:definition_uri biolink:is_excipient_of ;
    linkml:domain biolink:ChemicalSubstance ;
    linkml:inherited true ;
    linkml:is_a biolink:part_of ;
    linkml:multivalued true ;
    linkml:owner biolink:is_excipient_of ;
    linkml:range biolink:Drug ;
    linkml:slot_uri biolink:is_excipient_of .

biolink:is_metabolite_of a linkml:SlotDefinition ;
    dct:description "holds between two chemical substances in which the first one is derived from the second one as a product of metabolism" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_metabolite ;
    ns1:exactMatch OBO:CHEBI_25212 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "The CHEBI ID represents a role rather than a predicate" ;
    linkml:definition_uri biolink:is_metabolite_of ;
    linkml:domain biolink:ChemicalSubstance ;
    linkml:inherited true ;
    linkml:is_a biolink:derives_from ;
    linkml:multivalued true ;
    linkml:owner biolink:is_metabolite_of ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:is_metabolite_of .

biolink:located_in a linkml:SlotDefinition ;
    dct:description "holds between a material entity and a material entity or site within which it is located (but of which it is not considered a part)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:location_of ;
    ns1:exactMatch OBO:FMA_has_location,
        OBO:RO_0001025 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch HMDB:at_cellular_location,
        HMDB:at_tissue,
        HMDB:in_biospecimen,
        RTXKG1:disease_has_location,
        LOINC:has_imaging_focus,
        OBO:BSPO_0000107,
        OBO:BSPO_0000108,
        OBO:BSPO_0000120,
        OBO:BSPO_0000121,
        OBO:BSPO_0000122,
        OBO:BSPO_0000123,
        OBO:BSPO_0000124,
        OBO:BSPO_0000125,
        OBO:BSPO_0000126,
        OBO:BSPO_0001100,
        OBO:BSPO_0001101,
        OBO:BSPO_0001107,
        OBO:BSPO_0015101,
        OBO:BSPO_0015102,
        OBO:BSPO_0015202,
        OBO:FMA_has_location,
        OBO:GOREL_0001004,
        OBO:NCIT_R100,
        OBO:NCIT_R145,
        OBO:NCIT_R155,
        OBO:NCIT_R156,
        OBO:NCIT_R165,
        OBO:NCIT_R166,
        OBO:NCIT_R167,
        OBO:NCIT_R168,
        OBO:NCIT_R169,
        OBO:NCIT_R170,
        OBO:NCIT_R171,
        OBO:NCIT_R40,
        OBO:NCIT_is_location_of_anatomic_structure,
        OBO:RO_0002303,
        OBO:SNOMED_has_finding_site,
        OBO:SNOMED_has_indirect_procedure_site,
        OBO:SNOMED_has_inherent_location,
        UBERON_CORE:in_central_side_of,
        UBERON_CORE:in_innermost_side_of,
        UBERON_CORE:in_outermost_side_of,
        <http://www.ebi.ac.uk/efo/EFO_0000784> ;
    linkml:definition_uri biolink:located_in ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:located_in ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:located_in .

biolink:location_of a linkml:SlotDefinition ;
    dct:description "holds between material entity or site and a material entity that is located within it (but not considered a part of it)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:located_in ;
    ns1:exactMatch RTXKG1:site_of,
        OBO:FMA_location_of,
        OBO:RO_0001015,
        <https://skr3.nlm.nih.gov/SemMedDBLOCATION_OF>,
        <https://skr3.nlm.nih.gov/SemMedDBlocation_of>,
        WIKIDATA_PROPERTY:P276 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:SNOMED_inherent_location_of ;
    linkml:definition_uri biolink:location_of ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:location_of ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:location_of .

biolink:model_of a linkml:SlotDefinition ;
    dct:description "holds between a thing and some other thing it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_0003301 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:FOODON_00001301 ;
    linkml:definition_uri biolink:model_of ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:similar_to ;
    linkml:multivalued true ;
    linkml:owner biolink:model_of ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:model_of .

biolink:narrow_match a linkml:SlotDefinition ;
    dct:description "a list of terms from different schemas or terminology systems that have a narrower, more specific meaning. Narrower terms are typically shown as children in a hierarchy or tree." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:broad_match ;
    ns1:exactMatch skos:narrowMatch,
        WIKIDATA:Q39893967 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:narrow_match ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:narrow_match ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:narrow_match .

biolink:negatively_regulated_by a linkml:SlotDefinition ;
    owl:inverseOf biolink:negatively_regulates ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:negatively_regulated_by ;
    linkml:domain biolink:PhysicalEssenceOrOccurrent ;
    linkml:inlined true ;
    linkml:is_a biolink:regulated_by ;
    linkml:mixin true ;
    linkml:owner biolink:negatively_regulated_by ;
    linkml:range biolink:PhysicalEssenceOrOccurrent ;
    linkml:slot_uri biolink:negatively_regulated_by .

biolink:nutrient_of a linkml:SlotDefinition ;
    dct:description "holds between a one or more chemical substances present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_nutrient ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:nutrient_of ;
    linkml:domain biolink:ChemicalSubstance ;
    linkml:inherited true ;
    linkml:is_a biolink:food_component_of ;
    linkml:multivalued true ;
    linkml:owner biolink:nutrient_of ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:nutrient_of .

biolink:phase a linkml:SlotDefinition ;
    dct:description "The phase for a coding sequence entity. For example, phase of a CDS as represented in a GFF3 with a value of 0, 1 or 2." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:phase ;
    linkml:domain biolink:CodingSequence ;
    linkml:domain_of biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:sequence_localization_attribute ;
    linkml:owner biolink:phase ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:phase .

biolink:phenotype_of a linkml:SlotDefinition ;
    dct:description "holds between a phenotype and a biological entity, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature)." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_phenotype ;
    ns1:editorialNote "check the domain" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:phenotype_of ;
    linkml:domain biolink:PhenotypicFeature ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:phenotype_of ;
    linkml:range biolink:BiologicalEntity ;
    linkml:slot_uri biolink:phenotype_of .

biolink:physically_interacts_with a linkml:SlotDefinition ;
    dct:description "holds between two entities that make physical contact as part of some interaction" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch DRUGBANK:target,
        CHEMBL.MECHANISM:binding_agent,
        CHEMBL.MECHANISM:chelating_agent,
        CHEMBL.MECHANISM:cross-linking_agent,
        CHEMBL.MECHANISM:oxidative_enzyme,
        CHEMBL.MECHANISM:sequestering_agent,
        CHEMBL.MECHANISM:substrate ;
    ns1:exactMatch RTXKG1:physically_interacts_with,
        WIKIDATA_PROPERTY:P129 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch DRUGBANK:drug-interaction,
        OBO:FMA_adheres_to,
        OBO:NCIT_A7,
        OBO:PR_non-covalently_bound_to,
        <https://skr3.nlm.nih.gov/SemMedDBINTERACTS_WITH>,
        <https://skr3.nlm.nih.gov/SemMedDBinteracts_with> ;
    linkml:definition_uri biolink:physically_interacts_with ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:interacts_with ;
    linkml:multivalued true ;
    linkml:owner biolink:physically_interacts_with ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:physically_interacts_with ;
    linkml:symmetric true .

biolink:positively_regulated_by a linkml:SlotDefinition ;
    owl:inverseOf biolink:positively_regulates ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:positively_regulated_by ;
    linkml:domain biolink:PhysicalEssenceOrOccurrent ;
    linkml:inlined true ;
    linkml:is_a biolink:regulated_by ;
    linkml:mixin true ;
    linkml:owner biolink:positively_regulated_by ;
    linkml:range biolink:PhysicalEssenceOrOccurrent ;
    linkml:slot_uri biolink:positively_regulated_by .

biolink:preceded_by a linkml:SlotDefinition ;
    dct:description "holds between two processes, where the other is completed before the one begins" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:precedes ;
    ns1:broadMatch OBO:GENEPIO_0001739 ;
    ns1:exactMatch OBO:BFO_0000062 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:FMA_transforms_from,
        OBO:RO_0002087,
        OBO:RO_0002285 ;
    linkml:definition_uri biolink:preceded_by ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:temporally_related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:preceded_by ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:preceded_by .

biolink:precedes a linkml:SlotDefinition ;
    dct:description "holds between two processes, where one completes before the other begins" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:preceded_by ;
    ns1:broadMatch WIKIDATA_PROPERTY:P156 ;
    ns1:closeMatch OBO:RO_0002263,
        OBO:RO_0002264 ;
    ns1:exactMatch OBO:BFO_0000063,
        OBO:SNOMED_occurs_before,
        <https://skr3.nlm.nih.gov/SemMedDBPRECEDES>,
        <https://skr3.nlm.nih.gov/SemMedDBprecedes> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:FMA_transforms_into,
        OBO:RO_0002090,
        OBO:RO_0002411,
        OBO:RO_0002412 ;
    linkml:definition_uri biolink:precedes ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:temporally_related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:precedes ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:precedes .

biolink:prevented_by a linkml:SlotDefinition ;
    dct:description "holds between a potential outcome of which the likelihood was reduced by the application or use of an entity." ;
    owl:inverseOf biolink:prevents ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:prevented_by ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:prevented_by ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:prevented_by .

biolink:prevents a linkml:SlotDefinition ;
    dct:description "holds between an entity whose application or use reduces the likelihood of a potential outcome. Typically used to associate a chemical substance, exposure, activity, or medical intervention that can prevent the onset a disease or phenotypic feature." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:prevented_by ;
    ns1:exactMatch <https://skr3.nlm.nih.gov/SemMedDBPREVENTS>,
        <https://skr3.nlm.nih.gov/SemMedDBprevents> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:RO_0002599 ;
    linkml:definition_uri biolink:prevents ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:affects_risk_for ;
    linkml:multivalued true ;
    linkml:owner biolink:prevents ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:prevents .

biolink:process_negatively_regulated_by_process a linkml:SlotDefinition ;
    owl:inverseOf biolink:process_negatively_regulates_process ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:process_negatively_regulated_by_process ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:process_regulated_by_process ;
    linkml:multivalued true ;
    linkml:owner biolink:process_negatively_regulated_by_process ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:process_negatively_regulated_by_process .

biolink:process_negatively_regulates_process a linkml:SlotDefinition ;
    owl:inverseOf biolink:process_negatively_regulated_by_process ;
    ns1:exactMatch OBO:RO_0002212 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:process_negatively_regulates_process ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:process_regulates_process ;
    linkml:mixins biolink:negatively_regulates ;
    linkml:multivalued true ;
    linkml:owner biolink:process_negatively_regulates_process ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:process_negatively_regulates_process .

biolink:process_positively_regulated_by_process a linkml:SlotDefinition ;
    owl:inverseOf biolink:process_positively_regulates_process ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:process_positively_regulated_by_process ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:process_regulated_by_process ;
    linkml:multivalued true ;
    linkml:owner biolink:process_positively_regulated_by_process ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:process_positively_regulated_by_process .

biolink:process_positively_regulates_process a linkml:SlotDefinition ;
    owl:inverseOf biolink:process_positively_regulated_by_process ;
    ns1:exactMatch OBO:RO_0002213 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:process_positively_regulates_process ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:process_regulates_process ;
    linkml:mixins biolink:positively_regulates ;
    linkml:multivalued true ;
    linkml:owner biolink:process_positively_regulates_process ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:process_positively_regulates_process .

biolink:produced_by a linkml:SlotDefinition ;
    owl:inverseOf biolink:produces ;
    ns1:exactMatch OBO:RO_0003001 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:produced_by ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:produced_by ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:produced_by .

biolink:produces a linkml:SlotDefinition ;
    dct:description "holds between a material entity and a product that is generated through the intentional actions or functioning of the material entity" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:produced_by ;
    ns1:exactMatch OBO:RO_0003000,
        <https://skr3.nlm.nih.gov/SemMedDBPRODUCES>,
        <https://skr3.nlm.nih.gov/SemMedDBproduces>,
        WIKIDATA_PROPERTY:P1056 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_R29,
        OBO:SNOMED_has_process_output,
        OBO:SNOMED_specimen_procedure_of ;
    ns1:relatedMatch OBO:GOREL_0001010 ;
    linkml:definition_uri biolink:produces ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:produces ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:produces .

biolink:sequence_feature_relationship_object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:SequenceFeatureRelationship ;
    linkml:domain_of biolink:SequenceFeatureRelationship ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:SequenceFeatureRelationship ;
    linkml:range biolink:GenomicEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:sequence_feature_relationship_subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:SequenceFeatureRelationship ;
    linkml:domain_of biolink:SequenceFeatureRelationship ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:SequenceFeatureRelationship ;
    linkml:range biolink:GenomicEntity ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:superclass_of a linkml:SlotDefinition ;
    dct:description "holds between two classes where the domain class is a super class of the range class" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:subclass_of ;
    ns1:exactMatch MESH:inverse_isa,
        RXNORM:inverse_isa,
        OBO:GO_inverse_isa,
        CHEMBL.MECHANISM:superset_of,
        VANDF:inverse_isa,
        WIKIDATA:Q66088480 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLS:RB,
        OBO:NCIT_cdrh_parent_of,
        OBO:NCIT_ctcae_5_parent_of,
        OBO:NCIT_subset_includes_concept,
        OBO:OMIM_has_manifestation,
        OBO:SNOMED_has_basic_dose_form ;
    linkml:definition_uri biolink:superclass_of ;
    linkml:domain biolink:OntologyClass ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:superclass_of ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:superclass_of .

biolink:symbol a linkml:SlotDefinition ;
    dct:description "Symbol for a particular thing" ;
    ns1:exactMatch gpi:DB_Object_Symbol,
        alliancegenome:symbol ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:symbol ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:Gene ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:symbol ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:symbol .

biolink:transcribed_from a linkml:SlotDefinition ;
    dct:description "x is transcribed from y if and only if x is synthesized from template y" ;
    owl:inverseOf biolink:transcribed_to ;
    ns1:exactMatch OBO:RO_0002510,
        <http://semanticscience.org/resource/SIO_010081> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:transcribed_from ;
    linkml:domain biolink:Transcript ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:transcribed_from ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:transcribed_from .

biolink:transcribed_to a linkml:SlotDefinition ;
    dct:description "inverse of transcribed from" ;
    owl:inverseOf biolink:transcribed_from ;
    ns1:exactMatch OBO:RO_0002511,
        <http://semanticscience.org/resource/SIO_010080> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:transcribed_to ;
    linkml:domain biolink:Gene ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:transcribed_to ;
    linkml:range biolink:Transcript ;
    linkml:slot_uri biolink:transcribed_to .

biolink:translates_to a linkml:SlotDefinition ;
    dct:description "x (amino acid chain/polypeptide) is the ribosomal translation of y (transcript) if and only if a ribosome reads y (transcript) through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces x (amino acid chain/polypeptide)" ;
    owl:inverseOf biolink:translation_of ;
    ns1:closeMatch OBO:RO_0002513,
        <http://semanticscience.org/resource/SIO_010082> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:translates_to ;
    linkml:domain biolink:Transcript ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:translates_to ;
    linkml:range biolink:Protein ;
    linkml:slot_uri biolink:translates_to .

biolink:translation_of a linkml:SlotDefinition ;
    dct:description "inverse of translates to" ;
    owl:inverseOf biolink:translates_to ;
    ns1:closeMatch OBO:RO_0002512,
        <http://semanticscience.org/resource/SIO_010083> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:translation_of ;
    linkml:domain biolink:Protein ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:translation_of ;
    linkml:range biolink:Transcript ;
    linkml:slot_uri biolink:translation_of .

biolink:BiologicalSex a linkml:ClassDefinition ;
    ns1:exactMatch OBO:PATO_0000047 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:BiologicalSex ;
    linkml:definition_uri biolink:BiologicalSex ;
    linkml:is_a biolink:Attribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:CellLineAsAModelOfDiseaseAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:CellLineAsAModelOfDiseaseAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:CellLineAsAModelOfDiseaseAssociation ;
    linkml:is_a biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:mixins biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:cell_line_as_a_model_of_disease_association_subject,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:source .

biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation a linkml:ClassDefinition ;
    dct:description "An interaction between a chemical entity and a phenotype or disease, where the presence of the chemical gives rise to or exacerbates the phenotype." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://semanticscience.org/resource/SIO_000993> ;
    linkml:class_uri biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:ChemicalToEntityAssociationMixin,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:chemical_to_disease_or_phenotypic_feature_association_object,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:ChemicalToGeneAssociation a linkml:ClassDefinition ;
    dct:description "An interaction between a chemical entity and a gene or gene product." ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_001257> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ChemicalToGeneAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:ChemicalToGeneAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:ChemicalToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:chemical_to_gene_association_object,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:ChemicalToPathwayAssociation a linkml:ClassDefinition ;
    dct:description "An interaction between a chemical entity and a biological process or pathway." ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_001250> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ChemicalToPathwayAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:ChemicalToPathwayAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:ChemicalToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:chemical_to_pathway_association_object,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:ClinicalFinding a linkml:ClassDefinition ;
    dct:description "this category is currently considered broad enough to tag clinical lab measurements and other biological attributes taken as 'clinical traits' with some statistical score, for example, a p value in genetic associations." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ClinicalFinding ;
    linkml:definition_uri biolink:ClinicalFinding ;
    linkml:id_prefixes "EFO",
        "LOINC",
        "NCIT" ;
    linkml:is_a biolink:PhenotypicFeature ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:clinical_finding_has_attribute,
        biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:ClinicalMeasurement a linkml:ClassDefinition ;
    dct:description "A clinical measurement is a special kind of attribute which results from a laboratory observation from a subject individual or sample. Measurements can be connected to their subject by the 'has attribute' slot." ;
    ns1:exactMatch <http://www.ebi.ac.uk/efo/EFO_0001444> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ClinicalMeasurement ;
    linkml:definition_uri biolink:ClinicalMeasurement ;
    linkml:is_a biolink:ClinicalAttribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:clinical_measurement_has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:DiseaseOrPhenotypicFeatureAssociationToLocationAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DiseaseOrPhenotypicFeatureAssociationToLocationAssociation ;
    linkml:definition_uri biolink:DiseaseOrPhenotypicFeatureAssociationToLocationAssociation ;
    linkml:deprecated "This association class name is deprecated in favor of the 'disease or phenotypic feature to location association' class." ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:disease_or_phenotypic_feature_association_to_location_association_object,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:DiseaseOrPhenotypicFeatureToLocationAssociation a linkml:ClassDefinition ;
    dct:description "An association between either a disease or a phenotypic feature and an anatomical entity, where the disease/feature manifests in that site." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DiseaseOrPhenotypicFeatureToLocationAssociation ;
    linkml:definition_uri biolink:DiseaseOrPhenotypicFeatureToLocationAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:disease_or_phenotypic_feature_to_location_association_object,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:DrugToGeneAssociation a linkml:ClassDefinition ;
    dct:description "An interaction between a drug and a gene or gene product." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch <http://semanticscience.org/resource/SIO_001257> ;
    linkml:class_uri biolink:DrugToGeneAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:DrugToGeneAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:DrugToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:drug_to_gene_association_object,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:ExposureEventToPhenotypicFeatureAssociation a linkml:ClassDefinition ;
    dct:description "Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ExposureEventToPhenotypicFeatureAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:ExposureEventToPhenotypicFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:exposure_event_to_phenotypic_feature_association_subject,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:sex_qualifier,
        biolink:source .

biolink:GeneAsAModelOfDiseaseAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneAsAModelOfDiseaseAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:GeneAsAModelOfDiseaseAssociation ;
    linkml:is_a biolink:GeneToDiseaseAssociation ;
    linkml:mixins biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:gene_as_a_model_of_disease_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:source .

biolink:GeneToGeneCoexpressionAssociation a linkml:ClassDefinition ;
    dct:description "Indicates that two genes are co-expressed, generally under the same conditions." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneToGeneCoexpressionAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:GeneToGeneCoexpressionAssociation ;
    linkml:is_a biolink:GeneToGeneAssociation ;
    linkml:mixins biolink:GeneExpressionMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:expression_site,
        biolink:gene_expression_mixin_quantifier_qualifier,
        biolink:gene_to_gene_association_object,
        biolink:gene_to_gene_association_subject,
        biolink:gene_to_gene_coexpression_association_predicate,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:phenotypic_state,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:stage_qualifier .

biolink:GeneToGeneHomologyAssociation a linkml:ClassDefinition ;
    dct:description "A homology association between two genes. May be orthology (in which case the species of subject and object should differ) or paralogy (in which case the species may be the same)" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneToGeneHomologyAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:GeneToGeneHomologyAssociation ;
    linkml:is_a biolink:GeneToGeneAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:gene_to_gene_association_object,
        biolink:gene_to_gene_association_subject,
        biolink:gene_to_gene_homology_association_predicate,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:GeneToPhenotypicFeatureAssociation a linkml:ClassDefinition ;
    ns1:exactMatch <http://bio2rdf.org/wormbase_vocabularyGene-Phenotype-Association> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneToPhenotypicFeatureAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GeneToPhenotypicFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:GeneToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:gene_to_phenotypic_feature_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:sex_qualifier,
        biolink:source .

biolink:GenotypeAsAModelOfDiseaseAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GenotypeAsAModelOfDiseaseAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:GenotypeAsAModelOfDiseaseAssociation ;
    linkml:is_a biolink:GenotypeToDiseaseAssociation ;
    linkml:mixins biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:genotype_as_a_model_of_disease_association_subject,
        biolink:genotype_to_disease_association_object,
        biolink:genotype_to_disease_association_predicate,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:onset_qualifier,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:source .

biolink:MacromolecularMachineToBiologicalProcessAssociation a linkml:ClassDefinition ;
    dct:description "A functional association between a macromolecular machine (gene, gene product or complex) and a biological process or pathway (as represented in the GO biological process branch), where the entity carries out some part of the process, regulates it, or acts upstream of it." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MacromolecularMachineToBiologicalProcessAssociation ;
    linkml:definition_uri biolink:MacromolecularMachineToBiologicalProcessAssociation ;
    linkml:is_a biolink:FunctionalAssociation ;
    linkml:mixins biolink:MacromolecularMachineToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:functional_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:macromolecular_machine_to_biological_process_association_object,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:MacromolecularMachineToCellularComponentAssociation a linkml:ClassDefinition ;
    dct:description "A functional association between a macromolecular machine (gene, gene product or complex) and a cellular component (as represented in the GO cellular component branch), where the entity carries out its function in the cellular component." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MacromolecularMachineToCellularComponentAssociation ;
    linkml:definition_uri biolink:MacromolecularMachineToCellularComponentAssociation ;
    linkml:is_a biolink:FunctionalAssociation ;
    linkml:mixins biolink:MacromolecularMachineToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:functional_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:macromolecular_machine_to_cellular_component_association_object,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:MacromolecularMachineToMolecularActivityAssociation a linkml:ClassDefinition ;
    dct:description "A functional association between a macromolecular machine (gene, gene product or complex) and a molecular activity (as represented in the GO molecular function branch), where the entity carries out the activity, or contributes to its execution." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MacromolecularMachineToMolecularActivityAssociation ;
    linkml:definition_uri biolink:MacromolecularMachineToMolecularActivityAssociation ;
    linkml:is_a biolink:FunctionalAssociation ;
    linkml:mixins biolink:MacromolecularMachineToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:functional_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:macromolecular_machine_to_molecular_activity_association_object,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:OrganismalEntityAsAModelOfDiseaseAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:OrganismalEntityAsAModelOfDiseaseAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:OrganismalEntityAsAModelOfDiseaseAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:organismal_entity_as_a_model_of_disease_association_subject,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:source .

biolink:PathologicalEntityMixin a linkml:ClassDefinition ;
    dct:description "A pathological (abnormal) structure or process." ;
    ns1:exactMatch OBO:MPATH_0 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:HP_0000118 ;
    linkml:class_uri biolink:PathologicalEntityMixin ;
    linkml:definition_uri biolink:PathologicalEntityMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:PhysicalEntity a linkml:ClassDefinition ;
    dct:description "An entity that has material reality (a.k.a. physical essence)." ;
    ns1:exactMatch UMLSSC:T072,
        UMLSST:phob ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T073,
        UMLSST:mnob ;
    linkml:class_uri biolink:PhysicalEntity ;
    linkml:definition_uri biolink:PhysicalEntity ;
    linkml:is_a biolink:NamedThing ;
    linkml:mixins biolink:PhysicalEssence ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:PhysicalEssence a linkml:ClassDefinition ;
    dct:description "Semantic mixin concept.  Pertains to entities that have physical properties such as mass, volume, or charge." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PhysicalEssence ;
    linkml:definition_uri biolink:PhysicalEssence ;
    linkml:is_a biolink:PhysicalEssenceOrOccurrent ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:PlanetaryEntity a linkml:ClassDefinition ;
    dct:description "Any entity or process that exists at the level of the whole planet" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PlanetaryEntity ;
    linkml:definition_uri biolink:PlanetaryEntity ;
    linkml:is_a biolink:NamedThing ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Protein a linkml:ClassDefinition ;
    dct:description "A gene product that is composed of a chain of amino acid sequences and is produced by ribosome-mediated translation of mRNA" ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "polypeptide" ;
    ns1:broadMatch UMLSSC:T116,
        UMLSST:aapp ;
    ns1:exactMatch OBO:PR_000000001,
        OBO:SO_0000104,
        <http://semanticscience.org/resource/SIO_010043>,
        UMLSSC:T087,
        UMLSST:amas,
        WIKIDATA:Q8054 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Protein ;
    linkml:definition_uri biolink:Protein ;
    linkml:id_prefixes "ENSEMBL",
        "FB",
        "PR",
        "UMLS",
        "UniProtKB" ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:mixins biolink:GeneProductMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:synonym,
        biolink:type,
        biolink:xref .

biolink:RelationshipQuantifier a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:RelationshipQuantifier ;
    linkml:definition_uri biolink:RelationshipQuantifier ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:SocioeconomicExposure a linkml:ClassDefinition ;
    dct:description "A socioeconomic exposure is a factor relating to social and financial status of an affected individual (e.g. poverty)." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SocioeconomicExposure ;
    linkml:definition_uri biolink:SocioeconomicExposure ;
    linkml:is_a biolink:Behavior ;
    linkml:mixins biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:socioeconomic_exposure_has_attribute,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:VariantAsAModelOfDiseaseAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:VariantAsAModelOfDiseaseAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:VariantAsAModelOfDiseaseAssociation ;
    linkml:is_a biolink:VariantToDiseaseAssociation ;
    linkml:mixins biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:onset_qualifier,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:source,
        biolink:variant_as_a_model_of_disease_association_subject,
        biolink:variant_to_disease_association_object,
        biolink:variant_to_disease_association_predicate .

biolink:VariantToGeneExpressionAssociation a linkml:ClassDefinition ;
    dct:description "An association between a variant and expression of a gene (i.e. e-QTL)" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:VariantToGeneExpressionAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:VariantToGeneExpressionAssociation ;
    linkml:is_a biolink:VariantToGeneAssociation ;
    linkml:mixins biolink:GeneExpressionMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:expression_site,
        biolink:gene_expression_mixin_quantifier_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:phenotypic_state,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:stage_qualifier,
        biolink:subject,
        biolink:variant_to_gene_association_object,
        biolink:variant_to_gene_expression_association_predicate .

biolink:VariantToPhenotypicFeatureAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:VariantToPhenotypicFeatureAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:VariantToPhenotypicFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:VariantToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:sex_qualifier,
        biolink:source,
        biolink:variant_to_phenotypic_feature_association_subject .

biolink:affects_abundance_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one changes the amount of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_abundance_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_abundance_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_abundance_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_abundance_of .

biolink:affects_activity_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one changes the activity of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_activity_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.renci.org/GAMMA_allosteric_modulator>,
        <http://translator.renci.org/GAMMA_modulator>,
        <http://translator.renci.org/GAMMA_regulator>,
        <https://www.dgidb.org/interaction_typesallosteric_modulator>,
        <https://www.dgidb.org/interaction_typesmodulator> ;
    linkml:definition_uri biolink:affects_activity_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_activity_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_activity_of .

biolink:affects_degradation_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one impacts the rate of degradation of the other within a system of interest, where chemical degradation is defined act or process of simplifying or breaking down a molecule into smaller parts, either naturally or artificially (Oxford English Dictionary, UK, 1995)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_degradation_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/CTD_affects_cleavage>,
        <http://translator.ncats.nih.gov/CTD_affects_hydrolysis> ;
    linkml:definition_uri biolink:affects_degradation_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_degradation_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_degradation_of .

biolink:affects_folding_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one changes the rate or quality of folding of the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_folding_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_folding_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_folding_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_folding_of .

biolink:affects_localization_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one changes the localization of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:GOREL_0002003,
        <http://translator.ncats.nih.gov/CTD_affects_localization_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch <http://translator.renci.org/GAMMA_storage> ;
    linkml:definition_uri biolink:affects_localization_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_localization_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_localization_of .

biolink:affects_metabolic_processing_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one impacts the metabolic processing of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_metabolic_processing_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch <http://translator.renci.org/GAMMA_catalytic_activity> ;
    linkml:definition_uri biolink:affects_metabolic_processing_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_metabolic_processing_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_metabolic_processing_of .

biolink:affects_molecular_modification_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one leads changes in the molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_molecular_modification_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://translator.ncats.nih.gov/CTD_affects_ADP-ribosylation>,
        <http://translator.ncats.nih.gov/CTD_affects_N-linked_glycosylation>,
        <http://translator.ncats.nih.gov/CTD_affects_O-linked_glycosylation>,
        <http://translator.ncats.nih.gov/CTD_affects_acetylation>,
        <http://translator.ncats.nih.gov/CTD_affects_acylation>,
        <http://translator.ncats.nih.gov/CTD_affects_alkylation>,
        <http://translator.ncats.nih.gov/CTD_affects_amination>,
        <http://translator.ncats.nih.gov/CTD_affects_carbamoylation>,
        <http://translator.ncats.nih.gov/CTD_affects_carboxylation>,
        <http://translator.ncats.nih.gov/CTD_affects_ethylation>,
        <http://translator.ncats.nih.gov/CTD_affects_farnesylation>,
        <http://translator.ncats.nih.gov/CTD_affects_geranoylation>,
        <http://translator.ncats.nih.gov/CTD_affects_glucuronidation>,
        <http://translator.ncats.nih.gov/CTD_affects_glutathionylation>,
        <http://translator.ncats.nih.gov/CTD_affects_glycation>,
        <http://translator.ncats.nih.gov/CTD_affects_glycosylation>,
        <http://translator.ncats.nih.gov/CTD_affects_hydroxylation>,
        <http://translator.ncats.nih.gov/CTD_affects_lipidation>,
        <http://translator.ncats.nih.gov/CTD_affects_methylation>,
        <http://translator.ncats.nih.gov/CTD_affects_myristoylation>,
        <http://translator.ncats.nih.gov/CTD_affects_nitrosation>,
        <http://translator.ncats.nih.gov/CTD_affects_nucleotidylation>,
        <http://translator.ncats.nih.gov/CTD_affects_oxidation>,
        <http://translator.ncats.nih.gov/CTD_affects_palmitoylation>,
        <http://translator.ncats.nih.gov/CTD_affects_phosphorylation>,
        <http://translator.ncats.nih.gov/CTD_affects_prenylation>,
        <http://translator.ncats.nih.gov/CTD_affects_reduction>,
        <http://translator.ncats.nih.gov/CTD_affects_ribosylation>,
        <http://translator.ncats.nih.gov/CTD_affects_sulfation>,
        <http://translator.ncats.nih.gov/CTD_affects_sumoylation>,
        <http://translator.ncats.nih.gov/CTD_affects_ubiquitination> ;
    linkml:definition_uri biolink:affects_molecular_modification_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_molecular_modification_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_molecular_modification_of .

biolink:affects_mutation_rate_of a linkml:SlotDefinition ;
    dct:description "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity impacts the rate of mutation of the genomic entity within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_affects_mutagenesis> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_mutation_rate_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_mutation_rate_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_mutation_rate_of ;
    linkml:range biolink:GenomicEntity ;
    linkml:slot_uri biolink:affects_mutation_rate_of .

biolink:affects_response_to a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one impacts the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_response_to> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_response_to ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_response_to ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_response_to .

biolink:affects_risk_for a linkml:SlotDefinition ;
    dct:description "holds between two entities where exposure to one entity alters the chance of developing the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_risk_for ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_risk_for ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:affects_risk_for .

biolink:affects_secretion_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one impacts the rate of secretion of the other out of a cell, gland, or organ" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_affects_export> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_secretion_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_secretion_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_secretion_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_secretion_of .

biolink:affects_splicing_of a linkml:SlotDefinition ;
    dct:description "holds between a molecular entity and an mRNA where the action or effect of the molecular entity impacts the splicing of the mRNA" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_affects_splicing_of> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_RNA_splicing> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_splicing_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_splicing_of ;
    linkml:range biolink:Transcript ;
    linkml:slot_uri biolink:affects_splicing_of .

biolink:affects_stability_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one impacts the stability of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch <http://translator.renci.org/GAMMA_stabilization> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_stability_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_stability_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_stability_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_stability_of .

biolink:affects_synthesis_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one impacts the rate of chemical synthesis of the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_synthesis_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_synthesis_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_synthesis_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_synthesis_of .

biolink:affects_transport_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one impacts the rate of transport of the other across some boundary in a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_transport_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:RO_0002313,
        OBO:RO_0002340,
        OBO:RO_0002345 ;
    linkml:definition_uri biolink:affects_transport_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_transport_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_transport_of .

biolink:affects_uptake_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one impacts the rate of uptake of the other into of a cell, gland, or organ" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:broadMatch <http://translator.ncats.nih.gov/CTD_affects_import> ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_uptake_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_uptake_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_uptake_of ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:affects_uptake_of .

biolink:associated_environmental_context a linkml:SlotDefinition ;
    dct:description "An attribute that can be applied to an association where the association holds between two entities located or occurring in a particular environment. For example, two microbial taxa may interact in the context of a human gut; a disease may give rise to a particular phenotype in a particular environmental exposure." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:associated_environmental_context ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:associated_environmental_context .

biolink:catalyst_qualifier a linkml:SlotDefinition ;
    dct:description "a qualifier that connects an association between two causally connected entities (for example, two chemical entities, or a chemical entity in that changes location) and the gene product, gene, or complex that enables or catalyzes the change." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:catalyst_qualifier ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:association_slot ;
    linkml:multivalued true ;
    linkml:owner biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:range biolink:MacromolecularMachineMixin ;
    linkml:slot_uri biolink:catalyst_qualifier .

biolink:causes a linkml:SlotDefinition ;
    dct:description "holds between two entities where the occurrence, existence, or activity of one causes the occurrence or generation of the other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:caused_by ;
    ns1:broadMatch OBO:RO_0002410 ;
    ns1:exactMatch OBO:RO_0002506,
        OBO:SNOMED_cause_of,
        <https://skr3.nlm.nih.gov/SemMedDBCAUSES>,
        <https://skr3.nlm.nih.gov/SemMedDBcauses>,
        WIKIDATA_PROPERTY:P1542 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLS:has_physiologic_effect,
        RTXKG1:capable_of_part_of,
        OBO:GOREL_0000040,
        OBO:MONDO_disease_causes_feature,
        OBO:MONDO_disease_triggers,
        OBO:NCIT_allele_has_abnormality,
        OBO:NCIT_biological_process_has_result_biological_process,
        OBO:NCIT_chemical_or_drug_has_physiologic_effect,
        OBO:NCIT_chemical_or_drug_initiates_biological_process,
        OBO:NCIT_chromosome_mapped_to_disease,
        OBO:NCIT_disease_has_normal_tissue_origin,
        OBO:NCIT_process_initiates_biological_process,
        OBO:RO_0002256,
        OBO:RO_0002315,
        OBO:RO_0002507,
        OBO:RO_0002509,
        OBO:RO_0004001,
        OBO:SNOMED_causative_agent_of,
        OBO:SNOMED_has_realization,
        <http://purl.obolibrary.org/obo/nbo#in_response_to>,
        <http://www.orpha.net/ORDO/Orphanet_317343>,
        <http://www.orpha.net/ORDO/Orphanet_317344>,
        <http://www.orpha.net/ORDO/Orphanet_317346>,
        <http://www.orpha.net/ORDO/Orphanet_410295>,
        <http://www.orpha.net/ORDO/Orphanet_410296> ;
    linkml:definition_uri biolink:causes ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:contributes_to ;
    linkml:multivalued true ;
    linkml:owner biolink:causes ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:causes .

biolink:expressed_in a linkml:SlotDefinition ;
    dct:description "holds between a gene or gene product and an anatomical entity in which it is expressed" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:expresses ;
    ns1:exactMatch OBO:RO_0002206 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch RTXKG1:expressed_in,
        OBO:NCIT_R46,
        OBO:NCIT_R49 ;
    linkml:definition_uri biolink:expressed_in ;
    linkml:domain biolink:GeneOrGeneProduct ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:expressed_in ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:slot_uri biolink:expressed_in .

biolink:expression_site a linkml:SlotDefinition ;
    dct:description "location in which gene or protein expression takes place. May be cell, tissue, or organ." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:expression_site ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:GeneExpressionMixin ;
    linkml:examples [ a linkml:Example ;
            dct:description "cerebellum" ;
            ns1:example "UBERON:0002037" ] ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:GeneExpressionMixin ;
    linkml:range biolink:AnatomicalEntity ;
    linkml:slot_uri biolink:expression_site .

biolink:food_component_of a linkml:SlotDefinition ;
    dct:description "holds between a one or more chemical substances present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_food_component ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:food_component_of ;
    linkml:domain biolink:ChemicalSubstance ;
    linkml:inherited true ;
    linkml:is_a biolink:part_of ;
    linkml:multivalued true ;
    linkml:owner biolink:food_component_of ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:food_component_of .

biolink:functional_association_object a linkml:SlotDefinition ;
    dct:description "class describing the activity, process or localization of the gene product" ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:FunctionalAssociation ;
    linkml:domain_of biolink:FunctionalAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "postsynaptic membrane" ;
            ns1:example "GO:0045211" ],
        [ a linkml:Example ;
            dct:description "kinase activity" ;
            ns1:example "GO:0016301" ] ;
    linkml:inlined true ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:FunctionalAssociation ;
    linkml:range biolink:GeneOntologyClass ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" ;
    linkml:values_from biolink:go .

biolink:functional_association_subject a linkml:SlotDefinition ;
    dct:description "gene, product or macromolecular complex mixin that has the function associated with the GO term" ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:FunctionalAssociation ;
    linkml:domain_of biolink:FunctionalAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "twist1b" ;
            ns1:example "ZFIN:ZDB-GENE-050417-357" ] ;
    linkml:inlined true ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:FunctionalAssociation ;
    linkml:range biolink:MacromolecularMachineMixin ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:gene_to_gene_association_object a linkml:SlotDefinition ;
    dct:description "the object gene in the association. If the relation is symmetric, subject vs object is arbitrary. We allow a gene product to stand as a proxy for the gene or vice versa." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    ns1:prefLabel "object" ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:GeneToGeneAssociation ;
    linkml:domain_of biolink:GeneToGeneAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:object ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "descriptor" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with incoming relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToGeneAssociation ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:object ;
    linkml:usage_slot_name "object" .

biolink:gene_to_gene_association_subject a linkml:SlotDefinition ;
    dct:description "the subject gene in the association. If the relation is symmetric, subject vs object is arbitrary. We allow a gene product to stand as a proxy for the gene or vice versa." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    ns1:prefLabel "subject" ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:GeneToGeneAssociation ;
    linkml:domain_of biolink:GeneToGeneAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:subject ;
    linkml:is_usage_slot true ;
    linkml:local_names [ linkml:ga4gh [ ns1:altLabel "annotation subject" ;
                    linkml:local_name_source "ga4gh" ] ;
            linkml:neo4j [ ns1:altLabel "node with outgoing relationship" ;
                    linkml:local_name_source "neo4j" ] ] ;
    linkml:owner biolink:GeneToGeneAssociation ;
    linkml:range biolink:GeneOrGeneProduct ;
    linkml:required true ;
    linkml:slot_uri rdf:subject ;
    linkml:usage_slot_name "subject" .

biolink:has_food_component a linkml:SlotDefinition ;
    dct:description "holds between food and one or more chemical substances composing it, irrespective of nutritional value (i.e. could also be a contaminant or additive)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:food_component_of ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_food_component ;
    linkml:domain biolink:ChemicalSubstance ;
    linkml:inherited true ;
    linkml:is_a biolink:has_part ;
    linkml:multivalued true ;
    linkml:owner biolink:has_food_component ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:has_food_component .

biolink:has_gene a linkml:SlotDefinition ;
    dct:description "connects an entity associated with one or more genes" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_gene ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:SequenceVariant ;
    linkml:is_a biolink:has_gene_or_gene_product ;
    linkml:multivalued true ;
    linkml:owner biolink:SequenceVariant ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:has_gene .

biolink:has_gene_product a linkml:SlotDefinition ;
    dct:description "holds between a gene and a transcribed and/or translated product generated from it" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:gene_product_of ;
    ns1:closeMatch OBO:PR_has_gene_template ;
    ns1:exactMatch OBO:NCIT_gene_encodes_gene_product,
        OBO:RO_0002205,
        WIKIDATA_PROPERTY:P688 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_R178 ;
    linkml:definition_uri biolink:has_gene_product ;
    linkml:domain biolink:Gene ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:has_gene_product ;
    linkml:range biolink:GeneProductMixin ;
    linkml:slot_uri biolink:has_gene_product .

biolink:has_phenotype a linkml:SlotDefinition ;
    dct:description "holds between a biological entity and a phenotype, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature)." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:phenotype_of ;
    ns1:broadMatch OBO:NCIT_R115,
        OBO:OMIM_has_phenotype,
        <http://translator.ncats.nih.gov/hetio_PRESENTS_DpS> ;
    ns1:closeMatch OBO:OMIM_phenotype_of ;
    ns1:editorialNote "check the range" ;
    ns1:exactMatch RTXKG1:has_phenotype,
        OBO:RO_0002200,
        OBO:SNOMED_characterized_by ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_R89,
        OBO:RO_0004022,
        <http://purl.obolibrary.org/obo/doid#has_symptom> ;
    linkml:definition_uri biolink:has_phenotype ;
    linkml:domain biolink:BiologicalEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:has_phenotype ;
    linkml:range biolink:PhenotypicFeature ;
    linkml:slot_uri biolink:has_phenotype .

biolink:interbase_coordinate a linkml:SlotDefinition ;
    dct:description "A position in interbase coordinates. This is applied to a sequence localization edge." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:interbase_coordinate ;
    linkml:domain biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:sequence_localization_attribute ;
    linkml:owner biolink:interbase_coordinate ;
    linkml:range biolink:integer ;
    linkml:slot_uri biolink:interbase_coordinate .

biolink:issue a linkml:SlotDefinition ;
    dct:description "issue of a newspaper, a scientific journal or magazine for reference purpose" ;
    ns1:exactMatch WIKIDATA_PROPERTY:P433 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:issue ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Article,
        biolink:Serial ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:issue ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:issue .

biolink:latitude a linkml:SlotDefinition ;
    dct:description "latitude" ;
    ns1:exactMatch <http://www.w3.org/2003/01/geo/wgs84_poslat> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:latitude ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:GeographicLocation ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:GeographicLocation ;
    linkml:range biolink:float ;
    linkml:slot_uri biolink:latitude .

biolink:longitude a linkml:SlotDefinition ;
    dct:description "longitude" ;
    ns1:exactMatch <http://www.w3.org/2003/01/geo/wgs84_poslong> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:longitude ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:GeographicLocation ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:GeographicLocation ;
    linkml:range biolink:float ;
    linkml:slot_uri biolink:longitude .

biolink:macromolecular_machine_mixin_name a linkml:SlotDefinition ;
    dct:description "genes are typically designated by a short symbol and a full name. We map the symbol to the default display name and use an additional slot for full name" ;
    oboInOwl:inSubset biolink:samples,
        biolink:translator_minimal ;
    ns1:altLabel "display name",
        "label",
        "title" ;
    ns1:exactMatch gff3:Name,
        gpi:DB_Object_Name ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdfs:label ;
    ns1:narrowMatch dct:title,
        WIKIDATA_PROPERTY:P1476 ;
    ns1:prefLabel "name" ;
    linkml:definition_uri biolink:name ;
    linkml:domain biolink:MacromolecularMachineMixin ;
    linkml:domain_of biolink:MacromolecularMachineMixin ;
    linkml:is_a biolink:name ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:MacromolecularMachineMixin ;
    linkml:range biolink:symbol_type ;
    linkml:slot_uri rdfs:label ;
    linkml:usage_slot_name "name" .

biolink:overlaps a linkml:SlotDefinition ;
    dct:description "holds between entities that overlap in their extents (materials or processes)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_0002131 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:BSPO_0005001,
        OBO:RO_0002100,
        OBO:RO_0002102,
        OBO:RO_0002433,
        CHEMBL.MECHANISM:overlaps_with ;
    linkml:definition_uri biolink:overlaps ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:overlaps ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:overlaps ;
    linkml:symmetric true .

biolink:pages a linkml:SlotDefinition ;
    dct:description "page number of source referenced for statement or publication" ;
    ns1:exactMatch WIKIDATA_PROPERTY:P304 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:pages ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Publication ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:Publication ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:pages .

biolink:phenotypic_state a linkml:SlotDefinition ;
    dct:description "in experiments (e.g. gene expression) assaying diseased or unhealthy tissue, the phenotypic state can be put here, e.g. MONDO ID. For healthy tissues, use XXX." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:phenotypic_state ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:GeneExpressionMixin ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:GeneExpressionMixin ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_uri biolink:phenotypic_state .

biolink:publication_id a linkml:SlotDefinition ;
    dct:description "Different kinds of publication subtypes will have different preferred identifiers (curies when feasible). Precedence of identifiers for scientific articles is as follows: PMID if available; DOI if not; actual alternate CURIE otherwise. Enclosing publications (i.e. referenced by 'published in' node property) such as books and journals, should have industry-standard identifier such as from ISBN and ISSN." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch gff3:ID,
        gpi:DB_Object_ID,
        alliancegenome:primaryId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "id" ;
    linkml:definition_uri biolink:id ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Publication ;
    linkml:identifier true ;
    linkml:is_a biolink:id ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Publication ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri biolink:id ;
    linkml:usage_slot_name "id" .

biolink:publication_name a linkml:SlotDefinition ;
    dct:description "the 'title' of the publication is generally recorded in the 'name' property (inherited from NamedThing). The field name 'title' is now also tagged as an acceptable alias for the node property 'name' (just in case)." ;
    oboInOwl:inSubset biolink:samples,
        biolink:translator_minimal ;
    ns1:altLabel "display name",
        "label",
        "title" ;
    ns1:exactMatch gff3:Name,
        gpi:DB_Object_Name ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdfs:label ;
    ns1:narrowMatch dct:title,
        WIKIDATA_PROPERTY:P1476 ;
    ns1:prefLabel "name" ;
    linkml:definition_uri biolink:name ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Publication ;
    linkml:is_a biolink:name ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Publication ;
    linkml:range biolink:label_type ;
    linkml:slot_uri rdfs:label ;
    linkml:usage_slot_name "name" .

biolink:publication_pages a linkml:SlotDefinition ;
    dct:description "When a 2-tuple of page numbers are provided, they represent the start and end page of the publication within its parent publication context. For books, this may be set to the total number of pages of the book." ;
    ns1:exactMatch WIKIDATA_PROPERTY:P304 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "pages" ;
    linkml:definition_uri biolink:pages ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Publication ;
    linkml:is_a biolink:pages ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:Publication ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:pages ;
    linkml:usage_slot_name "pages" .

biolink:publication_type a linkml:SlotDefinition ;
    dct:description "Ontology term for publication type may be drawn from Dublin Core types (https://www.dublincore.org/specifications/dublin-core/dcmi-type-vocabulary/), FRBR-aligned Bibliographic Ontology (https://sparontologies.github.io/fabio/current/fabio.html), the MESH publication types (https://www.nlm.nih.gov/mesh/pubtypes.html), the Confederation of Open Access Repositories (COAR) Controlled Vocabulary for Resource Type Genres (http://vocabularies.coar-repositories.org/documentation/resource_types/), Wikidata (https://www.wikidata.org/wiki/Wikidata:Publication_types), or equivalent publication type ontology. When a given publication type ontology term is used within a given knowledge graph, then the CURIE identified term must be documented in the graph as a concept node of biolink:category biolink:OntologyClass." ;
    ns1:exactMatch gff3:type,
        gpi:DB_Object_Type,
        alliancegenome:soTermId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation dct:type ;
    ns1:prefLabel "type" ;
    linkml:definition_uri biolink:type ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Publication ;
    linkml:is_a biolink:type ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Publication ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri dct:type ;
    linkml:usage_slot_name "type" ;
    linkml:values_from biolink:COAR_RESOURCE,
        biolink:MESH_PUB,
        biolink:WIKIDATA,
        biolink:dctypes,
        biolink:fabio .

biolink:related_condition a linkml:SlotDefinition ;
    ns1:exactMatch OBO:GENO_0000790 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:related_condition ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:related_condition ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:related_condition ;
    linkml:symmetric true .

biolink:temporally_related_to a linkml:SlotDefinition ;
    dct:description "holds between two entities with a temporal relationship" ;
    ns1:exactMatch OBO:SNOMED_temporally_related_to ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:RO_0002082,
        OBO:RO_0002083,
        OBO:RO_0002092,
        OBO:RO_0002093,
        OBO:RO_0002223,
        OBO:RO_0002224,
        OBO:RO_0002229,
        OBO:RO_0002230,
        OBO:RO_0002488,
        OBO:RO_0002489,
        OBO:RO_0002492,
        OBO:RO_0002493,
        OBO:RO_0002496,
        OBO:RO_0002497 ;
    linkml:definition_uri biolink:temporally_related_to ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:temporally_related_to ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:temporally_related_to ;
    linkml:symmetric true .

biolink:treated_by a linkml:SlotDefinition ;
    dct:description "holds between a disease or phenotypic feature and a therapeutic process or chemical substance that is used to treat the condition" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:treats ;
    ns1:exactMatch OBO:MONDO_disease_responds_to,
        WIKIDATA_PROPERTY:P2176 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:RO_0002302 ;
    linkml:definition_uri biolink:treated_by ;
    linkml:domain biolink:DiseaseOrPhenotypicFeature ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:treated_by ;
    linkml:range biolink:Treatment ;
    linkml:slot_uri biolink:treated_by .

biolink:treats a linkml:SlotDefinition ;
    dct:description "holds between a therapeutic procedure or chemical substance and a disease or phenotypic feature that it is used to treat" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:treated_by ;
    ns1:altLabel "is substance that treats" ;
    ns1:broadMatch OBO:RO_0003307 ;
    ns1:exactMatch DRUGBANK:treats,
        <https://skr3.nlm.nih.gov/SemMedDBTREATS>,
        <https://skr3.nlm.nih.gov/SemMedDBtreats>,
        WIKIDATA_PROPERTY:P2175 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch REPODB:clinically_tested_approved_unknown_phase,
        REPODB:clinically_tested_suspended_phase_0,
        REPODB:clinically_tested_suspended_phase_1,
        REPODB:clinically_tested_suspended_phase_1_or_phase_2,
        REPODB:clinically_tested_suspended_phase_2,
        REPODB:clinically_tested_suspended_phase_2_or_phase_3,
        REPODB:clinically_tested_suspended_phase_3,
        REPODB:clinically_tested_terminated_phase_0,
        REPODB:clinically_tested_terminated_phase_1,
        REPODB:clinically_tested_terminated_phase_1_or_phase_2,
        REPODB:clinically_tested_terminated_phase_2,
        REPODB:clinically_tested_terminated_phase_2_or_phase_3,
        REPODB:clinically_tested_terminated_phase_3,
        REPODB:clinically_tested_withdrawn_phase_0,
        REPODB:clinically_tested_withdrawn_phase_1,
        REPODB:clinically_tested_withdrawn_phase_1_or_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2_or_phase_3,
        REPODB:clinically_tested_withdrawn_phase_3,
        RTXKG1:indicated_for,
        OBO:NCIT_regimen_has_accepted_use_for_disease,
        OBO:RO_0002606,
        OBO:SNOMED_plays_role ;
    ns1:relatedMatch OBO:MONDO_disease_responds_to ;
    linkml:definition_uri biolink:treats ;
    linkml:domain biolink:ChemicalOrDrugOrTreatment ;
    linkml:inherited true ;
    linkml:is_a biolink:ameliorates ;
    linkml:multivalued true ;
    linkml:owner biolink:treats ;
    linkml:range biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_uri biolink:treats .

biolink:CaseToEntityAssociationMixin a linkml:ClassDefinition ;
    dct:description "An abstract association for use where the case is the subject" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:CaseToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:CaseToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:case_to_entity_association_mixin_subject .

biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation a linkml:ClassDefinition ;
    dct:description "An relationship between a cell line and a disease or a phenotype, where the cell line is derived from an individual with that disease or phenotype." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:definition_uri biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:CellLineToEntityAssociationMixin,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:cell_line_to_disease_or_phenotypic_feature_association_subject,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:CellLineToEntityAssociationMixin a linkml:ClassDefinition ;
    dct:description "An relationship between a cell line and another entity" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:CellLineToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:CellLineToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:cell_line_to_entity_association_mixin_subject .

biolink:ChemicalOrDrugOrTreatment a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ChemicalOrDrugOrTreatment ;
    linkml:definition_uri biolink:ChemicalOrDrugOrTreatment ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:ChemicalToChemicalAssociation a linkml:ClassDefinition ;
    dct:description "A relationship between two chemical entities. This can encompass actual interactions as well as temporal causal edges, e.g. one chemical converted to another." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ChemicalToChemicalAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:ChemicalToChemicalAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:ChemicalToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:chemical_to_chemical_association_object,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:ClinicalAttribute a linkml:ClassDefinition ;
    dct:description "Attributes relating to a clinical manifestation" ;
    ns1:exactMatch UMLSSC:T201,
        UMLSST:clna ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ClinicalAttribute ;
    linkml:definition_uri biolink:ClinicalAttribute ;
    linkml:is_a biolink:Attribute ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:DatasetDistribution a linkml:ClassDefinition ;
    dct:description "an item that holds distribution level information about a dataset." ;
    ns1:exactMatch dcat:Distribution ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DatasetDistribution ;
    linkml:definition_uri biolink:DatasetDistribution ;
    linkml:is_a biolink:InformationContentEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:creation_date,
        biolink:description,
        biolink:distribution_download_url,
        biolink:format,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:license,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:rights,
        biolink:source,
        biolink:type .

biolink:Disease a linkml:ClassDefinition ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "condition",
        "disorder",
        "medical condition" ;
    ns1:exactMatch OBO:DOID_4,
        OBO:MONDO_0000001,
        OBO:NCIT_C2991,
        <http://semanticscience.org/resource/SIO_010299>,
        UMLSSG:DISO,
        UMLSSC:T047,
        UMLSST:dsyn,
        WIKIDATA:Q12136 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T019,
        UMLSSC:T020,
        UMLSSC:T037,
        UMLSSC:T046,
        UMLSSC:T048,
        UMLSSC:T049,
        UMLSSC:T190,
        UMLSSC:T191,
        UMLSST:acab,
        UMLSST:anab,
        UMLSST:cgab,
        UMLSST:comd,
        UMLSST:inpo,
        UMLSST:mobd,
        UMLSST:neop,
        UMLSST:patf ;
    linkml:class_uri biolink:Disease ;
    linkml:definition_uri biolink:Disease ;
    linkml:id_prefixes "DOID",
        "EFO",
        "HP",
        "ICD0",
        "ICD10",
        "ICD9",
        "KEGG.DISEASE",
        "MEDDRA",
        "MESH",
        "MONDO",
        "MP",
        "NCIT",
        "OMIM",
        "ORPHANET",
        "SNOMEDCT",
        "UMLS",
        "medgen" ;
    linkml:is_a biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:DrugToEntityAssociationMixin a linkml:ClassDefinition ;
    dct:description "An interaction between a drug and another entity" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DrugToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:DrugToEntityAssociationMixin ;
    linkml:is_a biolink:MolecularEntityToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:drug_to_entity_association_mixin_subject .

biolink:EntityToExposureEventAssociationMixin a linkml:ClassDefinition ;
    dct:description "An association between some entity and an exposure event." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EntityToExposureEventAssociationMixin ;
    linkml:defining_slots biolink:object ;
    linkml:definition_uri biolink:EntityToExposureEventAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:entity_to_exposure_event_association_mixin_object .

biolink:EntityToOutcomeAssociationMixin a linkml:ClassDefinition ;
    dct:description "An association between some entity and an outcome" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EntityToOutcomeAssociationMixin ;
    linkml:defining_slots biolink:object ;
    linkml:definition_uri biolink:EntityToOutcomeAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:entity_to_outcome_association_mixin_object .

biolink:ExposureEventToEntityAssociationMixin a linkml:ClassDefinition ;
    dct:description "An association between some exposure event and some entity." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ExposureEventToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:ExposureEventToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:exposure_event_to_entity_association_mixin_subject .

biolink:ExposureEventToOutcomeAssociation a linkml:ClassDefinition ;
    dct:description "An association between an exposure event and an outcome." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ExposureEventToOutcomeAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:ExposureEventToOutcomeAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToOutcomeAssociationMixin,
        biolink:ExposureEventToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:has_population_context,
        biolink:has_temporal_context,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:FrequencyQualifierMixin a linkml:ClassDefinition ;
    dct:description "Qualifier for frequency type associations" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:FrequencyQualifierMixin ;
    linkml:definition_uri biolink:FrequencyQualifierMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:frequency_qualifier .

biolink:MaterialSampleToEntityAssociationMixin a linkml:ClassDefinition ;
    dct:description "An association between a material sample and something." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MaterialSampleToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:MaterialSampleToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:material_sample_to_entity_association_mixin_subject .

biolink:affects_expression_of a linkml:SlotDefinition ;
    dct:description "holds between two molecular entities where the action or effect of one changes the level of expression of the other within a system of interest" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <http://translator.ncats.nih.gov/CTD_affects_expression_of> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affects_expression_of ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:multivalued true ;
    linkml:owner biolink:affects_expression_of ;
    linkml:range biolink:GenomicEntity ;
    linkml:slot_uri biolink:affects_expression_of .

biolink:derives_from a linkml:SlotDefinition ;
    dct:description "holds between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" ;
    oboInOwl:inSubset biolink:samples,
        biolink:translator_minimal ;
    owl:inverseOf biolink:derives_into ;
    ns1:exactMatch OBO:FMA_derives_from,
        OBO:RO_0001000,
        <http://purl.obolibrary.org/obo/doid#derives_from> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:CHEBI_has_functional_parent,
        OBO:SNOMED_has_specimen_source_topography ;
    linkml:definition_uri biolink:derives_from ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:derives_from ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:derives_from .

biolink:derives_into a linkml:SlotDefinition ;
    dct:description "holds between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:derives_from ;
    ns1:exactMatch OBO:FMA_derives,
        OBO:NCIT_is_normal_cell_origin_of_disease,
        OBO:NCIT_may_be_normal_cell_origin_of_disease,
        OBO:RO_0001001,
        <https://skr3.nlm.nih.gov/SemMedDBCONVERTS_TO>,
        <https://skr3.nlm.nih.gov/SemMedDBconverts_to> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:derives_into ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:derives_into ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:derives_into .

biolink:double a linkml:TypeDefinition ;
    dct:description "A real number that conforms to the xsd:double specification" ;
    ns1:inScheme linkml:types ;
    linkml:base "float" ;
    linkml:definition_uri linkml:Double ;
    linkml:imported_from "linkml:types" ;
    linkml:uri xsd:double .

biolink:entity_regulated_by_entity a linkml:SlotDefinition ;
    owl:inverseOf biolink:entity_regulates_entity ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:entity_regulated_by_entity ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affected_by ;
    linkml:multivalued true ;
    linkml:owner biolink:entity_regulated_by_entity ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:entity_regulated_by_entity .

biolink:entity_regulates_entity a linkml:SlotDefinition ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:entity_regulated_by_entity ;
    ns1:altLabel "activity directly regulates activity of" ;
    ns1:exactMatch OBO:RO_0002448 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch WIKIDATA_PROPERTY:P128 ;
    linkml:definition_uri biolink:entity_regulates_entity ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:affects ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "activity directly regulates activity of" ;
            linkml:local_name_source "ro" ],
        [ a linkml:LocalName ;
            ns1:altLabel "regulates" ;
            linkml:local_name_source "translator" ] ;
    linkml:mixins biolink:regulates ;
    linkml:multivalued true ;
    linkml:owner biolink:entity_regulates_entity ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:entity_regulates_entity .

biolink:genetic_association a linkml:SlotDefinition ;
    dct:description "Co-occurrence of a certain allele of a genetic marker and the phenotype of interest in the same individuals at above-chance level" ;
    ns1:exactMatch WIKIDATA_PROPERTY:P2293 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:genetic_association ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:genetic_association ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:genetic_association ;
    linkml:symmetric true .

biolink:has_count a linkml:SlotDefinition ;
    dct:description "number of things with a particular property" ;
    ns1:exactMatch LOINC:has_count ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_count ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:FrequencyQuantifier ;
    linkml:is_a biolink:aggregate_statistic ;
    linkml:owner biolink:FrequencyQuantifier ;
    linkml:range biolink:integer ;
    linkml:slot_uri biolink:has_count .

biolink:has_quotient a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_quotient ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:FrequencyQuantifier ;
    linkml:is_a biolink:aggregate_statistic ;
    linkml:owner biolink:FrequencyQuantifier ;
    linkml:range biolink:double ;
    linkml:slot_uri biolink:has_quotient .

biolink:has_total a linkml:SlotDefinition ;
    dct:description "total number of things in a particular reference set" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_total ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:FrequencyQuantifier ;
    linkml:is_a biolink:aggregate_statistic ;
    linkml:owner biolink:FrequencyQuantifier ;
    linkml:range biolink:integer ;
    linkml:slot_uri biolink:has_total .

biolink:molecularly_interacts_with a linkml:SlotDefinition ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch RTXKG1:targets,
        OBO:RO_0002436,
        <http://translator.ncats.nih.gov/CTD_molecularly_interacts_with> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:relatedMatch <https://www.dgidb.org/interaction_typesantibody> ;
    linkml:definition_uri biolink:molecularly_interacts_with ;
    linkml:domain biolink:MolecularEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:physically_interacts_with ;
    linkml:multivalued true ;
    linkml:owner biolink:molecularly_interacts_with ;
    linkml:range biolink:MolecularEntity ;
    linkml:slot_uri biolink:molecularly_interacts_with ;
    linkml:symmetric true .

biolink:negatively_regulates a linkml:SlotDefinition ;
    owl:inverseOf biolink:negatively_regulated_by ;
    ns1:broadMatch OBO:RO_0004033 ;
    ns1:closeMatch OBO:RO_0002335 ;
    ns1:exactMatch OBO:RO_0002212,
        OBO:RO_0004035 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:RO_0002630,
        CHEMBL.MECHANISM:blocker,
        CHEMBL.MECHANISM:inhibitor,
        CHEMBL.MECHANISM:negative_allosteric_modulator,
        CHEMBL.MECHANISM:negative_modulator ;
    ns1:note "This is a grouping for negative process-process and entity-entity regulation." ;
    linkml:definition_uri biolink:negatively_regulates ;
    linkml:domain biolink:PhysicalEssenceOrOccurrent ;
    linkml:inlined true ;
    linkml:is_a biolink:regulates ;
    linkml:mixin true ;
    linkml:owner biolink:negatively_regulates ;
    linkml:range biolink:PhysicalEssenceOrOccurrent ;
    linkml:slot_uri biolink:negatively_regulates .

biolink:participates_in a linkml:SlotDefinition ;
    dct:description "holds between a continuant and a process, where the continuant is somehow involved in the process" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_participant ;
    ns1:exactMatch RTXKG1:participates_in,
        OBO:BFO_0000056,
        OBO:RO_0000056 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch DRUGBANK:pathway,
        HMDB:in_pathway,
        LOINC:is_given_pharmaceutical_substance_for,
        OBO:NCIT_R130,
        OBO:NCIT_R131,
        OBO:NCIT_R37,
        OBO:NCIT_R51,
        OBO:NCIT_R53,
        OBO:OBI_0000295,
        OBO:RO_0002216,
        OBO:RO_0002505,
        OBO:RO_0002565,
        OBO:SNOMED_has_direct_device ;
    linkml:definition_uri biolink:participates_in ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:participates_in ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:participates_in .

biolink:positively_regulates a linkml:SlotDefinition ;
    owl:inverseOf biolink:positively_regulated_by ;
    ns1:closeMatch OBO:RO_0002336 ;
    ns1:exactMatch OBO:RO_0002213 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:RO_0002629,
        OBO:RO_0004032,
        OBO:RO_0004034,
        <https://skr3.nlm.nih.gov/SemMedDBaugments>,
        <https://www.dgidb.org/interaction_typesactivator>,
        CHEMBL.MECHANISM:activator ;
    ns1:note "This is a grouping for positive process-process and entity-entity regulation." ;
    linkml:definition_uri biolink:positively_regulates ;
    linkml:domain biolink:PhysicalEssenceOrOccurrent ;
    linkml:inlined true ;
    linkml:is_a biolink:regulates ;
    linkml:mixin true ;
    linkml:owner biolink:positively_regulates ;
    linkml:range biolink:PhysicalEssenceOrOccurrent ;
    linkml:slot_uri biolink:positively_regulates .

biolink:process_regulated_by_process a linkml:SlotDefinition ;
    owl:inverseOf biolink:process_regulates_process ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:process_regulated_by_process ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:affected_by ;
    linkml:multivalued true ;
    linkml:owner biolink:process_regulated_by_process ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:process_regulated_by_process .

biolink:process_regulates_process a linkml:SlotDefinition ;
    owl:inverseOf biolink:process_regulated_by_process ;
    ns1:exactMatch OBO:RO_0002211 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:process_regulates_process ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:affects ;
    linkml:mixins biolink:regulates ;
    linkml:multivalued true ;
    linkml:owner biolink:process_regulates_process ;
    linkml:range biolink:Occurrent ;
    linkml:slot_uri biolink:process_regulates_process .

biolink:regulated_by a linkml:SlotDefinition ;
    owl:inverseOf biolink:regulates ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:regulated_by ;
    linkml:domain biolink:PhysicalEssenceOrOccurrent ;
    linkml:inlined true ;
    linkml:mixin true ;
    linkml:owner biolink:regulated_by ;
    linkml:range biolink:PhysicalEssenceOrOccurrent ;
    linkml:slot_uri biolink:regulated_by .

biolink:similar_to a linkml:SlotDefinition ;
    dct:description "holds between an entity and some other entity with similar features." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_HOM0000000,
        OBO:SO_similar_to ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:similar_to ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:similar_to ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:similar_to ;
    linkml:symmetric true .

biolink:volume a linkml:SlotDefinition ;
    dct:description "volume of a book or music release in a collection/series or a published collection of journal issues in a serial publication" ;
    ns1:exactMatch WIKIDATA_PROPERTY:P478 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:volume ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Article,
        biolink:BookChapter,
        biolink:Serial ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:volume ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:volume .

biolink:Behavior a linkml:ClassDefinition ;
    ns1:exactMatch OBO:GO_0007610,
        UMLSSC:T053,
        UMLSST:bhvr ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T041,
        UMLSSC:T054,
        UMLSSC:T055,
        UMLSST:inbe,
        UMLSST:menp,
        UMLSST:socb ;
    linkml:class_uri biolink:Behavior ;
    linkml:definition_uri biolink:Behavior ;
    linkml:is_a biolink:BiologicalProcess ;
    linkml:mixins biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Dataset a linkml:ClassDefinition ;
    dct:description "an item that refers to a collection of data from a data source." ;
    ns1:exactMatch OBO:IAO_0000100,
        dctypes:Dataset,
        schema:dataset ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Dataset ;
    linkml:definition_uri biolink:Dataset ;
    linkml:is_a biolink:InformationContentEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:license,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:rights,
        biolink:source,
        biolink:type .

biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:disease_or_phenotypic_feature_to_entity_association_mixin_subject .

biolink:DiseaseToEntityAssociationMixin a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DiseaseToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:DiseaseToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:disease_to_entity_association_mixin_subject .

biolink:GeneGroupingMixin a linkml:ClassDefinition ;
    dct:description "any grouping of multiple genes or gene products" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneGroupingMixin ;
    linkml:definition_uri biolink:GeneGroupingMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:has_gene_or_gene_product .

biolink:GeneHasVariantThatContributesToDiseaseAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneHasVariantThatContributesToDiseaseAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:GeneHasVariantThatContributesToDiseaseAssociation ;
    linkml:is_a biolink:GeneToDiseaseAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:gene_has_variant_that_contributes_to_disease_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:sequence_variant_qualifier,
        biolink:severity_qualifier,
        biolink:source .

biolink:GeneToDiseaseAssociation a linkml:ClassDefinition ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_000983> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "NCIT:R176 refers to the inverse relationship" ;
    linkml:class_uri biolink:GeneToDiseaseAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GeneToDiseaseAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToDiseaseAssociationMixin,
        biolink:GeneToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:gene_to_disease_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:source .

biolink:GeneToEntityAssociationMixin a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:GeneToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:gene_to_entity_association_mixin_subject .

biolink:GenotypeToEntityAssociationMixin a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GenotypeToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:GenotypeToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:genotype_to_entity_association_mixin_subject .

biolink:MolecularEntityToEntityAssociationMixin a linkml:ClassDefinition ;
    dct:description "An interaction between a molecular entity and another entity" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MolecularEntityToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:MolecularEntityToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:molecular_entity_to_entity_association_mixin_subject .

biolink:OrganismTaxonToEntityAssociation a linkml:ClassDefinition ;
    dct:description "An association between an organism taxon and another entity" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:OrganismTaxonToEntityAssociation ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:OrganismTaxonToEntityAssociation ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:organism_taxon_to_entity_association_subject .

biolink:PopulationOfIndividualOrganisms a linkml:ClassDefinition ;
    dct:description "A collection of individuals from the same taxonomic class distinguished by one or more characteristics.  Characteristics can include, but are not limited to, shared geographic location, genetics, phenotypes [Alliance for Genome Resources]" ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:exactMatch OBO:OBI_0000181,
        OBO:PCO_0000001,
        <http://semanticscience.org/resource/SIO_001061>,
        UMLSSC:T098,
        UMLSST:popg ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T099,
        UMLSSC:T100,
        UMLSSC:T101,
        UMLSST:aggp,
        UMLSST:famg,
        UMLSST:podg ;
    linkml:class_uri biolink:PopulationOfIndividualOrganisms ;
    linkml:definition_uri biolink:PopulationOfIndividualOrganisms ;
    linkml:id_prefixes "HANCESTRO" ;
    linkml:is_a biolink:OrganismalEntity ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "population" ;
            linkml:local_name_source "ga4gh" ],
        [ a linkml:LocalName ;
            ns1:altLabel "population" ;
            linkml:local_name_source "agr" ] ;
    linkml:mixins biolink:ThingWithTaxon ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:affected_by a linkml:SlotDefinition ;
    dct:description "describes an entity of which the state or quality is affected by another existing entity." ;
    owl:inverseOf biolink:affects ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:affected_by ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:affected_by ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:affected_by .

biolink:aggregate_statistic a linkml:SlotDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:definition_uri biolink:aggregate_statistic ;
    linkml:domain biolink:NamedThing ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:aggregate_statistic ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:aggregate_statistic .

biolink:authors a linkml:SlotDefinition ;
    dct:description "connects an publication to the list of authors who contributed to the publication. This property should be a comma-delimited list of author names. It is recommended that an author's name be formatted as \"surname, firstname initial.\".   Note that this property is a node annotation expressing the citation list of authorship which might typically otherwise be more completely documented in biolink:PublicationToProviderAssociation defined edges which point to full details about an author and possibly, some qualifiers which clarify the specific status of a given author in the publication." ;
    ns1:altLabel "author" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:authors ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Publication ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:Publication ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:authors .

biolink:coexists_with a linkml:SlotDefinition ;
    dct:description "holds between two entities that are co-located in the same aggregate object, process, or spatio-temporal region" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch <https://skr3.nlm.nih.gov/SemMedDBCOEXISTS_WITH>,
        <https://skr3.nlm.nih.gov/SemMedDBcoexists_with> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_lateral_anatomic_location,
        LOINC:has_lateral_location_presence,
        OBO:BSPO_0000096,
        OBO:BSPO_0000097,
        OBO:BSPO_0000098,
        OBO:BSPO_0000099,
        OBO:BSPO_0000100,
        OBO:BSPO_0000102,
        OBO:BSPO_0000104,
        OBO:BSPO_0000110,
        OBO:BSPO_0000113,
        OBO:BSPO_0015001,
        OBO:BSPO_0015002,
        OBO:BSPO_0015003,
        OBO:BSPO_0015005,
        OBO:BSPO_0015006,
        OBO:BSPO_0015007,
        OBO:BSPO_0015008,
        OBO:BSPO_0015009,
        OBO:BSPO_0015012,
        OBO:BSPO_0015014,
        OBO:BSPO_parallel_to,
        OBO:ENVO_01001307,
        OBO:FMA_adjacent_to,
        OBO:FMA_afferent_to,
        OBO:FMA_anterior_to,
        OBO:FMA_anteroinferior_to,
        OBO:FMA_anterolateral_to,
        OBO:FMA_anteromedial_to,
        OBO:FMA_anterosuperior_to,
        OBO:FMA_arterial_supply_of,
        OBO:FMA_articulates_with,
        OBO:FMA_attaches_to,
        OBO:FMA_bounded_by,
        OBO:FMA_bounds,
        OBO:FMA_branch_of,
        OBO:FMA_connection_type_of,
        OBO:FMA_continuation_branch_of,
        OBO:FMA_continuous_distally_with,
        OBO:FMA_continuous_proximally_with,
        OBO:FMA_corresponds_to,
        OBO:FMA_development_type_of,
        OBO:FMA_developmental_stage_of,
        OBO:FMA_direct_cell_shape_of,
        OBO:FMA_direct_left_of,
        OBO:FMA_direct_right_of,
        OBO:FMA_distal_to,
        OBO:FMA_drains_into,
        OBO:FMA_efferent_to,
        OBO:FMA_external_to,
        OBO:FMA_formed_by,
        OBO:FMA_forms,
        OBO:FMA_full_grown_phenotype_of,
        OBO:FMA_fuses_with,
        OBO:FMA_fusion_of,
        OBO:FMA_germ_origin_of,
        OBO:FMA_has_adherent,
        OBO:FMA_has_arterial_supply,
        OBO:FMA_has_branch,
        OBO:FMA_has_connection_type,
        OBO:FMA_has_continuation_branch,
        OBO:FMA_has_development_type,
        OBO:FMA_has_developmental_stage,
        OBO:FMA_has_direct_cell_shape,
        OBO:FMA_has_full_grown_phenotype,
        OBO:FMA_has_fusion,
        OBO:FMA_has_germ_origin,
        OBO:FMA_has_inherent_3d_shape,
        OBO:FMA_has_insertion,
        OBO:FMA_has_lymphatic_drainage,
        OBO:FMA_has_nerve_supply,
        OBO:FMA_has_observed_anatomical_entity,
        OBO:FMA_has_origin,
        OBO:FMA_has_primary_segmental_supply,
        OBO:FMA_has_projection,
        OBO:FMA_has_regional_part,
        OBO:FMA_has_related_developmental_entity,
        OBO:FMA_has_secondary_segmental_supply,
        OBO:FMA_has_segmental_composition,
        OBO:FMA_has_segmental_supply,
        OBO:FMA_has_tributary,
        OBO:FMA_has_venous_drainage,
        OBO:FMA_inferior_to,
        OBO:FMA_inferolateral_to,
        OBO:FMA_inferomedial_to,
        OBO:FMA_inherent_3d_shape_of,
        OBO:FMA_insertion_of,
        OBO:FMA_internal_to,
        OBO:FMA_lateral_to,
        OBO:FMA_left_lateral_to,
        OBO:FMA_left_medial_to,
        OBO:FMA_lymphatic_drainage_of,
        OBO:FMA_matures_from,
        OBO:FMA_matures_into,
        OBO:FMA_medial_to,
        OBO:FMA_merges_with,
        OBO:FMA_nerve_supply_of,
        OBO:FMA_origin_of,
        OBO:FMA_posterior_to,
        OBO:FMA_posteroinferior_to,
        OBO:FMA_posterolateral_to,
        OBO:FMA_posteromedial_to,
        OBO:FMA_posterosuperior_to,
        OBO:FMA_primary_segmental_supply_of,
        OBO:FMA_projects_from,
        OBO:FMA_projects_to,
        OBO:FMA_proximal_to,
        OBO:FMA_receives_attachment_from,
        OBO:FMA_receives_drainage_from,
        OBO:FMA_receives_input_from,
        OBO:FMA_receives_projection,
        OBO:FMA_related_part,
        OBO:FMA_right_lateral_to,
        OBO:FMA_right_medial_to,
        OBO:FMA_secondary_segmental_supply_of,
        OBO:FMA_segmental_composition_of,
        OBO:FMA_segmental_supply_of,
        OBO:FMA_sends_output_to,
        OBO:FMA_superior_to,
        OBO:FMA_superolateral_to,
        OBO:FMA_superomedial_to,
        OBO:FMA_surrounded_by,
        OBO:FMA_surrounds,
        OBO:FMA_tributary_of,
        OBO:FMA_venous_drainage_of,
        OBO:RO_0002219,
        OBO:RO_0002220,
        OBO:RO_0002221,
        OBO:SO_has_origin,
        OBO:UBERON_anastomoses_with,
        OBO:UBERON_anteriorly_connected_to,
        OBO:UBERON_channel_for,
        OBO:UBERON_channels_from,
        OBO:UBERON_channels_into,
        OBO:UBERON_conduit_for,
        OBO:UBERON_distally_connected_to,
        OBO:UBERON_existence_starts_and_ends_during,
        OBO:UBERON_extends_fibers_into,
        OBO:UBERON_filtered_through,
        OBO:UBERON_in_central_side_of,
        OBO:UBERON_in_innermost_side_of,
        OBO:UBERON_in_outermost_side_of,
        OBO:UBERON_indirectly_supplies,
        OBO:UBERON_posteriorly_connected_to,
        OBO:UBERON_protects,
        OBO:UBERON_proximally_connected_to,
        OBO:UBERON_sexually_homologous_to,
        <http://purl.obolibrary.org/obo/core#distally_connected_to>,
        <http://purl.obolibrary.org/obo/core#subdivision_of>,
        UBERON_CORE:anastomoses_with,
        UBERON_CORE:anteriorly_connected_to,
        UBERON_CORE:channel_for,
        UBERON_CORE:channels_from,
        UBERON_CORE:channels_into,
        UBERON_CORE:conduit_for,
        UBERON_CORE:distally_connected_to,
        UBERON_CORE:extends_fibers_into,
        UBERON_CORE:filtered_through,
        UBERON_CORE:indirectly_supplies,
        UBERON_CORE:posteriorly_connected_to,
        UBERON_CORE:proximally_connected_to,
        UBERON_CORE:synapsed_by,
        UBERON_CORE:transitively_anteriorly_connected_to,
        UBERON_CORE:transitively_connected_to,
        UBERON_CORE:transitively_distally_connected_to,
        UBERON_CORE:transitively_proximally_connected_to ;
    linkml:definition_uri biolink:coexists_with ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:coexists_with ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:coexists_with ;
    linkml:symmetric true .

biolink:has_gene_or_gene_product a linkml:SlotDefinition ;
    dct:description "connects an entity with one or more gene or gene products" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_gene_or_gene_product ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:GeneGroupingMixin ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:GeneGroupingMixin ;
    linkml:range biolink:Gene ;
    linkml:slot_uri biolink:has_gene_or_gene_product .

biolink:has_participant a linkml:SlotDefinition ;
    dct:description "holds between a process and a continuant, where the continuant is somehow involved in the process" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:participates_in ;
    ns1:closeMatch WIKIDATA_PROPERTY:P2283 ;
    ns1:exactMatch OBO:RO_0000057,
        OBO:RO_has_participant ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_subject,
        OBO:BFO_0000167,
        OBO:NCIT_pathway_has_gene_element,
        OBO:NCIT_process_includes_biological_process,
        OBO:NCIT_process_involves_gene,
        OBO:OBI_0000293,
        OBO:RO_0004007,
        OBO:RO_0004020,
        OBO:RO_0004021,
        OBO:SNOMED_has_indirect_device,
        OBO:SNOMED_has_procedure_device,
        OBO:SNOMED_has_recipient_category,
        <http://purl.obolibrary.org/obo/nbo#has_participant>,
        PathWhiz:has_bound,
        PathWhiz:has_compound,
        PathWhiz:has_element_collection,
        PathWhiz:has_enzyme,
        PathWhiz:has_nucleic_acid,
        PathWhiz:has_protein,
        PathWhiz:has_reaction ;
    linkml:definition_uri biolink:has_participant ;
    linkml:domain biolink:Occurrent ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:has_participant ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_participant .

biolink:homologous_to a linkml:SlotDefinition ;
    dct:description "holds between two biological entities that have common evolutionary origin" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:altLabel "in homology relationship with" ;
    ns1:exactMatch OBO:RO_HOM0000001,
        <http://semanticscience.org/resource/SIO_010302> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UBERON_CORE:sexually_homologous_to ;
    ns1:note "typically used to describe homology relationships between genes or gene products" ;
    linkml:definition_uri biolink:homologous_to ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:similar_to ;
    linkml:multivalued true ;
    linkml:owner biolink:homologous_to ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:homologous_to ;
    linkml:symmetric true .

biolink:integer a linkml:TypeDefinition ;
    dct:description "An integer" ;
    ns1:inScheme linkml:types ;
    linkml:base "int" ;
    linkml:definition_uri linkml:Integer ;
    linkml:imported_from "linkml:types" ;
    linkml:uri xsd:integer .

biolink:iso_abbreviation a linkml:SlotDefinition ;
    dct:description "Standard abbreviation for periodicals in the International Organization for Standardization (ISO) 4 system See https://www.issn.org/services/online-services/access-to-the-ltwa/. If the 'published in' property is set, then the iso abbreviation pertains to the broader publication context (the journal) within which the given publication node is embedded, not the publication itself." ;
    ns1:exactMatch WIKIDATA_PROPERTY:P1160 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:iso_abbreviation ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Article,
        biolink:Serial ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:iso_abbreviation ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:iso_abbreviation .

biolink:keywords a linkml:SlotDefinition ;
    dct:description "keywords tagging a publication" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:keywords ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Publication ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:Publication ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:keywords .

biolink:mesh_terms a linkml:SlotDefinition ;
    dct:description "mesh terms tagging a publication" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:mesh_terms ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Publication ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:Publication ;
    linkml:range biolink:uriorcurie ;
    linkml:slot_uri biolink:mesh_terms ;
    linkml:values_from biolink:MESH .

biolink:sequence_localization_attribute a linkml:SlotDefinition ;
    dct:description "An attribute that can be applied to a genome sequence localization edge. These edges connect a genomic entity such as an exon to an entity such as a chromosome. Edge properties are used to ascribe specific positional information and other metadata to the localization. In pragmatic terms this can be thought of as columns in a GFF3 line." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:sequence_localization_attribute ;
    linkml:domain biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:sequence_localization_attribute ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:sequence_localization_attribute .

biolink:summary a linkml:SlotDefinition ;
    dct:description "executive  summary of a publication" ;
    ns1:altLabel "abstract" ;
    ns1:exactMatch dct:abstract,
        WIKIDATA:Q333291 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:summary ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Publication ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:Publication ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:summary .

biolink:BehaviorToBehavioralFeatureAssociation a linkml:ClassDefinition ;
    dct:description "An association between an aggregate behavior and a behavioral feature manifested by the individual exhibited or has exhibited the behavior." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:BehaviorToBehavioralFeatureAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:BehaviorToBehavioralFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:behavior_to_behavioral_feature_association_object,
        biolink:behavior_to_behavioral_feature_association_subject,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:onset_qualifier,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:sex_qualifier,
        biolink:source .

biolink:BiologicalProcess a linkml:ClassDefinition ;
    dct:description "One or more causally connected executions of molecular functions" ;
    ns1:broadMatch WIKIDATA:P682 ;
    ns1:exactMatch OBO:GO_0008150,
        <http://semanticscience.org/resource/SIO_000006>,
        WIKIDATA:Q2996394 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:BiologicalProcess ;
    linkml:definition_uri biolink:BiologicalProcess ;
    linkml:id_prefixes "GO",
        "KEGG.MODULE",
        "MetaCyc",
        "REACT" ;
    linkml:is_a biolink:BiologicalProcessOrActivity ;
    linkml:mixins biolink:Occurrent,
        biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Book a linkml:ClassDefinition ;
    dct:description "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Book ;
    linkml:definition_uri biolink:Book ;
    linkml:id_prefixes "NLMID",
        "isbn" ;
    linkml:is_a biolink:Publication ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:authors,
        biolink:book_id,
        biolink:book_type,
        biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:iri,
        biolink:keywords,
        biolink:license,
        biolink:mesh_terms,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:publication_name,
        biolink:publication_pages,
        biolink:rights,
        biolink:source,
        biolink:summary,
        biolink:xref .

biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    linkml:defining_slots biolink:object ;
    linkml:definition_uri biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:entity_to_disease_or_phenotypic_feature_association_mixin_object .

biolink:EntityToFeatureOrDiseaseQualifiersMixin a linkml:ClassDefinition ;
    dct:description "Qualifiers for entity to disease or phenotype associations." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EntityToFeatureOrDiseaseQualifiersMixin ;
    linkml:definition_uri biolink:EntityToFeatureOrDiseaseQualifiersMixin ;
    linkml:is_a biolink:FrequencyQualifierMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:frequency_qualifier,
        biolink:onset_qualifier,
        biolink:severity_qualifier .

biolink:ExonToTranscriptRelationship a linkml:ClassDefinition ;
    dct:description "A transcript is formed from multiple exons" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ExonToTranscriptRelationship ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:ExonToTranscriptRelationship ;
    linkml:is_a biolink:SequenceFeatureRelationship ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:exon_to_transcript_relationship_object,
        biolink:exon_to_transcript_relationship_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:GeneToGoTermAssociation a linkml:ClassDefinition ;
    ns1:altLabel "functional association" ;
    ns1:exactMatch <http://bio2rdf.org/wormbase_vocabularyGene-GO-Association> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneToGoTermAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GeneToGoTermAssociation ;
    linkml:is_a biolink:FunctionalAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:gene_to_go_term_association_object,
        biolink:gene_to_go_term_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:GenotypeToPhenotypicFeatureAssociation a linkml:ClassDefinition ;
    dct:description "Any association between one genotype and a phenotypic feature, where having the genotype confers the phenotype, either in isolation or through environment" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GenotypeToPhenotypicFeatureAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GenotypeToPhenotypicFeatureAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:GenotypeToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:genotype_to_phenotypic_feature_association_predicate,
        biolink:genotype_to_phenotypic_feature_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:onset_qualifier,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:sex_qualifier,
        biolink:source .

biolink:GeographicLocation a linkml:ClassDefinition ;
    dct:description "a location that can be described in lat/long coordinates" ;
    ns1:exactMatch UMLSSG:GEOG,
        UMLSSC:T083,
        UMLSST:geoa ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeographicLocation ;
    linkml:definition_uri biolink:GeographicLocation ;
    linkml:is_a biolink:PlanetaryEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:latitude,
        biolink:longitude,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:MacromolecularMachineToEntityAssociationMixin a linkml:ClassDefinition ;
    dct:description "an association which has a macromolecular machine mixin as a subject" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MacromolecularMachineToEntityAssociationMixin ;
    linkml:definition_uri biolink:MacromolecularMachineToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:macromolecular_machine_to_entity_association_mixin_subject .

biolink:Mixture a linkml:ClassDefinition ;
    dct:description "The physical combination of two or more molecular entities in which the identities are retained and are mixed in the form of solutions, suspensions and colloids." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Mixture ;
    linkml:definition_uri biolink:Mixture ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:has_constituent .

biolink:PhenotypicFeature a linkml:ClassDefinition ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "endophenotype",
        "phenotype",
        "sign",
        "symptom",
        "trait" ;
    ns1:exactMatch OBO:UPHENO_0001001,
        <http://semanticscience.org/resource/SIO_010056>,
        WIKIDATA:Q104053 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T184,
        UMLSST:sosy,
        WIKIDATA:Q169872,
        WIKIDATA:Q25203551 ;
    linkml:class_uri biolink:PhenotypicFeature ;
    linkml:definition_uri biolink:PhenotypicFeature ;
    linkml:id_prefixes "APO",
        "EFO",
        "FBcv",
        "HP",
        "MEDDRA",
        "MESH",
        "MP",
        "NCIT",
        "SNOMEDCT",
        "UMLS",
        "UPHENO",
        "WBPhenotype",
        "ZP" ;
    linkml:is_a biolink:DiseaseOrPhenotypicFeature ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:SequenceVariantModulatesTreatmentAssociation a linkml:ClassDefinition ;
    dct:description "An association between a sequence variant and a treatment or health intervention. The treatment object itself encompasses both the disease and the drug used." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "An alternate way to model the same information could be via a qualifier" ;
    linkml:abstract true ;
    linkml:class_uri biolink:SequenceVariantModulatesTreatmentAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:SequenceVariantModulatesTreatmentAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:sequence_variant_modulates_treatment_association_object,
        biolink:sequence_variant_modulates_treatment_association_subject,
        biolink:source .

biolink:TranscriptToGeneRelationship a linkml:ClassDefinition ;
    dct:description "A gene is a collection of transcripts" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:TranscriptToGeneRelationship ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:TranscriptToGeneRelationship ;
    linkml:is_a biolink:SequenceFeatureRelationship ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:transcript_to_gene_relationship_object,
        biolink:transcript_to_gene_relationship_subject .

biolink:contributor a linkml:SlotDefinition ;
    ns1:exactMatch dct:contributor ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "This is a grouping for predicates relating entities to their associated contributors realizing them" ;
    linkml:abstract true ;
    linkml:definition_uri biolink:contributor ;
    linkml:domain biolink:InformationContentEntity ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:contributor ;
    linkml:range biolink:Agent ;
    linkml:slot_uri biolink:contributor .

biolink:correlated_with a linkml:SlotDefinition ;
    dct:description "holds between any two named thing entities. For example, correlated_with holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:PATO_correlates_with,
        OBO:RO_0002610 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch RTXKG1:associated_with_disease,
        LOINC:associated_with,
        OBO:NCIT_is_associated_disease_of,
        OBO:NCIT_is_cytogenetic_abnormality_of_disease,
        OBO:RO_0004029,
        OBO:SNOMED_associated_with,
        OBO:SNOMED_has_associated_finding,
        <http://www.orpha.net/ORDO/Orphanet_317345>,
        PDQ:associated_disease ;
    linkml:definition_uri biolink:correlated_with ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:correlated_with ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:correlated_with ;
    linkml:symmetric true .

biolink:has_part a linkml:SlotDefinition ;
    dct:description "holds between wholes and their parts (material entities or processes)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:part_of ;
    ns1:broadMatch RXNORM:contains,
        OBO:FMA_contains,
        OBO:RO_0001019 ;
    ns1:exactMatch RTXKG1:has_part,
        RXNORM:consists_of,
        RXNORM:has_part,
        OBO:BFO_0000051,
        OBO:BFO_0000055,
        OBO:RO_0001019,
        WIKIDATA_PROPERTY:P527 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch MEDDRA:has_member,
        UMLS:has_component,
        RTXKG1:composed_primarily_of,
        RTXKG1:contains_process,
        RTXKG1:has_plasma_membrane_part,
        LOINC:has_component,
        LOINC:has_member,
        NDDF:has_ingredient,
        RXNORM:has_ingredient,
        OBO:BFO_0000117,
        OBO:FMA_has_constitutional_part,
        OBO:FMA_has_member,
        OBO:FMA_has_part,
        OBO:FOODON_00001563,
        OBO:FOODON_00002420,
        OBO:MONDO_disease_has_major_feature,
        OBO:NCIT_R50,
        OBO:NCIT_complex_has_physical_part,
        OBO:RO_0002104,
        OBO:RO_0002180,
        OBO:RO_0002351,
        OBO:RO_0002473,
        OBO:RO_0002524,
        OBO:RO_0002551,
        OBO:SNOMED_has_component,
        PathWhiz:has_element_in_bound,
        PathWhiz:has_protein_in_complex,
        PDQ:has_component ;
    linkml:definition_uri biolink:has_part ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:overlaps ;
    linkml:multivalued true ;
    linkml:owner biolink:has_part ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_part .

biolink:interacts_with a linkml:SlotDefinition ;
    dct:description "holds between any two entities that directly or indirectly interact with each other" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch OBO:RO_0002434 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:RO_0002103,
        OBO:RO_0002120,
        OBO:RO_0002130,
        <https://skr3.nlm.nih.gov/SemMedDBcomplicates> ;
    linkml:definition_uri biolink:interacts_with ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:interacts_with ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:interacts_with ;
    linkml:symmetric true .

biolink:label_type a linkml:TypeDefinition ;
    dct:description "A string that provides a human-readable name for an entity" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "str" ;
    linkml:definition_uri biolink:LabelType ;
    linkml:typeof biolink:string ;
    linkml:uri xsd:string .

biolink:part_of a linkml:SlotDefinition ;
    dct:description "holds between parts and wholes (material entities or processes)" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:has_part ;
    ns1:broadMatch RXNORM:contained_in,
        OBO:FMA_contained_in,
        OBO:RO_0001018 ;
    ns1:exactMatch RXNORM:constitutes,
        RXNORM:part_of,
        OBO:BFO_0000050,
        OBO:FMA_part_of,
        <https://skr3.nlm.nih.gov/SemMedDBPART_OF>,
        <https://skr3.nlm.nih.gov/SemMedDBpart_of>,
        WIKIDATA_PROPERTY:P361 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch DRUGBANK:component_of,
        MEDDRA:member_of,
        UMLS:component_of,
        UMLS:has_owning_affiliate,
        UMLS:owning_subsection_of,
        LOINC:component_of,
        LOINC:has_supersystem,
        LOINC:member_of,
        LOINC:multipart_of,
        NDDF:ingredient_of,
        RXNORM:ingredient_of,
        RXNORM:ingredients_of,
        RXNORM:precise_ingredient_of,
        OBO:BSPO_0001106,
        OBO:BSPO_0001108,
        OBO:BSPO_0001113,
        OBO:BSPO_0001115,
        OBO:CHEBI_is_substituent_group_from,
        OBO:FMA_constitutional_part_of,
        OBO:FMA_member_of,
        OBO:FMA_regional_part_of,
        OBO:FMA_related_developmental_entity_of,
        OBO:MONDO_part_of_progression_of_disease,
        OBO:NCIT_R27,
        OBO:NCIT_R82,
        OBO:NCIT_is_component_of_chemotherapy_regimen,
        OBO:RO_0002007,
        OBO:RO_0002350,
        OBO:RO_0002376,
        OBO:RO_0002380,
        OBO:RO_0002571,
        OBO:RO_0002572,
        OBO:RO_0002576,
        OBO:SNOMED_active_ingredient_of,
        OBO:SNOMED_basis_of_strength_substance_of,
        OBO:SNOMED_component_of,
        OBO:SNOMED_direct_substance_of,
        OBO:SNOMED_during,
        OBO:SNOMED_focus_of,
        OBO:SNOMED_has_dependent,
        OBO:SNOMED_part_anatomy_structure_of,
        OBO:SNOMED_precise_active_ingredient_of,
        OBO:UBERON_subdivision_of,
        UBERON_CORE:layer_part_of,
        UBERON_CORE:subdivision_of,
        UBERON_CORE:trunk_part_of,
        CPT:panel_element_of,
        CPT:panel_element_of_possibly_included,
        PDQ:component_of,
        VANDF:ingredient_of ;
    linkml:definition_uri biolink:part_of ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:overlaps ;
    linkml:multivalued true ;
    linkml:owner biolink:part_of ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:part_of .

biolink:quantifier_qualifier a linkml:SlotDefinition ;
    dct:description "A measurable quantity for the object of the association" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLS:measures,
        LOINC:analyzes,
        LOINC:measured_by,
        LOINC:property_of,
        <https://skr3.nlm.nih.gov/SemMedDBmeasures> ;
    linkml:definition_uri biolink:quantifier_qualifier ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:GeneExpressionMixin,
        biolink:GeneToExpressionSiteAssociation ;
    linkml:inlined true ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:GeneToExpressionSiteAssociation ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:quantifier_qualifier .

biolink:regulates a linkml:SlotDefinition ;
    owl:inverseOf biolink:regulated_by ;
    ns1:closeMatch OBO:RO_0002334 ;
    ns1:exactMatch OBO:RO_0002211 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch RTXKG1:regulates_activity_of,
        RTXKG1:regulates_expression_of,
        OBO:RO_0002295,
        OBO:RO_0002332,
        OBO:RO_0002578,
        CHEMBL.MECHANISM:modulator,
        WIKIDATA_PROPERTY:P128 ;
    ns1:note "This is a grouping for process-process and entity-entity regulation." ;
    linkml:definition_uri biolink:regulates ;
    linkml:domain biolink:PhysicalEssenceOrOccurrent ;
    linkml:inlined true ;
    linkml:mixin true ;
    linkml:owner biolink:regulates ;
    linkml:range biolink:PhysicalEssenceOrOccurrent ;
    linkml:slot_uri biolink:regulates .

biolink:stage_qualifier a linkml:SlotDefinition ;
    dct:description "stage during which gene or protein expression of takes place." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:stage_qualifier ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:GeneExpressionMixin,
        biolink:GeneToExpressionSiteAssociation ;
    linkml:examples [ a linkml:Example ;
            dct:description "larval stage" ;
            ns1:example "UBERON:0000069" ] ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:GeneToExpressionSiteAssociation ;
    linkml:range biolink:LifeStage ;
    linkml:slot_uri biolink:stage_qualifier .

biolink:subclass_of a linkml:SlotDefinition ;
    dct:description "holds between two classes where the domain class is a specialization of the range class" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:superclass_of ;
    ns1:closeMatch LOINC:class_of,
        LOINC:has_class ;
    ns1:exactMatch MESH:isa,
        RTXKG1:subclass_of,
        RXNORM:isa,
        OBO:GO_isa,
        rdfs:subClassOf,
        <https://skr3.nlm.nih.gov/SemMedDBIS_A>,
        <https://skr3.nlm.nih.gov/SemMedDBisa>,
        CHEMBL.MECHANISM:subset_of,
        VANDF:isa,
        WIKIDATA_PROPERTY:P279 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_archetype,
        LOINC:has_parent_group,
        LOINC:is_presence_guidance_for,
        NDDF:has_dose_form,
        RXNORM:has_dose_form,
        RXNORM:has_doseformgroup,
        OBO:CHEBI_has_parent_hydride,
        OBO:NCIT_A11,
        OBO:NCIT_A14,
        OBO:NCIT_A16,
        OBO:NCIT_A3,
        OBO:NCIT_R36,
        OBO:NCIT_R42,
        OBO:NCIT_gene_product_has_chemical_classification,
        OBO:SNOMED_entire_anatomy_structure_of,
        OBO:SNOMED_has_dose_form,
        OBO:intersection_of,
        rdfs:subPropertyOf ;
    linkml:definition_uri biolink:subclass_of ;
    linkml:domain biolink:OntologyClass ;
    linkml:inherited true ;
    linkml:inlined true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:subclass_of ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:subclass_of .

biolink:ChemicalToEntityAssociationMixin a linkml:ClassDefinition ;
    dct:description "An interaction between a chemical entity and another entity" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ChemicalToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:ChemicalToEntityAssociationMixin ;
    linkml:is_a biolink:MolecularEntityToEntityAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:chemical_to_entity_association_mixin_subject .

biolink:DatasetSummary a linkml:ClassDefinition ;
    dct:description "an item that holds summary level information about a dataset." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DatasetSummary ;
    linkml:definition_uri biolink:DatasetSummary ;
    linkml:is_a biolink:InformationContentEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:license,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:rights,
        biolink:source,
        biolink:source_logo,
        biolink:source_web_page,
        biolink:type .

biolink:PairwiseGeneToGeneInteraction a linkml:ClassDefinition ;
    dct:description "An interaction between two genes or two gene products. May be physical (e.g. protein binding) or genetic (between genes). May be symmetric (e.g. protein interaction) or directed (e.g. phosphorylation)" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PairwiseGeneToGeneInteraction ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:PairwiseGeneToGeneInteraction ;
    linkml:is_a biolink:GeneToGeneAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:gene_to_gene_association_object,
        biolink:gene_to_gene_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:pairwise_gene_to_gene_interaction_predicate,
        biolink:pairwise_gene_to_gene_interaction_relation,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:source .

biolink:QuantityValue a linkml:ClassDefinition ;
    dct:description "A value of an attribute that is quantitative and measurable, expressed as a combination of a unit and a numeric value" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:QuantityValue ;
    linkml:definition_uri biolink:QuantityValue ;
    linkml:is_a biolink:Annotation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:has_numeric_value,
        biolink:has_unit .

biolink:VariantToEntityAssociationMixin a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:VariantToEntityAssociationMixin ;
    linkml:defining_slots biolink:subject ;
    linkml:definition_uri biolink:VariantToEntityAssociationMixin ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "variant annotation" ;
            linkml:local_name_source "ga4gh" ] ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:variant_to_entity_association_mixin_subject .

biolink:VariantToGeneAssociation a linkml:ClassDefinition ;
    dct:description "An association between a variant and a gene, where the variant has a genetic association with the gene (i.e. is in linkage disequilibrium)" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:VariantToGeneAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:VariantToGeneAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:VariantToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject,
        biolink:variant_to_gene_association_object,
        biolink:variant_to_gene_association_predicate .

biolink:has_constituent a linkml:SlotDefinition ;
    dct:description "one or more chemical substances within a mixture" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_constituent ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:Mixture ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:Mixture ;
    linkml:range biolink:ChemicalSubstance ;
    linkml:slot_uri biolink:has_constituent .

biolink:published_in a linkml:SlotDefinition ;
    dct:description "CURIE identifier of a broader publication context within which the publication may be placed, e.g. a specified book or journal." ;
    ns1:exactMatch WIKIDATA_PROPERTY:P1433 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:published_in ;
    linkml:domain biolink:Publication ;
    linkml:domain_of biolink:Article,
        biolink:BookChapter ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:published_in ;
    linkml:range biolink:uriorcurie ;
    linkml:slot_uri biolink:published_in ;
    linkml:values_from biolink:NLMID,
        biolink:isbn,
        biolink:issn .

biolink:AnatomicalEntityToAnatomicalEntityAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:class_uri biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:anatomical_entity_to_anatomical_entity_association_object,
        biolink:anatomical_entity_to_anatomical_entity_association_subject,
        biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:BiologicalProcessOrActivity a linkml:ClassDefinition ;
    dct:description "Either an individual molecular activity, or a collection of causally connected molecular activities in a biological system." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:BiologicalProcessOrActivity ;
    linkml:definition_uri biolink:BiologicalProcessOrActivity ;
    linkml:id_prefixes "GO",
        "REACT" ;
    linkml:is_a biolink:BiologicalEntity ;
    linkml:mixins biolink:Occurrent,
        biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:enabled_by,
        biolink:has_attribute,
        biolink:has_input,
        biolink:has_output,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:BookChapter a linkml:ClassDefinition ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:BookChapter ;
    linkml:definition_uri biolink:BookChapter ;
    linkml:is_a biolink:Publication ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:authors,
        biolink:book_chapter_published_in,
        biolink:chapter,
        biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:iri,
        biolink:keywords,
        biolink:license,
        biolink:mesh_terms,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:publication_id,
        biolink:publication_name,
        biolink:publication_pages,
        biolink:publication_type,
        biolink:rights,
        biolink:source,
        biolink:summary,
        biolink:volume,
        biolink:xref .

biolink:GeneProductMixin a linkml:ClassDefinition ;
    dct:description "The functional molecular product of a single gene locus. Gene products are either proteins or functional RNA molecules." ;
    ns1:exactMatch OBO:GENO_0000907,
        OBO:NCIT_C26548,
        WIKIDATA:Q424689 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneProductMixin ;
    linkml:definition_uri biolink:GeneProductMixin ;
    linkml:id_prefixes "PR",
        "UniProtKB",
        "gtpo" ;
    linkml:is_a biolink:GeneOrGeneProduct ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:macromolecular_machine_mixin_name,
        biolink:synonym,
        biolink:xref .

biolink:Genotype a linkml:ClassDefinition ;
    dct:description "An information content entity that describes a genome by specifying the total variation in genomic sequence and/or gene expression, relative to some established background" ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:exactMatch OBO:GENO_0000536,
        <http://semanticscience.org/resource/SIO_001079> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "Consider renaming as genotypic entity" ;
    linkml:class_uri biolink:Genotype ;
    linkml:definition_uri biolink:Genotype ;
    linkml:id_prefixes "FB",
        "ZFIN" ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:has_zygosity,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:OrganismTaxonToOrganismTaxonAssociation a linkml:ClassDefinition ;
    dct:description "A relationship between two organism taxon nodes" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:class_uri biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:OrganismTaxonToEntityAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:organism_taxon_to_organism_taxon_association_object,
        biolink:organism_taxon_to_organism_taxon_association_subject,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:category a linkml:SlotDefinition ;
    dct:description """Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class.
 * In a neo4j database this MAY correspond to the neo4j label tag.
 * In an RDF database it should be a biolink model class URI.
This field is multi-valued. It should include values for ancestors of the biolink class; for example, a protein such as Shh would have category values `biolink:Protein`, `biolink:GeneProduct`, `biolink:MolecularEntity`, ...
In an RDF database, nodes will typically have an rdf:type triples. This can be to the most specific biolink class, or potentially to a class more specific than something in biolink. For example, a sequence feature `f` may have a rdf:type assertion to a SO class such as TF_binding_site, which is more specific than anything in biolink. Here we would have categories {biolink:GenomicEntity, biolink:MolecularEntity, biolink:NamedThing}""" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:category ;
    linkml:domain biolink:Entity ;
    linkml:domain_of biolink:Entity ;
    linkml:is_a biolink:type ;
    linkml:is_class_field true ;
    linkml:multivalued true ;
    linkml:owner biolink:Entity ;
    linkml:range biolink:category_type ;
    linkml:slot_uri biolink:category .

biolink:is_sequence_variant_of a linkml:SlotDefinition ;
    dct:description "holds between a sequence variant and a genomic entity" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_gene_product_sequence_variation_encoded_by_gene_mutant,
        OBO:NCIT_gene_product_variant_of_gene_product,
        OBO:OMIM_allelic_variant_of,
        WIKIDATA:P3433 ;
    linkml:definition_uri biolink:is_sequence_variant_of ;
    linkml:domain biolink:SequenceVariant ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:is_sequence_variant_of ;
    linkml:range biolink:GenomicEntity ;
    linkml:slot_uri biolink:is_sequence_variant_of .

biolink:sex_qualifier a linkml:SlotDefinition ;
    dct:description "a qualifier used in a phenotypic association to state whether the association is specific to a particular sex." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:sex_qualifier ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:inlined true ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:range biolink:BiologicalSex ;
    linkml:slot_uri biolink:sex_qualifier .

biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation a linkml:ClassDefinition ;
    dct:description "A relationship between two anatomical entities where the relationship is ontogenic, i.e. the two entities are related by development. A number of different relationship types can be used to specify the precise nature of the relationship." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:defining_slots biolink:predicate ;
    linkml:definition_uri biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    linkml:is_a biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:anatomical_entity_to_anatomical_entity_ontogenic_association_object,
        biolink:anatomical_entity_to_anatomical_entity_ontogenic_association_predicate,
        biolink:anatomical_entity_to_anatomical_entity_ontogenic_association_subject,
        biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation a linkml:ClassDefinition ;
    dct:description "A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood. This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:defining_slots biolink:predicate ;
    linkml:definition_uri biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation ;
    linkml:is_a biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:anatomical_entity_to_anatomical_entity_part_of_association_object,
        biolink:anatomical_entity_to_anatomical_entity_part_of_association_predicate,
        biolink:anatomical_entity_to_anatomical_entity_part_of_association_subject,
        biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:BiologicalEntity a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://semanticscience.org/resource/SIO_010046>,
        UMLSSC:T050,
        UMLSST:emod,
        WIKIDATA:Q28845870 ;
    linkml:abstract true ;
    linkml:class_uri biolink:BiologicalEntity ;
    linkml:definition_uri biolink:BiologicalEntity ;
    linkml:is_a biolink:NamedThing ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Drug a linkml:ClassDefinition ;
    dct:description "A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease" ;
    ns1:broadMatch UMLSSC:T121,
        UMLSST:phsu ;
    ns1:exactMatch OBO:CHEBI_23888,
        UMLSSC:T200,
        UMLSST:clnd,
        WIKIDATA:Q12140 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T195,
        UMLSST:antb ;
    ns1:note "The CHEBI ID represents a role rather than a substance" ;
    linkml:class_uri biolink:Drug ;
    linkml:definition_uri biolink:Drug ;
    linkml:id_prefixes "NDC",
        "PHARMGKB.DRUG",
        "RXCUI" ;
    linkml:is_a biolink:MolecularEntity ;
    linkml:mixins biolink:ChemicalOrDrugOrTreatment,
        biolink:Mixture,
        biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_constituent,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:FrequencyQuantifier a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:FrequencyQuantifier ;
    linkml:definition_uri biolink:FrequencyQuantifier ;
    linkml:is_a biolink:RelationshipQuantifier ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:has_count,
        biolink:has_percentage,
        biolink:has_quotient,
        biolink:has_total .

biolink:GeneRegulatoryRelationship a linkml:ClassDefinition ;
    dct:description "A regulatory relationship between two genes" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneRegulatoryRelationship ;
    linkml:definition_uri biolink:GeneRegulatoryRelationship ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:gene_regulatory_relationship_object,
        biolink:gene_regulatory_relationship_predicate,
        biolink:gene_regulatory_relationship_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:GeneToGeneAssociation a linkml:ClassDefinition ;
    dct:description "abstract parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction." ;
    ns1:altLabel "molecular or genetic interaction" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:class_uri biolink:GeneToGeneAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GeneToGeneAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:gene_to_gene_association_object,
        biolink:gene_to_gene_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:GeneToGeneProductRelationship a linkml:ClassDefinition ;
    dct:description "A gene is transcribed and potentially translated to a gene product" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneToGeneProductRelationship ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GeneToGeneProductRelationship ;
    linkml:is_a biolink:SequenceFeatureRelationship ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:gene_to_gene_product_relationship_object,
        biolink:gene_to_gene_product_relationship_predicate,
        biolink:gene_to_gene_product_relationship_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:GenotypeToGeneAssociation a linkml:ClassDefinition ;
    dct:description "Any association between a genotype and a gene. The genotype have have multiple variants in that gene or a single one. There is no assumption of cardinality" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GenotypeToGeneAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GenotypeToGeneAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:genotype_to_gene_association_object,
        biolink:genotype_to_gene_association_predicate,
        biolink:genotype_to_gene_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:GenotypeToGenotypePartAssociation a linkml:ClassDefinition ;
    dct:description "Any association between one genotype and a genotypic entity that is a sub-component of it" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GenotypeToGenotypePartAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GenotypeToGenotypePartAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:genotype_to_genotype_part_association_object,
        biolink:genotype_to_genotype_part_association_predicate,
        biolink:genotype_to_genotype_part_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:GenotypeToVariantAssociation a linkml:ClassDefinition ;
    dct:description "Any association between a genotype and a sequence variant." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GenotypeToVariantAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GenotypeToVariantAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:genotype_to_variant_association_object,
        biolink:genotype_to_variant_association_predicate,
        biolink:genotype_to_variant_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:MaterialSampleDerivationAssociation a linkml:ClassDefinition ;
    dct:description "An association between a material sample and the material entity from which it is derived." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MaterialSampleDerivationAssociation ;
    linkml:defining_slots biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:MaterialSampleDerivationAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:material_sample_derivation_association_object,
        biolink:material_sample_derivation_association_predicate,
        biolink:material_sample_derivation_association_subject,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:OrganismTaxonToEnvironmentAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:class_uri biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:definition_uri biolink:OrganismTaxonToEnvironmentAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:OrganismTaxonToEntityAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:organism_taxon_to_environment_association_object,
        biolink:organism_taxon_to_environment_association_predicate,
        biolink:organism_taxon_to_environment_association_subject,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:OrganismTaxonToOrganismTaxonSpecialization a linkml:ClassDefinition ;
    dct:description "A child-parent relationship between two taxa. For example: Homo sapiens subclass_of Homo" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:defining_slots biolink:predicate ;
    linkml:definition_uri biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    linkml:is_a biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:organism_taxon_to_organism_taxon_specialization_object,
        biolink:organism_taxon_to_organism_taxon_specialization_predicate,
        biolink:organism_taxon_to_organism_taxon_specialization_subject,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:Outcome a linkml:ClassDefinition ;
    dct:description "An entity that has the role of being the consequence of an exposure event. This is an abstract mixin grouping of various categories of possible biological or non-biological (e.g. clinical) outcomes." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Outcome ;
    linkml:definition_uri biolink:Outcome ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:PopulationToPopulationAssociation a linkml:ClassDefinition ;
    dct:description "An association between a two populations" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PopulationToPopulationAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:PopulationToPopulationAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:population_to_population_association_object,
        biolink:population_to_population_association_predicate,
        biolink:population_to_population_association_subject,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:SequenceFeatureRelationship a linkml:ClassDefinition ;
    dct:description "For example, a particular exon is part of a particular transcript or gene" ;
    ns1:exactMatch CHADO:feature_relationship ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:SequenceFeatureRelationship ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:SequenceFeatureRelationship ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:sequence_feature_relationship_object,
        biolink:sequence_feature_relationship_subject,
        biolink:source .

biolink:Serial a linkml:ClassDefinition ;
    dct:description "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "journal" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Serial ;
    linkml:definition_uri biolink:Serial ;
    linkml:id_prefixes "NLMID",
        "issn" ;
    linkml:is_a biolink:Publication ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:authors,
        biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:iri,
        biolink:iso_abbreviation,
        biolink:issue,
        biolink:keywords,
        biolink:license,
        biolink:mesh_terms,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:publication_name,
        biolink:publication_pages,
        biolink:rights,
        biolink:serial_id,
        biolink:serial_type,
        biolink:source,
        biolink:summary,
        biolink:volume,
        biolink:xref .

biolink:ThingWithTaxon a linkml:ClassDefinition ;
    dct:description "A mixin that can be used on any entity that can be taxonomically classified. This includes individual organisms; genes, their products and other molecular entities; body parts; biological processes" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ThingWithTaxon ;
    linkml:definition_uri biolink:ThingWithTaxon ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:in_taxon .

biolink:Treatment a linkml:ClassDefinition ;
    dct:description "A treatment is targeted at a disease or phenotype and may involve multiple drug 'exposures', medical devices and/or procedures" ;
    ns1:altLabel "medical action",
        "medical intervention" ;
    ns1:exactMatch OBO:OGMS_0000090,
        <http://semanticscience.org/resource/SIO_001398> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Treatment ;
    linkml:definition_uri biolink:Treatment ;
    linkml:is_a biolink:NamedThing ;
    linkml:mixins biolink:ChemicalOrDrugOrTreatment,
        biolink:ExposureEvent ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_device,
        biolink:has_drug,
        biolink:has_procedure,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:timepoint,
        biolink:type .

biolink:uriorcurie a linkml:TypeDefinition ;
    dct:description "a URI or a CURIE" ;
    ns1:inScheme linkml:types ;
    linkml:base "URIorCURIE" ;
    linkml:definition_uri linkml:Uriorcurie ;
    linkml:imported_from "linkml:types" ;
    linkml:repr "str" ;
    linkml:uri xsd:anyURI .

biolink:Article a linkml:ClassDefinition ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Article ;
    linkml:definition_uri biolink:Article ;
    linkml:id_prefixes "PMID" ;
    linkml:is_a biolink:Publication ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:article_iso_abbreviation,
        biolink:article_published_in,
        biolink:authors,
        biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:iri,
        biolink:issue,
        biolink:keywords,
        biolink:license,
        biolink:mesh_terms,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:publication_id,
        biolink:publication_name,
        biolink:publication_pages,
        biolink:publication_type,
        biolink:rights,
        biolink:source,
        biolink:summary,
        biolink:volume,
        biolink:xref .

biolink:DatasetVersion a linkml:ClassDefinition ;
    dct:description "an item that holds version level information about a dataset." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:DatasetVersion ;
    linkml:definition_uri biolink:DatasetVersion ;
    linkml:is_a biolink:InformationContentEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:has_dataset,
        biolink:has_distribution,
        biolink:id,
        biolink:ingest_date,
        biolink:iri,
        biolink:license,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:rights,
        biolink:source,
        biolink:type .

biolink:FunctionalAssociation a linkml:ClassDefinition ;
    dct:description "An association between a macromolecular machine mixin (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:FunctionalAssociation ;
    linkml:definition_uri biolink:FunctionalAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:functional_association_object,
        biolink:functional_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:GenotypeToDiseaseAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "TODO decide no how to model pathogenicity" ;
    linkml:class_uri biolink:GenotypeToDiseaseAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:GenotypeToDiseaseAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToDiseaseAssociationMixin,
        biolink:GenotypeToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:genotype_to_disease_association_object,
        biolink:genotype_to_disease_association_predicate,
        biolink:genotype_to_disease_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:onset_qualifier,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:source .

biolink:MolecularActivity a linkml:ClassDefinition ;
    dct:description "An execution of a molecular function carried out by a gene product or macromolecular complex." ;
    ns1:altLabel "molecular event",
        "molecular function",
        "reaction" ;
    ns1:exactMatch OBO:GO_0003674,
        UMLSSC:T044,
        UMLSST:moft ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MolecularActivity ;
    linkml:definition_uri biolink:MolecularActivity ;
    linkml:id_prefixes "EC",
        "GO",
        "KEGG.ENZYME",
        "KEGG.RCLASS",
        "KEGG.REACTION",
        "MetaCyc",
        "REACT",
        "RHEA",
        "TCDB" ;
    linkml:is_a biolink:BiologicalProcessOrActivity ;
    linkml:mixins biolink:Occurrent,
        biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:molecular_activity_enabled_by,
        biolink:molecular_activity_has_input,
        biolink:molecular_activity_has_output,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:OrganismalEntity a linkml:ClassDefinition ;
    dct:description "A named entity that is either a part of an organism, a whole organism, population or clade of organisms, excluding molecular entities" ;
    ns1:exactMatch UMLSSG:LIVB,
        WIKIDATA:Q7239 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:class_uri biolink:OrganismalEntity ;
    linkml:definition_uri biolink:OrganismalEntity ;
    linkml:is_a biolink:BiologicalEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Transcript a linkml:ClassDefinition ;
    dct:description "An RNA synthesized on a DNA or RNA template by an RNA polymerase." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:exactMatch OBO:SO_0000673,
        <http://semanticscience.org/resource/SIO_010450>,
        WIKIDATA:Q7243183 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Transcript ;
    linkml:definition_uri biolink:Transcript ;
    linkml:id_prefixes "ENSEMBL",
        "FB" ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:VariantToDiseaseAssociation a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "TODO decide no how to model pathogenicity" ;
    linkml:class_uri biolink:VariantToDiseaseAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:VariantToDiseaseAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:EntityToDiseaseAssociationMixin,
        biolink:VariantToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:onset_qualifier,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:severity_qualifier,
        biolink:source,
        biolink:variant_to_disease_association_object,
        biolink:variant_to_disease_association_predicate,
        biolink:variant_to_disease_association_subject .

biolink:EntityToDiseaseAssociationMixin a linkml:ClassDefinition ;
    dct:description "mixin class for any association whose object (target node) is a disease" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EntityToDiseaseAssociationMixin ;
    linkml:defining_slots biolink:object ;
    linkml:definition_uri biolink:EntityToDiseaseAssociationMixin ;
    linkml:is_a biolink:EntityToFeatureOrDiseaseQualifiersMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:entity_to_disease_association_mixin_object,
        biolink:frequency_qualifier,
        biolink:onset_qualifier,
        biolink:severity_qualifier .

biolink:GeneExpressionMixin a linkml:ClassDefinition ;
    dct:description "Observed gene expression intensity, context (site, stage) and associated phenotypic status within which the expression occurs." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneExpressionMixin ;
    linkml:definition_uri biolink:GeneExpressionMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:expression_site,
        biolink:gene_expression_mixin_quantifier_qualifier,
        biolink:phenotypic_state,
        biolink:stage_qualifier .

biolink:MacromolecularMachineMixin a linkml:ClassDefinition ;
    dct:description "A union of gene locus, gene product, and macromolecular complex mixin. These are the basic units of function in a cell. They either carry out individual biological activities, or they encode molecules which do this." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:MacromolecularMachineMixin ;
    linkml:definition_uri biolink:MacromolecularMachineMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:macromolecular_machine_mixin_name .

biolink:ModelToDiseaseAssociationMixin a linkml:ClassDefinition ;
    dct:description "This mixin is used for any association class for which the subject (source node) plays the role of a 'model', in that it recapitulates some features of the disease in a way that is useful for studying the disease outside a patient carrying the disease" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ModelToDiseaseAssociationMixin ;
    linkml:definition_uri biolink:ModelToDiseaseAssociationMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:model_to_disease_association_mixin_predicate,
        biolink:model_to_disease_association_mixin_subject .

biolink:synonym a linkml:SlotDefinition ;
    dct:description "Alternate human-readable names for a thing" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:altLabel "alias" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch RXNORM:has_tradename,
        OBO:IAO_0000136,
        <http://www.ebi.ac.uk/ancestro/ancestro_0330>,
        oboInOwl:hasBroadSynonym,
        oboInOwl:hasExactSynonym,
        oboInOwl:hasNarrowSynonym,
        oboInOwl:hasRelatedSynonym,
        gff3:Alias,
        gpi:DB_Object_Synonyms,
        alliancegenome:synonyms,
        skos:altLabel ;
    linkml:definition_uri biolink:synonym ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:Gene,
        biolink:GeneProductMixin ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:synonym ;
    linkml:range biolink:label_type ;
    linkml:slot_uri biolink:synonym .

biolink:ContributorAssociation a linkml:ClassDefinition ;
    dct:description "Any association between an entity (such as a publication) and various agents that contribute to its realisation" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ContributorAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:ContributorAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:contributor_association_object,
        biolink:contributor_association_predicate,
        biolink:contributor_association_qualifiers,
        biolink:contributor_association_subject,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:relation,
        biolink:source .

biolink:creation_date a linkml:SlotDefinition ;
    dct:description "date on which an entity was created. This can be applied to nodes or edges" ;
    ns1:altLabel "publication date" ;
    ns1:exactMatch dct:createdOn,
        WIKIDATA_PROPERTY:P577 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:creation_date ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:InformationContentEntity ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:InformationContentEntity ;
    linkml:range biolink:date ;
    linkml:slot_uri biolink:creation_date .

biolink:format a linkml:SlotDefinition ;
    ns1:exactMatch dct:format,
        WIKIDATA_PROPERTY:P2701 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:format ;
    linkml:domain biolink:InformationContentEntity ;
    linkml:domain_of biolink:InformationContentEntity ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:InformationContentEntity ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:format .

biolink:license a linkml:SlotDefinition ;
    ns1:exactMatch dct:license ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch WIKIDATA_PROPERTY:P275 ;
    linkml:definition_uri biolink:license ;
    linkml:domain biolink:InformationContentEntity ;
    linkml:domain_of biolink:InformationContentEntity ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:InformationContentEntity ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:license .

biolink:rights a linkml:SlotDefinition ;
    ns1:exactMatch dct:rights ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:rights ;
    linkml:domain biolink:InformationContentEntity ;
    linkml:domain_of biolink:InformationContentEntity ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:InformationContentEntity ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:rights .

biolink:attribute_name a linkml:SlotDefinition ;
    dct:description "The human-readable 'attribute name' can be set to a string which reflects its context of interpretation, e.g. SEPIO evidence/provenance/confidence annotation or it can default to the name associated with the 'has attribute type' slot ontology term." ;
    oboInOwl:inSubset biolink:samples,
        biolink:translator_minimal ;
    ns1:altLabel "display name",
        "label",
        "title" ;
    ns1:exactMatch gff3:Name,
        gpi:DB_Object_Name ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdfs:label ;
    ns1:narrowMatch dct:title,
        WIKIDATA_PROPERTY:P1476 ;
    ns1:prefLabel "name" ;
    linkml:definition_uri biolink:name ;
    linkml:domain biolink:Attribute ;
    linkml:domain_of biolink:Attribute ;
    linkml:is_a biolink:name ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Attribute ;
    linkml:range biolink:label_type ;
    linkml:slot_uri rdfs:label ;
    linkml:usage_slot_name "name" .

biolink:is_metabolite a linkml:SlotDefinition ;
    dct:description "indicates whether a chemical substance is a metabolite" ;
    ns1:exactMatch OBO:CHEBI_25212 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:is_metabolite ;
    linkml:domain biolink:ChemicalSubstance ;
    linkml:domain_of biolink:ChemicalSubstance ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:ChemicalSubstance ;
    linkml:range biolink:boolean ;
    linkml:slot_uri biolink:is_metabolite .

biolink:organismal_entity_has_attribute a linkml:SlotDefinition ;
    dct:description "may often be an organism attribute" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:closeMatch OBO:OBI_0001927 ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_000008> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch DRUGBANK:category,
        UMLS:has_structural_class,
        UMLS:has_supported_concept_property,
        UMLS:has_supported_concept_relationship,
        UMLS:may_be_qualified_by,
        LOINC:has_action_guidance,
        LOINC:has_adjustment,
        LOINC:has_aggregation_view,
        LOINC:has_approach_guidance,
        LOINC:has_divisor,
        LOINC:has_exam,
        LOINC:has_method,
        LOINC:has_modality_subtype,
        LOINC:has_object_guidance,
        LOINC:has_scale,
        LOINC:has_suffix,
        LOINC:has_time_aspect,
        LOINC:has_time_modifier,
        LOINC:has_timing_of,
        OBO:INO_0000154,
        OBO:NCIT_disease_is_grade,
        OBO:NCIT_disease_is_stage,
        OBO:NCIT_eo_disease_has_property_or_attribute,
        OBO:NCIT_has_data_element,
        OBO:NCIT_has_pharmaceutical_administration_method,
        OBO:NCIT_has_pharmaceutical_basic_dose_form,
        OBO:NCIT_has_pharmaceutical_intended_site,
        OBO:NCIT_has_pharmaceutical_release_characteristics,
        OBO:NCIT_has_pharmaceutical_state_of_matter,
        OBO:NCIT_has_pharmaceutical_transformation,
        OBO:NCIT_is_qualified_by,
        OBO:NCIT_qualifier_applies_to,
        OBO:NCIT_role_has_domain,
        OBO:NCIT_role_has_range,
        OBO:OMIM_has_inheritance_type,
        OBO:RO_0000053,
        OBO:RO_0000086,
        OBO:RO_0000087,
        OBO:SNOMED_has_access,
        OBO:SNOMED_has_clinical_course,
        OBO:SNOMED_has_count_of_base_of_active_ingredient,
        OBO:SNOMED_has_dose_form_administration_method,
        OBO:SNOMED_has_dose_form_release_characteristic,
        OBO:SNOMED_has_dose_form_transformation,
        OBO:SNOMED_has_finding_context,
        OBO:SNOMED_has_finding_informer,
        OBO:SNOMED_has_inherent_attribute,
        OBO:SNOMED_has_intent,
        OBO:SNOMED_has_interpretation,
        OBO:SNOMED_has_laterality,
        OBO:SNOMED_has_measurement_method,
        OBO:SNOMED_has_method,
        OBO:SNOMED_has_priority,
        OBO:SNOMED_has_procedure_context,
        OBO:SNOMED_has_process_duration,
        OBO:SNOMED_has_property,
        OBO:SNOMED_has_revision_status,
        OBO:SNOMED_has_scale_type,
        OBO:SNOMED_has_severity,
        OBO:SNOMED_has_specimen,
        OBO:SNOMED_has_state_of_matter,
        OBO:SNOMED_has_subject_relationship_context,
        OBO:SNOMED_has_surgical_approach,
        OBO:SNOMED_has_technique,
        OBO:SNOMED_has_temporal_context,
        OBO:SNOMED_has_time_aspect,
        OBO:SNOMED_has_units,
        OBAN:association_has_object_property,
        OBAN:association_has_subject_property,
        <http://www.ebi.ac.uk/ancestro/ancestro_0301>,
        <http://www.ebi.ac.uk/ancestro/ancestro_0308>,
        <http://www.ebi.ac.uk/efo/EFO_is_executed_in>,
        <http://www.orpha.net/ORDO/Orphanet_C016>,
        <http://www.orpha.net/ORDO/Orphanet_C017>,
        CPT:has_possibly_included_panel_element ;
    ns1:prefLabel "has attribute" ;
    linkml:definition_uri biolink:has_attribute ;
    linkml:domain biolink:OrganismalEntity ;
    linkml:domain_of biolink:OrganismalEntity ;
    linkml:inlined true ;
    linkml:is_a biolink:has_attribute ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:OrganismalEntity ;
    linkml:range biolink:Attribute ;
    linkml:slot_uri biolink:has_attribute ;
    linkml:usage_slot_name "has attribute" .

biolink:ChemicalToChemicalDerivationAssociation a linkml:ClassDefinition ;
    dct:description """A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction:
  IF
  R has-input C1 AND
  R has-output C2 AND
  R enabled-by P AND
  R type Reaction
  THEN
  C1 derives-into C2 <<catalyst qualifier P>>""" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:ChemicalToChemicalDerivationAssociation ;
    linkml:is_a biolink:ChemicalToChemicalAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:chemical_to_chemical_derivation_association_catalyst_qualifier,
        biolink:chemical_to_chemical_derivation_association_object,
        biolink:chemical_to_chemical_derivation_association_predicate,
        biolink:chemical_to_chemical_derivation_association_subject,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:OrganismTaxonToOrganismTaxonInteraction a linkml:ClassDefinition ;
    dct:description "An interaction relationship between two taxa. This may be a symbiotic relationship (encompassing mutualism and parasitism), or it may be non-symbiotic. Example: plague transmitted_by flea; cattle domesticated_by Homo sapiens; plague infects Homo sapiens" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:defining_slots biolink:predicate ;
    linkml:definition_uri biolink:OrganismTaxonToOrganismTaxonInteraction ;
    linkml:is_a biolink:OrganismTaxonToOrganismTaxonAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:organism_taxon_to_organism_taxon_interaction_associated_environmental_context,
        biolink:organism_taxon_to_organism_taxon_interaction_object,
        biolink:organism_taxon_to_organism_taxon_interaction_predicate,
        biolink:organism_taxon_to_organism_taxon_interaction_subject,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:PhysicalEssenceOrOccurrent a linkml:ClassDefinition ;
    dct:description "Either a physical or processual entity." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PhysicalEssenceOrOccurrent ;
    linkml:definition_uri biolink:PhysicalEssenceOrOccurrent ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:EntityToPhenotypicFeatureAssociationMixin a linkml:ClassDefinition ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:defining_slots biolink:object ;
    linkml:definition_uri biolink:EntityToPhenotypicFeatureAssociationMixin ;
    linkml:is_a biolink:EntityToFeatureOrDiseaseQualifiersMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:entity_to_phenotypic_feature_association_mixin_description,
        biolink:entity_to_phenotypic_feature_association_mixin_object,
        biolink:frequency_qualifier,
        biolink:onset_qualifier,
        biolink:severity_qualifier,
        biolink:sex_qualifier .

biolink:VariantToPopulationAssociation a linkml:ClassDefinition ;
    dct:description "An association between a variant and a population, where the variant has particular frequency in the population" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:VariantToPopulationAssociation ;
    linkml:defining_slots biolink:object,
        biolink:subject ;
    linkml:definition_uri biolink:VariantToPopulationAssociation ;
    linkml:is_a biolink:Association ;
    linkml:mixins biolink:FrequencyQualifierMixin,
        biolink:FrequencyQuantifier,
        biolink:VariantToEntityAssociationMixin ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:frequency_qualifier,
        biolink:has_attribute,
        biolink:has_percentage,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:variant_to_population_association_has_count,
        biolink:variant_to_population_association_has_quotient,
        biolink:variant_to_population_association_has_total,
        biolink:variant_to_population_association_object,
        biolink:variant_to_population_association_subject .

biolink:has_qualitative_value a linkml:SlotDefinition ;
    dct:description "connects an attribute to a value" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_qualitative_value ;
    linkml:domain biolink:Attribute ;
    linkml:domain_of biolink:Attribute ;
    linkml:owner biolink:Attribute ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_qualitative_value .

biolink:has_quantitative_value a linkml:SlotDefinition ;
    dct:description "connects an attribute to a value" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:exactMatch qud:quantityValue ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:SNOMED_has_concentration_strength_numerator_value,
        OBO:SNOMED_has_presentation_strength_denominator_value,
        OBO:SNOMED_has_presentation_strength_numerator_value ;
    linkml:definition_uri biolink:has_quantitative_value ;
    linkml:domain biolink:Attribute ;
    linkml:domain_of biolink:Attribute ;
    linkml:inlined true ;
    linkml:multivalued true ;
    linkml:owner biolink:Attribute ;
    linkml:range biolink:QuantityValue ;
    linkml:slot_uri biolink:has_quantitative_value .

biolink:AnatomicalEntity a linkml:ClassDefinition ;
    dct:description "A subcellular location, cell type or gross anatomical part" ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:exactMatch OBO:UBERON_0001062,
        UMLSSG:ANAT,
        WIKIDATA:Q4936952 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T022,
        UMLSSC:T029,
        UMLSSC:T030,
        UMLSSC:T031,
        UMLSST:bdsu,
        UMLSST:bdsy,
        UMLSST:blor,
        UMLSST:bsoj ;
    linkml:class_uri biolink:AnatomicalEntity ;
    linkml:definition_uri biolink:AnatomicalEntity ;
    linkml:id_prefixes "CL",
        "GO",
        "MESH",
        "NCIT",
        "UBERON",
        "UMLS" ;
    linkml:is_a biolink:OrganismalEntity ;
    linkml:mixins biolink:PhysicalEssence,
        biolink:ThingWithTaxon ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organismal_entity_has_attribute,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:samples a linkml:SubsetDefinition ;
    dct:description "Sample/biosample datamodel" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:Samples .

biolink:timepoint a linkml:SlotDefinition ;
    dct:description "a point in time" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:timepoint ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:ExposureEvent,
        biolink:GeographicLocationAtTime ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:ExposureEvent ;
    linkml:range biolink:time_type ;
    linkml:slot_uri biolink:timepoint .

biolink:xref a linkml:SlotDefinition ;
    dct:description "Alternate CURIEs for a thing" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:altLabel "DbXref",
        "Dbxref",
        "dbxref" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch gff3:Dbxref,
        gpi:DB_Xrefs ;
    linkml:definition_uri biolink:xref ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:Gene,
        biolink:GeneProductMixin,
        biolink:Publication ;
    linkml:is_a biolink:node_property ;
    linkml:multivalued true ;
    linkml:owner biolink:xref ;
    linkml:range biolink:iri_type ;
    linkml:slot_uri biolink:xref .

biolink:OrganismTaxon a linkml:ClassDefinition ;
    dct:description "A classification of a set of organisms. Example instances: NCBITaxon:9606 (Homo sapiens), NCBITaxon:2 (Bacteria). Can also be used to represent strains or subspecies." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "taxon",
        "taxonomic classification" ;
    ns1:exactMatch WIKIDATA:Q16521 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T002,
        UMLSSC:T004,
        UMLSSC:T005,
        UMLSSC:T007,
        UMLSSC:T008,
        UMLSSC:T010,
        UMLSSC:T011,
        UMLSSC:T012,
        UMLSSC:T013,
        UMLSSC:T014,
        UMLSSC:T015,
        UMLSSC:T016,
        UMLSSC:T194,
        UMLSSC:T204,
        UMLSST:amph,
        UMLSST:anim,
        UMLSST:arch,
        UMLSST:bact,
        UMLSST:bird,
        UMLSST:euka,
        UMLSST:fish,
        UMLSST:fngs,
        UMLSST:humn,
        UMLSST:mamm,
        UMLSST:plnt,
        UMLSST:rept,
        UMLSST:virs,
        UMLSST:vtbt ;
    linkml:class_uri biolink:OrganismTaxon ;
    linkml:definition_uri biolink:OrganismTaxon ;
    linkml:id_prefixes "MESH",
        "NCBITaxon" ;
    linkml:is_a biolink:NamedThing ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:organism_taxon_has_taxonomic_rank,
        biolink:organism_taxon_subclass_of,
        biolink:provided_by,
        biolink:source,
        biolink:type ;
    linkml:values_from biolink:NCBITaxon .

biolink:PairwiseMolecularInteraction a linkml:ClassDefinition ;
    dct:description "An interaction at the molecular level between two physical entities" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:PairwiseMolecularInteraction ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:PairwiseMolecularInteraction ;
    linkml:is_a biolink:PairwiseGeneToGeneInteraction ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:interacting_molecules_category,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:pairwise_molecular_interaction_id,
        biolink:pairwise_molecular_interaction_object,
        biolink:pairwise_molecular_interaction_predicate,
        biolink:pairwise_molecular_interaction_relation,
        biolink:pairwise_molecular_interaction_subject,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:source .

biolink:has_attribute_type a linkml:SlotDefinition ;
    dct:description "connects an attribute to a class that describes it" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_modality_type,
        LOINC:has_view_type ;
    linkml:definition_uri biolink:has_attribute_type ;
    linkml:domain biolink:Attribute ;
    linkml:domain_of biolink:Attribute ;
    linkml:inlined true ;
    linkml:owner biolink:Attribute ;
    linkml:range biolink:OntologyClass ;
    linkml:required true ;
    linkml:slot_uri biolink:has_attribute_type .

biolink:Agent a linkml:ClassDefinition ;
    dct:description "person, group, organization or project that provides a piece of information (i.e. a knowledge association)" ;
    ns1:altLabel "group" ;
    ns1:exactMatch dct:Agent,
        prov:Agent ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSG:ORGA,
        UMLSSC:T092,
        UMLSSC:T093,
        UMLSSC:T094,
        UMLSSC:T095,
        UMLSSC:T096,
        UMLSSC:T097,
        UMLSST:grup,
        UMLSST:hcro,
        UMLSST:orgt,
        UMLSST:prog,
        UMLSST:pros,
        UMLSST:shro ;
    linkml:class_uri biolink:Agent ;
    linkml:definition_uri biolink:Agent ;
    linkml:id_prefixes "GSID",
        "ORCID",
        "ResearchID",
        "ScopusID",
        "isbn",
        "isni" ;
    linkml:is_a biolink:AdministrativeEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:address,
        biolink:affiliation,
        biolink:agent_id,
        biolink:agent_name,
        biolink:description,
        biolink:has_attribute,
        biolink:iri,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:enabled_by a linkml:SlotDefinition ;
    dct:description "holds between a process and a physical entity, where the physical entity executes the process" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:enables ;
    ns1:exactMatch OBO:RO_0002333 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:enabled_by ;
    linkml:domain biolink:BiologicalProcessOrActivity ;
    linkml:domain_of biolink:BiologicalProcessOrActivity ;
    linkml:inherited true ;
    linkml:is_a biolink:has_participant ;
    linkml:multivalued true ;
    linkml:owner biolink:BiologicalProcessOrActivity ;
    linkml:range biolink:PhysicalEntity ;
    linkml:slot_uri biolink:enabled_by .

biolink:has_input a linkml:SlotDefinition ;
    dct:description "holds between a process and a continuant, where the continuant is an input into the process" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch OBO:RO_0002352 ;
    ns1:exactMatch OBO:RO_0002233,
        <https://skr3.nlm.nih.gov/SemMedDBUSES>,
        <https://skr3.nlm.nih.gov/SemMedDBuses> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch LOINC:has_fragments_for_synonyms,
        LOINC:has_system,
        OBO:RO_0002590,
        OBO:RO_0004009,
        OBO:SNOMED_has_finding_method,
        OBO:SNOMED_has_precondition,
        OBO:SNOMED_has_specimen_source_identity,
        OBO:SNOMED_has_specimen_substance,
        OBO:SNOMED_uses_access_device,
        OBO:SNOMED_uses_device,
        OBO:SNOMED_uses_energy,
        OBO:SNOMED_uses_substance,
        PathWhiz:has_left_element ;
    linkml:definition_uri biolink:has_input ;
    linkml:domain biolink:Occurrent ;
    linkml:domain_of biolink:BiologicalProcessOrActivity ;
    linkml:inherited true ;
    linkml:is_a biolink:has_participant ;
    linkml:multivalued true ;
    linkml:owner biolink:has_input ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_input .

biolink:has_output a linkml:SlotDefinition ;
    dct:description "holds between a process and a continuant, where the continuant is an output of the process" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:closeMatch RTXKG1:output_of,
        OBO:RO_0002353,
        OBO:RO_0002354 ;
    ns1:exactMatch OBO:RO_0002234 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_R31,
        OBO:OBI_0000299,
        OBO:RO_0002296,
        OBO:RO_0002297,
        OBO:RO_0002298,
        OBO:RO_0002299,
        OBO:RO_0002588,
        OBO:RO_0004008,
        PathWhiz:has_right_element ;
    linkml:definition_uri biolink:has_output ;
    linkml:domain biolink:Occurrent ;
    linkml:domain_of biolink:BiologicalProcessOrActivity ;
    linkml:inherited true ;
    linkml:is_a biolink:has_participant ;
    linkml:multivalued true ;
    linkml:owner biolink:has_output ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:has_output .

biolink:GeneToExpressionSiteAssociation a linkml:ClassDefinition ;
    dct:description "An association between a gene and an expression site, possibly qualified by stage/timing info." ;
    rdfs:seeAlso <https://github.com/monarch-initiative/ingest-artifacts/tree/master/sources/BGee> ;
    ns1:editorialNote "TBD: introduce subclasses for distinction between wild-type and experimental conditions?" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneToExpressionSiteAssociation ;
    linkml:defining_slots biolink:object,
        biolink:predicate,
        biolink:subject ;
    linkml:definition_uri biolink:GeneToExpressionSiteAssociation ;
    linkml:is_a biolink:Association ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:gene_to_expression_site_association_object,
        biolink:gene_to_expression_site_association_predicate,
        biolink:gene_to_expression_site_association_quantifier_qualifier,
        biolink:gene_to_expression_site_association_stage_qualifier,
        biolink:gene_to_expression_site_association_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source .

biolink:onset_qualifier a linkml:SlotDefinition ;
    dct:description "a qualifier used in a phenotypic association to state when the phenotype appears is in the subject" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:onset_qualifier ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:EntityToFeatureOrDiseaseQualifiersMixin ;
    linkml:inlined true ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:EntityToFeatureOrDiseaseQualifiersMixin ;
    linkml:range biolink:Onset ;
    linkml:slot_uri biolink:onset_qualifier .

biolink:severity_qualifier a linkml:SlotDefinition ;
    dct:description "a qualifier used in a phenotypic association to state how severe the phenotype is in the subject" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:severity_qualifier ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:EntityToFeatureOrDiseaseQualifiersMixin ;
    linkml:inlined true ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:EntityToFeatureOrDiseaseQualifiersMixin ;
    linkml:range biolink:SeverityValue ;
    linkml:slot_uri biolink:severity_qualifier .

biolink:ExposureEvent a linkml:ClassDefinition ;
    dct:description "A (possibly time bounded) incidence of a feature of the environment of an organism that influences one or more phenotypic features of that organism, potentially mediated by genes" ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "experimental condition",
        "exposure" ;
    ns1:broadMatch UMLSSC:T051,
        UMLSST:evnt ;
    ns1:exactMatch OBO:XCO_0000000 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:ExposureEvent ;
    linkml:definition_uri biolink:ExposureEvent ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:timepoint .

biolink:has_biological_sequence a linkml:SlotDefinition ;
    dct:description "connects a genomic feature to its sequence" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:has_biological_sequence ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:GenomicEntity ;
    linkml:is_a biolink:node_property ;
    linkml:owner biolink:GenomicEntity ;
    linkml:range biolink:biological_sequence ;
    linkml:slot_uri biolink:has_biological_sequence .

biolink:DiseaseOrPhenotypicFeature a linkml:ClassDefinition ;
    dct:description "Either one of a disease or an individual phenotypic feature. Some knowledge resources such as Monarch treat these as distinct, others such as MESH conflate." ;
    ns1:altLabel "phenome" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T033,
        UMLSST:fndg ;
    linkml:class_uri biolink:DiseaseOrPhenotypicFeature ;
    linkml:definition_uri biolink:DiseaseOrPhenotypicFeature ;
    linkml:is_a biolink:BiologicalEntity ;
    linkml:mixins biolink:ThingWithTaxon ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type ;
    linkml:union_of biolink:Disease,
        biolink:PhenotypicFeature .

biolink:Entity a linkml:ClassDefinition ;
    dct:description "Root Biolink Model class for all things and informational relationships, real or imagined." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:class_uri biolink:Entity ;
    linkml:definition_uri biolink:Entity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:category,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:frequency_qualifier a linkml:SlotDefinition ;
    dct:description "a qualifier used in a phenotypic association to state how frequent the phenotype is observed in the subject" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:frequency_qualifier ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:FrequencyQualifierMixin ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:FrequencyQualifierMixin ;
    linkml:range biolink:frequency_value ;
    linkml:slot_uri biolink:frequency_qualifier .

biolink:InformationContentEntity a linkml:ClassDefinition ;
    dct:description "a piece of information that typically describes some topic of discourse or is used as support." ;
    ns1:altLabel "information",
        "information artefact",
        "information entity" ;
    ns1:exactMatch OBO:IAO_0000030 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSG:CONC,
        UMLSSC:T077,
        UMLSSC:T078,
        UMLSSC:T079,
        UMLSSC:T080,
        UMLSSC:T081,
        UMLSSC:T082,
        UMLSSC:T089,
        UMLSSC:T102,
        UMLSSC:T169,
        UMLSSC:T171,
        UMLSSC:T185,
        UMLSST:clas,
        UMLSST:cnce,
        UMLSST:ftcn,
        UMLSST:grpa,
        UMLSST:idcn,
        UMLSST:lang,
        UMLSST:qlco,
        UMLSST:qnco,
        UMLSST:rnlw,
        UMLSST:spco,
        UMLSST:tmco ;
    linkml:abstract true ;
    linkml:class_uri biolink:InformationContentEntity ;
    linkml:definition_uri biolink:InformationContentEntity ;
    linkml:id_prefixes "doi" ;
    linkml:is_a biolink:NamedThing ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:license,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:rights,
        biolink:source,
        biolink:type .

biolink:model_organism_database a linkml:SubsetDefinition ;
    dct:description "Subset that is relevant for a typical Model Organism Database (MOD)" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:ModelOrganismDatabase .

biolink:Attribute a linkml:ClassDefinition ;
    dct:description "A property or characteristic of an entity. For example, an apple may have properties such as color, shape, age, crispiness. An environmental sample may have attributes such as depth, lat, long, material." ;
    oboInOwl:inSubset biolink:samples ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_000614> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Attribute ;
    linkml:definition_uri biolink:Attribute ;
    linkml:id_prefixes "EDAM-DATA",
        "EDAM-FORMAT",
        "EDAM-OPERATION",
        "EDAM-TOPIC" ;
    linkml:is_a biolink:Annotation ;
    linkml:mixins biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:attribute_name,
        biolink:has_attribute_type,
        biolink:has_qualitative_value,
        biolink:has_quantitative_value,
        biolink:iri,
        biolink:source .

biolink:GeneOrGeneProduct a linkml:ClassDefinition ;
    dct:description "A union of gene loci or gene products. Frequently an identifier for one will be used as proxy for another" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GeneOrGeneProduct ;
    linkml:definition_uri biolink:GeneOrGeneProduct ;
    linkml:id_prefixes "CHEMBL.TARGET",
        "IUPHAR.FAMILY" ;
    linkml:is_a biolink:MacromolecularMachineMixin ;
    linkml:mixin true ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:macromolecular_machine_mixin_name .

biolink:GenomicSequenceLocalization a linkml:ClassDefinition ;
    dct:description "A relationship between a sequence feature and a genomic entity it is localized to. The reference entity may be a chromosome, chromosome region or information entity such as a contig." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:GenomicSequenceLocalization ;
    linkml:definition_uri biolink:GenomicSequenceLocalization ;
    linkml:is_a biolink:SequenceAssociation ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:end_interbase_coordinate,
        biolink:genome_build,
        biolink:genomic_sequence_localization_object,
        biolink:genomic_sequence_localization_predicate,
        biolink:genomic_sequence_localization_subject,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:phase,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:start_interbase_coordinate,
        biolink:strand .

biolink:affects a linkml:SlotDefinition ;
    dct:description "describes an entity that has a direct affect on the state or quality of another existing entity. Use of the 'affects' predicate implies that the affected entity already exists, unlike predicates such as 'affects risk for' and 'prevents, where the outcome is something that may or may not come to be." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    owl:inverseOf biolink:affected_by ;
    ns1:exactMatch RTXKG1:affects,
        <https://skr3.nlm.nih.gov/SemMedDBAFFECTS>,
        <https://skr3.nlm.nih.gov/SemMedDBaffects>,
        <https://www.dgidb.org/interaction_typesaffects> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:GOREL_0001006,
        OBO:NCIT_R100,
        OBO:NCIT_R101,
        OBO:NCIT_R102,
        OBO:NCIT_R113,
        OBO:NCIT_R124,
        OBO:NCIT_R133,
        OBO:NCIT_R146,
        OBO:NCIT_R150,
        OBO:NCIT_R158,
        OBO:NCIT_R160,
        OBO:NCIT_R173,
        OBO:NCIT_R23,
        OBO:NCIT_R25,
        OBO:NCIT_R30,
        OBO:NCIT_R72,
        OBO:NCIT_gene_mapped_to_disease,
        OBO:RO_0002263,
        OBO:RO_0002264,
        OBO:RO_0002343,
        OBO:RO_0002355,
        OBO:RO_0002591,
        OBO:RO_0002592,
        OBO:RO_0012003,
        OBO:SNOMED_has_pathological_process,
        OBO:UPHENO_0000001,
        <http://translator.ncats.nih.gov/CTD_inferred>,
        <http://translator.ncats.nih.gov/CTD_prediction_hypothesis>,
        <https://skr3.nlm.nih.gov/SemMedDBadministered_to> ;
    ns1:relatedMatch DRUGBANK:pathway ;
    linkml:definition_uri biolink:affects ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:affects ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:affects .

biolink:Gene a linkml:ClassDefinition ;
    dct:description "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene locus may include regulatory regions, transcribed regions and/or other functional sequence regions." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "locus" ;
    ns1:exactMatch OBO:SO_0000704,
        <http://semanticscience.org/resource/SIO_010035>,
        WIKIDATA:Q7187 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Gene ;
    linkml:definition_uri biolink:Gene ;
    linkml:id_prefixes "ENSEMBL",
        "FB",
        "HGNC",
        "KEGG.GENE",
        "MGI",
        "NCBIGene",
        "OMIM",
        "POMBASE",
        "RGD",
        "SGD",
        "UMLS",
        "WB",
        "WormBase",
        "ZFIN",
        "dictyBase" ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:mixins biolink:GeneOrGeneProduct ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:symbol,
        biolink:synonym,
        biolink:type,
        biolink:xref .

biolink:predicate_type a linkml:TypeDefinition ;
    dct:description "A CURIE from the biolink related_to hierarchy. For example, biolink:related_to, biolink:causes, biolink:treats." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:base "URIorCURIE" ;
    linkml:definition_uri biolink:PredicateType ;
    linkml:repr "str" ;
    linkml:typeof biolink:uriorcurie ;
    linkml:uri xsd:anyURI .

biolink:GenomicEntity a linkml:ClassDefinition ;
    dct:description "an entity that can either be directly located on a genome (gene, transcript, exon, regulatory region) or is encoded in a genome (protein)" ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "sequence feature" ;
    ns1:exactMatch OBO:GENO_0000897,
        OBO:SO_0000110,
        UMLSSG:GENE ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch UMLSSC:T028,
        UMLSSC:T086,
        UMLSST:gngm,
        UMLSST:nusq ;
    linkml:class_uri biolink:GenomicEntity ;
    linkml:definition_uri biolink:GenomicEntity ;
    linkml:is_a biolink:MolecularEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:has_biological_sequence,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:SequenceVariant a linkml:ClassDefinition ;
    dct:description "An allele that varies in its sequence from what is considered the reference allele at that locus." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:altLabel "allele" ;
    ns1:broadMatch OBO:SO_0001060 ;
    ns1:exactMatch OBO:GENO_0000002,
        OBO:SO_0001059,
        <http://semanticscience.org/resource/SIO_010277>,
        VMC:Allele,
        WIKIDATA:Q15304597 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "This class is for modeling the specific state at a locus. A single DBSNP rs ID could correspond to more than one sequence variants (e.g CIViC:1252 and CIViC:1253, two distinct BRCA2 alleles for rs28897743)" ;
    linkml:alt_descriptions [ a linkml:AltDescription ;
            dct:description "An entity that describes a single affected, endogenous allele. These can be of any type that matches that definition" ;
            linkml:source "AGR" ],
        [ a linkml:AltDescription ;
            dct:description "A contiguous change at a Location" ;
            linkml:source "VMC" ] ;
    linkml:class_uri biolink:SequenceVariant ;
    linkml:definition_uri biolink:SequenceVariant ;
    linkml:id_prefixes "CAID",
        "CLINVAR",
        "ClinVarVariant",
        "DBSNP",
        "FB",
        "MGI",
        "WB",
        "WIKIDATA",
        "WormBase",
        "ZFIN" ;
    linkml:is_a biolink:GenomicEntity ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "allele" ;
            linkml:local_name_source "agr" ] ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:sequence_variant_has_biological_sequence,
        biolink:sequence_variant_has_gene,
        biolink:sequence_variant_id,
        biolink:source,
        biolink:type .

biolink:OntologyClass a linkml:ClassDefinition ;
    dct:description "a concept or class in an ontology, vocabulary or thesaurus. Note that nodes in a biolink compatible KG can be considered both instances of biolink classes, and OWL classes in their own right. In general you should not need to use this class directly. Instead, use the appropriate biolink class. For example, for the GO concept of endocytosis (GO:0006897), use bl:BiologicalProcess as the type." ;
    rdfs:seeAlso <https://github.com/biolink/biolink-model/issues/486> ;
    ns1:exactMatch schema:Class,
        owl:Class ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "Note that formally this is a metaclass. Instances of this class are instances in the graph, but can be the object of 'type' edges. For example, if we had a node in the graph representing a specific brain of a specific patient (e.g brain001), this could have  a category of bl:Sample, and by typed more specifically with an ontology class UBERON:nnn, which has as category bl:AnatomicalEntity",
        "This is modeled as a mixin. 'ontology class' should not be the primary type of a node in the KG. Instead you should use an informative bioloink category, such as AnatomicalEntity (for Uberon classes), ChemicalSubstance (for CHEBI or CHEMBL), etc" ;
    linkml:class_uri biolink:OntologyClass ;
    linkml:definition_uri biolink:OntologyClass ;
    linkml:examples [ a linkml:Example ;
            dct:description "the class 'brain' from the Uberon anatomy ontology" ;
            ns1:example "UBERON:0000955" ] ;
    linkml:id_prefixes "KEGG.BRITE",
        "MESH",
        "UMLS" ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:Occurrent a linkml:ClassDefinition ;
    dct:description "A processual entity." ;
    ns1:exactMatch OBO:BFO_0000003 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:Occurrent ;
    linkml:definition_uri biolink:Occurrent ;
    linkml:is_a biolink:PhysicalEssenceOrOccurrent ;
    linkml:mixin true ;
    linkml:slot_usage [ ] .

biolink:association_slot a linkml:SlotDefinition ;
    dct:description "any slot that relates an association to another entity" ;
    ns1:altLabel "edge property",
        "statement property" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:abstract true ;
    linkml:definition_uri biolink:association_slot ;
    linkml:domain biolink:Association ;
    linkml:owner biolink:association_slot ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:association_slot .

biolink:ChemicalSubstance a linkml:ClassDefinition ;
    dct:description "May be a chemical entity or a formulation with a chemical entity as active ingredient, or a complex material with multiple chemical entities as part" ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:broadMatch UMLSSC:T167,
        UMLSST:sbst ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_010004>,
        UMLSSC:T103,
        UMLSST:chem,
        WIKIDATA:Q79529 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:CHEBI_24431,
        UMLSSC:T104,
        UMLSSC:T109,
        UMLSSC:T114,
        UMLSSC:T120,
        UMLSSC:T122,
        UMLSSC:T130,
        UMLSSC:T131,
        UMLSSC:T196,
        UMLSSC:T197,
        UMLSST:bodm,
        UMLSST:chvf,
        UMLSST:chvs,
        UMLSST:elii,
        UMLSST:hops,
        UMLSST:inch,
        UMLSST:irda,
        UMLSST:nnon,
        UMLSST:orch ;
    linkml:class_uri biolink:ChemicalSubstance ;
    linkml:definition_uri biolink:ChemicalSubstance ;
    linkml:id_prefixes "Aeolus",
        "CAS",
        "CHEBI",
        "CHEMBL.COMPOUND",
        "ChemBank",
        "DRUGBANK",
        "DrugCentral",
        "GTOPDB",
        "HMDB",
        "INCHI",
        "INCHIKEY",
        "KEGG.COMPOUND",
        "KEGG.DGROUP",
        "KEGG.DRUG",
        "KEGG.ENVIRON",
        "KEGG.GLYCAN",
        "MESH",
        "PUBCHEM.COMPOUND",
        "PUBCHEM.SUBSTANCE",
        "SIDER.DRUG",
        "UNII" ;
    linkml:is_a biolink:MolecularEntity ;
    linkml:mixins biolink:OntologyClass ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:is_metabolite,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:Publication a linkml:ClassDefinition ;
    dct:description "Any published piece of information. Can refer to a whole publication, its encompassing publication (i.e. journal or book) or to a part of a publication, if of significant knowledge scope (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web, as well as printed materials, either directly or in one of the Publication Biolink category subclasses." ;
    oboInOwl:inSubset biolink:model_organism_database ;
    ns1:exactMatch OBO:IAO_0000311 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:IAO_0000013,
        UMLSSC:T170,
        UMLSST:inpr ;
    linkml:class_uri biolink:Publication ;
    linkml:definition_uri biolink:Publication ;
    linkml:id_prefixes "NLMID" ;
    linkml:is_a biolink:InformationContentEntity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:authors,
        biolink:creation_date,
        biolink:description,
        biolink:format,
        biolink:has_attribute,
        biolink:iri,
        biolink:keywords,
        biolink:license,
        biolink:mesh_terms,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:publication_id,
        biolink:publication_name,
        biolink:publication_pages,
        biolink:publication_type,
        biolink:rights,
        biolink:source,
        biolink:summary,
        biolink:xref .

biolink:node_property a linkml:SlotDefinition ;
    dct:description "A grouping for any property that holds between a node and a value" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:node_property ;
    linkml:domain biolink:NamedThing ;
    linkml:owner biolink:node_property ;
    linkml:range biolink:string ;
    linkml:slot_uri biolink:node_property .

biolink:string a linkml:TypeDefinition ;
    dct:description "A character string" ;
    ns1:inScheme linkml:types ;
    linkml:base "str" ;
    linkml:definition_uri linkml:String ;
    linkml:imported_from "linkml:types" ;
    linkml:uri xsd:string .

biolink:related_to a linkml:SlotDefinition ;
    dct:description "A relationship that is asserted between two named things" ;
    ns1:broadMatch owl:topObjectProperty ;
    ns1:exactMatch UMLS:related_to,
        <https://skr3.nlm.nih.gov/SemMedDBASSOCIATED_WITH>,
        <https://skr3.nlm.nih.gov/SemMedDBassociated_with>,
        skos:relatedMatch ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch HMDB:disease,
        HMDB:has_protein_association,
        MESH:RO,
        MESH:has_mapping_qualifier,
        MESH:mapped_to,
        UMLS:RO,
        UMLS:RQ,
        UMLS:class_code_classified_by,
        UMLS:exhibited_by,
        UMLS:has_context_binding,
        UMLS:has_form,
        UMLS:has_mapping_qualifier,
        UMLS:larger_than,
        UMLS:mapped_to,
        UMLS:owning_section_of,
        RTXKG1:functionally_related_to,
        LOINC:has_answer,
        LOINC:has_challenge,
        LOINC:has_evaluation,
        LOINC:mapped_to,
        LOINC:mth_has_expanded_form,
        HCPCS:mapped_to,
        RXNORM:has_form,
        RXNORM:reformulated_to,
        OBO:BFO_0000054,
        OBO:BFO_0000068,
        OBO:BFO_0000069,
        OBO:BTO_related_to,
        OBO:CHEBI_is_conjugate_acid_of,
        OBO:CHEBI_is_conjugate_base_of,
        OBO:FMA_connected_to,
        OBO:FMA_continuous_with,
        OBO:FMA_homonym_of,
        OBO:FMA_related_developmental_entity_of,
        OBO:GOREL_0002005,
        OBO:GOREL_0012006,
        OBO:IAO_0000136,
        OBO:MONDO_disease_shares_features_of,
        OBO:NCIT_disease_may_have_associated_disease,
        OBO:NCIT_human_disease_maps_to_eo_disease,
        OBO:NCIT_is_abnormal_cell_of_disease,
        OBO:NCIT_is_related_to_endogenous_product,
        OBO:RO_0000052,
        OBO:RO_0000053,
        OBO:RO_0002001,
        OBO:RO_0002002,
        OBO:RO_0002003,
        OBO:RO_0002008,
        OBO:RO_0002084,
        OBO:RO_0002092,
        OBO:RO_0002093,
        OBO:RO_0002134,
        OBO:RO_0002150,
        OBO:RO_0002159,
        OBO:RO_0002176,
        OBO:RO_0002177,
        OBO:RO_0002178,
        OBO:RO_0002179,
        OBO:RO_0002314,
        OBO:RO_0002322,
        OBO:RO_0002328,
        OBO:RO_0002332,
        OBO:RO_0002338,
        OBO:RO_0002339,
        OBO:RO_0002341,
        OBO:RO_0002342,
        OBO:RO_0002344,
        OBO:RO_0002348,
        OBO:RO_0002349,
        OBO:RO_0002356,
        OBO:RO_0002371,
        OBO:RO_0002372,
        OBO:RO_0002373,
        OBO:RO_0002374,
        OBO:RO_0002385,
        OBO:RO_0002387,
        OBO:RO_0002451,
        OBO:RO_0002494,
        OBO:RO_0002495,
        OBO:RO_0002568,
        OBO:RO_0002573,
        OBO:RO_0004026,
        OBO:RO_0004027,
        OBO:RO_0009001,
        OBO:RO_0009004,
        OBO:SNOMED_has_associated_morphology,
        OBO:SNOMED_has_associated_procedure,
        OBO:SNOMED_has_direct_morphology,
        OBO:SNOMED_has_disposition,
        OBO:SNOMED_has_indirect_morphology,
        OBO:SNOMED_has_modification,
        OBO:SNOMED_has_procedure_morphology,
        OBO:SNOMED_has_specimen_source_morphology,
        OBO:SNOMED_inheres_in,
        OBO:SNOMED_is_interpreted_by,
        OBO:SNOMED_relative_to_part_of,
        OBO:UBERON_synapsed_by,
        <http://purl.obolibrary.org/obo/core#connected_to>,
        <http://purl.obolibrary.org/obo/core#innervated_by>,
        <http://purl.obolibrary.org/obo/envo#has_increased_levels_of>,
        OBO:has_role,
        <http://purl.obolibrary.org/obo/nbo#is_about>,
        PATO-PROPERTY:decreased_in_magnitude_relative_to,
        PATO-PROPERTY:has_cross_section,
        PATO-PROPERTY:has_relative_magnitude,
        PATO-PROPERTY:increased_in_magnitude_relative_to,
        PATO-PROPERTY:reciprocal_of,
        UBERON_CORE:protects,
        <http://www.ebi.ac.uk/efo/EFO_0006351>,
        <https://skr3.nlm.nih.gov/SemMedDBcompared_with>,
        <https://skr3.nlm.nih.gov/SemMedDBhigher_than>,
        <https://skr3.nlm.nih.gov/SemMedDBlower_than>,
        CPT:has_add_on_code,
        CPT:mapped_to ;
    linkml:definition_uri biolink:related_to ;
    linkml:domain biolink:NamedThing ;
    linkml:inherited true ;
    linkml:multivalued true ;
    linkml:owner biolink:related_to ;
    linkml:range biolink:NamedThing ;
    linkml:slot_uri biolink:related_to ;
    linkml:symmetric true .

biolink:in_taxon a linkml:SlotDefinition ;
    dct:description "connects an entity to its taxonomic classification. Only certain kinds of entities can be taxonomically classified; see 'thing with taxon'" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:altLabel "instance of" ;
    ns1:closeMatch OBO:NCIT_is_organism_source_of_gene_product,
        OBO:NCIT_organism_has_gene ;
    ns1:exactMatch WIKIDATA_PROPERTY:P703 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch OBO:NCIT_gene_found_in_organism,
        OBO:NCIT_gene_product_has_organism_source,
        OBO:RO_0002160 ;
    ns1:relatedMatch OBO:RO_0002162 ;
    linkml:definition_uri biolink:in_taxon ;
    linkml:domain biolink:ThingWithTaxon ;
    linkml:domain_of biolink:ThingWithTaxon ;
    linkml:inherited true ;
    linkml:is_a biolink:related_to ;
    linkml:multivalued true ;
    linkml:owner biolink:ThingWithTaxon ;
    linkml:range biolink:OrganismTaxon ;
    linkml:slot_uri biolink:in_taxon .

biolink:association_category a linkml:SlotDefinition ;
    dct:description """Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class.
 * In a neo4j database this MAY correspond to the neo4j label tag.
 * In an RDF database it should be a biolink model class URI.
This field is multi-valued. It should include values for ancestors of the biolink class; for example, a protein such as Shh would have category values `biolink:Protein`, `biolink:GeneProduct`, `biolink:MolecularEntity`, ...
In an RDF database, nodes will typically have an rdf:type triples. This can be to the most specific biolink class, or potentially to a class more specific than something in biolink. For example, a sequence feature `f` may have a rdf:type assertion to a SO class such as TF_binding_site, which is more specific than anything in biolink. Here we would have categories {biolink:GenomicEntity, biolink:MolecularEntity, biolink:NamedThing}""" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "category" ;
    linkml:definition_uri biolink:category ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Association ;
    linkml:is_a biolink:category ;
    linkml:is_class_field true ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:Association ;
    linkml:range biolink:category_type ;
    linkml:slot_uri biolink:category ;
    linkml:usage_slot_name "category" .

biolink:negated a linkml:SlotDefinition ;
    dct:description "if set to true, then the association is negated i.e. is not true" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:negated ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:Association ;
    linkml:range biolink:boolean ;
    linkml:slot_uri biolink:negated .

biolink:publications a linkml:SlotDefinition ;
    dct:description "connects an association to publications supporting the association" ;
    ns1:altLabel "publication" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:publications ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:multivalued true ;
    linkml:owner biolink:Association ;
    linkml:range biolink:Publication ;
    linkml:slot_uri biolink:publications .

biolink:association_type a linkml:SlotDefinition ;
    dct:description "connects an association to the category of association (e.g. gene to phenotype)",
        "rdf:type of biolink:Association should be fixed at rdf:Statement" ;
    ns1:exactMatch gff3:type,
        gpi:DB_Object_Type,
        alliancegenome:soTermId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:type ;
    ns1:prefLabel "type" ;
    linkml:definition_uri biolink:association_type,
        biolink:type ;
    linkml:deprecated "This slot is deprecated in favor of 'category' slot." ;
    linkml:deprecated_element_has_exact_replacement biolink:category ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Association ;
    linkml:is_a biolink:association_slot,
        biolink:type ;
    linkml:is_usage_slot true ;
    linkml:owner biolink:Association,
        biolink:association_type ;
    linkml:range biolink:category_type,
        biolink:string ;
    linkml:slot_uri rdf:type,
        biolink:association_type ;
    linkml:usage_slot_name "type" .

biolink:qualifiers a linkml:SlotDefinition ;
    dct:description "connects an association to qualifiers that modify or qualify the meaning of that association" ;
    ns1:altLabel "qualifier" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:qualifiers ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Association ;
    linkml:inlined true ;
    linkml:is_a biolink:association_slot ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "annotation qualifier" ;
            linkml:local_name_source "ga4gh" ] ;
    linkml:multivalued true ;
    linkml:owner biolink:Association ;
    linkml:range biolink:OntologyClass ;
    linkml:slot_uri biolink:qualifiers .

biolink:relation a linkml:SlotDefinition ;
    dct:description "The relation which describes an association between a subject and an object in a more granular manner. Usually this is a term from Relation Ontology, but it can be any edge CURIE." ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:relation ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Association ;
    linkml:id_prefixes "BSPO",
        "RO",
        "SIO" ;
    linkml:is_a biolink:association_slot ;
    linkml:owner biolink:Association ;
    linkml:range biolink:uriorcurie ;
    linkml:required true ;
    linkml:slot_uri biolink:relation .

biolink:Association a linkml:ClassDefinition ;
    dct:description "A typed association between two entities, supported by evidence" ;
    ns1:exactMatch OBAN:association,
        rdf:Statement,
        owl:Axiom ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:note "This is roughly the model used by biolink and ontobio at the moment" ;
    linkml:class_uri biolink:Association ;
    linkml:definition_uri biolink:Association ;
    linkml:is_a biolink:Entity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:association_category,
        biolink:association_type,
        biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:negated,
        biolink:object,
        biolink:predicate,
        biolink:provided_by,
        biolink:publications,
        biolink:qualifiers,
        biolink:relation,
        biolink:source,
        biolink:subject .

biolink:predicate a linkml:SlotDefinition ;
    dct:description "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    ns1:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    ns1:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:predicate ;
    linkml:definition_uri biolink:predicate ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "annotation predicate" ;
            linkml:local_name_source "ga4gh" ],
        [ a linkml:LocalName ;
            ns1:altLabel "predicate" ;
            linkml:local_name_source "translator" ] ;
    linkml:owner biolink:Association ;
    linkml:range biolink:predicate_type ;
    linkml:required true ;
    linkml:slot_uri rdf:predicate .

biolink:named_thing_category a linkml:SlotDefinition ;
    dct:description """Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class.
 * In a neo4j database this MAY correspond to the neo4j label tag.
 * In an RDF database it should be a biolink model class URI.
This field is multi-valued. It should include values for ancestors of the biolink class; for example, a protein such as Shh would have category values `biolink:Protein`, `biolink:GeneProduct`, `biolink:MolecularEntity`, ...
In an RDF database, nodes will typically have an rdf:type triples. This can be to the most specific biolink class, or potentially to a class more specific than something in biolink. For example, a sequence feature `f` may have a rdf:type assertion to a SO class such as TF_binding_site, which is more specific than anything in biolink. Here we would have categories {biolink:GenomicEntity, biolink:MolecularEntity, biolink:NamedThing}""" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:prefLabel "category" ;
    linkml:definition_uri biolink:category ;
    linkml:domain biolink:NamedThing ;
    linkml:domain_of biolink:NamedThing ;
    linkml:is_a biolink:category ;
    linkml:is_class_field true ;
    linkml:is_usage_slot true ;
    linkml:multivalued true ;
    linkml:owner biolink:NamedThing ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri biolink:category ;
    linkml:usage_slot_name "category" .

biolink:type a linkml:SlotDefinition ;
    ns1:exactMatch gff3:type,
        gpi:DB_Object_Type,
        alliancegenome:soTermId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:type ;
    linkml:definition_uri biolink:type ;
    linkml:domain_of biolink:Entity ;
    linkml:owner biolink:Entity ;
    linkml:range biolink:string ;
    linkml:slot_uri rdf:type .

biolink:MolecularEntity a linkml:ClassDefinition ;
    dct:description "A gene, gene product, small molecule or macromolecule (including protein complex)\"" ;
    ns1:altLabel "bioentity" ;
    ns1:exactMatch OBO:CHEBI_24431 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch <http://semanticscience.org/resource/SIO_010341>,
        UMLSSG:CHEM,
        UMLSSC:T085,
        UMLSSC:T123,
        UMLSSC:T125,
        UMLSSC:T126,
        UMLSSC:T129,
        UMLSSC:T192,
        UMLSST:bacs,
        UMLSST:enzy,
        UMLSST:horm,
        UMLSST:imft,
        UMLSST:mosq,
        UMLSST:rcpt,
        WIKIDATA:Q43460564 ;
    linkml:class_uri biolink:MolecularEntity ;
    linkml:definition_uri biolink:MolecularEntity ;
    linkml:is_a biolink:BiologicalEntity ;
    linkml:mixins biolink:OntologyClass,
        biolink:PhysicalEssence,
        biolink:ThingWithTaxon ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:in_taxon,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:object a linkml:SlotDefinition ;
    dct:description "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:object ;
    linkml:definition_uri biolink:object ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "node with incoming relationship" ;
            linkml:local_name_source "neo4j" ],
        [ a linkml:LocalName ;
            ns1:altLabel "descriptor" ;
            linkml:local_name_source "ga4gh" ] ;
    linkml:owner biolink:Association ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri rdf:object .

biolink:translator_minimal a linkml:SubsetDefinition ;
    dct:description "Minimum subset of translator work" ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:TranslatorMinimal .

biolink:has_attribute a linkml:SlotDefinition ;
    dct:description "connects any entity to an attribute" ;
    oboInOwl:inSubset biolink:samples ;
    ns1:closeMatch OBO:OBI_0001927 ;
    ns1:exactMatch <http://semanticscience.org/resource/SIO_000008> ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:narrowMatch DRUGBANK:category,
        UMLS:has_structural_class,
        UMLS:has_supported_concept_property,
        UMLS:has_supported_concept_relationship,
        UMLS:may_be_qualified_by,
        LOINC:has_action_guidance,
        LOINC:has_adjustment,
        LOINC:has_aggregation_view,
        LOINC:has_approach_guidance,
        LOINC:has_divisor,
        LOINC:has_exam,
        LOINC:has_method,
        LOINC:has_modality_subtype,
        LOINC:has_object_guidance,
        LOINC:has_scale,
        LOINC:has_suffix,
        LOINC:has_time_aspect,
        LOINC:has_time_modifier,
        LOINC:has_timing_of,
        OBO:INO_0000154,
        OBO:NCIT_disease_is_grade,
        OBO:NCIT_disease_is_stage,
        OBO:NCIT_eo_disease_has_property_or_attribute,
        OBO:NCIT_has_data_element,
        OBO:NCIT_has_pharmaceutical_administration_method,
        OBO:NCIT_has_pharmaceutical_basic_dose_form,
        OBO:NCIT_has_pharmaceutical_intended_site,
        OBO:NCIT_has_pharmaceutical_release_characteristics,
        OBO:NCIT_has_pharmaceutical_state_of_matter,
        OBO:NCIT_has_pharmaceutical_transformation,
        OBO:NCIT_is_qualified_by,
        OBO:NCIT_qualifier_applies_to,
        OBO:NCIT_role_has_domain,
        OBO:NCIT_role_has_range,
        OBO:OMIM_has_inheritance_type,
        OBO:RO_0000053,
        OBO:RO_0000086,
        OBO:RO_0000087,
        OBO:SNOMED_has_access,
        OBO:SNOMED_has_clinical_course,
        OBO:SNOMED_has_count_of_base_of_active_ingredient,
        OBO:SNOMED_has_dose_form_administration_method,
        OBO:SNOMED_has_dose_form_release_characteristic,
        OBO:SNOMED_has_dose_form_transformation,
        OBO:SNOMED_has_finding_context,
        OBO:SNOMED_has_finding_informer,
        OBO:SNOMED_has_inherent_attribute,
        OBO:SNOMED_has_intent,
        OBO:SNOMED_has_interpretation,
        OBO:SNOMED_has_laterality,
        OBO:SNOMED_has_measurement_method,
        OBO:SNOMED_has_method,
        OBO:SNOMED_has_priority,
        OBO:SNOMED_has_procedure_context,
        OBO:SNOMED_has_process_duration,
        OBO:SNOMED_has_property,
        OBO:SNOMED_has_revision_status,
        OBO:SNOMED_has_scale_type,
        OBO:SNOMED_has_severity,
        OBO:SNOMED_has_specimen,
        OBO:SNOMED_has_state_of_matter,
        OBO:SNOMED_has_subject_relationship_context,
        OBO:SNOMED_has_surgical_approach,
        OBO:SNOMED_has_technique,
        OBO:SNOMED_has_temporal_context,
        OBO:SNOMED_has_time_aspect,
        OBO:SNOMED_has_units,
        OBAN:association_has_object_property,
        OBAN:association_has_subject_property,
        <http://www.ebi.ac.uk/ancestro/ancestro_0301>,
        <http://www.ebi.ac.uk/ancestro/ancestro_0308>,
        <http://www.ebi.ac.uk/efo/EFO_is_executed_in>,
        <http://www.orpha.net/ORDO/Orphanet_C016>,
        <http://www.orpha.net/ORDO/Orphanet_C017>,
        CPT:has_possibly_included_panel_element ;
    linkml:definition_uri biolink:has_attribute ;
    linkml:domain biolink:Entity ;
    linkml:domain_of biolink:Entity ;
    linkml:inlined true ;
    linkml:multivalued true ;
    linkml:owner biolink:Entity ;
    linkml:range biolink:Attribute ;
    linkml:slot_uri biolink:has_attribute .

biolink:NamedThing a linkml:ClassDefinition ;
    dct:description "a databased entity or concept/class" ;
    ns1:exactMatch OBO:BFO_0000001,
        UMLSSG:OBJC,
        UMLSSC:T071,
        UMLSST:enty,
        WIKIDATA:Q35120 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:class_uri biolink:NamedThing ;
    linkml:definition_uri biolink:NamedThing ;
    linkml:is_a biolink:Entity ;
    linkml:slot_usage [ ] ;
    linkml:slots biolink:description,
        biolink:has_attribute,
        biolink:id,
        biolink:iri,
        biolink:name,
        biolink:named_thing_category,
        biolink:provided_by,
        biolink:source,
        biolink:type .

biolink:subject a linkml:SlotDefinition ;
    dct:description "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    ns1:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdf:subject ;
    linkml:definition_uri biolink:subject ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Association ;
    linkml:is_a biolink:association_slot ;
    linkml:local_names [ a linkml:LocalName ;
            ns1:altLabel "node with outgoing relationship" ;
            linkml:local_name_source "neo4j" ],
        [ a linkml:LocalName ;
            ns1:altLabel "annotation subject" ;
            linkml:local_name_source "ga4gh" ] ;
    linkml:owner biolink:Association ;
    linkml:range biolink:NamedThing ;
    linkml:required true ;
    linkml:slot_uri rdf:subject .

biolink:provided_by a linkml:SlotDefinition ;
    dct:description "connects an association to the agent (person, organization or group) that provided it" ;
    ns1:exactMatch pav:providedBy ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:provided_by ;
    linkml:domain biolink:Association ;
    linkml:domain_of biolink:Entity ;
    linkml:is_a biolink:association_slot ;
    linkml:multivalued true ;
    linkml:owner biolink:Entity ;
    linkml:range biolink:Agent ;
    linkml:slot_uri biolink:provided_by .

biolink:description a linkml:SlotDefinition ;
    dct:description "a human-readable description of an entity" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:altLabel "definition" ;
    ns1:exactMatch OBO:IAO_0000115,
        skos:definitions ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation dct:description ;
    ns1:narrowMatch gff3:Description ;
    linkml:definition_uri biolink:description ;
    linkml:domain_of biolink:Entity ;
    linkml:owner biolink:Entity ;
    linkml:range biolink:narrative_text ;
    linkml:slot_uri dct:description .

biolink:name a linkml:SlotDefinition ;
    dct:description "A human-readable name for an attribute or entity." ;
    oboInOwl:inSubset biolink:samples,
        biolink:translator_minimal ;
    ns1:altLabel "display name",
        "label",
        "title" ;
    ns1:exactMatch gff3:Name,
        gpi:DB_Object_Name ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    ns1:mappingRelation rdfs:label ;
    ns1:narrowMatch dct:title,
        WIKIDATA_PROPERTY:P1476 ;
    linkml:definition_uri biolink:name ;
    linkml:domain_of biolink:Attribute,
        biolink:Entity,
        biolink:MacromolecularMachineMixin ;
    linkml:owner biolink:MacromolecularMachineMixin ;
    linkml:range biolink:label_type ;
    linkml:slot_uri rdfs:label .

biolink:id a linkml:SlotDefinition ;
    dct:description "A unique identifier for an entity. Must be either a CURIE shorthand for a URI or a complete URI" ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:exactMatch gff3:ID,
        gpi:DB_Object_ID,
        alliancegenome:primaryId ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:id ;
    linkml:domain_of biolink:Entity ;
    linkml:identifier true ;
    linkml:owner biolink:Entity ;
    linkml:range biolink:string ;
    linkml:required true ;
    linkml:slot_uri biolink:id .

biolink:iri a linkml:SlotDefinition ;
    dct:description "An IRI for an entity. This is determined by the id using expansion rules." ;
    oboInOwl:inSubset biolink:samples,
        biolink:translator_minimal ;
    ns1:exactMatch WIKIDATA_PROPERTY:P854 ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:iri ;
    linkml:domain_of biolink:Attribute,
        biolink:Entity ;
    linkml:owner biolink:Entity ;
    linkml:range biolink:iri_type ;
    linkml:slot_uri biolink:iri .

biolink:source a linkml:SlotDefinition ;
    dct:description "a lightweight analog to the association class 'has provider' slot, which is the string name, or the authoritative (i.e. database) namespace, designating the origin of the entity to which the slot belongs." ;
    oboInOwl:inSubset biolink:translator_minimal ;
    ns1:inScheme <https://w3id.org/biolink/biolink-model> ;
    linkml:definition_uri biolink:source ;
    linkml:domain_of biolink:Attribute,
        biolink:Entity ;
    linkml:owner biolink:Entity ;
    linkml:range biolink:label_type ;
    linkml:slot_uri biolink:source .


